Clinical trials: Orthostatic Intolerance
Orthostatic Hypotension, Ischemia
Evaluation of the ORTHO-LBNP System
The pilot study aims to evaluate a prototype system that enables military pilots to train under conditions of orthostatic hypotension and ischemic hypoxia.
- Conditions
- Orthostatic Hypotension, Ischemia, Hypoxia
- Trial name
- ORTHO-LBNP (NCT03354234)
- Testing
- Head up tilt (HUT), Lower body negative pressure (LBNP), Head down tilt (HDT)
- Where
- Poland
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Military Institute of Aviation Medicine
Hypotension, Orthostatic Hypotension
Orthostatic Hypotension Among Veterans
Orthostatic hypotension (OH) is defined as a fall in blood pressure when standing. Several different underlying diseases, conditions, or combinations of medicines may contribute to OH; therefore the cause of the condition varies…
- Trial name
- OH (NCT02123303)
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Hypertension, Elevated Blood Pressure
Blood Pressure Following Isometric Exercise in Inactive Adults
This study investigates how isometric exercise training (IET) affects blood pressure in physically inactive adults. Isometric exercise involves sustained muscle contractions without movement-for example, pushing against a fixed…
- Conditions
- Hypertension, Elevated Blood Pressure, Sedentary Lifestlye
- Trial name
- BELIEF-BP (NCT06937164)
- Testing
- Isometric Exercise Training (IET), Expectation-Enhancing Informational Framing
- Where
- United Kingdom
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Canterbury Christ Church University
POTS - Postural Orthostatic Tachycardia Syndrome
Does a Periaqueductal Gray-vagus Nerve Interface Malfunction Explain the Nat hx With Its Numerous Co-morbidities?
Postural tachycardia syndrome (POTS) is a common and disabling disorder among adolescents. No epidemiologic data exist to support the often cited 0.5 to 2% prevalence.
- Trial name
- NCT06616363
- Testing
- Questionnaires to be competed, Provide list of medication and lifetime events, Use phone App to record new life events
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Cardiovascular Abnormalities, Weightlessness
Electroacupuncture is Effective in Cardiac Deconditioning Induced by Head-down Bed Rest
To investigate the changes of cardiovascular function during short-term simulated weightlessness after electroacupuncture (EA) treatment．
- Trial name
- NCT02300207
- Testing
- electronic acupuncture treatment instrument
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Air Force Military Medical University, China
Post-Exercise Hypotension
Resistance Exercise Modify Cardiovascular Responses of Professors During Teaching and Sleep
Both work activity and reduced nocturnal dipping of blood pressure are related to increased cardiovascular risk. The aim of the present study was to assess the hemodynamic and autonomic responses of university professors during…
- Trial name
- NCT02650089
- Testing
- Resistance Exercise Low intensity, Resistance Exercise High intensity, Control
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Universidade Federal do vale do São Francisco
Tachycardia, Chronic Orthostatic Intolerance
Treatment of Orthostatic Intolerance
This trial is designed to study the effects of various mechanistically unique medications in controlling excessive increases in heart rate with standing and in improving the symptoms of orthostatic intolerance in patients with…
- Trial name
- NCT00262470
- Testing
- Acetazolamide, Atomoxetine, NO Drug
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Satish R. Raj
Spinal Cord Injuries, Autonomic Imbalance
Deciphering Preserved Autonomic Function After Spinal Cord Injury
This study looks to characterize gradients of dysfunction in the autonomic nervous system after spinal cord injury. The autonomic nervous system plays key roles in regulation of blood pressure, skin blood flow, and bladder…
- Conditions
- Spinal Cord Injuries, Autonomic Imbalance, Autonomic Dysreflexia, Orthostatic Hypotension
- Trial name
- NCT04493372
- Testing
- Tests of sympathetic inhibition, Tests of sympathetic activation, Testing of autonomic dysreflexia
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Blood Pressure, Orthostatic Hypotension
Effects of Blueberries in Older Adults
This randomized, parallel-design trial will evaluate specific clinical and physiological effects of whole blueberries in adults 70 years of age or older.
- Conditions
- Blood Pressure, Orthostatic Hypotension, Vascular Diseases
- Trial name
- BnD (NCT05358210)
- Testing
- Blueberry Consumption, Dried Date Consumption
- Where
- 2 sites in United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Orthostatic Hypotension
Assessment of Hand-grip in the Prevention of Postural Orthostatic Hypotension
The study is aimed to assess the efficacy of hand-grip in preventing orthostatic hypotension in 20 patients diagnosed with autonomic failure. Five healthy subjects will be studied for comparison.
