Clinical trials: Osteoarthrosis of Knee
Neuropathic Pain, Knee Osteoarthritis
Osteoarthritis Structural Changes Assessed by Magnetic Resonance Imaging and Neuropathic Pain in Knee Osteoarthritis
The primary objective of this study is to identify osteoarthritis (OA) structural changes, as assessed by MRI, that best correlate with the presence of neuropathic pain (NP) using the PainDETECT questionnaire (PainDETECT ≥ 13) on…
- Trial name
- NCT01733277
- Testing
- Magnetic Resonance Imaging (MRI)
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- ArthroLab Inc.
Osteoarthritis of Knee
Phase IV Clinical Trial to Evaluate the Efficacy and Safety of PlbCR and Aceclofenac in the Treatment of Patients With Osteoarthritis of the Knee
A multicenter, randomized, double-blinded, parallel, active-controlled, phase IV clinical trial to evaluate the efficacy and safety of PlbCR and aceclofenac in the treatment of patients with osteoarthritis of the knee
- Trial name
- NCT02682524
- Testing
- Pelubiprofen CR 45mg tab., Aceclofenac 100mg tab.
- Where
- South Korea
- Volunteers
- 191 people
- Sponsor
- Daewon Pharmaceutical Co., Ltd.
Osteoarthritis, Knee
A Study to Evaluate the Conformis iTotal Identity Knee Replacement System
This is a prospective multicenter study located in the United States. Subjects will be implanted with an iTotal Identity Knee Replacement System and followed for 10 years post implantation.
- Trial name
- NCT04667559
- Testing
- Conformis iTotal Identity Knee Replacement System
- Where
- 2 sites in United States
- Volunteers
- 22 people
- Sponsor
- Restor3D
Osteoarthritis of the Knee, Arthroplasty, Replacement, Knee
Flex Intramedullary Rod Study
The purpose of this study is to compare the effect of post-operative ROM between Flex IM rod and Rigid IM rod, to collect bone morphology of Japanese lower extremity and to research the incidence of overhung with Flex IM rod.
- Trial name
- NCT02543489
- Testing
- Flex IM rod
- Where
- 3 sites in Japan
- Volunteers
- 100 people
- Sponsor
- Stryker Japan K.K.
Osteoarthritis
A Study of Pain Relief in Osteoarthritis
The purpose of this study is to compare the safety and pain-relieving ability of Vicodin CR to placebo in subjects with osteoarthritis (OA) of the hip or knee.
- Trial name
- NCT00298974
- Testing
- hydrocodone / acetaminophen extended release
- Where
- 83 sites in United States
- Volunteers
- 873 people
- Sponsor
- Abbott
Osteoarthritis, Knee
Osteoarthritis of the Knee, Inflammation, and the Effect of Adalimumab (OKINADA)
This is a Canadian randomized, double-blind, placebo-controlled, multicenter study designed to evaluate the clinical efficacy and safety of adalimumab versus placebo when used to treat subjects with a diagnosis of osteoarthritis…
- Trial name
- OKINADA (NCT02471118)
- Testing
- Adalimumab 40 mg
- Where
- 7 sites in Canada
- Volunteers
- 62 people
- Sponsor
- CARE ARTHRITIS LTD.
Knee Osteoarthritis
Assessment of Safety and Efficacy of ARTHRUM 2.5% for Treatment of Painful Osteoarthritis of the Knee
ARTHRUM 2.5% MONO-INJECTION as symptomatic treatment by joint injection extends the conservative therapeutic arsenal in Knee osteoarthritis.
- Trial name
- ART-ONE75 (NCT06228274)
- Testing
- ARTHRUM 2.5%
- Volunteers
- 218 people
- Sponsor
- LCA Pharmaceutical
Osteoarthritis
A Study Of The Effect Of CE-224535 On Knee OA (Osteoarthritis) Pain
CE-224535 is a new medication being developed as an analgesic and anti-inflammatory agent for the treatment of the signs and symptoms of osteoarthritis (OA).
- Trial name
- NCT00418782
- Testing
- naproxen, CE-224535
- Where
- 46 sites in United States
- Volunteers
- 212 people
- Sponsor
- Pfizer
Osteoarthritis of the Knee
A Prospective, Multicenter Study to Evaluate the ConforMIS iTotal® (CR) Knee Replacement System
This study is designed to observe the long term clinical outcomes of patient-specific knee arthroplasty in patients with osteoarthritis.
- Trial name
- NCT01820650
- Testing
- iTotal G2 CR Knee Replacement System
- Where
- 9 sites in United States
- Volunteers
- 359 people
- Sponsor
- Restor3D
Osteoarthritis, Knee
The Impact of Procedural Awareness of Knee Injections for Osteoarthritis on Patient Perceptions of Effectiveness
The purpose of this study is to determine whether outcomes for patients receiving intra-articular platelet-rich plasma (PRP) injections for knee osteoarthritis are influenced by observation of the preparatory steps to the…
- Trial name
- NCT04111718
- Testing
- Platelet-rich plasma (PRP), Viewing of preparation
- Where
- Canada
- Volunteers
- 158 people
- Sponsor
- ArthroBiologix Inc.
