Clinical trials: Osteocalcin
CKD 5D, Hemodialysis
Vitamin K2 Supplementation to Activate Matrix Gla Protein (MGP) as Endogenous Inhibitor of Vascular Calcification in Hemodialysis Patients
Vascular calcification (VC) is a predictor of cardiovascular morbidity and mortality. Hemodialysis (HD) patients suffer from severe vascular calcifications.
- Trial name
- NCT01407601
- Testing
- daily supplementation of MK-7 over 6 weeks
- Where
- 3 sites in Germany
- Volunteers
- 53 people
- Sponsor
- RWTH Aachen University
Nutritional Rickets, Bone Turnover Rate Disorder
Effectiveness of Vitamin C Supplementation in Treatment of Rickets
Effectiveness of therapeutic dose of vitamin C in infants and children with nutritional rickets as an adjuvant therapy with vitamin D and calcium The study is two armed Randomized Control Trial, to validate the role of Vit C…
- Trial name
- NCT05310760
- Testing
- Vit C
- Where
- Egypt
- Volunteers
- 88 people
- Sponsor
- Cairo University
Diabetes Mellitus, Type 2, Bone Loss
Effect of Vitamins D3 and K2 in uOc and Insulin Serum Levels in Patients With Diabetes Mellitus
Introduction: Patients with DM2 have chronic hyperglycemia derived from a decrease in insulin sensitivity, cause of comorbidities such as bone demineralization, decreasing quality of life and increasing mortality.
- Conditions
- Diabetes Mellitus, Type 2, Bone Loss, Insulin Resistance
- Trial name
- NCT04041492
- Testing
- Supplementation with Vitamin D3 y K2
- Where
- Mexico
- Volunteers
- 100 people
- Sponsor
- University of Guadalajara
Menopausal Patients, Chronic Periodontitis
Treatment of Periodontitis in Menopausal Patients
The goal of this clinical trial is to compare the effectiveness of polyunsaturated fatty acids (PUFAs) [omega-3] as an adjunctive treatment to scaling and root planing for menopausal women with periodontitis versus scaling and…
- Conditions
- Menopausal Patients, Chronic Periodontitis, Omega 3 Fatty Acids
- Trial name
- NCT06254118
- Testing
- Polyunsaturated Fatty Acids, olive oil
- Where
- Saudi Arabia
- Volunteers
- 20 people
- Sponsor
- Hadir F. El-Dessouky
Healthy
The Effect of Vitamin K Supplementation on Osteocalcin Carboxylation in Healthy Children
Background of the study: Results from several studies show that vitamin K has an important function in bone metabolism. In a previous cross-sectional study conducted by our department, evidence for a poor vitamin K status of bone…
- Trial name
- NCT00402974
- Testing
- menaquinone 7
- Where
- Netherlands
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- UMC Utrecht
Breast Neoplasms, Bone Metastases
Circulating Osteocalcin-positive Cells in Breast Cancer Bone Metastasis
Bone metastasis (i.e. cancer cell spreading to bone) is the major clinical problem of advanced breast cancer patients. Bone metastasis is not curable nor preventable.
- Trial name
- COP-BREAST (NCT03814811)
- Testing
- Circulating Osteocalcin-positive (cOC) cells
- Where
- 2 sites in South Korea
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Obesity, Insulin Resistance
Vitamin K and Glucose Metabolism in Children at Risk for Diabetes (Vita-K 'n' Kids Study)
The undercarboxylated fractions of the two vitamin K-dependent proteins osteocalcin and matrix Gla protein have been shown to play key roles in type 2 diabetes and cardiovascular disease (at least in mouse models).
- Conditions
- Obesity, Insulin Resistance, Insulin Sensitivity, Prediabetes
- Trial name
- NCT01972113
- Testing
- Low-Dose Vitamin K2 (menaquinone-7; 45 mcg/d), High-Dose Vitamin K2 (menaquinone-7; 90 mcg/d)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Augusta University
Overweight and Obesity, Cardiometabolic Risk Factors
Effect of Vitamin K2 Over Osteocalcin, Leptin, Cytokines, and Cardiovascular Risk in Young Adults With Overweight and Obesity
The goal of this clinical trial is to compare de effect of vitamin K2 in young adults with overweight or obesity. The main questions to answer are: What is the effect of Vitamin K2 supplementation on methylation, serum…
- Trial name
- NCT05995522
- Testing
- Vitamin K2, Cornstarch
- Where
- Mexico
- Volunteers
- 51 people
- Sponsor
- University of Guadalajara
Bone Density, Overweight
Nutritional Problems After Lung and Heart Transplantation
Part 1) Bone health after transplantation - possible influence of vitamin K Part 2) Fat metabolism and endocrine parameters - possible predictors for developement of overweight after transplantation
- Trial name
- NCT00826254
- Testing
- Vitamin K
- Where
- Norway
- Volunteers
- 94 people
- Sponsor
- Oslo University Hospital
Osteoporosis
The Effect of Vitamin K2 on Bone Turnover
To investigate the effect of menatetrenone on bone turnover in postmenopausal patients with osteoporosis. One month of menatetrenone therapy enhanced the secretion and gamma-carboxylation of osteocalcin.
