Clinical trials: Osteoarthritis (OA)
Knee Osteoarthritis (Knee OA), IPACK Block Multimodal Analgesia
Efficacy of IPACK Block Combined With Intra-articular Steroid Injection in Advanced Knee Osteoarthritis: A Retrospective Cohort Study
Osteoarthritis (OA) is a degenerative joint disease characterized by the progressive degeneration of articular cartilage resulting from the interaction of genetic, metabolic, and biochemical factors and is often accompanied by…
- Conditions
- Knee Osteoarthritis (Knee OA), IPACK Block Multimodal Analgesia, Intraarticular Injection, Ultrasound Guided Injection
- Trial name
- NCT07269444
- Where
- Turkey (Türkiye)
- Volunteers
- 98 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Osteoarthritis, Knee
Reducing Knee Compression When Sleeping in Those With Knee OA
To determine whether a change in sleeping position so as to prevent the knee being 'pushed' into full extension when lying supine provides pain relief and/or symptom improvement in individuals with knee osteoarthritis (OA).
- Trial name
- NCT04188054
- Testing
- Change in sleeping position, No change in sleeping position
- Where
- United Kingdom
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- University of Bradford
Cartilage Injury, OA Knee
Tissue Engineered Cartilage to Repairing Articular Cartilage Defects
The joint cartilage constructed by combining bone marrow mesenchymal stem cells with three-dimensional materials has achieved the goal of repairing joint cartilage.
- Trial name
- NCT07094100
- Testing
- Tissue engineered cartilage
- Where
- China
- Volunteers
- 30 people
- Sponsor
- The First Affiliated Hospital of Xinxiang Medical College
Osteoarthritis, Knee
The Safety/Efficacy of hUC Mesenchymal Stem Cells（19#iSCLife®-OA） Therapy for Patients With Osteoarthritis
The purpose of this study is verify the efficacy and safety of Human Umbilical Cord Mesenchymal Stem Cells (UC-MSC) therapy for patients with Osteoarthritis, and in addition, provide basis for exploring the treatment regimen of…
- Trial name
- NCT03383081
- Testing
- Low dose mesenchymal stem cells, High dose mesenchymal stem cells, Intraarticular injection
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Sclnow Biotechnology Co., Ltd.
Osteoarthritis, Knee
Bayer OA Knee Pain Pilot
The objective of this study is to investigate if MRI can be used to evaluated effect of knee artery embolization for knee osteoarthritis.
- Trial name
- NCT05349682
- Testing
- dynamic contrast enhanced MRI, geniculate artery embolization
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Medical University of South Carolina
Osteoarthritis, Knee
The Instant Effect of Kinesiology Taping in Patients With Knee OA
The aim of this study is to determine instant effect of kinesiology taping applied to the rectus femoris on muscle activation, physical performance and proprioception in patients with knee osteoarthritis.
- Trial name
- NCT05160246
- Testing
- kinesiology tape
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Kırıkkale University
Primary Osteoarthritis Patients Scheduled for Total Knee Replacement Surgery, Osteoarthritis (OA) of the Knee
Does the Use of Patient Specific Instrumentation Improve Outcomes in Knee Arthroplasty Surgery for Osteoarthritis When Compared to Standard Posterior Referenced Instrumentation?
The goal of this randomized study is to see if using patient-specific instruments (PSI) during total knee replacement surgery improves outcomes compared to standard instruments.
- Trial name
- PRIPSI (NCT06720012)
- Testing
- Patient specific instrumentation (PSI), Conventional instruments, Cemented Total Knee Arthroplasty
- Where
- Sweden
- Volunteers
- 70 people
- Sponsor
- Vastra Gotaland Region
Osteoarthritis of the Knee
A 4-week Study to Evaluate the Efficacy and Safety of HP-5000 in Subjects With Knee Osteoarthritis
A 4-week, Randomized, Double-blind, Multicenter, Placebo-controlled Phase 2 Study to Evaluate the Efficacy and Safety of HP-5000 in Subjects with Osteoarthritis (OA) of the Knee
- Trial name
- HP-5000 (NCT03277066)
- Testing
- Diclofenac Sodium Active Topical Patch 1, Diclofenac Sodium Active Topical Patch 2
- Where
- United States
- Volunteers
- 289 people
- Sponsor
- Noven Pharmaceuticals, Inc.