- Trial name
- NCT01521221
- Testing
- Hand grip maneuver
- Where
- Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Post-acute COVID-19 Syndrome, Postural Tachycardia Syndrome (POTS)
Cardiovascular Autonomic and Immune Mechanism of Post COVID-19 Tachycardia Syndrome
The term post-acute COVID-19 syndrome or Long COVID is a disabling syndrome that persists beyond the 3-month convalescence period after COVID-19 infections.
- Conditions
- Post-acute COVID-19 Syndrome, Postural Tachycardia Syndrome (POTS), Long COVID, SARS CoV 2 Infection
- Trial name
- NCT05421208
- Testing
- Levels of inflammatory cytokine ( IL-6) in post-COVID-19 POTS and controls, Levels of inflammatory cytokine ( IL-6) in controls, Effect on inflammation after chronic PNS stimulation
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Postural Tachycardia Syndrome
Dopamine in Orthostatic Tolerance
One goal of this study is to determine whether people with different amounts of dopamine-beta-hydroxylase (DBH) have different responses to events that affect blood pressure and heart rate.
- Trial name
- NCT00748228
- Testing
- dietary sodium
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University
Hypotension, Orthostatic, Hypotension
Dose Response to the Norepinephrine Precursor Droxidopa in Hypotensive Individuals With Spinal Cord Injury
The goal of this study is to determine the efficacy of the drug Droxidopa (Northera) in increasing blood pressure in subject with hypotension, low blood pressure, which is classified as blood pressure less than 110/70 in males…
- Conditions
- Hypotension, Orthostatic, Hypotension, Spinal Cord Injuries
- Trial name
- NCT03602014
- Testing
- Northera
- Where
- 2 sites in United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Parkinson Disease, Orthostatic Hypotension
Deciphering the Mechanisms of Central BP Regulation in Patients With PD Associated With Orthostatic Hypotension
Phase 1 objective: test the feasibility of using a 3Tesla MRI scanner instead of a 7Tesla MRI scanner to measure brainstem responses to LBNP in healthy participants.
- Trial name
- HYPOPARK (NCT07139756)
- Testing
- Lower body negative pressure
- Where
- Switzerland
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Postural Orthostatic Tachycardia Syndrome
CRI in POTS in Adolescents
The investigators aim to study whether the Compensatory Reserve Index (CRI) (an FDA approved device that assesses intravascular volume) can be used to evaluate severity of Postural Orthostatic Tachycardia Syndrome (POTS) and…
- Trial name
- POTS (NCT03974737)
- Testing
- CRI device (non-invasive vitals sign measurement)
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Tachycardia, Postural Orthostatic Tachycardia Syndrome
Pathophysiology of Orthostatic Intolerance
The purpose of this study is to describe the mechanism of orthostatic intolerance, relying on cardiovascular physiological studies.
- Trial name
- NCT00608725
- Testing
- DAXOR, QSweat, Intrinsic Heart Rate
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Satish R. Raj
Orthostatic Hypotension
Dawn Simulation and Postural Hypotension
One of the most physiologically demanding things that older people do every day is to get up in the morning. After spending a night laying flat, where the blood distributes evenly across the body, when they stand in the morning…
- Trial name
- NCT02632318
- Testing
- Light
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- VA Palo Alto Health Care System
Postural Orthostatic Tachycardia Syndrome
Dietary Sodium's Effect on Urinary Sodium and Dopamine Excretion in Patients With Postural Tachycardia Syndrome
Patients with Postural Tachycardia Syndrome (POTS) may not adequately expand their plasma volume in response to a high sodium diet.
- Trial name
- NCT01563107
- Testing
- Plasma Volume, Exercise Capacity Test - Bicycle, Posture Study
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Diabetes Mellitus, Type 2, Hyperglycemia, Postprandial
Exercise-meal Timing and Postprandial Glucose Control
Physical activity helps maintain optimal postprandial blood glucose control. However, there is a lack of clear information regarding the optimal meal-activity timing required to maximize blood glucose control.
- Conditions
- Diabetes Mellitus, Type 2, Hyperglycemia, Postprandial, Physical Activity, Glucose Intolerance
- Trial name
- NCT03730727
- Testing
- Physical activity, Meal
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Postural Tachycardia Syndrome, Ehlers-Danlos Syndrome
Standing Cognition and Co-morbidities of POTS Evaluation
The purpose of this study is to evaluate cognition in patients with postural tachycardia syndrome (POTS) while lying down and standing and to assess the prevalence of hypermobile Ehlers-Danlos Syndrome in POTS.
- Trial name
- SCOPE (NCT03602482)
- Testing
- Standing, Supine
- Where
- United States
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center