- Trial name
- NCT00548509
- Testing
- Menatetrenone (Vitamin K2)
- Where
- 4 sites in Japan
- Volunteers
- 131 people
- Sponsor
- Eisai Limited
Healthy Women, Osteocalcin
Jarlsberg Cheese Compared to Camembert Cheese
The study objective consists of the following three aims: 1. To compare the effect of daily intake of Jarlsberg cheese and Camembert cheese in change of the Osteocalcin level in healthy women after 6 weeks. 2.
- Trial name
- NCT04189796
- Testing
- Cheese
- Where
- Norway
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Prof Stig Larsen
Healthy Aging
Daily Dose Estimation of Jarlsberg Cheese in Healthy Norwegian Elderly Male and Female
Aim: To estimate OED of Jarlsberg cheese and the stabilized level of serum Osteocalcin in healthy elderly men and women. Study population consists of healthy men at least 65 years old and healthy post-menopausal women.
- Trial name
- HV-ID (NCT05434806)
- Testing
- Jarlsberg cheese
- Where
- Norway
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Meddoc
Osteopenia, Osteoporosis
The Long-term Effect of Daily Jarlsberg Cheese Intake in Patient With Osteopenia
Aim: To estimate the effect of daily optimal efficacy dose (OED) of Jarlsberg cheese in patients with Osteopeni (OP). Study population: Post-menopausal women and men above 55 years of age in risk of Osteoporosis Treatment: Daily…
- Trial name
- PF-JB3 (NCT06358443)
- Testing
- Jarlsberg cheese
- Where
- Norway
- Volunteers
- 20 people
- Sponsor
- Meddoc
Osteoporosis, Type 2 Diabetes Mellitus
Effect of Diabetic Medications on Bone Metabolism
Subjects with diabetes and pre-diabetes are said to have increased bone loss when compared to the general population. Pioglitazone a thiazolidinedione, is a Food and Drug Administration (FDA) approved oral anti-diabetic agent for…
- Trial name
- NCT00467285
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Heathy Women, Pre Menopausal Age
Estimation of Minimum Efficacy Daily Dose of Jarlsberg Cheese
Aim: To estimate an oral administered recommended minimum efficacy daily dose (MED) of Jarlsberg cheese in order to obtain the needed increased level of Osteocalcin defined as the ratio [Carboxylated / Under Carboxylated]…
- Conditions
- Heathy Women, Pre Menopausal Age, Exlution Criteria: Gastrointestinal Disorder, Liver Disease
- Trial name
- NCT04185454
- Testing
- Jarlsberg cheese
- Where
- Norway
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Prof Stig Larsen
Diabetes Mellitus, Type 2
Investigation for Health Efficacy of Infrared-C Radiation on Diabetes Patients in Senior's Activity Center
Hyperglycemia caused by diabetes will bring us the long-term damage，it causes glycation. The combination of sugar molecules and protein molecules will transform to advanced glycation end products (AGEs) and produce a lot of free…
- Trial name
- NCT04177420
- Testing
- FIR-C mattress, FIR-C abdominal pad, fake FIR-C mattress
- Where
- Taiwan
- Volunteers
- 64 people
- Sponsor
- Nanhua University
Type 2 Diabetes Mellitus, Menopause
Effect of Anti-diabetic Drugs on Bone Metabolism and Glycemic Variability
This is a Monocentric, Prospective, Randomized, Open-label, Comparative, Phase IV Study, to compare the effects of Vildagliptin and Gliclazide MR on Markers of Bone Remodeling, Bone Mineral Density and Glycemic Variability in…
- Conditions
- Type 2 Diabetes Mellitus, Menopause, Osteoporosis, Osteopenia
- Trial name
- BoneGlyc (NCT01679899)
- Testing
- Vildagliptin, Gliclazide MR
- Where
- Brazil
- Volunteers
- 56 people
- Sponsor
- Centro de Diabetes Curitiba Ltda
Tooth Movement
OC and ICTP in Gingival Crevicular Fluid During Piezocision Accelerated Orthodontic Treatment
The aim of this study was to evaluate the tooth movement with and without piezocision with regard to the levels of osteocalcin and cross-linked C-terminal telopeptides of type I collagen in the gingival crevicular fluid.
- Trial name
- NCT04611984
- Testing
- Piezocision, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Marmara University
Asthma
A Randomized Study Evaluating Steroid Hormone Levels, Safety And Tolerability Of GW870086X In Healthy Volunteers
GW870086X is a novel inhaled steroid that has an improved safety profile over other steroids but is also less potent. This study will look at higher doses to confirm the improved safety profile.
- Trial name
- NCT00549497
- Testing
- GW870086X
- Where
- Australia
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Vitamin D Deficiency
Effect of Vitamin d and Omega 3 on Osteocalcin
Assessing the combined effect of omega-3 fatty acid and vitamin D 3 on plasma osteocalcin levels
- Trial name
- NCT04005612
- Testing
- vitamin D3, omega-3 fatty acid, vitamin D3 and omega-3 fatty acid
- Where
- Jordan
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Applied Science Private University