Clinical trials: Osteoarthritis Arthritis
Hand Osteoarthritis
Manual Therapy for Hand Osteoarthritis
Osteoarthritis (OA) of the hand is a major cause of pain and functional limitation, central sensitization of pain can be one of the causes: this hypothesis opens avenues for research in the modulation of pain pathways.
- Trial name
- NCT02701335
- Testing
- Neural mobilization, Gloreha device, Standardized exercise
- Where
- Italy
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Osteoarthritis, Arthroplasty
Heidelberg Registry for Hip and Knee Joint Implants and Revisions
The Endoprosthesis Registry Heidelberg (EPR-HD) is a clinical registry designed to systematically collect and analyze data from patients undergoing primary implantation or revision surgery of artificial hip and knee joints.
- Trial name
- EPR-HD (NCT06850818)
- Where
- Germany
- Volunteers
- 10,000 people
- Sponsor
- University Hospital Heidelberg
Knee Osteoarthritis
Prosthesis and Surgery Guide System for Personalized Total Knee Arthroplasty
The subject is planned to carry out the clinical trails of femoral condyle prosthesis, tibial tray prosthesis and meniscus prosthesis; At the same time, in order to achieve personalized precision bone resection, the clinical…
- Trial name
- NCT04963491
- Testing
- Personalized TKA prosthesis, Zimmer NexGen prostheses
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Patient Satisfaction, Hip Osteoarthritis
Dual Mobility Cup: Does it Improve Patient's Satisfaction After Total Hip Arthroplastry?
Although the success of total hip arthroplasty, many patients were dissatisfied postoperatively. Patient's reported outcome measures become of a great importance in assessment of the results after joint replacement.
- Trial name
- NCT04333316
- Testing
- large head, dual mobility cup
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Tanta University
Pain, Arthrofibrosis
Intravenous (IV) Hydrocortisone for TKA (Total Knee Arthroplasty)
In this study, total knee replacement patients will be determined to be stiff or non-stiff preoperatively. Stiffness designation is determined by preoperative range of motion (if flexion is < 100 degrees, or extension lag is > 10…
- Conditions
- Pain, Arthrofibrosis, Osteoarthritis, Knee
- Trial name
- NCT04082533
- Testing
- Hydrocortisone, Dextrose 5% in water (D5W)
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Osteoarthritis
Investigating Medical Research Trends in Osteoarthritis Clinical Trials
Clinical research participation percentages haven't always been fully representative of a given demographic. The goal is to find out which aspects of a clinical trial may make it more difficult for patients to take part or see it…
- Trial name
- NCT05811858
- Volunteers
- 500 people
- Sponsor
- Power Life Sciences Inc.
Osteoarthritis, Chronic Pain
Imaging Pain Relief in Osteoarthritis
Osteoarthritis (OA) is a degenerative joint disease and is the most common form of arthritis. Pain reduction and functional recovery are the key elements of the clinical management of OA.
- Trial name
- IPRO (NCT02208778)
- Testing
- Duloxetine, Remifentanil
- Where
- United Kingdom
- Volunteers
- 77 people
- Sponsor
- University of Nottingham
Knee Osteoarthritis
Combined Effect of Laser Acupuncture and Electroacupuncture in Knee Osteoarthritis Patients
Background: Knee osteoarthritis (KOA) is a common degenerative joint disorder affected 250 million people globally. It can not only result in disability, but also associated with cardiovascular disease and mortality.
- Trial name
- NCT04188925
- Testing
- Laser Acupuncture
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Knee Osteoarthritis
End-range Mobilization on Time Curve of Pressure Pain Threshold
Pain in knee osteoarthritis (OA) represents increased pain intensity due to peripheral and central sensitivity. Pressure pain threshold (PPT) is a widely applied technique for measuring the magnitude of peripheral and central…
- Trial name
- NCT04629625
- Testing
- End-range mobilization, Non end-range mobilization
- Where
- 2 sites in Hungary
- Volunteers
- 66 people
- Sponsor
- University of Pecs
Stroke, Traumatic Brain Injury
Targeting Osteosarcopaenia and Multimorbidity for Frailty Prevention
The aging population and its accompanying burden from non-communicable chronic diseases predicts an increasing impact imposed by frailty on healthcare systems.
