Clinical trials: Osteochondritis
Defect of Articular Cartilage, Osteochondral Lesion of Talus
DeNovo NT Ankle LDC Study
The purpose of this post-market clinical study is to collect long-term outcomes for DeNovo NT Graft treatment of articular cartilage lesions in the ankle in a standard clinical setting.
- Conditions
- Defect of Articular Cartilage, Osteochondral Lesion of Talus, Osteochondritis Dissecans
- Trial name
- NCT01347892
- Testing
- DeNovo NT Natural Tissue Graft
- Where
- 8 sites in United States
- Volunteers
- 205 people
- Sponsor
- Zimmer Orthobiologics, Inc.
Juvenile Osteochondritis Dissecans
Study of Two Surgical Drilling Techniques to Treat Juvenile Osteochondritis Dissecans of the Knee
The purpose of this study is to compare the functional, clinical and radiographic outcomes associated with trans-articular drilling versus retro-articular drilling, two commonly employed techniques of operative treatment for…
- Trial name
- NCT01754298
- Testing
- Retro-articular drilling, Trans-articular drilling
- Where
- 14 sites in United States, Canada
- Volunteers
- 91 people
- Sponsor
- Boston Children's Hospital
Articular Cartilage Defect, Chondral Defect
Introduction of ACI for Cartilage Repair
This study was aimed to evaluate effectiveness and safety of autologous chondrocyte suspension for treatment of knee articular cartilage defects.
- Conditions
- Articular Cartilage Defect, Chondral Defect, Osteochondritis
- Trial name
- NCT04296487
- Testing
- autologous chondrocytes
- Where
- Switzerland
- Volunteers
- 218 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Osteochondritis Dissecans
Repair of Articular Osteochondral Defect
Background: Matrix-associated autologous chondrocyte implantation (MACI) has been recently used to treat cartilage defects. The investigators had previously developed a biphasic osteochondral composite as the construct for…
- Trial name
- NCT01409447
- Testing
- Biphasic osteochondral composite
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- National Taiwan University Hospital
Chondral Defect, Articular Cartilage Defect
A Study of MACI in Patients Aged 17 to 65 Years With Symptomatic Chondral or Osteochondral Defects of the Ankle
The objective of this study is to demonstrate the superiority of MACI (autologous cultured chondrocytes on porcine collagen membrane) versus Bone Marrow Stimulation in the treatment of patients aged 17 to 65 years with…
- Trial name
- MASCOT (NCT06915233)
- Testing
- autologous cultured chondrocytes on porcine collagen membrane, Bone Marrow Stimulation
- Where
- 9 sites in United States
- Volunteers
- 309 people
- Sponsor
- Vericel Corporation
Elbow Osteochondritis Dissecans
The Effectiveness of Extracorporeal Shock Wave Therapy for Elbow Osteochondritis Dissecans (OCD)
Extracorporeal shock wave therapy was performed on athletes aged 15-18 years with lateral maxillary chondritis of the elbow, and X-ray, blood tests, and MRI were conducted to evaluate the treatment progress.
- Trial name
- NCT07884578
- Testing
- Extracorporeal Shock Wave Therapy, Extracorporeal Shock Wave Therapy(no-energy)
- Where
- Taiwan
- Volunteers
- 9 people
- Sponsor
- Chang Gung Memorial Hospital
OCD - Osteochondritis Dissecans
MRI Findings of Epiphyseal Growth Plate in Healthy Children
The purpose of the study is to determine if by using MRI changes can be identified changes early on in the knees of young children that may be at risk for developing osteochondritis dissecans.
- Trial name
- NCT03190200
- Testing
- MRI
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Knee Pathology, Osteoarthritis, Knee
Knee Registry (Knieregister)
Rationale: In view of patient care, patient characteristics and treatment parameters are registered for all patients visiting the Mobility Clinic of the University Medical Center Utrecht for orthopaedic knee treatment.
- Conditions
- Knee Pathology, Osteoarthritis, Knee, Osteochondritis Dissecans, Chondral Defect
- Trial name
- NCT04364334
- Where
- Netherlands
- Volunteers
- 1,000,000 people
- Sponsor
- UMC Utrecht
Avascular Necrosis of Bone
Talar Avascular Necrosis: Surgical Angiogenesis vs. Core Decompression
The purpose of this study is to determine if surgical angiogenesis performed in talar avascular necrosis by free microvascular bone grafts from the medial femoral condyle is a superior technique compared to core decompression and…
- Trial name
- TalarAVN (NCT02289976)
- Testing
- core decompression
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- BG Trauma Center Ludwigshafen
Osteochondral Defect, Osteochondritis Dissecans
Evaluation of Clinical and Radiological Outcomes in Patients Undergoing Fixation of Osteochondral Fragments With Reasorbable Screws in the Knee Joint
Various techniques for the fixation of unstable osteochondral fragments have been used over the years, each with associated advantages and disadvantages, and differing clinical outcomes.
- Conditions
- Osteochondral Defect, Osteochondritis Dissecans, Osteochondral Fracture, Osteochondral Fracture of Patella
- Trial name
- OC-FIX (NCT06462040)
- Testing
- Fixation of osteochdral fragments with reabsorbable screws
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Istituto Ortopedico Rizzoli
Osteoarthritis Elbow Left, Osteoarthritis Elbow Right
Elbow Arthroscopy Data Analysis
The purpose of this study is to evaluate preoperative objective measurements and operative objective measurements to determine if there is any effect to postoperative outcomes.
