Clinical trials: Osteoarthritis Pain
Chronic Pain, PERIPHERAL NEUROPATHY
Prospective Case Series Evaluating 6-Month and 12-Month Outcomes After Cryoneurolysis for Chronic Pain
To prospectively describe patient-centered and health utilization outcomes through 12 months after cryoneurolysis performed as routine clinical care for chronic pain at Yale.
- Conditions
- Chronic Pain, PERIPHERAL NEUROPATHY, Occipital Neuralgia, Chronic Hip Pain
- Trial name
- NCT07639060
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Yale University
Osteoarthritis of the Knee
A Pragmatic Trial To Determine the Benefit of Exercise Incentives and Corticosteroid Injections in Osteoarthritis of the Knee
Knee osteoarthritis (KOA) is one of the most common and disabling conditions among Veterans. Management of KOA is challenging as there are few effective treatments other than joint replacement.
- Trial name
- MOVE-OK (NCT03835910)
- Testing
- Social Incentives and Gamification to Promote Exercise, Corticosteroid Injection given in A-B order, No Social Incentive applied
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- VA Office of Research and Development
Osteoarthritis of the Knee
A Study of ABT-652 in Combination With a Nonsteroidal Anti-Inflammatory Drug (NSAID) in Adults With Osteoarthritis Pain of the Knee
To evaluate the safety and efficacy of ABT-652 in combination with a Non-steroidal Anti-inflammatory Drug (NSAID) compared to NSAID alone in adults with osteoarthritis (OA) of the knee.
- Trial name
- NCT01444365
- Testing
- ABT-652 NSAID
- Where
- 31 sites in United States
- Volunteers
- 202 people
- Sponsor
- AbbVie (prior sponsor, Abbott)
Osteoarthritis, Knee
Is Botox Effective in Relieving Pain From Knee Osteoarthritis?
Patients with painful knee osteoarthritis will be randomly allocated to one of three groups. Each group will receive a knee injection of: 1) cortisone, 2) low dose Botox, or 3) high dose Botox.
- Trial name
- NCT00279903
- Testing
- Botulinum toxin type A (Btx-A), Cortisone
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Mayo Clinic
Osteoarthritis of the Knee
Extended and Controlled Release Liposomal Formulated Dexamethasone for Chronic Knee OA Pain
Phase 3 randomized, double-blind, placebo- and active comparator-controlled study of TLC599.
- Trial name
- EXCELLENCE (NCT04123561)
- Testing
- TLC599, DSP, Normal Saline
- Where
- 46 sites in United States, Australia
- Volunteers
- 504 people
- Sponsor
- Taiwan Liposome Company
Knee Arthropathy, Knee Osteoarthritis
NLR and PLR Levels Following IPACK Block in Knee Arthroplasty
Effect of iPACK block on NLR and PLR following knee arthroplasty
- Conditions
- Knee Arthropathy, Knee Osteoarthritis, Knee Pain Chronic
- Trial name
- NCT06304298
- Testing
- 0.9% Sodium Chloride Injection, Ropivacaine 0.2% Injectable Solution
- Where
- Poland
- Volunteers
- 60 people
- Sponsor
- Poznan University of Medical Sciences
Osteoarthritis, Back Pain
A Study to Compare Oxycodone/Naloxone Prolonged Release Against Codeine/Paracetamol in the Treatment of Moderate to Severe Chronic Low Back Pain or Pain Due to Osteoarthritis
The purpose of this study is to compare oxycodone/naloxone combination tablet and codeine/paracetamol tablets in the treatment of moderate to severe chronic low back pain or pain due to osteoarthritis.
- Trial name
- NCT00784810
- Testing
- Oxycodone/Naloxone, Codeine/Paracetamol
- Where
- United Kingdom
- Volunteers
- 247 people
- Sponsor
- Napp Pharmaceuticals Limited
Osteoarthritis
Brain Imaging To Examine The Effect Of Naproxen In Hand Osteoarthritis Patients
The study hypothesis is that the relief of pain in patients with osteoarthritis in the hand can be detected by a form of brain scanning that detects which parts of the brain are activated when pain is felt.
- Trial name
- NCT00830050
- Testing
- Naproxen
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- Pfizer
Osteoarthritis
Joint Injections for Osteoarthritic Knee Pain
The purpose of this study is to determine whether prolotherapy (PrT), a therapy based on injection of a sugar solution in and around the knee, can decrease pain and disability from knee osteoarthritis (OA).
- Trial name
- NCT00085722
- Testing
- Dextrose Prolotherapy, Saline Prolotherapy, At-home physical therapy exercise group
- Where
- 2 sites in United States
- Volunteers
- 98 people
- Sponsor
- University of Wisconsin, Madison
Osteoarthritis Knee Pain
A Study of Duloxetine in Patients With Osteoarthritis Knee Pain
The primary purpose of this study is to determine if duloxetine 60 mg once daily (QD) reduces pain severity in patients with osteoarthritis (OA) knee pain compared with placebo.
