Clinical trials: Osteoarthritis, active
Osteoarthritis, Knee
Effect of Anti-inflammatory Diet in Osteoarthritis
In a previous exploratory study, the investigators observed an effect on disease activity outcomes of anti-inflammatory diet. The investigators also observed change in microbiome and circulating metabolites.
- Trial name
- NCT06080347
- Testing
- Anti-inflammatory Diet, Healthy Diet
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of California, San Diego
Osteoarthritis (OA) of the Hip
Effectiveness of Therapeutic Exercises on Spinopelvic Mobility
The purpose of this study is to examine the extent to which spinopelvic exercises may affect either sagittal spinal deformity or spinopelvic mobility and identifying patients at risk for hip instability following a total hip…
- Trial name
- NCT06838455
- Testing
- Spinopelvic mobility exercise
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Colorado Joint Replacement
Osteoarthritis, Knee
Single vs Triple Hyaluronic Acid in Knee Osteoarthritis
The goal of this clinical trial is to directly compare two hyaluronic acid injection protocols in adults with knee osteoarthritis: a single intra-articular injection of Innoryos 2.5% (Single-Shot) and a three-week injection…
- Trial name
- DR-HAKOA (NCT07352540)
- Testing
- Three intra-articular hyaluronic acid (HA) injections, One intra-articular hyaluronic acid (HA) injection
- Where
- Germany
- Volunteers
- 46 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Knee Osteoarthritis (Knee OA)
Holistic Healing for Knee Osteoarthritis
This study is a single-center, three-arm, open-label randomized controlled trial designed to compare the effectiveness of integrated care, standard medical care, and Ayurvedic care in adults with early knee osteoarthritis…
- Trial name
- HEAL-KOA (NCT07768709)
- Testing
- Trayodashang Guggulu, Ashwagandha Churna, Janubasti
- Where
- India
- Volunteers
- 300 people
- Sponsor
- All India Institute of Medical Sciences, Jodhpur
Knee Osteoarthritis
Exploring Factors Linked to Worsening Over Time in People With Early-stage Knee Osteoarthritis and Those With Prior Proven Acute Knee Injury.
The goal of this observational, non-interventional cohort study is to identify tests or markers in blood or knee fluid, or any genetic risk factors that might contribute to worsening or improvement of knee osteoarthritis.
- Trial name
- KNEE (NCT07833488)
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Imperial College London
Osteoarthritis of the Knee
The Feasibility of a Virtual/Home-based OA Treatment Program in Older Adults With OA and Multimorbidity
Knee Osteoarthritis is one of the most common causes of chronic joint pain. Although clinical guidelines recommend weight loss and regular physical activity as first line treatments this can be difficult for patients to do.
- Trial name
- NCT07921563
- Testing
- Home-based exercise and weight management program
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Osteoarthritis, Knee
Effect of Anti-inflammatory (ITIS) Diet in Knee Osteoarthritis
To study the effect of anti-inflammatory diet on clinical and biological outcomes in patients with knee osteoarthritis
- Trial name
- NCT05559463
- Testing
- ITIS diet
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, San Diego
Osteoarthritis, Knee, Diabetic Neuropathic Pain
A Master Protocol Study (LY900028) of Multiple Intervention-Specific-Appendices (ISAs) in Participants With Chronic Pain
The purpose of the chronic pain master protocol is to compare independent pain interventions and establish an overarching structure for the disease-state addenda (DSA) and intervention-specific appendices (ISAs).
- Conditions
- Osteoarthritis, Knee, Diabetic Neuropathic Pain, Chronic Low-back Pain
- Trial name
- CPMP (NCT05986292)
- Testing
- LY3016859 ISA, LY3556050 ISA, LY3526318 ISA
- Where
- 64 sites in United States, Puerto Rico
- Volunteers
- 10,000 people
- Sponsor
- Eli Lilly and Company
Hip Osteoarthritis
Effects of EDUcation and EXercise Compared to Education Alone on Clinical and Physiological Outcomes in Patients With Hip Osteoarthritis
The EDUEX trial will determine whether the addition of progressive resistance training (PRT) to a patient education program (EDU) will improve clinical outcomes in patients with hip OA.
- Trial name
- EDUEX (NCT06391554)
- Testing
- PRT, EDU
- Where
- 2 sites in Denmark
- Volunteers
- 150 people
- Sponsor
- University of Aarhus
Hand Osteoarthritis
Balneotherapy in Hand Osteoarthritis
There are a limited number of studies in the literature on the effectiveness of balneotherapy in hand osteoarthritis. The aim of this study was to evaluate the effects of balneotherapy on pain, manual skills, functionality and…
- Trial name
- NCT06702514
- Testing
- Exercise, Paraffin, Balneotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Afyonkarahisar Health Sciences University
Knee Pain Chronic, Knee Osteoarthritis
BioPoly® Partial Resurfacing Knee Implant IDE
The goal of this randomized controlled clinical trial is to demonstrate the safety and effectiveness of the BioPoly® Partial Resurfacing Knee Implant for the treatment of cartilage defects of the distal femur in adult patients…
- Conditions
- Knee Pain Chronic, Knee Osteoarthritis, Cartilage Damage, Cartilage Defects of the Knee
- Trial name
- NCT06915363
- Testing
- BioPoly, surgical standard of care (SSOC)
- Where
- 5 sites in United States
- Volunteers
- 152 people
- Sponsor
- BioPoly LLC
Hip Osteoarthritis, Hip Arthropathy
PENG vs L-ESPB With S-ESPB for Analgesia in Total Hip Arthroplasty
The goal of this clinical trial is to evaluate whether different types of regional anesthesia can improve pain control and functional recovery after total hip arthroplasty in adult patients undergoing elective hip replacement…
- Conditions
- Hip Osteoarthritis, Hip Arthropathy, Hip Pain Chronic
- Trial name
- NCT07180979
- Testing
- Ropivacaine 0.5% Injectable Solution, Ropivacaine 0.2% Injectable Solution
- Where
- Poland
- Volunteers
- 90 people
- Sponsor
- Poznan University of Medical Sciences
Hip Osteoarthritis
Three Variants of the PENG Block With and Without Perineural Adjuvants in Older Adults
This study will compare three versions of the Pericapsular Nerve Group (PENG) block in adults aged 65 years and older who are undergoing hip surgery.