- Conditions
- Osteoarthritis Elbow Left, Osteoarthritis Elbow Right, Lateral Epicondylitis, Left Elbow, Lateral Epicondylitis, Right Elbow
- Trial name
- EA (NCT03656185)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- The Orthopaedic Research & Innovation Foundation
Osteochondritis Dissecans Knee, Osteochondritis Dissecans (OCD)
Treatment Outcomes for Osteochondritis Dissecans of the Knee: A Cohort Study
This is a non-randomized, observational, ambidirectional cohort study. Approximately 254 participants with knee OCD will be recruited from Peking University Third Hospital, China, comprising a prospective cohort (n=177) and a…
- Trial name
- NCT07439107
- Testing
- Clinical Management for OCD (Observed)
- Where
- China
- Volunteers
- 254 people
- Sponsor
- Peking University Third Hospital
Osteochondritis Dissecans
Prospective 2-year Data Collection of the First 10 Patients After Ankle Spacer Implantation
Osteochondral defects (OCD) of the talus are pathologic lesions of the talar cartilage and its subchondral bone and might severely deteriorate the quality of life.
- Trial name
- NCT04297449
- Where
- Germany
- Volunteers
- 8 people
- Sponsor
- Hannover Medical School
Other Articular Cartilage Disorders, Osteochondritis Dissecans
Knee Articular Cartilage Repair: Cartilage Autograft Implantation System Versus Conventional Microfracture
The Cartilage Autograft Implantation System (CAIS) is a single-stage procedure in which cartilage is harvested from non-critical regions of articular cartilage, but then immediately morcellated and loaded onto a polymer…
- Trial name
- CAIS (NCT01498029)
- Testing
- Microfracture, Cartilage Autograft Implantation System (CAIS)
- Where
- Singapore
- Volunteers
- 36 people
- Sponsor
- Singapore General Hospital
Osteochondritis Dissecans Knee, Psychological Stress
Psychological Response and Readiness Associated With OCD of the Knee
This study primarily aims to determine whether patients diagnosed with osteochondritis dissecans (OCD) of the knee experience psychological stress due to their diagnosis and treatment plan.
- Trial name
- NCT04649905
- Testing
- Surgical Treatment, Nonoperative Treatment
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Boston Children's Hospital
Articular Cartilage Disorder, Degeneration; Articular Cartilage
Chondrofix Osteochondral Allograft Prospective Study
The overall study objective is to evaluate Chondrofix Osteochondral Allograft ("Chondrofix") for the repair of osteochondral lesions in the knee.
- Conditions
- Articular Cartilage Disorder, Degeneration; Articular Cartilage, Chronic Cartilage Injury, Acute Cartilage Injury
- Trial name
- NCT01410136
- Testing
- Chondrofix Osteochondral Allograft
- Where
- 5 sites in United States
- Volunteers
- 29 people
- Sponsor
- Zimmer Orthobiologics, Inc.
Osteochondritis Dissecans
Intra Articular Injections With Platelet Rich Plasma in Patients With Juvenile Osteochondritis Dissecans of the Knee
This study plans to learn more about ways to treat a joint problem in the knee called Juvenile Osteochondritis Dissecans (OCD). The goal of this study is to see if injecting platelet-rich plasma (PRP) into the knee can help knee…
- Trial name
- NCT02397278
- Testing
- Platelet rich plasma (PRP)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Colorado, Denver
Osteochondritis, Osteochondritis Dissecans
Safety and Efficacy Study of Cells Sheet-Autologous Chondrocyte Implantation to Treat Articular Cartilage Defects
In this study,the Autologous chondrocyte implantation (ACI)technology and cell sheet technology are used to Cells Sheet-Autologous Chondrocyte Implantation(CS-ACI) for treating Cartilage Defects.The Safety and Efficacy Study of…
- Conditions
- Osteochondritis, Osteochondritis Dissecans, Joint Diseases
- Trial name
- CS-ACI (NCT01694823)
- Testing
- CS-ACI
- Where
- 3 sites in China
- Volunteers
- 10 people
- Sponsor
- Yan Jin
Chondral Defect, Osteochondritis Dissecans (OCD)
A Study of MACI in Patients Aged 10 to 17 Years With Symptomatic Chondral or Osteochondral Defects of the Knee
The objective of this study is to compare the efficacy and safety of MACI® vs arthroscopic microfracture in the treatment of participants aged 10 to 17 years with symptomatic articular chondral or osteochondral defects of the…
- Conditions
- Chondral Defect, Osteochondritis Dissecans (OCD), Articular Cartilage Defect, Articular Cartilage Disorder of Knee
- Trial name
- PEAK (NCT03588975)
- Testing
- MACI, microfracture
- Where
- 14 sites in United States
- Volunteers
- 45 people
- Sponsor
- Vericel Corporation
Cartilage Diseases, Osteochondritis Dissecans
Evaluation of the Agili-C Biphasic Implant in the Knee Joint
The purpose of this study is to determine the performance of the Agili-C implants. The study hypothesis is that Agili-C implants are effective in the treatment of focal cartilage and cartilage-bone joint surface defects.
- Trial name
- NCT01471236
- Testing
- Agili-C Bi-phasic Implant, mini-arthrotomy
- Where
- 9 sites in Croatia, Czechia and 6 more
- Volunteers
- 65 people
- Sponsor
- Smith & Nephew, Inc.