Clinical trials: Osteoarthritis Pain
Musculoskeletal Pain, Knee Osteoarthritis
Impact of Mesenchymal Stem Cells in Knee Osteoarthritis
Many patients with osteoarthritis of the knee fail non-operative measures and elect to have knee arthroplasty to improve their quality of life.
- Conditions
- Musculoskeletal Pain, Knee Osteoarthritis, Cartilage Injury, Cartilage Degeneration
- Trial name
- NCT03477942
- Testing
- Autologous Mesenchymal Stem Cells
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
Knee Pain Chronic, Osteo Arthritis Knee
Individual Patient Expanded Access IND of Autologous HB-adMSCS for the Treatment of Bilateral Knee Pain.
This is an Individual Patient Expanded Access IND of autologous adipose derived Mesenchymal Stem Cells with the primary goal of treating 1 individual with bilateral knee pain who has exhausted all treatment options, his condition…
- Trial name
- NCT04604288
- Testing
- HB-adMSC
- Where
- United States
- Sponsor
- Hope Biosciences Research Foundation
Knee Osteoarthritis
Optimization of Synvisc-One for Knee OA
The study hypothesis is that the use of Synvisc-One will improve physical therapy compliance and performance, resulting in improved knee function and pain when compared to a group that receives a sham injection (an injection that…
- Trial name
- NCT02029703
- Testing
- Synvisc-One Injection
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Elaine Husni
Knee Osteoarthritis, Total Knee Arthroplasty (TKA)
How Variations in Pharmacogenomic Profiles Affect Pain and Narcotic Needs Following Total Knee Arthroplasty (TKA)
The purpose of the study is to gain a better understanding of how genetic variations can affect pain experience and the need and type of pain control medication after a total knee replacement.
- Trial name
- NCT04020471
- Testing
- Pain Scale/Medication Log
- Where
- United States
- Volunteers
- 375 people
- Sponsor
- Endeavor Health
Osteoarthritis of Knee, Healthy Participants
Evaluation of Muscle Oxygenation and Recovery Dynamics in Individuals With Knee Osteoarthritis
Knee osteoarthritis (OA) is a degenerative joint disease characterized by pain, muscle weakness, and functional limitations that significantly affect lower limb muscle performance.
- Trial name
- NCT07471204
- Testing
- No intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Bahçeşehir University
Patellofemoral Osteoarthritis
Proximal and Distal Therapeutic Approach in Pain and Lower Limb Kinematic in People With Patellofemoral Osteoarthritis
This is a crossover study that will investigate the immediate effects of a proximal therapeutic approach (SERF strap) and a distal one (foot orthoses) on knee pain intensity, global change, symptoms, ease of performance and…
- Trial name
- NCT04332900
- Testing
- Elastic hip strap, Insole
- Volunteers
- 30 people
- Sponsor
- Universidade Federal de Sao Carlos
Osteoarthritis
Efficacy of Proprietary Cherry Juice Blend in Osteoarthritis of the Knee
The primary purpose of this research study is to test the ability of a proprietary cherry juice blend to be helpful in the treatment of osteoarthritis (OA) of the knee.
- Trial name
- NCT00443092
- Testing
- proprietary cherry juice blend (food), control juice (kool aid blend)
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- CherryPharm
Knee Osteoarthritis (Knee OA), Osteoarthritis
Retro-walking Versus Forward-walking Training Using Underwater Treadmill in Patients With Knee Osteoarthritis
The purpose of this study Will investigate and compare the effects of retro-walking and forward-walking underwater treadmill training on pain, function and ROM in subjects with chronic knee OA
- Trial name
- NCT06896032
- Testing
- physical therapy intervention
- Where
- 2 sites in Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nourhan Atwa Said
Knee Osteoarthritis
The Impact of Therapeutic Alliance in the Rehabilitation of Knee Osteoarthritis.
The therapeutic alliance (TA) is the working relationship or positive social bond between the patient and the therapist. TA is based on collaboration, communication, empathy of the therapist and mutual respect.
- Trial name
- ALLIANCE (NCT04390932)
- Testing
- Enhanced TA, Limited TA, Therapeutic exercise protocol.
- Where
- Chile
- Volunteers
- 24 people
- Sponsor
- Universidad Catolica de Temuco
Knee Osteoarthritis
"Effectiveness of Mulligan Mobilization Technique and Proprioceptive Exercises Among Patients With Knee Osteoarthritis"
This research analyzes the effectiveness of Mulligan mobilization in comparison to proprioceptive exercises for treating patients with mild to moderate Knee osteoarthritis whose condition falls under Kellgren and Lawrence grading…
- Trial name
- MWMPETKOA (NCT06971016)
- Testing
- Mulligan Mobilization technique, Proprioceptive Exercises, Traditional Physical therapy
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- National Healthcare Center
Knee Osteoarthritis
Psychological and Pain Factors in Knee Osteoarthritis
This study aims to determine if baseline measures of psychology and pain sensitivity can predict changes in physical function at 1 year in patients with knee osteoarthritis.
