Clinical trials: Osteoarthritis Pain
Arthritis, Degenerative
Intraoperative Sedatives and Postoperative Pain
In this study, based on the hypothesis that dexmedetomidine administered intraoperatively for sedation can reduce postoperative pain than that of propofol, the investigators examined the ability of dexmedetomidine to reduce…
- Trial name
- NCT02784626
- Testing
- Dexmedetomidine, Propofol
- Where
- South Korea
- Volunteers
- 48 people
- Sponsor
- Seoul National University Bundang Hospital
Muscle Soreness, Headache
Adverse Events in Dry Needling
The purpose of this prospective cohort survey study is to further explore the incidence of adverse events with dry needling by physical therapists - as well as any differences or similarities between patient-reported vs…
- Conditions
- Muscle Soreness, Headache, Knee Osteoarthritis, Back Pain
- Trial name
- NCT03612843
- Testing
- Observational dry needle
- Where
- 8 sites in United States
- Volunteers
- 250 people
- Sponsor
- Elizabeth Lane
Osteoarthritis, Knee
A Phase 3 Efficacy and Safety Study of Intra-articular CNTX-4975-05 (Capsaicin) vs Placebo in Subjects With OA Knee Pain
This is a phase 3, randomized, double-blind, placebo-controlled, single injection, 52-week study to evaluate the analgesic efficacy and safety of a single intra-articular (IA) CNTX-4975-05 (capsaicin), compared to IA placebo, in…
- Trial name
- NCT03429049
- Testing
- CNTX-4975-05
- Where
- 33 sites in United States
- Volunteers
- 332 people
- Sponsor
- Centrexion Therapeutics
Osteoarthritis, Knee, Quality of Life
Yoga for Managing Knee Osteoarthritis in Older Women: a Feasibility Study
The study hypothesized that it is feasible and safe to use Hatha yoga in older women with knee osteoarthritis (OA), and practicing Hatha yoga regularly will help reduce pain and stiffness, enhance physical function, and improve…
- Conditions
- Osteoarthritis, Knee, Quality of Life, Poor Quality Sleep, Physical Impairment
- Trial name
- NCT01832155
- Testing
- Hatha yoga
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Minnesota
Osteoarthritis, Knee
A Cost-efficiency Analysis of Primary Assessors for Patients With Knee Pain in Primary Care
Background: Almost half of the Swedish population are overweight or obese. This will probably affect the incidence of osteoarthritis since overweight is a strong risk factor.
- Trial name
- NCT03822533
- Testing
- Physiotherapist as primary assessor, Physician as primary assessor
- Where
- 9 sites in Sweden
- Volunteers
- 363 people
- Sponsor
- Vastra Gotaland Region
Osteoarthritis of the Shoulder, Shoulder Pain
Improving Pain Management After Total Shoulder Replacement Using Bupivacaine Liposome
To improve pain control and decrease opioid requirements for subjects undergoing Total Shoulder Replacement.
- Conditions
- Osteoarthritis of the Shoulder, Shoulder Pain, Pain, Postoperative
- Trial name
- NCT04134442
- Testing
- Bupivacaine Liposome Injection, Standard Therapy
- Where
- United States
- Sponsor
- University of Massachusetts, Worcester
Osteoarthritis
Intraarticular Pulse Radiofrequency to Treat Chronic Knee Pain
The purpose of this study is to determine whether bipolar intraarticular pulsed radiofrequency method has a superiority to unipolar mode in the treatment of chronic knee pain.
- Trial name
- NCT02141529
- Testing
- Unipolar pulsed radiofrequency thermocoagulation, Bipolar pulsed radiofrequency thermocoagulation
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Cukurova University
Degenerative Arthritis and Postoperative Pain
Effect of Gabapentin on Orthopedic Pain
This study is being done to determine if a drug called gabapentin helps in the postoperative management of patients undergoing hip and knee operations.
- Trial name
- NCT01546857
- Testing
- Gapabentin
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Rutgers, The State University of New Jersey
Osteoarthritis, Knee
A Study To Investigate Whether PF-04457845 Is Effective In Treating Pain, Is Safe And Tolerable In Patients With Osteoarthritis Of The Knee
Inactivation of the FAAH (Fatty Acid Amide Hydrolase) enzyme has been shown to relieve pain and inflammation in animal studies. PF-04457845 has been shown to inactivate the FAAH enzyme in animals and healthy human volunteers.
- Trial name
- NCT00981357
- Testing
- PF-04457845, Naproxen
- Where
- 7 sites in United States, Canada and 1 more
- Volunteers
- 76 people
- Sponsor
- Pfizer
Knee Osteoarthritis (Knee OA)
Randomized Controlled Study Evaluating Genicular Artery Embolization Against Intra-Articular Corticosteroid Knee Injection for Osteoarthritic Knee Pain
Multi-center, prospective, randomized trial of GAE using Nexsphere-F against steroid injection
- Trial name
- RESORB (NCT06872567)
- Testing
- genicular artery embolization, Corticosteroid Injection
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- North American Science Associates Ltd.
