Clinical trials: Osteo Arthritis
Osteo Arthritis Knee
Effect of LANCONONE in Weight-bearing Joint Pain
The current study has been designed to primarily assess the effect of Lanconone® in comparison to placebo on pain in weight bearing joints.
- Trial name
- NCT03658369
- Testing
- Lanconone®, Methyl crystalline cellulose
- Where
- 4 sites in India
- Volunteers
- 72 people
- Sponsor
- Vedic Lifesciences Pvt. Ltd.
Osteo Arthritis Knee
Clinical and Radiographic Outcomes of Medial Open-wedge High Tibial Osteotomy
Osteoarthritis is a common degenerative disorder of the articular cartilage . Risk factors include genetics, female sex, past trauma, advancing age, and obesity.
- Trial name
- NCT04036266
- Testing
- medial open wedge high tibial osteotomy
- Volunteers
- 60 people
- Sponsor
- Assiut University
Osteo Arthritis Knee, Osteoarthritis
Comparison of Alignment Achieved Using the VELYS Robotic-Assisted Solution Versus Manual Instrumentation in Total Knee Arthroplasty
The purpose of this post-market research study is to gather clinical and radiographic (X-ray) information about total knee replacement surgeries completed with the VELYS Robotic-Assisted Solution and with standard manual…
- Trial name
- NCT04730271
- Testing
- Total Knee Replacement
- Where
- 5 sites in United States
- Volunteers
- 200 people
- Sponsor
- DePuy Orthopaedics
Arthropathy of Knee, Osteo Arthritis Knee
Muscle Strength and Total Knee Replacement
Purposes: To compare knee extensor muscle strength, physical function and self-reported function before and after total knee replacement with healthy age-matched controls.
- Trial name
- NCT05248815
- Where
- 3 sites in Sweden
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Vastra Gotaland Region
Osteoarthritis, Knee, Osteoarthritis, Hip
Surgical Joint Registry MBJRF
The purpose of this study is to follow the patient's short term and long term clinical outcome after undergoing joint replacement surgery.
- Trial name
- MBJRFREG (NCT03484325)
- Where
- United States
- Volunteers
- 990 people, healthy volunteers welcome
- Sponsor
- Memorial Bone and Joint Research Foundation
Bone Lesion, Cartilage Degeneration
Efficacy of Bioceramic Materials for Bone Defects Repair
The purpose of this study is to demonstrate the effect of bioceramic implants on the repair of human bone defects, and to explore the application of bioceramic materials in bone defects, bone implantation, and bone fusion.
- Conditions
- Bone Lesion, Cartilage Degeneration, Osteo Arthritis Knee, Bone Fracture
- Trial name
- NCT06249906
- Testing
- Commercial bone implant product Group, Mirco-structured Bioceramic Group
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Osteo Arthritis Knee, Knee Osteoarthritis
Knee Arthritis Treatment With Autologous Fragmented Adipose Tissue and PRP - Comparison of Two Treatment Methods
This is a prospective, randomized, controlled study. The purpose of this study is to assess functional and clinical changes among patients with symptomatic knee OA treated with intra-articular injections of autologous adipose…
- Conditions
- Osteo Arthritis Knee, Knee Osteoarthritis, Knee Pain Chronic, Knee Arthritis
- Trial name
- NCT04321629
- Testing
- autologous adipose tissue transfer, PRP injections
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Rehasport Clinic
Unicompartmental Knee Replacement, Osteo Arthritis Knee
RCT: Mako Medial Unicondylar Knee Arthroplasty vs Oxford Unicondylar Knee Arthroplasty
The overall aim of this prospective, randomised, single-blinded, controlled trial is to compare clinical outcomes and accuracy of implant positioning in Mako robotic UKA versus jig-based Oxford UKA with navigation control.
- Conditions
- Unicompartmental Knee Replacement, Osteo Arthritis Knee, Surgery
- Trial name
- NCT04095637
- Testing
- Medial knee arthroplasty
- Where
- United Kingdom
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University College, London
Osteo Arthritis Knee, Chronic Pain
Addition of Transcranial Direct Current Stimulation and Transcutaneous Electrical Nerve Stimulation to an Education and Exercise Program in Subjects With Chronic Pain Due to Knee Osteoarthritis
Knee osteoarthritis has a very high prevalence in the population over 50 years of age. Patients with osteoarthritis often suffer from chronic pain that becomes disabling, affecting both quality of life and mental and physical…
- Trial name
- NCT05138471
- Testing
- transcranial direct current stimulation (tDCS), TENS, Exercise and General Education
- Where
- Spain
- Volunteers
- 65 people
- Sponsor
- Universidad de Murcia
Osteo Arthritis Knee, Obesity
Effect of Prebiotics on Function and Pain in Patients with Osteoarthritis and Obesity
The purpose of the present study is to determine if prebiotic supplementation can, through changes in the intestinal gut microbiota, lead to improvements in knee function and physical performance and reduce knee pain in adults…
- Trial name
- NCT04172688
- Testing
- Prebiotic oligofructose-enriched inulin
- Where
- Canada
- Volunteers
- 54 people
- Sponsor
- University of Calgary
Osteoarthritis, Osteo Arthritis Knee
Exercise on Knee OA With the Star Excursion Balance Test
Osteoarthritis is a prevalent and disabling condition. Exercise is recommended to maintain strength and mobility, and to decrease pain.