- Trial name
- NCT00945945
- Testing
- Duloxetine (DLX)
- Where
- 26 sites in United States, Germany and 6 more
- Volunteers
- 424 people
- Sponsor
- Eli Lilly and Company
Osteoarthitis
Effects of Kinesiotaping in Osteoarthritis
Knee osteoarthritis will be recognized as a leading cause of pain and functional disability, and conventional physiotherapy will remain a cornerstone of its management.
- Trial name
- Taping (NCT07606157)
- Testing
- Kinesiotaping
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nazli Cigercioglu
Knee Osteoarthritis, Chronic Pain
Self Transcranial Direct Current Stimulation for Pain in Older Adults With Knee Osteoarthritis
The purpose of this study is to determine the feasibility and preliminary efficacy of two weeks of self Transcranial Direct Current Stimulation (tDCS) for pain in older patients with knee osteoarthritis (OA).
- Trial name
- NCT03425019
- Testing
- Soterix 1x1 tDCS mini-CT Stimulator device
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- The University of Texas Health Science Center, Houston
Osteoarthritis, Quality of Life
Quality-of-life and Pain After Spa Treatment in Elderly With Osteoarthritis
The aim of the study was to evaluate the short- and long-term effects of spa therapy on quality of life and pain in patients aged 65 years and older with osteoarthritis.
- Conditions
- Osteoarthritis, Quality of Life, Elderly, Balneology
- Trial name
- NCT03388801
- Testing
- Spa therapy
- Volunteers
- 70 people
- Sponsor
- University of Rzeszow
Knee Osteoarthritis, Pain, Acute
The Effect of Exercises of Different Intensity Applied After Total Knee Arthroplasty on Exercise-Induced Hypoalgesia
The aim of this study was to investigate whether exercise-induced hypoalgesia (EIH) is present following exercise in patient after total knee arthroplasty (TKA) and if so, if it changes with exercise intensity.
- Trial name
- NCT05781230
- Testing
- High Intensity Exercises Program, Low Intensity Exercises Program
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people
- Sponsor
- Hacettepe University
Pain
A Study to Characterize Diclofenac's Plasma and Knee Exposure After Application of Diclofenac Gel to the Knee of Subjects With Osteoarthritis That Have a Scheduled Arthroplasty
The purpose of this study is to evaluate the exposure of diclofenac in the plasma and in the knee joint following topical administration of DDEA gel 4 gram (g) applied twice daily for 7 days.
- Trial name
- NCT03497039
- Testing
- Diclofenac Diethylamine (DDEA) gel
- Where
- 5 sites in Germany, United Kingdom
- Volunteers
- 47 people
- Sponsor
- GlaxoSmithKline
Knee Osteoarthritis
Hip Abductor Strengthening Exercises in Knee Osteoarthritis
The aim of this randomized controlled trial is to find the effect of hip abductor strengthening exercises on pain, range of motion, functional disability and balance in patient with knee osteoarthritis.
- Trial name
- NCT06845657
- Testing
- Hip Abductor Strengthening Exercises, Conventional Treatment
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Riphah International University
Knee Osteoarthritis, Total Knee Arthroplasty (TKA)
How Variations in Pharmacogenomic Profiles Affect Pain and Narcotic Needs Following Total Knee Arthroplasty (TKA)
The purpose of the study is to gain a better understanding of how genetic variations can affect pain experience and the need and type of pain control medication after a total knee replacement.
- Trial name
- NCT04020471
- Testing
- Pain Scale/Medication Log
- Where
- United States
- Volunteers
- 375 people
- Sponsor
- Endeavor Health
Hip Osteoarthritis, Chronic Pain
Ultrasound-Guided Hip Joint Cooled Radiofrequency Denervation
Hip osteoarthritis (HOA) is a common cause of pain and disability in aging population. Conservative treatment is based on lifestyle modifications, physical therapy, analgesic and anti-inflammatory medications and intra articular…
- Trial name
- NCT02546336
- Testing
- Ultrasound-Guided Cooled Radiofrequency Hip Denervation
- Where
- Canada
- Sponsor
- Women's College Hospital
Osteoarthritis
An Investigation of ReNu™ Knee Injection in Patients With Osteoarthritis
This is a Prospective, Randomized study evaluating the efficacy of ReNu for the treatment of Kellgren-Lawrence grade 2 or 3 osteoarthritis.
- Trial name
- NCT02318511
- Testing
- Knee injection, ReNu amniotic allograft, Hyaluronic Acid
- Where
- 12 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- NuTech Medical, Inc
Osteoarthritis of the Knee
Coolief Cooled Radiofrequency vs. Conventional Radiofrequency to Manage OA Knee Pain
This study is being performed to assess the relative effectiveness of genicular nerve ablation with the COOLIEF* Cooled Radiofrequency probe to manage moderate to severe knee pain in patients with osteoarthritis (OA) of the knee…
- Trial name
- NCT04145011
- Testing
- Cooled Radiofrequency, Standard Radiofrequency
- Where
- 7 sites in United States
- Volunteers
- 153 people
- Sponsor
- Avanos Medical
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