Clinical trials: Orthostatic Intolerance
Postural Orthostatic Tachycardia Syndrome
CRI in POTS in Adolescents
The investigators aim to study whether the Compensatory Reserve Index (CRI) (an FDA approved device that assesses intravascular volume) can be used to evaluate severity of Postural Orthostatic Tachycardia Syndrome (POTS) and…
- Trial name
- POTS (NCT03974737)
- Testing
- CRI device (non-invasive vitals sign measurement)
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Hypertension, Autonomic Dysfunction
Autonomic Regulation of Blood Pressure and Heart Rate During Orthostasis and Exercise in Healthy and Hypertensive Individuals
The goal of this observational study is to assess arterial stiffness and autonomic regulation of blood pressure and heart rate in healthy adults and people with arterial hypertension during orthostatic stress and graded physical…
- Conditions
- Hypertension, Autonomic Dysfunction, Orthostatic Hypotension
- Trial name
- NCT07482462
- Where
- Slovenia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Syncope, Vasovagal, Pain Intensity
Safety/Efficacy Study of Local Anesthetic Prior to Femoral Artery Sheath Removal
This randomized controlled trial will examine the impact of local anesthetic on the frequency of vasovagal reactions and the patients perception of pain during femoral arterial sheath removal after percutaneous coronary…
- Trial name
- NCT00465439
- Testing
- Subcutaneous Lidocaine 2% (Xylocaine) without epinephrine
- Where
- Canada
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Spinal Cord Injuries, Orthostatic Hypotension
Speed of Robotic Leg Movements and Orthostatic Hypotension in Subacute SCI
This study seeks to evaluate whether the speed (cadence) of lower extremity robotic movement has an impact on orthostatic hypotension and upright tolerance when training with the ErigoPro robotic tilt-stepper.
- Trial name
- NCT04029974
- Testing
- ErigoPro
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Methodist Rehabilitation Center
Orthostatic Hypotension, Neurogenic Orthostatic Hypotension
Hypercapnia in Orthostatic Hypotension
The Autonomic (or "automatic") Nervous System (ANS) regulates internal processes, including control of heart rate and blood pressure (BP).
- Trial name
- NCT05295810
- Testing
- Sequential Gas Delivery
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Hypotension, Spinal Cord Injury
Prevention of Low Blood Pressure in Persons With Tetraplegia
The aim of this investigation is to determine the blood pressure response to NOS inhibition, with L-NAME, in persons with tetraplegia compared to non-SCI control subjects and to establish if blood pressure can be increased while…
- Trial name
- NCT00237770
- Testing
- N-Nitro L-arginine-methylester (L-NAME), Head-up Tilt maneuver
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Syncope, Vasovagal
Predictive Factors for Hypotensive Bradycardic Events During Arthroscopic Shoulder Surgery
Patients's demographics and perioperative factors affect the occurrence of hypotensive bradycardic events in the patients undergoing arthroscopic shoulder surgery in the sitting position under interscalene block.
- Trial name
- NCT01926561
- Testing
- Interscalene brachial plexus block
- Where
- South Korea
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Daegu Catholic University Medical Center
Postexercise Hypotension
Histamine as a Molecular Transducer of Adaptation to Exercise
This study is investigating the role of histamine in generating adaptation to exercise
- Trial name
- NCT05206227
- Testing
- Aerobic Exercise, alpha-FMH, Resistance and Aerobic Exercise
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Oregon
Postural Tachycardia Syndrome
Dopamine in Orthostatic Tolerance
One goal of this study is to determine whether people with different amounts of dopamine-beta-hydroxylase (DBH) have different responses to events that affect blood pressure and heart rate.
- Trial name
- NCT00748228
- Testing
- dietary sodium
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Orthostatic Intolerance, Parkinson's Disease
Treatment of Orthostatic Intolerance in Patients With Parkinson's Disease Using Midodrine
This study will evaluate whether treatment with the α1-agonist, midodrine, reduces subjective orthostatic lightheadedness as measured by the Non-Motor Symptoms Scale for Parkinson's Disease (NMSS) questionnaire, in patients with…
- Trial name
- NCT02365012
- Testing
- Midodrine
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Corporal Michael J. Crescenz VA Medical Center
Orthostatic Hypotension, Diabetes Mellitus Type 2
Orthostatic Hypotension and Diabetes Mellitus
Rationale: Orthostatic hypotension increases with age and is associated with increased vascular and all-cause mortality. The prevalence of orthostatic hypotension is also increased in diabetic subjects.
