Clinical trials: Osteoarthritic Knee Pain
Knee Osteoarthritis, Knee Pain Chronic
Genicular Artery Embolization (GAE) for Osteoarthritic Knee Pain
The objective of this investigation is to evaluate the safety of the geniculate artery embolization (GAE) procedure with HydroPearl® Microspheres in 30 patients with knee pain caused by osteoarthritis with 24 months follow-up.
- Conditions
- Knee Osteoarthritis, Knee Pain Chronic, Knee Pain Swelling, Knee Arthritis
- Trial name
- NCT04472091
- Testing
- Genicular artery embolization (GAE)
- Where
- United States
- Sponsor
- Andrew Picel
Osteoarthritic Knee Pain, Osteo Arthritis of the Knee
Percutaneous Transcatheter Genicular Embolization in Osteoarthritis
This clinical study investigates a minimally invasive treatment called percutaneous transcatheter embolization of knee arteries for patients with chronic knee pain caused by advanced knee osteoarthritis or persistent pain after…
- Conditions
- Osteoarthritic Knee Pain, Osteo Arthritis of the Knee, Osteoarthitis
- Trial name
- NCT07361198
- Testing
- genicular artery embolisation
- Where
- Czechia
- Volunteers
- 20 people
- Sponsor
- Masarykova Nemocnice v Usti nad Labem, Krajska Zdravotni a.s.
Knee Arthritis Osteoarthritis, Knee Arthritis, Osteoarthritis
Efficacy and Safety of GNSC-001 Intra-articular Injection for Knee Osteoarthritis
The goal of this clinical trial is to learn if GNSC-001 works to treat knee osteoarthritis in adults. It will also learn about the safety of GNSC-001. The main questions it aims to answer are: 1.
- Conditions
- Knee Arthritis Osteoarthritis, Knee Arthritis, Osteoarthritis, Knee Arthritis, Knee Arthritis Disease
- Trial name
- RAPHAEL (NCT07831577)
- Testing
- Gene Therapy GNSC-001
- Volunteers
- 240 people
- Sponsor
- Genascence Corporation
Osteoarthritic Knee Pain
Freedom-1 Study for Chronic Knee Pain
To demonstrate the potential benefits and risk of active sub-threshold stimulation in the treatment of chronic knee pain as compared to subjects that did not have active stimulation.
- Trial name
- NCT03877653
- Testing
- Wireless neuromodulation
- Where
- 13 sites in United States
- Volunteers
- 100 people
- Sponsor
- Curonix LLC
Osteoarthritis, Knee
Preliminary Evaluation of Safety, Tolerability, and Efficacy of XT-150 for the Treatment of Osteoarthritic Pain
Preliminary Evaluation of Safety, Tolerability, and Efficacy of XT-150 for the Treatment of Osteoarthritic Pain - Dose escalation
- Trial name
- NCT03282149
- Testing
- XT-150
- Where
- Australia
- Volunteers
- 24 people
- Sponsor
- Xalud Therapeutics, Inc.
Pain, Osteoarthritis
Comparison of BTDS (Buprenorphine Transdermal System) and Placebo in Osteoarthritic Pain
The primary objective of this study is to evaluate the efficacy and safety of BTDS compared to placebo in subjects with moderate to severe osteoarthritic pain of the hip or knee.
- Trial name
- NCT00345787
- Testing
- Buprenorphine Transdermal System
- Where
- 28 sites in Japan
- Volunteers
- 262 people
- Sponsor
- Mundipharma K.K.
Osteoarthritis, Knee
Study of StimRouter for Chronic Knee OA Pain
The goal of this study is to evaluate the use of StimRouter Neuromodulation System (StimRouter) in adult subjects with an established diagnosis of primary femorotibial osteoarthritis in the target knee (Kellgren-Lawrence ≥1) who…
- Trial name
- GLEAM (NCT05644639)
- Testing
- StimRouter Neuromodulation System
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Bioventus LLC
Osteoarthritis, Knee
The Impact of Hyaluronic Acid Injections on Osteoarthritic Knee Mechanics
The purpose of this study is to determine the impact of a regular course of treatment with Hyaluronic acid (HA) injections on gait in knee osteoarthritis (OA) patients.
- Trial name
- NCT00778076
- Testing
- Hyaluronic acid
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Western Ontario, Canada
Osteoarthritis
A Study of Orthotic Shoe Inserts for Controlling Osteoarthritic Knee Pain
Osteoarthritis is a degenerative joint disease and is the most common form of arthritis. This study will evaluate the effectiveness of customized shoe inserts in controlling and relieving the pain of knee osteoarthritis.
- Trial name
- NCT00076453
- Testing
- Lateral wedge orthotic shoe inserts, Standard orthotic shoe inserts
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Lower-limb Orthoses, Osteoarthritic Knee Pain
Enhancing Voluntary Motion in Broad Patient Populations With Modular Powered Orthoses Renewal
The overall goal of this project is to establish a novel design and control paradigm for modular, partial-assist powered orthoses (exoskeletons) to enhance voluntary lower-limb motion and manage pain in broad patient populations.