- Trial name
- NCT07330999
- Testing
- Ropivacaine 0.2% Injectable Solution, Dexamethasone 4mg, Dexmedetomidine
- Where
- Poland
- Volunteers
- 120 people
- Sponsor
- Poznan University of Medical Sciences
Knee Cartilage Defects
Phase 3 Pivotal Trial Comparing CARTISTEM® and Surgical Comparator for Knee Cartilage Lesions and Osteoarthritis
This study will test whether CARTISTEM is safe and works better than debridement (a surgery that cleans out damaged tissue) for people with knee cartilage damage and osteoarthritis.
- Trial name
- CARTISTEM23-01 (NCT07339111)
- Testing
- CARTISTEM® + Debridement, Debridement
- Where
- 37 sites in United States
- Volunteers
- 300 people
- Sponsor
- Medipost, Inc.
Knee Osteoarthritis
SII Levels Following iPACK Block With Adductor Canal Block in Knee Arthroplasty
This randomized controlled trial evaluates the effect of ultrasound-guided iPACK block with Adductor Canal Block (ACB) on the Systemic Immune-Inflammation Index (SII) in elderly patients undergoing total hip arthroplasty under…
- Trial name
- NCT07449442
- Testing
- sodium Chloride, Ropivacaine Hydrocloride
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Poznan University of Medical Sciences
Osteoarthritis, Hip, Hip Osteoarthritis
Intravenous Dexamethasone (0 vs 4 vs 8 mg) as an Adjunct to PENG Block for Postoperative Analgesia in Total Hip Arthroplasty
his study will test whether giving dexamethasone through a vein can improve pain control after total hip replacement surgery. Dexamethasone is commonly used to reduce nausea and may also help with pain, but it is not clear which…
- Trial name
- NCT07581470
- Testing
- Dexamethasone 4mg, Dexamethasone 8mg
- Where
- Poland
- Volunteers
- 198 people
- Sponsor
- Poznan University of Medical Sciences
Arthropathy of Hip, Hip Osteoarthritis
Comparison of Spinal Anesthesia With Intrathecal Morphine Versus PENG Block With or Without Dexamethasone in Hip Arthroplasty
The goal of this clinical trial is to learn which of three regional anesthesia approaches provides better pain relief and safety for older adults having planned hip replacement surgery.
- Trial name
- THA (NCT07584200)
- Testing
- Intrathecal Morphine, Pericapsular Nerve Group Block, Dexamethasone
- Where
- Poland
- Volunteers
- 90 people
- Sponsor
- Poznan University of Medical Sciences
Knee Osteoarthritis
ACB and iPACK Blocks With Intravenous Dexamethasone and Perineural Dexmedetomidine in Total Knee Arthroplasty
This prospective randomized controlled trial aims to compare the analgesic efficacy and safety of three adjuvant strategies for ultrasound-guided Adductor Canal Block (ACB) and iPACK block in patients undergoing elective total…
- Trial name
- NCT07677215
- Testing
- Ropivacaine 0.2% Injectable Solution, Dexamethasone, Dexmedetomidine
- Where
- 2 sites in Poland
- Volunteers
- 120 people
- Sponsor
- Poznan University of Medical Sciences
Hip Osteoarthritis
Intravenous Dexmedetomidine as a Perioperative Autonomic-Immune Neuromodulator
Surgical trauma induces activation of the sympathetic nervous system and triggers a systemic inflammatory response that may adversely affect postoperative recovery.
- Trial name
- NCT07743853
- Testing
- Dexmedetomidine
- Where
- Poland
- Volunteers
- 90 people
- Sponsor
- Poznan University of Medical Sciences
Obesity, Overweight
A Study to Learn About Study Medicine Called Berobenatide in Adults With Knee Pain and Overweight or Obesity (VESPER-OA 1)
The purpose of this clinical study is to learn about the safety and effects of berobenatide (PF-08653944) for the treatment of knee osteoarthritis in adults with overweight or obesity.
- Conditions
- Obesity, Overweight, Osteoarthritis of the Knee
- Trial name
- NCT07919678
- Testing
- Berobenatide
- Where
- 40 sites in United States, Canada
- Volunteers
- 656 people
- Sponsor
- Pfizer