Clinical trials: Osteoarthritis Arthritis
Osteoarthritis, Knee
MAKO Total Knee Artroplasty
The purpose of this study is to determine the early clinical and radiographic outcomes of robotically assisted total knee arthroplasty with the MAKO surgical robot using the Triathlon knee system.
- Trial name
- NCT05744895
- Testing
- Device: Robotic MAKO total knee, FocusMotion knee brace, Fitbit tracking device
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- Washington University School of Medicine
Osteoarthritis of the Hands
The Analgesic Activity of a Topical Formulation in Patients With Osteoarthritis of the Hands
Osteoarthritis (OA) affects over 30 million people in the United States and represents our nation's leading cause of disability.
- Trial name
- NCT02485145
- Testing
- A/B, B/A
- Volunteers
- 40 people
- Sponsor
- Transdermal Therapeutics, Inc.
Degenerative Arthritis
Efficacy and Safety Study of TissueGene-C to Degenerative Arthritis
The purpose of this study is to determine whether TissueGene-C, an allogeneic human chondrocytes expressing Transforming Growth Factor(TGF)-b1, is effective and safe in patients with degenerative arthritis
- Trial name
- NCT01671072
- Testing
- TissueGene-C, Normal Saline
- Where
- 3 sites in South Korea
- Volunteers
- 54 people
- Sponsor
- Kolon Life Science
Coxarthrosis, Avascular Necrosis of Hip
Effect of Peri-operative Glucocorticoids on Short-term Functional Outcome After THA
This randomized, single surgeon, placebo controlled, double blind study will be conducted in order to investigate whether or not peri-operative high doses of intravenous glucocorticoids improve short-term functional outcome after…
- Trial name
- DEXA (NCT04317872)
- Testing
- High dose of peri-operative intravenous dexamethasone, Low dose of peri-operative intravenous dexamethasone
- Where
- Belgium
- Volunteers
- 71 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Osteo Arthritis Knee
Cartilage Adaptation and Response to Interleukins and Exercise
This study will examine the effect of exercise on the turnover of collagen in articular cartilage and the content of cytokines in the synovial fluid from human adults with osteoarthritis.
- Trial name
- CARTILEX (NCT03410745)
- Testing
- Exercise.
- Where
- Denmark
- Volunteers
- 32 people
- Sponsor
- Bispebjerg Hospital
Osteoarthritis
Unicondylar Knee Arthroplasty Versus Total Knee Arthroplasty in Patients With Anteromedial Osteoarthritis of the Knee
This study is a randomized controlled trial comparing total knee arthroplasty (TKA) to unicompartmental knee arthroplasty (UKA) in patients with no to moderate anteromedial knee osteoarthritis.
- Trial name
- NCT02430129
- Testing
- Total knee arthroplasty, Unicompartment knee arthroplasty, Persona
- Where
- Canada
- Volunteers
- 38 people
- Sponsor
- Alberta Hip and Knee Clinic
Chronic Pain, Osteoarthritis
Hormone Function in Men Treated for Pain With Opioids or Placebo
This study will examine hormone function in men with osteoarthritis pain and how it is affected by opioid medication (such as Percocet, Vicodin, MS Contin and morphine) versus placebo.
- Trial name
- NCT00737737
- Testing
- MS Contin
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- National Institute of Nursing Research (NINR)
Osteoarthritis of the Knee
Targeted Rehabilitation to Improve Outcome After Knee Replacement- A Physiotherapy Study
The TRIO-physio study is looking at how well patients with osteoarthritis recover after knee replacement surgery (also known as Total Knee Arthroplasty (TKA)). Currently around 20% of patients are not satisfied after TKA.
- Trial name
- TRIO-Physio (NCT01849445)
- Testing
- Intensive physiotherapy, Home physiotherapy exercises
- Where
- 6 sites in United Kingdom
- Volunteers
- 334 people
- Sponsor
- University of Edinburgh
Pain, Postoperative, Anesthesia, Local
Ultrasound-guided Regional Anesthesia vs Local Infiltration Anesthesia With Dexmedetomidine and Ropivacaine
Evaluation of the Impact of dexmedetomidine as an adjunct for local infiltrations analgesia and ultrasound-based regional anaesthesia as pain medication in regard to patients' opioid need the first 48 hours after the total knee…
- Conditions
- Pain, Postoperative, Anesthesia, Local, Gonarthrosis
- Trial name
- NCT04697537
- Testing
- Ultrasound guided regional anesthesia, Local infiltration analgesia
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Medical University of Graz
Knee Osteoarthritis, Total Knee Replacement
TKR Rehabilitation Through the Immersive Virtual Reality in Aquatic Scenarios
This study is a multicenter non-randomized single-blind controlled trial, aimed at investigating the feasibility and efficacy of hydrotherapy based on IVR, for the patients with TKR(Total Knee Replacement), on the function, gait…
- Trial name
- HYDROKNEERVANA (NCT04241172)
- Testing
- Experimental: Immersive Virtual Reality (HIVR), Traditional Hydrotherapy (TH), Traditional Rehabilitation (TR)
- Where
- Italy
- Volunteers
- 96 people
- Sponsor
- IRCCS San Raffaele Roma
Knee Osteoarthritis
Serum COMP and MMP-3 in Knee Osteoarthritis
Knee osteoarthritis is a common degenerative joint disease characterized by pain, stiffness, and functional limitation, significantly affecting quality of life.
