Clinical trials: Osteoarthritis of Ankle
Osteoarthritis
Prevention of Post-Traumatic Osteoarthritis (OA)
Joint injury and trauma dramatically increase the risk of developing osteoarthritis (OA). The purpose of this study is to determine what factors lead to decreased pain, improved joint function, and repair of the joint surface in…
- Trial name
- NCT00054821
- Testing
- Ankle distraction permitting motion, Ankle distraction without motion
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Ned Amendola
Osteoarthritis, Hip, Osteoarthritis Thumb
Evaluate Clinical Benefit of Local Treatment With KD Intra-Articular® Gel in Patients With Osteoarthritis (NO-DOLOR2)
Prospective observational, national, multicentre, open study with a class III medical device with EC marking. Study to evaluate the clinical benefit of local treatment with KD intra-articular® gel in patients with osteoarthritis…
- Conditions
- Osteoarthritis, Hip, Osteoarthritis Thumb, Osteoarthritis Ankle
- Trial name
- NO-DOLOR2 (NCT05275244)
- Testing
- KD Intra-Articular® gel
- Where
- Spain
- Volunteers
- 67 people
- Sponsor
- Procare Health Iberia S.L.
Osteoarthritis, Osteoarthritis, Knee
Outcomes of Low-Impact Exercise Program for People With Ankle, Knee, and/or Hip Pain
The primary objective of this study is to study how low-impact group exercise classes affect pain scores in patients with knee, hip, and ankle pain when paired with concurrent standard of care dietitian and behavioral health…
- Conditions
- Osteoarthritis, Osteoarthritis, Knee, Osteoarthritis, Hip, Osteoarthritis Ankle
- Trial name
- NCT03711773
- Testing
- Group Physical Therapy Classes
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- University of Missouri-Columbia
Ankle Osteoarthritis
Prospective Randomized Evaluation of a Two and Three Piece Total Ankle Replacement
This is a randomized study to prospectively compare and evaluate the functional outcome and patient satisfaction of total ankle replacements for tibio-talar osteoarthritis using either the STAR or Salto-Talaris prothesis.
- Trial name
- NCT01504438
- Testing
- Salto-Talaris Total Ankle Replacement, STAR Total Ankle Replacement
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Duke University
Osteoarthritis
Treatment Outcomes for Ankle Arthritis
The purpose of this study is to determine any functional outcome differences in patients who have undergone surgical treatment for ankle osteoarthritis using surveys, step counts, and laboratory gait analysis.
- Trial name
- NCT00391365
- Testing
- Gait analysis
- Where
- United States
- Volunteers
- 368 people
- Sponsor
- VA Office of Research and Development
OSTEOARTHRITIS
Safety and Effectiveness of Agilus (Hyaluronic Acid) for Ankle Osteoarthritis
The purpose of this study is to determine whether Agilus is safe and effective in the treatment of mild to moderate ankle osteoarthritis.
- Trial name
- NCT00642382
- Testing
- Agilus, Normal saline
- Where
- 19 sites in United States
- Volunteers
- 17 people
- Sponsor
- Cartiva, Inc.
Primary Arthrosis, Post Traumatic Arthritis
2-Year Post-Approval Study to Investigate the Scandinavian Total Ankle Replacement System (STAR) Ankle Under Actual Conditions of Use
This post-approval study is being conducted to examine the performance of the STAR Ankle under actual conditions of use.
- Conditions
- Primary Arthrosis, Post Traumatic Arthritis, Rheumatoid Arthritis, Osteoarthritis
- Trial name
- STAR 2 PAS (NCT01284283)
- Testing
- Scandinavian Total Ankle Replacement System (STAR Ankle)
- Where
- 9 sites in United States
- Volunteers
- 102 people
- Sponsor
- Encore Medical, L.P.
Osteoarthritis
Total Ankle Replacement Versus Arthrodesis Trial
The purpose of TARVA is to determine whether Total Ankle Replacement (TAR) provides better clinical outcomes than ankle arthrodesis in patients aged 50-85 years with end-stage ankle osteoarthritis, and compare cost-effectiveness…
- Trial name
- TARVA (NCT02128555)
- Testing
- Total Ankle Replacement, Arthrodesis
- Where
- 17 sites in United Kingdom
- Volunteers
- 303 people, healthy volunteers welcome
- Sponsor
- University College, London
Ankle Osteoarthritis
Comparison of Customized and Standard Total Ankle Prostheses
The objective of this study is to compare primary total ankle replacement (TAR) performed with a customized procedure (prostheses customized for each patient based on his or her ankle morphology reconstructed from tomographic…
- Trial name
- NCT06193057
- Testing
- Total ankle arthroplasty
- Where
- Italy
- Volunteers
- 24 people
- Sponsor
- Istituto Ortopedico Rizzoli
Ankle Osteoarthritis, Knee Osteoarthritis
Gait Asymmetry Assessed Using Portable Gait Analysis System
To date, detailed analysis of movement patterns in orthopaedic conditions are mainly performed in research projects. Because these tests are time consuming, they are not feasible in clinical routine or in standard examinations.
- Conditions
- Ankle Osteoarthritis, Knee Osteoarthritis, Hip Osteoarthritis, Lumbar Spine Stenosis
- Trial name
- Asymmetry (NCT02489188)
- Testing
- arthroplasty, manual therapy, lumbar spinal stenosis decompression
- Where
- Switzerland
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Degenerative Arthritis, Rheumatoid Arthritis
Long Term Follow-up of Integra® Cadence™ Total Ankle System in Primary Ankle Joint Replacement
This study will evaluate the long term performance and safety data for the Cadence™ Total Ankle System (CTAS) when used for primary arthroplasty in patients with primary arthritis (e.g.
