Clinical trials: Orthopedics
Orthopedic Disorder, Trauma
An Imaging Framework for Clinically Testing New Treatments to Prevent Post-traumatic OA
The immediate goal of the proposed research is to test the value of a new low-cost, low-dose standing CT system for efficient early detection of both joint degeneration and elevated contact stress.
- Conditions
- Orthopedic Disorder, Trauma, Ankle Fractures, Post-traumatic Osteoarthritis
- Trial name
- NCT03809520
- Testing
- pedCAT
- Where
- United States
- Volunteers
- 97 people
- Sponsor
- J L Marsh
Postoperative Pain, Inflammation
Steroids in Total Knee Arthroplasty
The purpose of this study is to evaluate if the use of two small doses of intravenous (IV) steroids around the time of knee replacement surgery decrease a patient's pain or use of pain medication.
- Conditions
- Postoperative Pain, Inflammation, Osteoarthritis
- Trial name
- NCT02219581
- Testing
- Dexamethasone 10 mg, Dexamethasone 20 mg, Standard multimodal pain management regimen
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Thomas L Bradbury
Hip Fracture, Myocardial Ischemia
Pilot Study of Atorvastatin for Orthopedic Surgery Patients
Up to 35% of hip fracture patients have been shown to experience heart injury after surgery, and as many as 10% have a heart attack or die in the three months after surgery.
- Conditions
- Hip Fracture, Myocardial Ischemia, Inflammation
- Trial name
- POST-OP Pilot (NCT02197065)
- Testing
- Atorvastatin
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Hospital for Special Surgery, New York
Surgical Site Infection, Vancomycin
Pharmacokinetics of Preoperative Vancomycin
A study of plasma and tissue vancomycin pharmacokinetics in pediatric surgical patients.
- Trial name
- NCT03453684
- Testing
- Administration of Vancomycin
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Colorado, Denver
Other Surgical Procedures
Ultrasound Guided Distal Sciatic Nerve Block - a Comparison With Nerve Stimulator Technique
For distal sciatic nerve block this prospective, randomised comparison with ultrasound guided distal subepineural block tested the hypothesis, that intraepineural injection of local anesthetic using nerve stimulation technique is…
- Trial name
- NCT01643616
- Testing
- midazolam, Prilocaine 1%, Ropivacaine 0.75%
- Volunteers
- 250 people
- Sponsor
- Helios Research Center
Surgical Site Infection
Nasal Decolonization for Orthopedic Trauma Patients
Many surgical site infections are caused by bacteria that is transferred from a patient's nose to their open surgical wound. Some small studies have shown that putting povidone-iodine in a patient's nose reduces this risk.
- Trial name
- NCT04146116
- Testing
- intranasal povidone-iodine
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- University of Iowa
Radius Fractures
Orthopedic Study of the Aircast StabilAir Wrist Fracture Brace
Objectives: To obtain clinical evidence for the safety and efficacy in using the StabilAir Wrist Fracture Brace for the following cases: 1.
- Trial name
- NCT00587795
- Testing
- StabilAir Wrist Brace, Placement of sugar tong splint or plaster cast
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Mayo Clinic
Fractures, Closed, Wounds and Injuries
Antibiotic Prophylaxis in Orthopaedic Traumatology
It has been established that providing antibiotic prophylaxis after closed fracture fixation with implants or prosthetic devices has beneficial effects.
- Trial name
- NCT00610987
- Testing
- cefazolin
- Where
- United States
- Volunteers
- 178 people
- Sponsor
- University of Missouri-Columbia
Deep Vein Thrombosis
A Safety and Efficacy Study of BCD-080 Compared to Clexan for Deep Vein Thrombosis Prophylaxis at Orthopedic Surgeries
The purpose of the study is to prove equivalence of efficacy and safety of BCD-080 and Clexan for deep vein thrombosis and embolism prophylaxis at orthopedic surgeries.
- Trial name
- NCT02368314
- Testing
- Sodium Enoxaparine
- Where
- Russia
- Volunteers
- 124 people
- Sponsor
- Biocad
Orthopedic Disorders, Injury of Anterior Cruciate Ligament
Injection Pressure & Adductor Canal Block
This is a prospective, randomized, single-blinded human clinical trial that will examine how injection pressure influences the spread of a given volume of injectate in the adductor canal, during adductor canal nerve block.
- Trial name
- NCT02563990
- Testing
- High Pressure Injection, Low Pressure Injection
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Miami
Cerebral Palsy
Managing Post-operative Pain in Children With Cerebral Palsy Using a Pain Pump
The purpose of this study is to determine which pain management strategy continuous analgesic pump or orally-should be used in the management of children with cerebral palsy.
- Trial name
- NCT00884650
- Testing
- oral analgesic, intravenous analgesic per pump
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- University of Colorado, Denver
Delirium
Supporting the Health of Adults Undergoing Orthopedic Surgery During the Recovery Period
Delirium (acute confusion) is a highly prevalent condition among hospitalized elders with substantial morbidity within the hospital and beyond.
- Trial name
- SHARP (NCT00586196)
- Testing
- donepezil
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Beth Israel Deaconess Medical Center
Major Depressive Disorder, Surgery
Intraoperative Ketamine Versus Saline in Depressed Patients Undergoing Anesthesia for Non-cardiac Surgery
This study evaluates whether ketamine, given as part of an anesthetic, improves depression symptoms in depressed patients undergoing non-cardiac surgery.
- Conditions
- Major Depressive Disorder, Surgery, Orthopedic Disorder
- Trial name
- NCT03861988
- Testing
- Ketamine
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Stanford University
Venous Thromboembolism
An Observational Study On The Safety And Tolerability Of Prolonged Thrombosis Prophylaxis With Fragmin®
The objective of this study is to observe the safety, tolerability, and compliance in the use of Fragmin® for prolonged thromboprophylaxis in post-surgery high-risk orthopedic patients.
- Trial name
- NCT01046903
- Testing
- Fragmin® (Dalteparin Sodium)
- Volunteers
- 503 people
- Sponsor
- Pfizer