- Trial name
- NCT05949489
- Testing
- WOMAC pain subscale
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Ahram Canadian University
Knee Osteoarthritis
A Study to Compare Levels of Capsaicin After Intra-Articular Injection and Topical Application in Patients With Painful Knee Osteoarthritis
This is a Phase 1b, open-label, two-period, randomized crossover study in adult male and female participants with painful knee osteoarthritis.
- Trial name
- NCT03576508
- Testing
- CNTX-4975-05, Qutenza, Lidocaine (without epinephrine)
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Centrexion Therapeutics
Osteoarthritis, Arthritis, Rheumatoid
Low Dose Naltrexone for Chronic Pain From Arthritis
Over 100 million Americans report chronic pain. Veterans are disproportionately affected for multiple reasons, including injuries and post-traumatic stress disorder.
- Conditions
- Osteoarthritis, Arthritis, Rheumatoid, Arthritis, Psoriatic
- Trial name
- LDN-VA (NCT03008590)
- Testing
- Naltrexone
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- VA Office of Research and Development
Joint Pain
Genicular Nerve Phenol Neurolysis Versus Radiofrequency Ablation for Pain Relief in Grade 4 Knee Osteoarthritis
The goal of this clinical trial is to compare the efficiency and efficacy of genicular nerves blockade by chemical phenol neurolysis versus radiofrequency ablation in managing pain in patients suffering from grade IV KOA in term…
- Trial name
- NCT06864390
- Testing
- genicular nerve neurolysis
- Volunteers
- 114 people
- Sponsor
- Ain Shams University
Pain, Osteoarthritis, Knee
A Comparison of the Analgesic Efficacy and Safety of Once Daily Tramadol OAD Tablets to Twice Daily Tramadol BID for the Treatment of Osteoarthritis of the Knee (Extension Protocol) and Open Label Safety Follow-Up
The purpose of this study is to evaluate the long-term safety (up to one year) of Tramadol Once-A-Day (OAD) tablets at the highest doses: 200-400 mg
- Trial name
- NCT00912015
- Testing
- Tramadol OAD, Tramadol OAD 100mg
- Volunteers
- 238 people
- Sponsor
- Labopharm Inc.
Osteoarthritis, Knee
Nutramax Joint Health Formulation Biochemical Response Study
The Nutramax test article is a nutritional supplement that contains several ingredients shown to potentially provide benefit to patients suffering from a painful and sometimes debilitating condition of the knee called…
- Trial name
- NCT02614274
- Testing
- Nutraceutical joint health formulation
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Hip Osteoarthritis, Hip Pain Chronic
Continuous Radiofrequency in Hip Osteoarthritis Pain: A Randomized Clinical Trial.
This will be a prospective, single-center, double-blinded, randomized study designed to compare the efficacy of the intraarticular injection of a corticosteroid and the Conventional Radiofrequency (CRF) of the anterior sensory…
- Trial name
- NCT06221709
- Testing
- Conventional Radiofrequency (CRF group), Intraarticular Infiltration ( Control group)
- Where
- Brazil
- Volunteers
- 70 people
- Sponsor
- University of Brasilia
Osteoarthritis
Internet-Based Osteoarthritis Pain Coping Skills Intervention
The purpose of this study is to translate a proven pain coping skills intervention for osteoarthritis (OA) patients into an engaging and easy-to-use Internet-based intervention that uses innovative technologies to mimic…
- Trial name
- PainCOACH (NCT01638871)
- Testing
- PainCOACH
- Where
- 2 sites in United States
- Volunteers
- 113 people
- Sponsor
- University of North Carolina, Chapel Hill
Osteoarthritis, Knee
Melatonin for Knee Osteoarthritis Patients
By recruiting knee osteoarthritis patients and treating them with melatonin, this study aims to determine the efficacy and safety of melatonin in alleviating pain in this patient population.
- Trial name
- NCT06012175
- Testing
- Melatonin
- Where
- China
- Volunteers
- 340 people
- Sponsor
- Xiangya Hospital of Central South University
Osteoarthritis, Knee
Osteoarthritis Knee Pain Relief Study of 0.25% 920-CGS-200
This is a study of an over-the-counter, capsaicin-based (0.25%) topical analgesic for management of osteoarthritis knee pain meeting the US Food and Drug Administration's (FDAs) Tentative Final Monograph (TFM) guidance for…
- Trial name
- NCT03124407
- Testing
- Capsaicin Topical Solution, Drug product vehicle
- Where
- 3 sites in United States
- Volunteers
- 120 people
- Sponsor
- Propella Therapeutics
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