- Conditions
- Degenerative Arthritis, Rheumatoid Arthritis, Traumatic Arthritis
- Trial name
- NCT03247023
- Testing
- Implantation of Integra Cadence Total Ankle System
- Where
- 6 sites in Belgium, Canada and 3 more
- Volunteers
- 65 people
- Sponsor
- Smith & Nephew, Inc.
Osteoarthritis, Foot Osteoarthritis
Diagnostic Accuracy of Triphasic Bone Scan and SPECT/CT in Foot and Ankle Osteoarthritis
This cross-sectional study aims to assess the diagnostic accuracy of triphasic bone scintigraphy and SPECT/CT in evaluating foot and ankle osteoarthritis, using magnetic resonance imaging (MRI) as the reference standard, and to…
- Conditions
- Osteoarthritis, Foot Osteoarthritis, Joint Diseases, Ankle Osteoarthritis
- Trial name
- NCT07784257
- Volunteers
- 40 people
- Sponsor
- Assiut University
Osteoarthritis
A Double-blind RCT of a Single Dose of Hyaluronan in the Treatment of Osteoarthritis of the Ankle
To compare the therapeutic effect of single intra-articular injection of hyaluronate with a single intra-articular injection of normal saline (placebo) for osteoarthritis of the ankle.
- Trial name
- NCT01243814
- Testing
- hyaluronate intra-articular injection
- Where
- United States
- Volunteers
- 69 people
- Sponsor
- Henry DeGroot, M.D.
Degenerative Arthritis, Rheumatoid Arthritis
Zimmer Trabecular Metal Total Ankle PMCF
The primary objective of this study is to obtain implant survivorship and clinical outcome data for commercially available Zimmer Trabecular Metal Total Ankle implants used in primary or revision total ankle arthroplasty.
- Conditions
- Degenerative Arthritis, Rheumatoid Arthritis, Post Traumatic Arthritis
- Trial name
- NCT02038140
- Testing
- Zimmer Trabecular Metal Total Ankle System
- Where
- 11 sites in United States, Canada and 4 more
- Volunteers
- 120 people
- Sponsor
- Zimmer Biomet
Osteoarthritis, Osteo Arthritis Knee
Adipose-Derived Biocellular Regenerative Therapy for Osteoarthritis
Use of Biocellular and cellular approaches to treatment of Osteoarthritis (OA), musculoskeletal aging processes, pain, and degenerative changes are to be studied with minimally invasive protocols, and non-pharmaceutical means to…
- Conditions
- Osteoarthritis, Osteo Arthritis Knee, Osteo Arthritis Shoulders, Osteoarthritis of Multiple Joints
- Trial name
- GARM-MSK-ALD (NCT04238143)
- Testing
- Tissue Stromal Vascular Fraction (tSVF) Arm 1, PRP Concentrate Arm 1, Tissue Stromal Vascular Fraction (tSVF) Arm 2
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- Healeon Medical Inc
Ankle Osteoarthritis, Post-Traumatic Osteoarthritis of Ankle
Post- Approval Hintermann Series H® Study 1
The H3 TAR device received U.S. Food and Drug Administration (FDA) Premarket Approval (PMA) on June 4, 2019, and as a condition of that approval, this study is being conducted to provide long-term safety and effectiveness of the…
- Conditions
- Ankle Osteoarthritis, Post-Traumatic Osteoarthritis of Ankle, Osteoarthritis of Ankle Secondary to Inflammatory Arthritis (Disorder)
- Trial name
- NCT06514196
- Testing
- Hintermann Series H3 Total Ankle Replacement System
- Where
- Switzerland
- Volunteers
- 298 people
- Sponsor
- DT MedTech, LLC
Ankle Osteoarthritis, Knee
Development of Stance Control Orthotic Knee Joint For Improvement of KAFO Users
I want to design Stance control orthotic knee joint for improvement of KAFO users which is not available in Pakistan imported stance control orthotic knee joints are very expensive patients can't afford.
- Trial name
- NCT06404801
- Testing
- Stance Control
- Where
- Pakistan
- Volunteers
- 2 people
- Sponsor
- Superior University
Osteoarthritis, Ankle
Study of Cingal® for Symptomatic Relief of Osteoarthritis of Ankle Joint
This Trial will obtain clinical data to support an expanded indication for a single injection of Cingal® used for the symptomatic relief of osteoarthritis in the ankle joint.
- Trial name
- NCT04640974
- Testing
- Cingal
- Where
- 4 sites in Czechia, Poland
- Volunteers
- 25 people
- Sponsor
- Anika Therapeutics, Inc.
Post-traumatic; Arthrosis, Tibial Fractures
Does Joint Lavage Reduce Intraarticular Inflammation in High-energy Tibial Pilon Fractures?
High-energy tibial pilon fractures have historically been associated with poor outcomes largely due to the elevated risk of severe post-traumatic arthritis.
- Conditions
- Post-traumatic; Arthrosis, Tibial Fractures, Post-Traumatic Osteoarthritis of Ankle
- Trial name
- NCT05652881
- Testing
- Joint Lavage
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, San Diego
Osteoarthritis
Side Effects of Autologous Mesenchymal Stem Cell Transplantation in Ankle Joint Osteoartritis
Ankle osteoarthritis is a joint condition which results from damage and loss of the cartilage in a joint. Treatment options for ankle osteoarthritis are usually aimed at controlling pain and limiting motion that provokes the…
- Trial name
- NCT01436058
- Testing
- mesenchymal stem cell
- Where
- Iran
- Volunteers
- 6 people
- Sponsor
- Royan Institute