Clinical trials: Osteoarthritis Arthritis
Osteoarthritis
Tranexamic Acid in Knee Joint Surgery
Total knee joint replacement surgery can lead to significant blood loss, which can affect recovery after surgery. Tranexamic acid (TXA) is a medication which stops the breakdown of blood clots and therefore prevents blood loss.
- Trial name
- TRACKS (NCT02278263)
- Testing
- Tranexamic Acid, Normal saline (0.9% NaCl)
- Where
- 5 sites in New Zealand
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Andrew G Hill, MBChB, MD (Thesis), EdD, FACS, FRACS
Hip Osteoarthritis, Prosthesis Durability
Symax International Study
The uncemented Symax hip stem is developed through optimization of the uncemented Omnifit hip stem. The Symax stem design combines an anatomical anteverted proximal geometry with a straight distal section.
- Trial name
- NCT03469687
- Testing
- Symax uncemented hip stem
- Volunteers
- 80 people
- Sponsor
- Maastricht University Medical Center
Knee Osteoarthritis (OA)
A Clinical Study to Evaluate the Efficacy of Native CT-II® in Individuals With Knee Osteoarthritis
This randomized, double-blind, placebo-controlled clinical study evaluates the efficacy of Native CT-II® (undenatured type II collagen) in individuals with knee osteoarthritis using a parallel design.Participants are assigned to…
- Trial name
- NCT06917287
- Testing
- Native CT-II® (undenatured type II collagen), Glucosamine HCL + Chondroitin Sulphate (G+C) [Comparator]
- Where
- 5 sites in India
- Volunteers
- 114 people
- Sponsor
- Vedic Lifesciences Pvt. Ltd.
Osteoarthritis
Evaluation of FLEXOFYTOL® Versus PLACEBO
This study is a prospective, randomized, double-blind, placebo-controlled with 3 parallel-groups and multicenter trial in patients suffering from knee OA (osteoarthrosis).
- Trial name
- COPRA (NCT02909621)
- Testing
- FLEXOFYTOL®
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- Tilman S.A.
Knee Osteoarthritis, Multimorbidity
Preoperative Multimorbidity and Functional Recovery After Total Knee Arthroplasty
This prospective observational cohort study aims to investigate the association between preoperative multimorbidity burden and functional recovery after primary total knee arthroplasty (TKA) in patients with knee osteoarthritis.
- Trial name
- NCT07882316
- Where
- Turkey (Türkiye)
- Volunteers
- 230 people
- Sponsor
- Balikesir Ataturk City Hospital
Osteoarthritis, Rheumatoid Arthritis
Post Market Clinical Follow-up (PMCF) Study of the A.L.P.S. Proximal Humerus Plating System
This study is a multicenter, prospective, non-randomized, non-controlled post-market clinical follow-up study. The primary objective of this study is to confirm the safety and performance of the A.L.P.S.
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Post-Traumatic Arthritis, Psoriatic Arthritis
- Trial name
- NCT03626038
- Testing
- A.L.P.S. Proximal Humerus Plating System
- Where
- 7 sites in United States, Australia and 3 more
- Volunteers
- 135 people
- Sponsor
- Zimmer Biomet
Osteoarthritis, Total Knee Replacement
Static and Dynamic Balance in Correlation With Quality of Life, in Primary Total Knee Replacement
Knee osteoarthritis (OA) is one of the most prevalent musculoskeletal complaints worldwide, affecting 30-40% of the population by the age of 65 yr.Individuals with knee OA suffer progressive loss of function.Balance is an…
- Trial name
- NCT00256958
- Testing
- total knee replacement
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Hadassah Medical Organization
Osteoarthritis
Self-assessment of Flare in Osteoarthritis of Lower Limbs
The need for a tool to measure flare in lower limb osteoarthritis (OA of the hip and knee) is justified by the opportunities for development of clinical trials targeting hip and knee OA long-term treatment (slow acting drug…
- Trial name
- FLARE-OA (NCT02892058)
- Where
- 12 sites in Australia, Canada and 2 more
- Volunteers
- 398 people
- Sponsor
- Central Hospital, Nancy, France
Knee Osteoarthritis
Comparative Usability Evaluation of Sustained Acoustic Medicine (SAM) Devices and Topical Gel for OA Knee Pain
The purpose of this study is to evaluate the usability of the ultrasound devices and common pain relief gel. The ability of the three treatment approaches to reduce pain, stiffness, and functionality as measured by NRS scale and…
- Trial name
- NCT05050448
- Testing
- Sustained Acoustic Device with 2.5% Diclofenac Patch, 1% Diclofenac Topical Gel
- Where
- 3 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- ZetrOZ, Inc.
Osteoarthitis
Evaluating the Role of Genicular Artery Embolization in Treatment of Persistent Pain in Patients With Severe Knee Osteoarthritis
The goal of this randomized clinical trial is to evaluate the role of genicular artery embolization (GAE) in treating persistent pain in patients with severe knee osteoarthritis who have failed conservative treatment and may be…
- Trial name
- NCT07763158
- Testing
- embolization therapy, Conservative treatment
- Where
- Saudi Arabia
- Volunteers
- 60 people
- Sponsor
- King Abdullah International Medical Research Center
Knee Osteoarthritis
Clinical Importance of Occult Suprapatellar Effusion in Knee Osteoarthritis
Small amounts of fluid in the knee joint may not always be visible during a standard ultrasound examination performed while the leg is relaxed.
