Clinical trials: Osteoarthritis; Primary
Knee Osteoarthritis, Chronic Pain
Motor Cortex Plasticity and the Effect of Deep Intramuscular Needling Stimulation Therapy (DIMST) in Osteoarthritis Pain
The aim of this study is to evaluate the cortical excitability in pain of knee osteoarthritis (OA), as well as the effect of one session of a kind of electroacupuncture (deep needling intramuscular stimulation therapy - DIMST) in…
- Trial name
- NCT01855958
- Testing
- DIMST
- Where
- Brazil
- Volunteers
- 26 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Total Knee Replacement, Primary Knee Arthroplasty
The Use of Fibrin Sealant to Reduce Bleeding After Total Knee Replacement
A randomized controlled study is performed to address the question of whether the topical application of a novel fibrin sealant, Evicel (Johnson \& Johnson Wound Management, Ethicon, Somerville, NJ) in patient undergoing total…
- Conditions
- Total Knee Replacement, Primary Knee Arthroplasty, Osteoarthritis of the Knee
- Trial name
- NCT01816282
- Testing
- Evicel
- Where
- Italy
- Volunteers
- 62 people
- Sponsor
- University of Milan
Rheumatoid Arthritis, Degenerative Arthritis
Clinical Evaluation of Integra® Cadence™ Total Ankle System in Primary Ankle Joint Replacement (CADENCE)
A post market, prospective, non-randomized, multi-center, open-label,clinical study using survivorship as the reference performance goal to study the safety and efficacy of the Cadence Total Ankle System (TAS) when used for…
- Conditions
- Rheumatoid Arthritis, Degenerative Arthritis, Post Traumatic Arthritis
- Trial name
- Cadence (NCT03142958)
- Testing
- Integra Cadence Total Ankle System
- Where
- 11 sites in United States, Canada
- Volunteers
- 132 people
- Sponsor
- Smith & Nephew, Inc.
Osteoarthritis, Post-traumatic Arthritis
Postmarketing Study to Determine Performance of the SIGMA HP® PARTIAL KNEE SYSTEM
This is a postmarketing study to assess the overall performance and survivorship of the SIGMA HP® PARTIAL KNEE SYSTEM.
- Conditions
- Osteoarthritis, Post-traumatic Arthritis, Gout, Pseudo-gout
- Trial name
- NCT01529099
- Testing
- SIGMA HP PARTIAL KNEE
- Where
- 3 sites in Italy, Switzerland
- Volunteers
- 64 people
- Sponsor
- DePuy International
Osteoarthritis
Efficacy of Intravenous Versus Topical Tranexamic Acid in Primary Total Hip Arthroplasty
Bleeding during and after total hip replacement surgery is a primary concern to the surgical and anaesthetic team. Tranexamic acid is a commonly-used drug that helps blood clotting and decreases surgical bleeding.
- Trial name
- TeACH-R (NCT02056444)
- Testing
- Tranexamic Acid
- Where
- Canada
- Volunteers
- 149 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Non-inflammatory Degenerative Joint Disease
A Trial Evaluating TKR Compared to BKR Performed Using Stryker's Mako Robot
A prospective, randomised controlled trial evaluating Total Knee Replacement with the Stryker Triathlon Primary Total Knee System, compared to Bicompartmental Knee Replacement with Restoris MCK Multicompartmental Knee System…
- Trial name
- NCT02650284
- Testing
- Stryker Triathlon Primary Total Knee System, Restoris MCK Multicompartmental Knee System
- Where
- Australia
- Volunteers
- 18 people
- Sponsor
- Stryker South Pacific
Rheumatoid Arthritis, Osteoarthritis
A Multi-centre Study to Assess the Long-term Performance of the DePuy ASR™ System in Primary Hip Resurfacing Surgery
The purpose of this study is to monitor the performance and determine the metal ion release of the DePuy ASR™ System in the treatment of patients with hip joint disease requiring hip resurfacing surgery.
- Conditions
- Rheumatoid Arthritis, Osteoarthritis, Post-traumatic Arthritis, Collagen Disorders
- Trial name
- NCT00208377
- Testing
- DePuy ASR Hip System
- Where
- 3 sites in Australia, Germany and 1 more
- Volunteers
- 228 people
- Sponsor
- DePuy International
Knee Osteoarthritis
Evaluation of Safety and Efficacy of ReHub in Patients Who Underwent Primary Total Knee Arthroplasty
This is a randomized, non-blinded, parallel assignment, clinical trial for the evaluation of safety and efficacy of ReHub, a telerehabilitation system made up of a cloud platform and an exercise kit with smart sensors, for…
- Trial name
- REHAPT (NCT04155957)
- Testing
- Rapid Recovery Rehabilitation Programme, ReHub
- Where
- Spain
- Volunteers
- 52 people
- Sponsor
- Bio-Sensing Solutions S.L. (DyCare)
Knee Osteoarthritis, Pain Management
Phase 3 Adductor Canal Block With EXPAREL in Subjects Undergoing Primary Unilateral Total Knee Arthroplasty
The purpose of the study is to compare magnitude of postsurgical analgesic effect in different groups following a single dose of study drug when administered via adductor canal block in subjects undergoing primary unilateral…
- Trial name
- NCT05139030
- Testing
- bupivacaine liposome injectable suspension, Bupivacaine Hydrochloride
- Where
- 6 sites in United States
- Volunteers
- 167 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Osteo Arthritis Knee
Prospective Observational Study of Pain Evolution in Patients With Primary Knee Osteoarthritis Treated With Pronolis® HD
Prospective observational study of 6 months of follow-up, of national and multicenter scope with medical device with CE marking and according to the usual clinical practice.