Knee Osteoarthritis
Knee Biofeedback Rehabilitation Through Game Therapy
The goal of this study is to learn about the effect of video-game based rehabilitation exercise for patients with knee osteoarthritis.
- Trial name
- KneeBRIGHT (NCT06090097)
- Testing
- KneeBRIGHT System, Control Exercise
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Barron Associates, Inc.
Osteoarthritis, Knee, Pain, Knee
Study of Resiniferatoxin for Knee Pain in Moderate to Severe Osteoarthritis
This study evaluates the safety of resiniferatoxin in patients with moderate to severe knee pain due to osteoarthritis.
- Trial name
- NCT03542838
- Testing
- Resiniferatoxin, Saline
- Where
- 4 sites in United States
- Volunteers
- 94 people
- Sponsor
- Sorrento Therapeutics, Inc.
Osteoarthritis: Joint Replacement Surgery
Amniotic Umbilical Cord Particulate During Total Knee Arthroplasty
Total knee arthroplasty (TKA) is the most common joint replacement surgery and its incidence is expected to increase 673% to 3.48 million procedures annually by 2030.
- Trial name
- NCT03912116
- Testing
- CLARIX FLO, Saline
- Where
- United States
- Sponsor
- BioTissue Holdings, Inc
Degenerative Arthritis, Knee Arthritis
Investigator Initiated Trial to Evaluate Cartilage Regeneration by Arthroscopy After JOINTSTEM Administration
The purpose of this study is to confirm cartilage regeneration through arthroscopy after a single administration of autologous Adipose Tissue derived Mesenchymal stem cells(JOINTSTEM) in patients with degenerative arthritis of…
- Trial name
- NCT04821102
- Testing
- JOINTSTEM, Saline
- Where
- South Korea
- Volunteers
- 21 people
- Sponsor
- R-Bio
Osteoarthritis, Knee, Osteoarthrosis of Knee
Univation XM France
The study is set up due to regulatory purposes and to collect routine clinical data of the mobile-bearing implant univation XM. The study is designed as a prospective follow-up study with a historic patient cohort who have been…
- Conditions
- Osteoarthritis, Knee, Osteoarthrosis of Knee, Arthritis Knee, Unicompartmental Knee Arthroplasty
- Trial name
- NCT04199481
- Where
- France
- Sponsor
- Aesculap AG
Osteoarthritis
Intra-articular Polyacrylamide Hydrogel in Gonarthrosis
The OLE was aimed to assess long-term safety and efficacy of one and two courses of IA HBISA in patients with knee osteoarthritis.
- Trial name
- NCT06429319
- Testing
- Hydrous biopolymer with silver ions "Argiform" (HBISA) endoprosthesis of synovial fluid NOLTREX™
- Where
- 4 sites in Russia
- Volunteers
- 65 people
- Sponsor
- Research Centre BIOFORM
Osteoarthritis, Knee
Clinical Trial to Evaluate the Efficacy and Safety of MegaCarti® in Knee Cartilage Defects
The MegaCarti® is the decellularized allogeneic cartilage and acts as a cover after bone marrow stimulation to prevent the loss of blood clots and induces cartilage regeneration by assisting in the location of stem cells derived…
- Trial name
- NCT05440370
- Testing
- MegaCarti®, Microfracture
- Where
- 4 sites in South Korea
- Volunteers
- 90 people
- Sponsor
- L&C Bio
Meniscus; Degeneration, Knee Osteoarthritis
NUsurface Implant Registry
The purpose of this active post-market surveillance clinical registry study is to further characterize the therapeutic effect, the long-term safety and effectiveness of the NUsurface® meniscus implant in the real-world…
- Conditions
- Meniscus; Degeneration, Knee Osteoarthritis, Knee Pain Chronic
- Trial name
- NIR (NCT03953846)
- Where
- 6 sites in Belgium, Germany and 2 more
- Volunteers
- 36 people
- Sponsor
- Phoenix Kinetics
Osteoarthritis, Traumatic Arthritis
A Clinical Investigation of the Vanguard™ Complete Knee System
The purpose of this prospective clinical data-collection is to document the performance and clinical outcomes of the Vanguard™ Complete Knee System.
- Conditions
- Osteoarthritis, Traumatic Arthritis, Rheumatoid Arthritis, Lower Limb Deformity
- Trial name
- NCT00698854
- Testing
- Vanguard™ Complete Knee System, Vanguard™ Patient-Specific Femur
- Where
- 8 sites in United States
- Volunteers
- 552 people
- Sponsor
- Zimmer Biomet
Knee Pain Chronic, Osteoarthritis
Persona Total Knee Arthroplasty Outcomes Study
The primary objective of this study is to obtain implant survivorship and clinical outcomes data for commercially available Persona fixed bearing knee implants used in total knee arthroplasty.
- Conditions
- Knee Pain Chronic, Osteoarthritis, Rheumatoid Arthritis, Traumatic Arthritis
- Trial name
- NCT02255383
- Testing
- Zimmer Persona Total Knee System
- Where
- 14 sites in United States
- Volunteers
- 737 people
- Sponsor
- Zimmer Biomet
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