- Trial name
- NCT07876752
- Testing
- Static and Dynamic Suprapatellar Ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people
- Sponsor
- Mardin Artuklu University
Osteoarthritis
Patient Education Program for Osteoarthritis With Exercise Included
The purpose of this study is to investigate if inclusion of exercise in an education program for patients with osteoarthritis can improve self efficacy, self-perceived health and function.
- Trial name
- PEPOA-E (NCT01119547)
- Testing
- Exercise in a group, Home exercise
- Where
- Sweden
- Sponsor
- Lund University
Osteoarthritis, Knee, Physical Inactivity
Effect of Structured Exercise in Patients With Knee Osteoarthritis
The aim of this randomized controlled trial is to evaluate the effect of Nordic walking and inspiratory muscle training (IMT) on cardiopulmonary function in patients with knee osteoarthritis (OA).
- Trial name
- NCT06084949
- Testing
- Nordic walking or inspiratory muscle training
- Where
- Hong Kong
- Volunteers
- 80 people
- Sponsor
- The Hong Kong Polytechnic University
Knee Osteoarthritis, Mechanical Traction
MECHANICAL TRACTION APPLIED BEFORE VERSUS AFTER THERAPEUTIC EXERCISES IN PRIMARY KNEE OSTEOARTHRITIS
To study the effect of application of mechanical traction before versus after therapeutic exercises and exercise alone ,on pain severity , disability , knee joint range of motion , knee joint position sense , knee isometric…
- Trial name
- MT-KOA (NCT07613749)
- Testing
- Group A: Therapeutic exercise group, Group B: mechanical traction followed by therapeutic exercise, Group C: therapeutic exercise followed by mechanical traction
- Where
- Egypt
- Volunteers
- 63 people
- Sponsor
- Cairo University
Spinal Cord Injuries (SCI), Osteoarthritis (OA)
Ultrasonographic Evaluation of Talar Cartilage Thickness in Patients With Spinal Cord Injury
Spinal cord injury patients often present with musculoskeletal comorbidities, including osteoarthritis. Early detection of cartilage damage is important for preventing osteoarthritis progression.
- Trial name
- NCT07293949
- Where
- Turkey (Türkiye)
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Acetabular Labrum Tear, Femoro Acetabular Impingement
Arthroscopic Labral Repair Versus Physical Therapy for Tears of the Acetabular Labrum
Tears of the acetabular labrum appear to be common with the prevalence of asymptomatic tears in the general population approaching 66% and 70% based on cadaveric dissection and magnetic resonance imaging, respectively.
- Conditions
- Acetabular Labrum Tear, Femoro Acetabular Impingement, Hip Arthroscopy, Physical Therapy
- Trial name
- NCT03909178
- Testing
- Hip Arthroscopy Surgery with Acetabular Labral Repair (SPT group), Physical Therapy Focused on the Hip and Hemi-pelvis (PT group)
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Massachusetts General Hospital
Osteoarthritis of the Knee
To Compare the Efficacy and Safety of LAYLA in Osteoarthritis Patients
This is a randomized, double-blind study to compare the efficacy and safety of LAYLA tablet and Joins tablet in the treatment of osteoarthritis of the knee.
- Trial name
- NCT01768468
- Testing
- LAYLA tablet, JOINS tablet
- Where
- 6 sites in South Korea
- Volunteers
- 124 people
- Sponsor
- PMG Pharm Co., Ltd
Osteoarthritis, Knee
Monopolar Versus Biopolar Radiofrequency in OA Knee Pain
This is a prospective randomized controlled trial study will aim to evaluate the the efficacy and procedural pain of BRFA and to compare it with conventional technique (MRFA).
- Trial name
- NCT05591768
- Testing
- Monopolar radiofrequency, Bipolar radiofrequency
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Assiut University
Chronic Diseases, Knee Osteoarthritis
Pulsed Short Wave in Females With Knee Osteoarthritis
Study design: Randomized clinical trial. Objective: To evaluate the effect of PSW treatment in different doses and to compare to the control and placebo group.
- Trial name
- PSW (NCT01331174)
- Testing
- Pulsed short wave
- Volunteers
- 121 people
- Sponsor
- Irmandade da Santa Casa de Misericordia de Sao Paulo
Osteoarthritis, Knee, Nociceptive Pain
The Post-operative Analgesia of the Virtual Reality Using a Mirror Therapy After Total Knee Arthroplasty
It was well known that the mirror therapy could decrease pain of upper-limb amputated patients. The mirror therapy is known to make a plastic change some parts of the brain perceiving the painful body part and modulating its…
- Conditions
- Osteoarthritis, Knee, Nociceptive Pain, Virtual Reality
- Trial name
- NCT01979718
- Testing
- Mirrored Virtual reality
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Ulsan University Hospital
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