- Trial name
- NO-DOLOR (NCT04196764)
- Where
- Spain
- Volunteers
- 188 people
- Sponsor
- Procare Health Iberia S.L.
Osteoarthritis, Post-traumatic Arthritis
A Randomised Study to Compare Metal Ion Release and Long-term Performance of the Pinnacle™ Cup With a Ceramic-on-Metal or a Metal-on-Metal Bearing
The purpose of this study is to monitor the performance and compare the metal ion release of two bearing combinations, ceramic-on-metal and metal-on-metal in the treatment of patients with hip joint disease requiring a total hip…
- Conditions
- Osteoarthritis, Post-traumatic Arthritis, Collagen Disorders, Avascular Necrosis
- Trial name
- NCT00873444
- Testing
- Pinnacle™ Acetabular System
- Where
- Germany
- Volunteers
- 5 people
- Sponsor
- DePuy International
Osteoarthritis
Intraarticular Platelet-rich Plasma Injections Versus Corticosteroid Injections in Primary Knee Osteoarthritis
Aim: To study and compare the clinical effects of platelet-rich plasma (PRP) injections and intra-articular (IA) corticosteroid injections in patients with primary osteoarthritis (OA) of the knee.
- Trial name
- NCT01923909
- Testing
- Intra-articular platelet-rich plasma, Intra-articular corticosteroid injections
- Where
- Bahrain
- Sponsor
- King Hamad University Hospital, Bahrain
Knee Osteoarthritis, Knee Arthritis
Persona MC Retained PCL vs. Persona Posterior-stabilized vs. NexGen PS
This study compares and evaluates differences in movement analysis, patient-reported outcome and radiological assesment between patients undergoing total knee arthroplasty with use of either Zimmer Biomet NexGen and Zimmer Biomet…
- Conditions
- Knee Osteoarthritis, Knee Arthritis, Joint; Arthrosis, Primary
- Trial name
- Persona TKA (NCT04164147)
- Testing
- Total knee replacement, CT scan, Biomechanics
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Warsaw
Degenerative Joint Disease
R3 Delta Ceramic Acetabular System PAS U.S.
R3 Delta Post-Approval Study U.S.
- Trial name
- R3-PAS (NCT03056534)
- Testing
- R3 Biolox Delta Ceramic Acetabular System
- Where
- 8 sites in United States
- Volunteers
- 189 people
- Sponsor
- Smith & Nephew, Inc.
Osteoarthritis of Glenohumeral Joint
Columbia Shoulder Study (CSS)
This prospective study will evaluate the Bigliani/Flatow prosthesis. The aims of this study are to establish the safety, effectiveness, and value of the prosthetic system, and to collect information from expert shoulder surgeons…
- Trial name
- CSS (NCT01488006)
- Testing
- Bigliani/Flatow Shoulder System
- Where
- United States
- Volunteers
- 207 people
- Sponsor
- Columbia University
Osteoarthritis(Primary)
A Randomised Multi-centre Study to Compare the Short-term Outcomes of Minimally Invasive and Conventional Surgery in Primary Total Hip Replacement
The purpose of this study is to compare the short-term outcomes of two surgical techniques, minimally invasive and conventional, when used in the treatment of patients with hip joint disease requiring a total hip replacement.
- Trial name
- NCT00208416
- Testing
- DePuy MI System, Conventional surgical technique
- Where
- 2 sites in United Kingdom
- Volunteers
- 58 people
- Sponsor
- DePuy International
Knee Osteoarthritis
Study of AS902330 (rhFGF-18) Administered Intra-articularly in Patients With Knee Primary Osteoarthritis Who Are Candidates for Total Knee Replacement
Osteoarthritis (OA) is one of the most common diseases affecting the joints, usually those that are weight bearing such as the knees.
- Trial name
- NCT00911469
- Testing
- AS902330
- Where
- 19 sites in Bulgaria, Denmark and 4 more
- Volunteers
- 73 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Primary Osteoarthritis Patients Scheduled for Total Knee Replacement Surgery
First-in-human Single Ascending Dose Study of LNA043 in Patients Scheduled for Total Knee Replacement
This study is designed to evaluate the safety and tolerability of ascending single doses of LNA043 given intra-articularly into the human knee joint prior to its removal at total knee replacement surgery.
- Trial name
- NCT02491281
- Testing
- LNA043
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Novartis Pharmaceuticals
Arthroplasty, Replacement, Shoulder, Glenoid Cavity
Long Term Follow-up After Primary or Revision Shoulder Arthroplasty With a Patient- Specific Glenius Implant
This post-market follow-up study investigates improvement in clinical and radiological outcome after reversed total shoulder arthroplasty with the patient-specific Glenius Glenoid Reconstruction system
- Conditions
- Arthroplasty, Replacement, Shoulder, Glenoid Cavity, Osteoarthritis of the Shoulder
- Trial name
- NCT03806881
- Testing
- reversed glenoid prothesis
- Where
- 4 sites in Belgium, Netherlands
- Volunteers
- 24 people
- Sponsor
- Materialise
Primary Osteoarthritis, Rheumatoid Arthritis
TC-A Registration Study
This is a prospective, randomized, multicenter clinical study to compare the safety and efficacy of TC-A PS total knee system with TC-PLUS Solution PS total knee system in Chinese subjects.
- Conditions
- Primary Osteoarthritis, Rheumatoid Arthritis, Post-traumatic Arthritis, Avascular Necrosis
- Trial name
- NCT02139345
- Testing
- TC-A PS Total Knee Replacement System, TC-PLUS Solution PS Total Knee Replacement System
- Where
- 4 sites in China
- Volunteers
- 162 people
- Sponsor
- Smith & Nephew Medical (Shanghai) Ltd