Clinical trials: Osteochondral Defect
Osteochondral Defect
Study Protocol to Evaluate Clinical and Imaging Results of Knee Fresh Osteochondral Allografts
The main objective of this study is to assess the clinical and radiological results after carrying out a transplant of fresh osteochondral allograft in the knee.
- Trial name
- NCT04236492
- Testing
- Fresh osteochondral allografting
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Articular Cartilage Disorder, Degeneration; Articular Cartilage
Chondrofix Osteochondral Allograft Prospective Study
The overall study objective is to evaluate Chondrofix Osteochondral Allograft ("Chondrofix") for the repair of osteochondral lesions in the knee.
- Conditions
- Articular Cartilage Disorder, Degeneration; Articular Cartilage, Chronic Cartilage Injury, Acute Cartilage Injury
- Trial name
- NCT01410136
- Testing
- Chondrofix Osteochondral Allograft
- Where
- 5 sites in United States
- Volunteers
- 29 people
- Sponsor
- Zimmer Orthobiologics, Inc.
Osteochondral Defect
ReNu™ Marrow Stimulation Augmentation
To evaluate the use of ReNu™ allograft for the augmentation of marrow stimulation for osteochondral lesions
- Trial name
- NCT03036878
- Testing
- ReNu
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- NuTech Medical, Inc
Chondral Defect, Osteochondritis Dissecans (OCD)
A Study of MACI in Patients Aged 10 to 17 Years With Symptomatic Chondral or Osteochondral Defects of the Knee
The objective of this study is to compare the efficacy and safety of MACI® vs arthroscopic microfracture in the treatment of participants aged 10 to 17 years with symptomatic articular chondral or osteochondral defects of the…
- Conditions
- Chondral Defect, Osteochondritis Dissecans (OCD), Articular Cartilage Defect, Articular Cartilage Disorder of Knee
- Trial name
- PEAK (NCT03588975)
- Testing
- MACI, microfracture
- Where
- 14 sites in United States
- Volunteers
- 45 people
- Sponsor
- Vericel Corporation
Cartilage Lesion, Osteochondral Lesion
Cone Beam CT (CBCT) Arthrogram of the Ankle in Assessement of Osteochondral or Cartilage Lesions
This study aims to compare weight-bearing Cone Beam CT arthrogram and conventional CT arthrogram in assessement of patients with ankle osteo-chondral or cartilage lesions.
- Trial name
- Arthro-CBCT (NCT05203757)
- Testing
- ArthroCT scan, CBCT
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Knee Chondral, Osteochondral Defect
Comparison of Microfracture Treatment and CARTIPATCH® Chondrocyte Graft Treatment in Femoral Condyle Lesions
CARTIPATCH® is an Autologous Chondrocyte Implantation product including functional cells in a matrix, indicated for the treatment of isolated osteocartilaginous lesions.
- Trial name
- NCT00945399
- Testing
- CARTIPATCH® procedure, Microfracture
- Where
- Belgium
- Volunteers
- 40 people
- Sponsor
- TBF Genie Tissulaire
Symptomatic Osteochondral Defect(s), Cartilage, Meniscus, Ankle, Knee, Shoulder, Hip
Clinical Registry Assessment of the Missouri Osteochondral Allograft Preservation System - MOPS
With institutional review board approval and informed consent, patients are prospectively enrolled into a registry to follow outcomes after osteochondral allograft (OCA) and/or meniscal allograft transplantation.
- Trial name
- NCT02503228
- Testing
- Standard of care osteochondral and or meniscal allograft transplantation
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- University of Missouri-Columbia
Chondral Defect, Osteochondral Defect
EB-OC for the Treatment of Focal Chondral/Osteochondral Defects in the Knee
EB-OC is a tissue engineered osteochondral tissue graft comprising of a living tissue engineered cartilage layer attaching to a bone scaffold.
- Trial name
- NCT06895889
- Testing
- EB-OC Graft Implantation, Abrasion chondroplasty
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Epibone, Inc.
Defect of Articular Cartilage
A Study to Evaluate the Safety of Augment™ Bone Graft
Is Augment Bone Graft plus Allograft safe to use for the treatment of osteochondral defects of the knee?
- Trial name
- NCT01290991
- Testing
- Augment Bone Graft
- Where
- Canada
- Volunteers
- 1 people
- Sponsor
- Nova Scotia Health Authority
Knee Injuries, Cartilage Injury
Biomaterials and Mesenchymal Stem/Stromal Cells in the Treatment of Knee Articular Surface Lesions
The goal of this observational study is to evaluate the combined single-step approach with biomaterials and mesenchymal stem/stromal cells in the treatment of knee articular surface lesions.