- Conditions
- Lower-limb Orthoses, Osteoarthritic Knee Pain, Osteoarthritis (OA) of the Knee
- Trial name
- NCT07673328
- Testing
- Modular powered orthosis
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Osteoarthritis, Knee, Knee Pain Chronic
Phenol Neurolysis of Genicular Nerves for Osteoarthritic Knee Pain
As the aging and obese populations continue to increase, there is a rapidly growing number of people at risk for knee osteoarthritis. Treatment typically starts conservatively with analgesics, physical therapy, and bracing.
- Trial name
- NCT04989660
- Testing
- 6% aqueous phenol, Isotonic saline
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Kessler Foundation
Osteoarthritis of the Knee
Coolief Cooled Radiofrequency vs. Conventional Radiofrequency to Manage OA Knee Pain
This study is being performed to assess the relative effectiveness of genicular nerve ablation with the COOLIEF* Cooled Radiofrequency probe to manage moderate to severe knee pain in patients with osteoarthritis (OA) of the knee…
- Trial name
- NCT04145011
- Testing
- Cooled Radiofrequency, Standard Radiofrequency
- Where
- 7 sites in United States
- Volunteers
- 153 people
- Sponsor
- Avanos Medical
Osteoarthritis
Validation Study to Investigate the Effect of a New Treatment in Patients With Osteoarthritic Pain
The purpose of this clinical trial conducted in patients suffering from chronic pain is to study the relationship between individual patients' profile and their analgesic response
- Trial name
- NCT03174145
- Testing
- Positive behaviour, T4P1010 administration, Pharmacogenetic
- Where
- 6 sites in Belgium, France and 1 more
- Volunteers
- 73 people
- Sponsor
- Tools4Patient
Osteoarthritis, Knee
Safety, Tolerability, and Efficacy of XT-150 for the Treatment of Osteoarthritic Pain
Evaluation of Safety, Tolerability, and Efficacy of XT-150, a plasmid DNA with a variant of human IL-10 transgene. XT-150 will be a single injection into the knee synovial capsule for the Treatment of Osteoarthritic Pain.
- Trial name
- NCT03477487
- Testing
- XT-150
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Xalud Therapeutics, Inc.
Osteoarthritis, Knee
Intra-articular Lopain (MTX-071) Phase I/IIa Study in Chronic Osteoarthritic Knee Joint Pain
Phase I/IIa study to determine the safety and clinical effects of intra-articular injections of MTX-071 (Lopain) in patients with chronic osteoarthritic knee-joint pain.
- Trial name
- NCT02566564
- Testing
- Lopain
- Where
- Belgium
- Volunteers
- 23 people
- Sponsor
- Grünenthal GmbH
Osteoarthritis, Knee, Healthy Subjects
Predictors for Analgesic Effect to Standardized Exercise Therapy for Osteoarthritic Pain
Pain sensitization has been associated with pain severity in people with knee osteoarthritis (KOA) and a neuropathic pain component has been identified in up to 30% of KOA patients.
- Trial name
- NCT03718663
- Testing
- Physiotherapy-guided Evidence-based Exercise Therapy, Part 2: Military training
- Where
- Denmark
- Volunteers
- 28 people
- Sponsor
- Kristian Kjær Petersen
Osteoarthitis, Osteoarthritic Knee Pain
Patient Pain and Function in Medial Knee Osteoarthritis After Anteromedial vs Anterolateral Intra-Articular Corticosteroid Injection
The primary purpose of this study is to find out if there is a difference in pain experienced in patients with knee arthritis of the inside of their knee if they get a steroid injection on the inside or outside of their knee.
- Conditions
- Osteoarthitis, Osteoarthritic Knee Pain, Osteoarthritis (OA), Osteoarthritis (OA) of the Knee
- Trial name
- Medial OA CSI (NCT07804446)
- Testing
- Anteromedial Injection, Anterolateral Injection
- Where
- 5 sites in United States
- Volunteers
- 140 people
- Sponsor
- University of Chicago
Osteoarthritis
Muscle Strengthening Device for Knee Osteoarthritis
Studies have shown that isometric strengthening helps people with osteoarthritis of the knee. Isometric strengthening is muscle-strengthening exercise without movement, in which a person applies a force against a resistant…
- Trial name
- NCT00007241
- Testing
- Isometric exercise
- Where
- 6 sites in United States
- Volunteers
- 92 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Osteoarthritis
Safety and Efficacy of Buprenorphine Transdermal System in Subjects With Moderate to Severe Osteoarthritis of Hip or Knee
The objective of this study is to demonstrate the effectiveness and tolerability of the buprenorphine transdermal system (BTDS) (5, 10 and 20) in comparison to placebo transdermal system in subjects with moderate to severe…
- Trial name
- NCT00313846
- Testing
- Buprenorphine transdermal patch
- Where
- 44 sites in United States
- Volunteers
- 529 people
- Sponsor
- Purdue Pharma LP
Osteoarthritis (OA) of the Knee
Genicular Artery Embolization (GAE) vs inTra-articular Corticosteroid Injection for Osteoarthritic Knee Pain.
This study investigates genicular artery embolization (GAE) as a minimally invasive alternative to ntra-articular corticosteroid injections (IA) or treating knee osteoarthritis (OA) pain.
- Trial name
- GET-IN (NCT06929585)
- Testing
- Genicular artery embolization, Intra-articular injection with corticosteroids.
- Where
- Taiwan
- Volunteers
- 1 people
- Sponsor
- National Taiwan University Hospital