Clinical trials: Osteoarthritic Knee Pain
Knee Arthritis Osteoarthritis, Knee Arthritis, Osteoarthritis
Efficacy and Safety of GNSC-001 Intra-articular Injection for Knee Osteoarthritis
The goal of this clinical trial is to learn if GNSC-001 works to treat knee osteoarthritis in adults. It will also learn about the safety of GNSC-001. The main questions it aims to answer are: 1.
- Conditions
- Knee Arthritis Osteoarthritis, Knee Arthritis, Osteoarthritis, Knee Arthritis, Knee Arthritis Disease
- Trial name
- RAPHAEL (NCT07831577)
- Testing
- Gene Therapy GNSC-001
- Volunteers
- 240 people
- Sponsor
- Genascence Corporation
Osteoarthritis
Muscle Strengthening Device for Knee Osteoarthritis
Studies have shown that isometric strengthening helps people with osteoarthritis of the knee. Isometric strengthening is muscle-strengthening exercise without movement, in which a person applies a force against a resistant…
- Trial name
- NCT00007241
- Testing
- Isometric exercise
- Where
- 6 sites in United States
- Volunteers
- 92 people
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Osteoarthritis, Knee Pain
Phase II Study to Assess Safety and Efficacy of SL-1002 for Osteoarthritic Knee Pain
This is a multicenter, randomized, double-blind, placebo-controlled, single ascending dose escalation study to assess the safety and efficacy of single treatment exposure of an injectable formulation of SL-1002 for the treatment…
- Trial name
- COMPASS (NCT05470608)
- Testing
- SL-1002
- Where
- 15 sites in United States
- Volunteers
- 132 people
- Sponsor
- Saol Therapeutics Inc
Osteoarthritis, Knee
Intra-articular Lopain (MTX-071) Phase I/IIa Study in Chronic Osteoarthritic Knee Joint Pain
Phase I/IIa study to determine the safety and clinical effects of intra-articular injections of MTX-071 (Lopain) in patients with chronic osteoarthritic knee-joint pain.
- Trial name
- NCT02566564
- Testing
- Lopain
- Where
- Belgium
- Volunteers
- 23 people
- Sponsor
- Grünenthal GmbH
Osteoarthritis, Knee
Preliminary Evaluation of Safety, Tolerability, and Efficacy of XT-150 for the Treatment of Osteoarthritic Pain
Preliminary Evaluation of Safety, Tolerability, and Efficacy of XT-150 for the Treatment of Osteoarthritic Pain - Dose escalation
- Trial name
- NCT03282149
- Testing
- XT-150
- Where
- Australia
- Volunteers
- 24 people
- Sponsor
- Xalud Therapeutics, Inc.
Lower-limb Orthoses, Osteoarthritic Knee Pain
Enhancing Voluntary Motion in Broad Patient Populations With Modular Powered Orthoses Renewal
The overall goal of this project is to establish a novel design and control paradigm for modular, partial-assist powered orthoses (exoskeletons) to enhance voluntary lower-limb motion and manage pain in broad patient populations.
- Conditions
- Lower-limb Orthoses, Osteoarthritic Knee Pain, Osteoarthritis (OA) of the Knee
- Trial name
- NCT07673328
- Testing
- Modular powered orthosis
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Osteoarthritis
Safety and Efficacy of Buprenorphine Transdermal System in Subjects With Moderate to Severe Osteoarthritis of Hip or Knee
The objective of this study is to demonstrate the effectiveness and tolerability of the buprenorphine transdermal system (BTDS) (5, 10 and 20) in comparison to placebo transdermal system in subjects with moderate to severe…
- Trial name
- NCT00313846
- Testing
- Buprenorphine transdermal patch
- Where
- 44 sites in United States
- Volunteers
- 529 people
- Sponsor
- Purdue Pharma LP
Osteoarthritis
Safety of BTDS in Subjects With Osteoarthritic (OA) Pain of Hip or Knee: A 6-Month Open-label Extension Phase
The purpose of the extension phase is to evaluate the long-term safety and tolerability of buprenorphine transdermal system (BTDS).
- Trial name
- NCT01141283
- Testing
- Buprenorphine transdermal patch
- Where
- 42 sites in United States
- Volunteers
- 290 people
- Sponsor
- Purdue Pharma LP