- Conditions
- Knee Injuries, Cartilage Injury, Osteochondral Defect
- Trial name
- NCT06078072
- Testing
- Biomaterials augmented with mesenchymal stem/stromal cells
- Where
- Slovenia
- Volunteers
- 90 people
- Sponsor
- University Medical Centre Ljubljana
Osteochondral Defect
Follow-Up Study Evaluating the Long Term Outcome of ChondroMimetic in the Treatment of Osteochondral Defects in the Knee
To investigate the long-term efficacy and safety of the medical device, ChondroMimetic, in subjects who were treated in the interventional study 0MCM0107 for osteochondral defects of the knee.
- Trial name
- NCT03385642
- Testing
- ChondroMimetic
- Where
- Hungary
- Volunteers
- 15 people
- Sponsor
- Collagen Solutions
Osteoarthritis, Knee, Osteochondral Defect
The Impact of Covid-19 on Patients Waiting for Knee Surgery
The Covid-19 pandemic has led to the postponement and cancellation of elective orthopaedic surgeries worldwide. These delays to elective procedures combined with ongoing demand have led to increasingly longer waiting list times.
- Conditions
- Osteoarthritis, Knee, Osteochondral Defect, Cartilage Injury, Cartilage Damage
- Trial name
- NCT05124613
- Testing
- Survey
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- University of Manchester
Osteochondral Defect
Descriptive Study of the Reconstruction of Osteochondral Lesions of the Knee: Clinical and Imaging Results
The purpose of this study is to evaluate the clinical results and MRI imaging of autologous cartilage reconstructions or collagen matrix of the knee.
- Trial name
- NCT03908931
- Testing
- MRI
- Where
- France
- Volunteers
- 130 people
- Sponsor
- Versailles Hospital
Articular Cartilage Defect, Chondral Defect
Study Comparing Two Methods for the Treatment of Large Chondral and Osteochondral Defects of the Knee
The major objective of this study is to evaluate the efficacy of the MACT versus the AMT for the treatment of large cartilage defects in patellofemoral and femorotibial injuries.
- Conditions
- Articular Cartilage Defect, Chondral Defect, Osteochondritis
- Trial name
- NCT05651997
- Testing
- MACT, AMT
- Where
- 2 sites in Switzerland
- Volunteers
- 80 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Osteoarthritis, Hip, Femoroacetabular Impingement
Early Feasibility Study of Cartilage Defect Repair
Any patient aged 14 or older up to 64 years of age with hip disease, resulting in loss of articular cartilage integrity on the femoral head (e.g., femoroacetabular impingement or other structural deformity), has failed…
- Conditions
- Osteoarthritis, Hip, Femoroacetabular Impingement, Osteonecrosis, Legg-Calvé-Perthes Disease
- Trial name
- NCT06823089
- Testing
- ReNew Hip Implant
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Cytex Therapeutics, Inc.
Cartilage or Osteochondral Defects in the Knee
COPLA® Cartilage Implant Pilot Clinical Trial
This is a first-in-human clinical, open label, non-randomized, prospective investigation to assess the initial safety and performance of the COPLA® cartilage implant.
- Trial name
- NCT05685316
- Testing
- COPLA® cartilage implant
- Where
- 6 sites in Estonia, Finland and 1 more
- Volunteers
- 20 people
- Sponsor
- Askel Healthcare Ltd
Osteochondral Defect, Osteochondritis Dissecans
Post-Operative Rehabilitation of Knee Osteochondral Defect: A Case Series
A case-series review was performed on five collegiate athletes with osteochondral lesions of the knee at California State University, Northridge (CSUN). All subjects received surgical intervention to treat the defect.
- Trial name
- NCT03452098
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- California State University, Northridge
Knee Chondral or Osteochondral Defect
Comparison of Autologous Chondrocyte Implantation Versus Mosaicoplasty: a Randomized Trial
Numerous surgical techniques have been developped for the treatment of chondral and osteochondral defects of the knee. Among those techniques autologous chondrocyte transplantation (ACT) was promising but have potential…
- Trial name
- Cartipatch (NCT00560664)
- Testing
- Autologous chondrocytes transplantation, Mosaicoplasty
- Where
- 12 sites in France
- Volunteers
- 58 people
- Sponsor
- University Hospital, Brest
Osteochondral Defect of Talus
Ten Years Follow-up After the Arthroscopic Repair of Osteochondral Lesions of the Talus Via Autologous Matrix-induced Chondrogenesis (AMIC)
This clinical study evaluates the long-term, ten-year clinical and functional outcomes of patients who underwent arthroscopic repair of osteochondral lesions of the talus (OLT) using the autologous matrix-induced chondrogenesis…
- Trial name
- AMIC10Y (NCT07725770)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Outcomes of Allograft
Long Term Outcomes of Osteochondral Allografts for Osteochondral Defects of the Knee
The purpose of this study is to evaluate the functional and clinical outcomes of patients receiving femoral condyle osteochondral allografts, to evaluate potential predisposing factors to failure of such grafts, and to compare…
- Trial name
- LongTermOC (NCT02308358)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia