Clinical trials: Osteochondral Defect
Osteochondral Defect
Clinical Outcome After Episealer Talus Implant in Treatment of Osteochondral Lesion of the Talus
Autologous Chondrocyte Implantation (ACI) is an appealing technique whereby cartilage is harvested from the joint in a first operation.
- Trial name
- NCT06522139
- Testing
- Implantation of Episealer Talus Implant
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Stefano Zaffagnini
Symptomatic Osteochondral Defect(s), Cartilage, Meniscus, Ankle, Knee, Shoulder, Hip
Clinical Registry Assessment of the Missouri Osteochondral Allograft Preservation System - MOPS
With institutional review board approval and informed consent, patients are prospectively enrolled into a registry to follow outcomes after osteochondral allograft (OCA) and/or meniscal allograft transplantation.
- Trial name
- NCT02503228
- Testing
- Standard of care osteochondral and or meniscal allograft transplantation
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- University of Missouri-Columbia
Osteochondral Defect of Talus
Ten Years Follow-up After the Arthroscopic Repair of Osteochondral Lesions of the Talus Via Autologous Matrix-induced Chondrogenesis (AMIC)
This clinical study evaluates the long-term, ten-year clinical and functional outcomes of patients who underwent arthroscopic repair of osteochondral lesions of the talus (OLT) using the autologous matrix-induced chondrogenesis…
- Trial name
- AMIC10Y (NCT07725770)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Knee Pain Chronic, Knee Osteoarthritis
BioPoly® Partial Resurfacing Knee Implant IDE
The goal of this randomized controlled clinical trial is to demonstrate the safety and effectiveness of the BioPoly® Partial Resurfacing Knee Implant for the treatment of cartilage defects of the distal femur in adult patients…
- Conditions
- Knee Pain Chronic, Knee Osteoarthritis, Cartilage Damage, Cartilage Defects of the Knee
- Trial name
- NCT06915363
- Testing
- BioPoly, surgical standard of care (SSOC)
- Where
- 4 sites in United States
- Volunteers
- 152 people
- Sponsor
- BioPoly LLC
Ankle (Ligaments); Instability (Old Injury), Ankle Sprain
A Study on Reducing Opioid Use After Ankle Arthroscopy
Study Title Effect of a Postoperative Multimodal Analgesic Protocol Predominantly Based on Non-Opioid Medications vs Opioid-Based Analgesia on Pain After Ankle Arthroscopy: A Noninferiority Randomized Clinical Trial Purpose This…
- Conditions
- Ankle (Ligaments); Instability (Old Injury), Ankle Sprain, Talus Osteochondral Defect, Opioid Analgesia
- Trial name
- NCT07154433
- Testing
- Opioid Analgesic Regimen, Non-opioid analgesic regimen
- Where
- China
- Volunteers
- 112 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Osteochondral Defect
Descriptive Study of the Reconstruction of Osteochondral Lesions of the Knee: Clinical and Imaging Results
The purpose of this study is to evaluate the clinical results and MRI imaging of autologous cartilage reconstructions or collagen matrix of the knee.
- Trial name
- NCT03908931
- Testing
- MRI
- Where
- France
- Volunteers
- 130 people
- Sponsor
- Versailles Hospital
Osteochondral Defect, Osteochondritis Dissecans
Evaluation of Clinical and Radiological Outcomes in Patients Undergoing Fixation of Osteochondral Fragments With Reasorbable Screws in the Knee Joint
Various techniques for the fixation of unstable osteochondral fragments have been used over the years, each with associated advantages and disadvantages, and differing clinical outcomes.
- Conditions
- Osteochondral Defect, Osteochondritis Dissecans, Osteochondral Fracture, Osteochondral Fracture of Patella
- Trial name
- OC-FIX (NCT06462040)
- Testing
- Fixation of osteochdral fragments with reabsorbable screws
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Istituto Ortopedico Rizzoli
Avascular Necrosis of the Talus, Talar Osteochondral Defect of Ankle
Prospective Evaluation of Clinical and Radiographic Outcomes Following Total Talus Replacement (PROCLAIM)
This is a Humanitarian Device Exemption (HDE) approved device. The purpose of this study is to evaluate the continued safety and probable benefit of the restor3d Total Talus Replacement device in commercial use.
- Conditions
- Avascular Necrosis of the Talus, Talar Osteochondral Defect of Ankle, Talar Dysfunction
- Trial name
- NCT06311331
- Testing
- Total Talus Replacement (TTR)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Restor3D
Cartilage or Osteochondral Defects in the Knee, Up to Moderate Osteoarthritis
Agili-C™ Implant Performance Evaluation
The current study compares the efficacy and safety of the Agili-C implant to Surgical Standard of Care treatment in patients suffering from joint surface lesions of the knee.
- Trial name
- NCT03299959
- Testing
- Agili-C implant, SSOC
- Where
- 26 sites in United States, Belgium and 6 more
- Volunteers
- 251 people
- Sponsor
- Smith & Nephew, Inc.
Knee Chondral or Osteochondral Defect
Comparison of Autologous Chondrocyte Implantation Versus Mosaicoplasty: a Randomized Trial
Numerous surgical techniques have been developped for the treatment of chondral and osteochondral defects of the knee. Among those techniques autologous chondrocyte transplantation (ACT) was promising but have potential…
- Trial name
- Cartipatch (NCT00560664)
- Testing
- Autologous chondrocytes transplantation, Mosaicoplasty
- Where
- 12 sites in France
- Volunteers
- 58 people
- Sponsor
- University Hospital, Brest
Osteochondral Defect
Evaluating Cryopreserved Osteochondral Allograft Cores for the Treatment of Osteochondral Lesions in the Knee
The primary objective of this study is to obtain evidence of the effectiveness of Cryopreserved Osteochondral Allograft Core in the treatment of osteochondral lesions on the femoral condyle.
- Trial name
- NCT06216756
- Testing
- osteochondral transplant on the femoral condyle
- Where
- 6 sites in United States
- Volunteers
- 68 people
- Sponsor
- AlloSource
Osteochondral Defects of Talus, Gait Analysis
Gait Pattern Analysis After Arthroscopic Treament of Osteochondral Defects of Talus
The study will investigate alterations in post-surgical gait patterns among patients who have undergone all arthroscopic microfracture and biological scaffold implementation surgery for the osteochondral lesions of talus.
- Conditions
- Osteochondral Defects of Talus, Gait Analysis, Microfracture Procedure, Biological Scaffold
- Trial name
- NCT07161128
- Testing
- arthroscopic microfracture and biological scaffold implementation for osteochondral defects of talus
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Gazi University
Osteochondral; Defect
Autologous Osteo-periosteal Cylinder Graft Transplantation for Hepple V Osteochondral Lesions of the Talus
The trial evaluates the clinical efficacy and safety of autologous osteo-periosteal cylinder graft transplantation for Hepple V osteochondral lesions of the talus.
- Trial name
- NCT03347877
- Testing
- autologous osteo-periosteal cylinder graft transplantation, autologous osteochondral graft transplantation, autologous osteo-periosteal cylinder graft
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Peking University Third Hospital
Chondral Defect, Osteochondral Defect
EB-OC for the Treatment of Focal Chondral/Osteochondral Defects in the Knee
EB-OC is a tissue engineered osteochondral tissue graft comprising of a living tissue engineered cartilage layer attaching to a bone scaffold.
- Trial name
- NCT06895889
- Testing
- EB-OC Graft Implantation, Abrasion chondroplasty
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Epibone, Inc.
Cartilage or Osteochondral Defects in the Knee
Agili-C™ Implant Performance Evaluation in the Repair of Cartilage and Osteochondral Defects
Evaluate the performance of the Agili-C™ in the repair of Cartilage and Osteochondral defects.
- Trial name
- NCT02423629
- Testing
- Agili-C™ implantation procedure
- Where
- 8 sites in Austria, Belgium and 6 more
- Volunteers
- 143 people
- Sponsor
- Smith & Nephew, Inc.
Cartilage or Osteochondral Defects in the Knee
COPLA® Cartilage Implant Pilot Clinical Trial
This is a first-in-human clinical, open label, non-randomized, prospective investigation to assess the initial safety and performance of the COPLA® cartilage implant.
- Trial name
- NCT05685316
- Testing
- COPLA® cartilage implant
- Where
- 6 sites in Estonia, Finland and 1 more
- Volunteers
- 20 people
- Sponsor
- Askel Healthcare Ltd
Osteochondral Lesion of Talus, Chondral Defect
AMIC vs. MFx in the Ankle
This clinical investigation is a prospective, double blind, single-centre, randomised controlled trial comparing arthroscopic autologous matrix induced chondrogenesis (AMIC®) to microfracture alone in the treatment of…
- Conditions
- Osteochondral Lesion of Talus, Chondral Defect, Microfracture
- Trial name
- AMARTA (NCT05741983)
- Testing
- Microfracture (MFx), Chondro-Gide®
- Where
- United Kingdom
- Sponsor
- Geistlich Pharma AG
Osteochondral Defect
Clinical Investigation on the Outcome of Episealer Talus Post-operation for Treatment of Focal Osteochondral Defects
This is a retrospective, observational, single-arm, multi-centre, post-market clinical investigation designed to verify clinical performance and safety of Episealer Talus post-operation for treatment of focal osteochondral…
- Trial name
- NCT06225674
- Testing
- Episealer Talus implant
- Where
- 6 sites in Germany, Sweden
- Volunteers
- 25 people
- Sponsor
- Episurf Medical Inc.
Knee Pathology, Osteoarthritis, Knee
Knee Registry (Knieregister)
Rationale: In view of patient care, patient characteristics and treatment parameters are registered for all patients visiting the Mobility Clinic of the University Medical Center Utrecht for orthopaedic knee treatment.
- Conditions
- Knee Pathology, Osteoarthritis, Knee, Osteochondritis Dissecans, Chondral Defect
- Trial name
- NCT04364334
- Where
- Netherlands
- Volunteers
- 1,000,000 people
- Sponsor
- UMC Utrecht
Knee Injuries, Cartilage Injury
Biomaterials and Mesenchymal Stem/Stromal Cells in the Treatment of Knee Articular Surface Lesions
The goal of this observational study is to evaluate the combined single-step approach with biomaterials and mesenchymal stem/stromal cells in the treatment of knee articular surface lesions.
- Conditions
- Knee Injuries, Cartilage Injury, Osteochondral Defect
- Trial name
- NCT06078072
- Testing
- Biomaterials augmented with mesenchymal stem/stromal cells
- Where
- Slovenia
- Volunteers
- 90 people
- Sponsor
- University Medical Centre Ljubljana