Knee Osteoarthritis, Intra-Articular Injection
Innovative Tool to Analyse Synovial Fluid of Patients With Knee Ostearthritis After IA Injection of Synvisc-one®
The objective of this trial is to assess the clinical pertinence of an innovative analytical tool (SYNODIAG) to analyze the Synovial Fluid (SF) composition and guide the patient treatment in a Proof of Concept (PoC) study using…
- Trial name
- RESYF (NCT04321668)
- Testing
- Synvisc-One
- Where
- 3 sites in Belgium
- Volunteers
- 13 people
- Sponsor
- Pulsalys
Knee Osteoarthritis (Knee OA)
Cross-linked Hyaluronic Acid in Knee Osteoarthritis
Knee Osteoarthritis (Knee OA) leads to pain and loss of function, especially in recreational athletes. While hyaluronic acid (HA) injections are a common part of conservative treatment, comparative data on the efficacy of…
- Trial name
- NCT07241442
- Testing
- Straight-bonded hyaluronic acid, cross-linked hyaluronic acid
- Where
- Turkey (Türkiye)
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Knee OA, Knee Osteoarthristis
TcPRF for Knee Osteoarthritis
Objectives Primary Objective: To evaluate the efficacy of transcutaneous PRF treatment in reducing knee pain compared to a sham intervention Secondary Objectives: To assess the improvement in functional outcomes and patient…
- Trial name
- NCT07351981
- Testing
- Transcutaneous Pulsed Radiofrequency (PRF) Treatment for Knee Pain
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- National and Kapodistrian University of Athens
Knee Osteoarthritis
Effects of Steroid, Dextrose Prolotherapy, and Platelet-Rich Plasma Injections in Knee Joint OA Patients
The novelty of thisstudy lies in its comparative assessment of three latest intra-articular injection therapies including steroid injections, dextrose prolotherapy, and PRP, for knee OA associated impairments, with a focus on…
- Trial name
- NCT07243392
- Testing
- Intra articular steroid injection, Intra articular PRP, Intra articular dextrose prolotherapy
- Where
- Pakistan
- Volunteers
- 72 people
- Sponsor
- Lincoln University College
Osteoarthritis (OA) of the Knee
Cohort of Lower-Extremity Sports Injuries and Degeneration(Yongjiang Cohort)
This is an observational cohort study conducted at Ningbo No. 2 Hospital. The study will include patients with knee-related sports injuries or degenerative knee conditions who receive routine clinical care.
- Trial name
- NCT07592871
- Testing
- Routine Clinical Care
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Ningbo No.2 Hospital
Osteoarthrosis
Efficacy Study of Condrosulf in the Treatment of Symptomatic OA of the Hand
The goal of the present study is to investigate the effectiveness of Condrosulf® 800 mg tablets vs. placebo once a day for 6 months in the symptomatic treatment of finger joint osteoarthritis.
- Trial name
- NCT00291499
- Testing
- Chondroitin 4&6 sulfate (Condrosulf)
- Volunteers
- 163 people
- Sponsor
- IBSA Institut Biochimique SA
Knee Osteoarthritis
Derris Scandens Benth Extract VS Naproxen in Knee OA
Derris Scandens Benth (family : Leguminosae) is a woody vine growing throughout Southeast Asia, including Thailand. The stem of D.Scandens has been widely use in Thai traditional medicine, foe example of myalgia.
- Trial name
- NCT00503828
- Testing
- Derris scandens Benth extracts, naproxen
- Where
- Thailand
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Osteoarthritis
Safety of BTDS in Subjects With Osteoarthritic (OA) Pain of Hip or Knee: A 6-Month Open-label Extension Phase
The purpose of the extension phase is to evaluate the long-term safety and tolerability of buprenorphine transdermal system (BTDS).
- Trial name
- NCT01141283
- Testing
- Buprenorphine transdermal patch
- Where
- 42 sites in United States
- Volunteers
- 290 people
- Sponsor
- Purdue Pharma LP
Chronic Pain
A Double-blind Study of Controlled Release OROS Hydromorphone Compared to Placebo in Patients With Chronic Osteoarthritis (OA) Pain
To evaluate the efficacy of OROS Hydromorphone in reducing moderate to severe chronic pain in patients with Osteoarthritis (OA) Pain
- Trial name
- NCT00631319
- Testing
- OROS hydromorphone
- Volunteers
- 343 people
- Sponsor
- Mallinckrodt