Clinical trials: Osteoarthritis Pain
Osteo Arthritis Knee
Home-based tDCS and Mindfulness-based Meditation for Self-management of Clinical Pain and Symptoms
This clinical trial aims to evaluate whether a 2 week regimen of transcranial direct current stimulation (tDCS) paired with mindfulness-based meditation (MBM) can improve pain modulation, reduce clinical pain, and alleviate…
- Trial name
- NCT04375072
- Testing
- active tDCS paired with active MBM
- Where
- United States
- Volunteers
- 208 people
- Sponsor
- University of Arizona
Osteo Arthritis Knee
Self-Administered Transcranial Direct Current Stimulation for Pain in Older Adults With Knee Osteoarthritis
The purpose of this study is to assess the feasibility, acceptability, and efficacy of self-administered transcranial direct current stimulation (tDCS) in older adults with knee osteoarthritis (OA)
- Trial name
- NCT04016272
- Testing
- Active tDCS
- Where
- United States
- Volunteers
- 123 people
- Sponsor
- Florida State University
Gonarthrosis, Meniscus; Degeneration
Comparison of Ultrasound-Guided Perimeniscal Steroid and 5% Dextrose Injections in Knee Osteoarthritis
Introduction: The primary goal of treating knee osteoarthritis is to reduce pain and improve the patient's quality of life. Medial meniscal extrusion is a condition that is linked to pain and disability in knee osteoarthritis and…
- Conditions
- Gonarthrosis, Meniscus; Degeneration, Pain, Chronic
- Trial name
- NCT06308887
- Testing
- Triamcinolone Acetonide, Dextrose 5% in water
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Kastamonu University
Osteoarthritis, Rheumatoid Arthritis
Efficacy and Safety of Buprenorphine Transdermal Patch in Non-cancer Pain of Moderate Intensity
This is a phase IV, open-label and single-arm study of patients with non-malignant pain due to osteoarthritis, rheumatoid arthritis, low back pain and joint/muscle pain, who were not responding to non-opioid analgesics.
- Conditions
- Osteoarthritis, Rheumatoid Arthritis, Lower Back Pain, Joint Pain
- Trial name
- NCT02519387
- Testing
- Buprenorphine Transdermal Patch
- Where
- 3 sites in Malaysia
- Volunteers
- 78 people
- Sponsor
- Mundipharma Pharmaceuticals Sdn. Bhd.
Degenerative Arthritis, Inflammation
The Effects of Elmore Oil on Patients With Osteoarthritis
The treatment of osteoarthritis, a disease that eventually affects the majority of the older population, involves the alleviation of symptoms such as pain and stiffness, and the reduction of inflammation.
- Trial name
- NCT01684371
- Testing
- Two oily solutions (Blue Dotted and Orange Dotted Elmore Oils)
- Where
- Philippines
- Volunteers
- 60 people
- Sponsor
- Elmore Oil Company Pty Ltd
Knee Osteoarthritis, Chronic Knee Pain
Sonographic Thigh Adjustment Ratio and Subcutaneous Fat Thickness as Predictors of Genicular Nerve Block Response in Knee Osteoarthritis
Knee osteoarthritis (KOA) is a leading cause of chronic pain and disability. Although genicular nerve block (GNB) is an effective treatment for many patients, treatment response varies considerably.
- Trial name
- STAR-GNB (NCT07712419)
- Testing
- Ultrasound-Guided Genicular Nerve Block
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Osteoarthritis Hand, Neuropathic Pain
Capsaicin in Digital Osteoarthritis Versus Control
The objective of this multicentric, randomized controlled double-blind clinical trial is to demonstrate the efficacy of transdermal application of capsaicin in patients with painful digital osteoarthritis with a neuropathic pain…
- Trial name
- CADOR (NCT06444919)
- Testing
- Capsaicin 179 Mg Cutaneous Patch, Capsaicine low dose 0.04 %
- Where
- 4 sites in France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Clermont-Ferrand
Osteoarthritis, Knee, Postoperative Pain
Cryotherapy Versus Standard Care in Reducing Opioid Consumption After Total Knee Arthroplasty
The goal of this clinical trial is to learn if compressive cryotherapy can reduce postoperative opioid consumption in patients undergoing primary total knee arthroplasty.
- Conditions
- Osteoarthritis, Knee, Postoperative Pain, Total Knee Arthroplasty
- Trial name
- NCT07630337
- Testing
- Game Ready® compressive cryotherapy device, Standard cryotherapy (ice packs)
- Where
- Argentina
- Volunteers
- 74 people
- Sponsor
- Hospital Italiano de Buenos Aires
Knee Injuries, Knee Osteoarthritis
Digital Home-Exercise Therapy Application For Patients With Non-Surgical Knee Injuries
Knee pain is one of the most prevalent musculoskeletal disorders in the United States. Conservative treatments generally consist of pharmacological agents and physical therapy.
- Conditions
- Knee Injuries, Knee Osteoarthritis, Patellofemoral Syndrome
- Trial name
- NCT04323267
- Testing
- Limber Digital Application, Physical therapy Therapy
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Mayo Clinic
Osteoarthritis
Study of Intra-articular DLX105 Applied to Patients With Severely Painful Osteoarthritis of the Knee
The purpose of this study is to determine whether an intra-articular injection of DLX105 to the knee joint of patients suffering from severly painful osteoarthritis is safe and reduces pain.