- Trial name
- NCT03450486
- Testing
- exercise
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Western University, Canada
Osteo Arthritis Knee
Efficacy of Mesotherapy Added to Intra-articular Platelet-rich Plasma (PRP) in Patients With Knee Osteoarthritis
In this study, the investigators aimed to determine whether platelet rich plasma (PRP) and mesotherapy combined treatment is effective on pain and function compared to PRP alone in patients with knee osteoarthritis (OA).
- Trial name
- NCT05329116
- Testing
- Lidocaine 2% Injectable Solution, Platelet-rich plasma
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people
- Sponsor
- Necmettin Yildiz
Rhematoid Arthritis, Osteo Arthritis of the Knee
Persona SoluTion PPS Femur PMCF
The goal of this study is to generate clinical evidence and evaluate the safety and performance of the Persona® SoluTion® PPS Femurs in the US market, with data supporting global regulatory submissions, including CE marking under…
- Conditions
- Rhematoid Arthritis, Osteo Arthritis of the Knee, Traumatic Arthritis of Knee (Diagnosis), Polyarthritis
- Trial name
- NCT07286513
- Testing
- Total knee arthroplasty
- Where
- 4 sites in United States
- Volunteers
- 200 people
- Sponsor
- Zimmer Biomet
Osteoarthritis (OA) of the Knee
Total Osteo-Cartilage Replacement for the Treatment of Osteoarthritis of Knee
Young patients who require total knee arthroplasty with metallic and plastic implants will undergo femoral condyle cartilage and top of the tibia with meniscus replacement.
- Trial name
- NCT07769632
- Testing
- Total osteo-cartilage replacement of the distal femur and proximal tibia, including medial and lateral meniscus., allogenic bone and cartilage graft
- Where
- Bahrain
- Volunteers
- 10 people
- Sponsor
- AlSalam Hospital
Osteo Arthritis Knee
Long-Duration Ultrasound for Knee Osteoarthritis
This study will measure the 24-week pain relief from long-duration ultrasound on the symptoms of knee arthritis pain.
- Trial name
- NCT03800927
- Testing
- Long duration ultrasound
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- ZetrOZ, Inc.
Osteo Arthritis of Hip
Use of Cooled Radiofrequency for the Treatment of Hip Pain Associated With OA of the Hip Compared to Intra-articular Steroid Injections
This will be a single-center, prospective, single-blinded randomized clinical trial to investigate the effectiveness of using cooled RFA for the treatment of OA hip pain and function in subjects treated with cooled RFA compared…
- Trial name
- NCT03647332
- Testing
- Cooled RFA treatment, Steroid Drug
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Rothman Institute Orthopaedics
Neuropathic Pain, Osteo Arthritis Knee
WHIRLPOOL FOR OSTEOARHRITIS
Both neuropathic and nociceptive mechanisms may contribute to the OA pain experience. Aims: The aim of this study was to determine the efficacy of warm whirlpool on pain, disability, quality of life (QoL) and sleep for patients…
- Conditions
- Neuropathic Pain, Osteo Arthritis Knee, Sleep Disorder
- Trial name
- NCT03299114
- Testing
- Whirlpool
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ufuk University
Osteo Arthritis of the Knee
Lubricin-inspired Osteoarthritis Treatment: a Unique Solution
This goal of this open label study is to evaluate the safety and tolerability of a single intra-articular administration of ABR1 in adults with knee osteoarthritis with a KL grade from 2 to 4.
- Trial name
- LOTUS (NCT07611708)
- Testing
- ABR1
- Where
- Australia
- Volunteers
- 25 people
- Sponsor
- Pleryon Therapeutics (Hangzhou) Limited
Knee Osteoarthritis, Osteoarthritis
"Bimodal vs Unimodal High-Intensity Pulsed Electromagnetic Field Therapy in Older Adults With Knee Osteoarthritis"
This randomized, double-blind clinical trial aims to evaluate the effect of high-intensity pulsed electromagnetic field therapy (HI-PEMF) applied either exclusively on the knee joint or bimodally on the knee and quadriceps, in…
- Conditions
- Knee Osteoarthritis, Osteoarthritis, Osteo Arthritis of the Knee, Gonarthrosis
- Trial name
- HIPEMF-OAK (NCT07198750)
- Testing
- HI-PEMF - Knee (Chronic Pain Protocol), HI-PEMF - Quadriceps (Muscle Strengthening Protocol), Home-Based Exercise Program
- Where
- Mexico
- Volunteers
- 64 people
- Sponsor
- Hospital Civil de Guadalajara
Osteoarticular Infections
Molecular Microbiology in Osteo-arthritis Infection
Osteoarticular infections are painful and disabling diseases that require antimicrobial treatment adapted to the microorganisms implicated.
- Trial name
- MOLOS (NCT01193803)
- Testing
- Microbiological cultures and Molecular biology
- Where
- France
- Volunteers
- 229 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris