Clinical trials: Osteo Arthritis Knee
Osteo Arthritis Knee
Intraarticular Leukocyte-rich and Leukocyte-poor PRP for Osteoarthritis of the Knee
To compare the efficacy of intraarticular knee injection between leukocyte-rich and leukocyte-poor platelet-rich plasma in knee osteoarthritis treatment
- Trial name
- PRP (NCT05737173)
- Testing
- Leukocyte-rich platelet-rich plasma, Leukocyte-poor platelet-rich plasma, Corticosteroid
- Where
- Thailand
- Volunteers
- 93 people
- Sponsor
- Queen Savang Vadhana Memorial Hospital, Thailand
Osteo Arthritis Knee
Intra-articular Injection of Allogenic Lyophilized Growth Factors in Primary Knee Osteoarthritis
the study was conducted on 31-patients with symptomatic primary knee osteoarthritis. The patients were randomized into intervention and control groups. The control group was kept on their medications without intervention.
- Trial name
- NCT04331327
- Testing
- allogenic lyophilized growth factors
- Where
- Egypt
- Volunteers
- 31 people
- Sponsor
- Rasmia Elgohary
Osteo Arthritis Knee, Pain, Joint
Efficacy of Cannabidiol in Knee Osteoarthritis
Painful symptomatic osteoarthritis (OA) of the knee is a very common disease, especially in older people (lifetime prevalence 9.5%). Current systemic pharmacological treatment options are limited.
- Trial name
- NCT04607603
- Testing
- Cannabidiol Oral Product
- Where
- Austria
- Volunteers
- 86 people
- Sponsor
- Medical University of Vienna
Osteo Arthritis Knee
Rehabilitation Exercise Using Digital Healthcare System in Patients With Total Knee Arthroplasty
The study aims to examine the effect of short-term rehabilitation exercise support using digital healthcare system (Uincare homeplus) in the patients with total knee arthroplasty.
- Trial name
- NCT04513353
- Testing
- Rehabilitation using Digital Healthcare System (Uincare Homeplus), Conventional Rehabilitation
- Where
- 2 sites in South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Bundang Hospital
Osteo Arthritis Knee
Incorporating Patient-Reported Outcomes Into Shared Decision Making With Patients With Osteoarthritis of the Hip or Knee
Osteoarthritis (OA) of the knee constitutes a major public health problem. Treatment options for knee OA range from lifestyle changes to pharmacological management to total knee replacement surgery.
- Trial name
- NCT04805554
- Testing
- Joint Insights decision aid
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Osteo Arthritis of the Knee
Evaluation of Clinical Endpoints of Two Diclofenac Sodium Gel 1%
The objective of this study is to evaluate the clinical equivalence and safety of the Test formulation of diclofenac sodium topical gel 1% (Anchen Pharmaceuticals, Inc.) compared to the marketed formulation Voltaren® Gel…
- Trial name
- NCT01456611
- Testing
- Diclofenac
- Where
- 57 sites in United States
- Volunteers
- 749 people
- Sponsor
- Anchen Pharmaceuticals, Inc
Osteo Arthritis Knee, Total Knee Replacement
LEGION™ Primary Safety and Efficacy
This study will look at the health results of using the LEGION™ Primary Knee System over a period of ten (10) years. This type of surgery uses an artificial knee made of plastic and metal.
- Trial name
- NCT04040985
- Testing
- Total Knee Arthroplasty using LEGION™ Total Knee System
- Where
- 5 sites in United States
- Volunteers
- 128 people
- Sponsor
- Smith & Nephew, Inc.
Osteo Arthritis Knee
The Effect of Smart Ring Assisted Physiotherapeutic Intervention After TKR
The goal of this randomized controlled trial is to learn about the effect of a wearable activity tracker assisted physiotherapeutic intervention on the risk of poor patient reported outcome after a primary total knee replacement.
- Trial name
- SmarTKRing (NCT05599776)
- Testing
- Smart ring assisted physiotherapeutic intervention
- Where
- Finland
- Volunteers
- 338 people
- Sponsor
- Coxa, Hospital for Joint Replacement
Osteo Arthritis Knee, Varus Knee
The Effect of Body Mass Index on Short-term Results of HTO
The knee joint plays a major role in weight transmission of the body in day-to-day activities. The biomechanics of the knee and malalignment in lower limb anatomy are major risk factors for chronic knee pain, leaving Total Knee…
- Trial name
- NCT06590818
- Testing
- High tibial osteotomy (HTO
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Egymedicalpedia
Osteo Arthritis Knee
A Study to Evaluate the Safety of Human Allogeneic Bone-Marrow-Derived Mesenchymal Stromal Cell Product StromaForte for the Treatment of Knee Osteoarthritis
This open-label, single-arm, phase I/II study in mild-to-moderate stage knee osteoarthritis patients is designed to assess the safety and tolerability of intraarticular human allogeneic bone marrow-derived mesenchymal stromal…
- Trial name
- NCT06084988
- Testing
- Human Allogenic Bone-Marrow-Derived Mesenchymal Stromal Cell Product (StromaForte)
- Where
- United Arab Emirates
- Volunteers
- 12 people
- Sponsor
- Cellcolabs Clinical SPV Limited
Osteoarthritis, Osteo Arthritis Knee
Colchicine for the Treatment of Osteoarthritis of the Knee
This prospective, double-blinded, placebo-controlled, randomized trial will enroll 120 SKOA subjects at the NYU Center for Musculoskeletal Care.