- Trial name
- KOACOMP (NCT07528872)
- Testing
- Observational Study
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Osteoarthritis, Knee
Knee Osteoarthritis Treatment With Platelet-rich Plasma
Knee osteoarthritis (KOA) is a disease characterized by cartilage degeneration, synovium inflammation, bone remodeling, osteophyte formation, inflammations and loss of articular function.
- Trial name
- NCT05824806
- Testing
- PRP Protocol A, PRP Protocol B, Hyaluronic acid
- Where
- Brazil
- Volunteers
- 90 people
- Sponsor
- Instituto Nacional de Traumatologia e Ortopedia
Osteoarthritis, Knee
A Long-Term Safety Study of IDEA-033 in Comparison to Oral Naproxen for the Treatment of Osteoarthritis of the Knee
The purpose of this study is to evaluate the long-term safety of IDEA-033 (an anti-inflammatory pain-relieving drug applied to the skin) in comparison to naproxen (an anti-inflammatory pain-relieving drug taken by mouth) for the…
- Trial name
- NCT00265304
- Testing
- Ketoprofen
- Where
- 93 sites in United States
- Volunteers
- 550 people
- Sponsor
- IDEA AG
Osteoarthritis
A Clinical Trial Follow-up Study of the Genesis II Posterior Stabilized Total Knee Replacement
The purpose of this study is to look at the outcomes of the GENESIS II Posterior Stabilized Total Knee Replacement.
- Trial name
- NCT00351793
- Testing
- Knee Implant
- Where
- Canada
- Volunteers
- 186 people
- Sponsor
- Ross Leighton
Osteoarthritis, Pain
Study of Efficacy, Safety of Fulranumab Monotherapy for OA of Hip or Knee, PAI3003
The purpose of this study is to demonstrate the efficacy, safety, and tolerability of fulranumab as Monotherapy compared with placebo in participants with signs and symptoms of osteoarthritis of the hip or knee that are not…
- Trial name
- NCT02289716
- Testing
- Fulranumab 1 mg, Fulranumab 3 mg
- Where
- 28 sites in United States, Belgium and 6 more
- Volunteers
- 41 people
- Sponsor
- Janssen Research & Development, LLC
Osteoarthritis
Study to Evaluate the Efficacy of Milnacipran in the Treatment of Pain Due to Osteoarthritis
The present study will aim to evaluate the efficacy of milnacipran in the treatment of pain due to osteoarthritis (OA), that is, to determine whether milnacipran provides superior efficacy to placebo in patients with OA.
- Trial name
- NCT01329406
- Testing
- Milnacipran
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Analgesic Solutions
Shoulder Osteoarthritis
Fixed Inclination Humeral Cut
The purpose of the present study is to determine if a standard humeral cut using a fixed neck shaft angled prosthesis for patients undergoing anatomic TSA is able to restore normal glenohumeral relationships as compared to a…
- Trial name
- NCT03922763
- Testing
- Anatomical cut, Cutting guide
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Rothman Institute Orthopaedics
Knee Osteoarthritis
Effects of Blood Flow Restriction Training With Low Intensity Exercises in Knee Osteoarthritis
The aim of the study is to examine the effects of blood flow restriction training(BFRT) with low intensity exercises on pain, range of motion and quality of life in Knee Osteoarthritis.
- Trial name
- NCT06502587
- Testing
- blood flow restriction training, ultrasound therapy
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Riphah International University
Knee Osteoarthritis
Quantitative MRI For Detection and Tracking of Knee Osteoarthritis
The goal of this observational study is to develop whole-joint quantitative MRI techniques that aid in the detection and tracking of osteoarthritis disease progression at 3T and 7T MRI scanners. The research objectives are: 1.
- Trial name
- NCT06063304
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Osteoarthritis
Fixation of OsseoTi™ Porous Structure Versus PPS (Porous Plasma Spray) Coating on the G7™ Acetabular Component for Primary Total Hip Arthroplasty
The primary objective of this project is to investigate, using RSA, acetabular implant migration of the OsseoTi™ G7 acetabular cup in comparison to conventional PPS coated G7 acetabular cup, and compare liner wear of thinnest…
- Trial name
- NCT02316704
- Testing
- THA with G7 PPS coted acetabular component, THA with G7 OsseoTi coted acetabular component
- Where
- 2 sites in Denmark, Sweden
- Volunteers
- 98 people
- Sponsor
- Hvidovre University Hospital
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