- Trial name
- ODET (NCT00807976)
- Where
- Netherlands
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Medical Research Foundation, The Netherlands
Spinal Cord Injuries (SCI), Orthostatic Hypotension, Dysautonomic
Cardiovascular Function and Response to Stimulation Within the First Year After Spinal Cord Injury
The study aims to explore how cardiovascular function changes in the first year after a spinal cord injury, and to see how different treatments, like spinal stimulation through the skin (transcutaneous spinal stimulation), affect…
- Conditions
- Spinal Cord Injuries (SCI), Orthostatic Hypotension, Dysautonomic, Cardiovascular, Transcutaneous Spinal Stimulation
- Trial name
- NCT06841198
- Testing
- spinal cord transcutaneous stimulation, Ice testing
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Postural Tachycardia Syndrome, Orthostatic Tachycardia
Acute Salt Handling in Orthostatic Intolerance
The investigators will test the hypothesis that patients with chronic orthostatic intolerance or postural orthostatic tachycardia syndrome (OI or POTS) will be unable to conserve urinary sodium as compared to healthy control…
- Conditions
- Postural Tachycardia Syndrome, Orthostatic Tachycardia, Orthostatic Intolerance
- Trial name
- NCT00581633
- Testing
- normal saline (0.9%)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Tachycardia, Postural Orthostatic Tachycardia Syndrome
Pathophysiology of Orthostatic Intolerance
The purpose of this study is to describe the mechanism of orthostatic intolerance, relying on cardiovascular physiological studies.
- Trial name
- NCT00608725
- Testing
- DAXOR, QSweat, Intrinsic Heart Rate
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Satish R. Raj
Vitamin D Deficiency, Orthostatic Intolerance
Vitamin D Deficiency and Dysautonomia
In previous work the investigator identified a group of children between the ages of 10-18 years whose diagnostic workup for chronic nausea unexplained by conventional diagnostic tests has unexpectedly revealed underlying…
- Conditions
- Vitamin D Deficiency, Orthostatic Intolerance, Nausea
- Trial name
- NCT03032328
- Testing
- vitamin D supplement
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Postural Tachycardia Syndrome
Assessment of Vascular Endothelial Function in Postural Tachycardia Syndrome
The purpose of this study is to see if people with Postural Tachycardia Syndrome (POTS) have different levels of certain chemicals in their blood than people who don't have POTS.
- Trial name
- NCT01308099
- Testing
- Blood Pressure and Blood Flow
- Where
- 2 sites in United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Dysautonomia, Anxiety
Implementation of Transdx Group for POTS
The proposed intervention is focused on developing and implementing a psychological approach incorporated into a group-based outpatient intervention for pediatric autonomic dysfunction.
- Conditions
- Dysautonomia, Anxiety, Depression
- Trial name
- NCT03185247
- Testing
- Transdiagnostic Group-Based Treatment
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Postural Orthostatic Tachycardia Syndrome (POTS), POTS
Cardiovagal Baroreflex Deficits Impair Neurovascular Coupling and Cognition in POTS
Postural tachycardia syndrome (POTS), is the chronic form of orthostatic intolerance associated with excessive upright tachycardia, and occurs predominantly in young females (>85%).
- Conditions
- Postural Orthostatic Tachycardia Syndrome (POTS), POTS, Orthostatic Intolerance
- Trial name
- NCT03261570
- Testing
- Pyridostigmine, Digoxin
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- New York Medical College
Chronic Fatigue Syndrome in Adolescence, Postural Orthostatic Tachycardia Syndrome
POTS-CFS Study: Orthostatic Intolerance in the Context of Pediatric ME/CFS
Pilot-case-control study on exertion and orthostatic intolerance of adolescents with myalgic encephalomyelitis/ chronic fatigue syndrome (ME/CFS) compared to age-matched healthy controls (HC).
- Conditions
- Chronic Fatigue Syndrome in Adolescence, Postural Orthostatic Tachycardia Syndrome, Orthostatic Intolerance
- Trial name
- POTS-CFS (NCT06054958)
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Healthy
Effect of Sex on Orthostatic Intolerance and Cardiovascular Response During Lunar Descent and Ascent
The purpose of Lunar OI (Orthostatic Intolerance) is to determine if there are differences between males and females in tolerance to and cardiovascular responses during different angles of head-up tilt simulating gravity levels…
- Trial name
- Lunar OI (NCT06467825)
- Testing
- Potassium Supplement, Furosemide 20 MG, Compression Garment
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- National Aeronautics and Space Administration (NASA)