- Trial name
- NCT00819572
- Testing
- DLX105, a single-chain (scFv) antibody fragment against TNF-alpha
- Where
- 10 sites in Germany, Switzerland
- Volunteers
- 27 people
- Sponsor
- ESBATech AG
Myofascial Trigger Points, Chronic Musculoskeletal Pain
Clinical Study of Myofascial Trigger Points(MTrPs) Injection in the Treatment of Hip Osteoarthritis(OA)
Chronic musculoskeletal pain (CMP) is a common disease in China, with a high incidence among the elderly, and has a significant impact on patients' quality of life. Hip osteoarthritis is a common type of CMP.
- Conditions
- Myofascial Trigger Points, Chronic Musculoskeletal Pain, Hip Osteoarthritis
- Trial name
- NCT07347041
- Testing
- Joint Cavity Injection, MTrPs Injection
- Where
- China
- Volunteers
- 1,036 people
- Sponsor
- Beijing Tiantan Hospital
Knee Osteoarthritis
Aquatic Power Training
Knee Osteoarthritis (OA) accounts for a significant proportion of mobility limitations and is one of the most disabling problems facing the growing population of older adults.
- Trial name
- NCT00904319
- Testing
- Aquatic Power Training
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- University of Iowa
Knee Osteoarthritis
Effects of Blood Flow Restriction Training With Low Intensity Exercises in Knee Osteoarthritis
The aim of the study is to examine the effects of blood flow restriction training(BFRT) with low intensity exercises on pain, range of motion and quality of life in Knee Osteoarthritis.
- Trial name
- NCT06502587
- Testing
- blood flow restriction training, ultrasound therapy
- Where
- Pakistan
- Volunteers
- 36 people
- Sponsor
- Riphah International University
Osteoarthritis
A Phase II Study Looking at Moderate to Severe Osteoarthritis Knee Pain
The purpose of this study is to look at the effects of RN624 on moderate to severe knee pain due to osteoarthritis. This study will look at the safety and pain relieving effects of RN624 compared to placebo over a 4 month period.
- Trial name
- NCT00394563
- Testing
- RN624 (PF-04383119)
- Where
- 48 sites in United States
- Volunteers
- 450 people
- Sponsor
- Pfizer
Knee Osteoarthritis
Chronic Knee Pain Study
Specific Aims: 1) To examine differences between AA and white patients with knee OA in willingness to consider knee joint replacement.
- Trial name
- JRPIT (NCT00776932)
- Where
- United States
- Volunteers
- 852 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Osteo Arthritis Knee, Osteoarthritis
MRgFUS in the Treatment of Osteoarthritic Knee Pain
A double-blind placebo-controlled randomized clinical trial to evaluate the efficacy of magnetic resonance-guided focused ultrasound surgery (MRgFUS) in the treatment of pain caused by knee osteoarthritis (OA)
- Conditions
- Osteo Arthritis Knee, Osteoarthritis, Osteoarthritis, Knee
- Trial name
- NCT03453372
- Testing
- MRgFUS Treatment
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Istituto Ortopedico Rizzoli
Chronic Pain
A Study Comparing the Effectiveness and Safety of Extended Release Tramadol Versus Placebo for the Treatment of Osteoarthritis (OA) of the Knee
The purpose of this study is to compare the analgesic effectiveness and safety of tramadol HCl ER to placebo in patients with moderate to severe pain due to osteoarthritis (OA).
- Trial name
- NCT00348010
- Testing
- Tramadol HCl ER
- Volunteers
- 245 people
- Sponsor
- Bausch Health Americas, Inc.
Chronic Pain, Osteoarthritis, Hip
Long Term Safety and Efficacy Study of Tanezumab in Subjects With Osteoarthritis of the Hip or Knee
The purpose of this study is to compare the long-term joint safety and efficacy (pain relief) of the investigational study drug, tanezumab compared to non-steroidal anti inflammatory drugs (NSAIDs) in subjects with osteoarthritis…
- Conditions
- Chronic Pain, Osteoarthritis, Hip, Osteoarthritis, Knee
- Trial name
- NCT02528188
- Testing
- NSAID, Tanezumab 2.5 mg, Tanezumab 5 mg
- Where
- 507 sites in United States, Australia and 16 more
- Volunteers
- 3,021 people
- Sponsor
- Pfizer
Shoulder Arthroplasty, Shoulder Osteoarthritis
Programmed Intermittent Bolus During Continuous Interscalene Nerve Block for Shoulder Arthroplasty
A new infusion strategy named the 'programmed intermittent bolus' (PIB) technique delivers the hourly dose within minutes compared to the traditional infusion that delivers such dose over an hour.
- Conditions
- Shoulder Arthroplasty, Shoulder Osteoarthritis, Pain Management
- Trial name
- NCT03268837
- Testing
- Programmed Intermittent Bolus, Continuous Infusion
- Where
- Canada
- Volunteers
- 110 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Osteoarthritis, Knee
Ibuprofen Gel or Capsaicin Cream for my Painful Knee Osteoarthritis?
Despite evidence that topical non-steroidal anti-inflammatory drugs (NSAIDs) and capsaicin are effective in osteoarthritis (OA), it is still unclear why they work for some people but not others.
- Trial name
- NCT03146689
- Testing
- Topical NSAID, Topical Capsaicin
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- University of Nottingham
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