Myofascial Trigger Points, Migraine
Clinical Study of Myofascial Trigger Points(MTrPs) Injection in the Treatment of Knee Osteoarthritis(OA)
Chronic musculoskeletal pain (CMP) is a common disease in China, with a high incidence among the elderly, and has a significant impact on patients' quality of life. Knee osteoarthritis is a common type of CMP.
- Conditions
- Myofascial Trigger Points, Migraine, Cervicogenic Headache, Chronic Musculoskeletal Pain
- Trial name
- NCT07347028
- Testing
- MTrPs Injection, Intra-articular(IA) Injection
- Where
- China
- Volunteers
- 238 people
- Sponsor
- Beijing Tiantan Hospital
Ankle Osteoarthritis, Pain, Postoperative
New App for Monitoring Postoperative Pain in Total Ankle Replacement
The study evaluates a novel web-based application for monitoring the postoperative pain in patients undergoing total ankle replacement, from preoperative condition to 30 days follow-up.
- Trial name
- NCT03777072
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Osteoarthritis, Knee, Osteo Arthritis Knee
Safety and Pharmacodynamics of GNSC-001 Intra-articular Injection for Knee Osteoarthritis
The goal of this clinical study is to determine if a single injection of 1 or more dose levels of adeno-associated virus (AAV) gene therapy (GNSC-001) is safe and tolerated compared to placebo in participants with painful…
- Conditions
- Osteoarthritis, Knee, Osteo Arthritis Knee, Knee Osteoarthritis
- Trial name
- DONATELLO (NCT05835895)
- Testing
- GNSC-001, transient immune-modulation
- Where
- 9 sites in United States
- Volunteers
- 67 people
- Sponsor
- Genascence Corporation
Knee Osteoarthritis, Depression
A Randomized Pilot rTMS Trial for Knee Arthritis Pain and Depression
Osteoarthritis (OA) is a major public health problem, and involvement of the knee is especially disabling. Symptomatic knee OA has an incidence rate between 40 to 1,020 per 100,000 person years1 and is among the most common…
- Trial name
- NCT06906939
- Testing
- repetetive transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, Los Angeles
Knee Osteoarthritis, Joint Pain
Femoral Rotation and Patellar Positioning After TKA
Analysis of patellar positioning in the trochlear groove after TKA with and without the use of dynamic tensioner.
- Conditions
- Knee Osteoarthritis, Joint Pain, Joint Instability, Patella Disorder
- Trial name
- NCT05871112
- Testing
- Use of dynamic tensioner
- Where
- Poland
- Volunteers
- 125 people
- Sponsor
- Medical University of Warsaw
Chronic Knee Osteoarthritis
Ultrasound-guided Radiofrequency Ablation of the Genicular Nerve Versus Physical Therapy for Chronic Knee Osteoarthritis
The aim of this study is to compare the effects of conventional physiotherapy methods with ultrasound-guided radiofrequency ablation of the genicular nerve on pain and functional status in patients with stage 2-3 chronic knee…
- Trial name
- NCT06173830
- Testing
- radiofrequency ablation, physical therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Ankara City Hospital Bilkent
Pain, Osteoarthritis
Early Ambulation After Adductor Canal Block for Total Knee Arthroplasty
The purpose of this study is to assess early ambulation following total knee replacement in patients receiving continuous adductor canal block with posterior capsular injection compared to continuous femoral nerve block with…
- Trial name
- NCT01459861
- Testing
- Canal Block and Capsular Injection, Femoral Nerve Block with Tibial Nerve Block
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Trinity Health Of New England
Knee Osteoarthritis
Safety and Efficacy of Lorecivivint (SM04690) for the Treatment of Knee Osteoarthritis (STRIDES)
This phase 3 study was a multicenter, randomized, double-blind, placebo-controlled study of lorecivivint injected intra-articularly (IA) into the target (most painful) knee joint of moderately to severely symptomatic…
- Trial name
- NCT05603754
- Testing
- Lorecivivint
- Where
- 44 sites in United States
- Volunteers
- 499 people
- Sponsor
- Biosplice Therapeutics, Inc.
Arthroplasty, Replacement Material
Cryoneurolysis Prior to Total Knee Arthroplasty (CRYO-TKA Trial)
Approximately 20-30% of patients experience persistent pain after a Total Knee Arthroplasty (TKA). This study investigates whether percutaneous cryoneurolysis of genicular nerves can reduce pain and improve physical function when…
- Conditions
- Arthroplasty, Replacement Material, Knee Arthritis Osteoarthritis, Knee Arthroplasty, Total
- Trial name
- CRYO-TKA (NCT07425457)
- Testing
- CT-guided Cryoneurolysis of the Genicular Nerves
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Attikon Hospital
Joint Diseases, Arthritis
A Study to Compare the Frequency of Constipation Symptoms With Tapentadol Immediate Release (IR) Treatment Versus Oxycodone IR Treatment in Patients With End-stage Joint Disease
The purpose of this study is to compare bowel function/constipation that occurs during tapentadol treatment with that occuring during oxycodone treatment, as measured by the frequency of spontaneous bowel movements per week.
- Conditions
- Joint Diseases, Arthritis, Osteoarthritis
- Trial name
- NCT00784277
- Testing
- oxycodone CR, oxycodone IR, Tapentadol ER (CG5503)
- Volunteers
- 597 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
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