- Trial name
- CLOAK (NCT03913442)
- Testing
- Colchicine 0.8 mg or 0.6 mg orally once daily
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- NYU Langone Health
Osteo Arthritis Knee
Kinematic- Versus Ligament-balanced Mechanical Alignment in TKA
A promising new approach in total knee arthroplasty (TKA) for severe osteoarthritis of the knee joint is the the kinematic aligned procedure (KA).
- Trial name
- NCT04436211
- Testing
- Total Knee Arthroplasty
- Where
- Austria
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Osteo Arthritis of the Knee
Combination of Nerve Blocks and Local Infiltration Analgesia in Knee Arthroplasty
The aim of this clinical randomized trial is to compare local infiltration analgesia (LIA) alone versus the combination of LIA with saphenous nerve (SN) block, block of the nerve to vastus medialis (NVM), and anterior femoral…
- Trial name
- BALIA (NCT07350252)
- Testing
- Ropivacain 5 mg/ml + Clonidine
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Region Skane
Osteo Arthritis Knee, Knee Osteoarthritis
Knee Arthritis Treatment With Autologous Fragmented Adipose Tissue and PRP - Comparison of Two Treatment Methods
This is a prospective, randomized, controlled study. The purpose of this study is to assess functional and clinical changes among patients with symptomatic knee OA treated with intra-articular injections of autologous adipose…
- Conditions
- Osteo Arthritis Knee, Knee Osteoarthritis, Knee Pain Chronic, Knee Arthritis
- Trial name
- NCT04321629
- Testing
- autologous adipose tissue transfer, PRP injections
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Rehasport Clinic
Osteo Arthritis Knee
Effect of LANCONONE in Weight-bearing Joint Pain
The current study has been designed to primarily assess the effect of Lanconone® in comparison to placebo on pain in weight bearing joints.
- Trial name
- NCT03658369
- Testing
- Lanconone®, Methyl crystalline cellulose
- Where
- 4 sites in India
- Volunteers
- 72 people
- Sponsor
- Vedic Lifesciences Pvt. Ltd.
Osteo Arthritis Knee, Pain
Exercise-related Irisin on Inflammation and Pain
Osteoarthritis (OA) is a chronic disease that usually starts with cartilage damage in weight-bearing joints and then causes pain and loss of function secondary to damage in surrounding tissues.
- Conditions
- Osteo Arthritis Knee, Pain, Inflammation
- Trial name
- NCT05388994
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Firat University
Osteo Arthritis Knee, Arthritis
Sustained Acoustic Medicine for Symptomatic Treatment of Knee Pain Related to Osteoarthritis
The purpose of this study is to assess the ability of long-duration low intensity therapeutic ultrasound (LITUS) to alleviate knee Osteoarthritis pain over a 24-week period.
- Trial name
- NCT06257537
- Testing
- Sustained Acoustic Device with 2.5% Diclofenac Patch, Sustained Acoustic Device with 0% Diclofenac Patch, 2.5% Diclofenac Patches
- Where
- 3 sites in United States
- Volunteers
- 307 people, healthy volunteers welcome
- Sponsor
- ZetrOZ, Inc.
Osteo Arthritis Knee
High Versus Low Adductor Canal Block
The investigators will be comparing the efficacy of two different techniques for performing an adductor canal block to the saphenous nerve as a part of the multimodal pain control regimen for total knee arthroplasty.
- Trial name
- NCT04155983
- Testing
- Ropivacaine
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Carilion Clinic
Osteo Arthritis Knee, Knee Pain Chronic
Optimizing Pain Self-Management in Total Knee Arthroplasty
The purpose of this study is to investigate the efficacy of a positive affect enhancing intervention designed to reduce pain and augment reward system function in knee osteoarthritis (KOA) patients undergoing total knee…
- Conditions
- Osteo Arthritis Knee, Knee Pain Chronic, Surgery
- Trial name
- NCT06038240
- Testing
- Savoring Meditation, Pain Self-Management and Education
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Virginia
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
External Focus of Attention Posttraumatic Osteoarthritis
Knee injuries, especially those to the ACL, are common among physically active people. These injuries are frequently treated with surgical reconstruction (ACL reconstruction; ACLR).
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Tear, Osteo Arthritis Knee
- Trial name
- NCT04922268
- Testing
- Internal focus of attention feedback, External focus of attention feedback
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of North Carolina, Charlotte