- Conditions
- Stroke, Traumatic Brain Injury, Knee Osteoarthritis, Breast Cancer
- Trial name
- OPTIMA-C (NCT06073106)
- Where
- Singapore
- Volunteers
- 500 people
- Sponsor
- Tan Tock Seng Hospital
Osteoarthritis
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Preliminary Efficacy of Multiple Subcutaneous Doses of OLP-1002
This is a Phase 1b, randomised, double-blind, placebo-controlled, parallel study to evaluate the safety, tolerability, pharmacokinetics and preliminary efficacy of multiple SC doses of OLP-1002 in patients who have pain due to…
- Trial name
- NCT04677933
- Testing
- A: OLP-1002, B: OLP-1002
- Where
- 4 sites in Australia
- Volunteers
- 30 people
- Sponsor
- OliPass Australia Pty Ltd
Post-Traumatic Osteoarthritis of Ankle, Ankle Osteoarthritis
Indications for Osteochondral Allograft Transplantation
With IRB approval, a prospective single-cohort clinical trial will be performed to assess safety and efficacy of total biologic arthroplasty of the ankle.
- Conditions
- Post-Traumatic Osteoarthritis of Ankle, Ankle Osteoarthritis, Ankle Injuries
- Trial name
- NCT03711747
- Testing
- Osteochondral allograft ankle
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Missouri-Columbia
Knee Osteoarthritis
Intraosseous Tranexamic Acid for Reducing Blood Loss in Total Knee Arthroplasty
This prospective, single-center, randomized, double-blind, placebo-controlled trial aims to evaluate the efficacy and safety of local intraosseous tranexamic acid administration for reducing perioperative blood loss in patients…
- Trial name
- NCT07853885
- Testing
- Tranexamic Acid, Normal Saline
- Where
- China
- Volunteers
- 70 people
- Sponsor
- The Second Affiliated Hospital of Kunming Medical University
Osteoarthritis, Hip
Effect of Anti-gravity Treadmill Training After Total Hip Arthroplasty
Background/Objectives: Total hip arthroplasty is one of the most common orthopedic procedures. When the surgery is successful and followed by high-quality physiotherapy, patients' quality of life usually improves and they return…
- Trial name
- NCT07170215
- Testing
- antigravity treadmill (ALTERG VIA, Lifeward CA, Inc., Milmont Drive, Fremont, CA, U-SA)
- Where
- Croatia
- Volunteers
- 34 people
- Sponsor
- University of Rijeka
Osteoarthritis
Effects of Comprehensive Care for Knee OA
We will study 300 people with knee osteoarthritis (OA) who receive their medical care from a large health maintenance organization (HMO) in Indianapolis.
- Trial name
- NCT00000404
- Testing
- Patient education in self-care of knee OA
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Indiana University
Osteoarthritis, Knee
Quadriceps Exercise Before Total Knee Arthroplasty (The QUADX-1 Trial)
The trial investigates the efficacy of knee-extension exercise prior to total knee replacement. The participants are randomly allocated to one of three exercise dosages. There is no control group.
- Trial name
- QUADX-1 (NCT02931058)
- Testing
- Two knee-extension exercise sessions per week., Four knee-extension exercise sessions per week., Six knee-extension exercise sessions per week.
- Where
- Denmark
- Volunteers
- 140 people
- Sponsor
- Hvidovre University Hospital
Osteoarthritis
Local Anesthetic Infiltration and Infusion for Pain Control After Hip Replacement
The purpose of this study is to examine three different ways to control pain after hip replacement: 1. One time injection of ropivacaine before wound closure 2.
- Trial name
- NCT01409278
- Testing
- Ropivacaine infiltration and saline infusion., Ropivacaine infiltration and infusion., Normal Saline
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- Trinity Health Of New England
Knee Osteoarthritis, Knee Pain Chronic
Gabapentin Regimens and Their Effects on Opioid Consumption
The purpose of this study is to determine the best strategy of administering gabapentin in connection with our current approach to perioperative pain management.
- Conditions
- Knee Osteoarthritis, Knee Pain Chronic, Opioid Use, Opioid Dependence
- Trial name
- NCT03334903
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Preoperative Period, Nutritional Status
Preoperative Nutritional Status in Patients Undergoing Elective Total Knee Arthroplasty and In-hospital Postoperative Complications
Malnutrition has long been linked to postoperative complications and adverse outcomes in a variety of surgical fields , such as increased susceptibility to infection, delayed wound healing, and increased frequency of decubitus…
- Conditions
- Preoperative Period, Nutritional Status, Arthroplasty Knee
- Trial name
- NUTR TKA (NCT03549962)
- Testing
- TKA
- Where
- 2 sites in Hong Kong
- Volunteers
- 626 people
- Sponsor
- Chinese University of Hong Kong
Stroke
Strain Counterstrain and Muscle Energy Technique in Patients of Knee Osteoarthritis
This study aimed to evaluate the comparative effects of Strain Counterstrain (SCS) and Muscle Energy Technique (MET) on pain, range of motion (ROM), and functional disability in patients with knee osteoarthritis (KOA).
- Trial name
- NCT07066670
- Testing
- Strain Counterstrain with Routine Physical Therapy, Muscle Energy Technique with Routine Physical Therapy
- Where
- Pakistan
- Volunteers
- 76 people
- Sponsor
- University of Lahore
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