Clinical trials: Osteomyelitis of Lower Extremities
Osteomyelitis, Diabetes
The ACHILLS Trial; Application of Cerament in Heel Infection for Lower Limb Salvage
The ACHILLS Trial is a multicentre randomised controlled feasibility study comparing partial calcanectomy with and without the use of an antibiotic-impregnated bone graft substitute (Cerament G) for treating calcaneal…
- Conditions
- Osteomyelitis, Diabetes, Calcanectomy
- Trial name
- ACHILLS (NCT07057817)
- Testing
- Cerament G, Standard Surgical Managment
- Where
- Ireland
- Volunteers
- 30 people
- Sponsor
- Royal College of Surgeons, Ireland
Polydactyly Toe, Thumb Hypoplasia
Clonidine for Tourniquet-related Pain in Children
This study is designed as a randomized, placebo-controlled, double-blinded, clinical trial with two parallel groups. This study investigates the association between a single dose of the drug, Clonidine, and the total amount of…
- Conditions
- Polydactyly Toe, Thumb Hypoplasia, Trigger Finger, Polydactyly; Fingers
- Trial name
- CLOTCH (NCT04564430)
- Testing
- Catapresan, Saline
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Diabetic Foot Infection, Surgical Wound
Optimal Antibiotics for Operated Diabetic Foot Infections
Diabetic foot problems, especially infections (DFI), require multiple resources including iterative surgeries and amputations, long-lasting antibiotic therapies, education, off-loading and eventually revascularization and…
- Conditions
- Diabetic Foot Infection, Surgical Wound, Antibiotic Side Effect, Infection
- Trial name
- NCT04081792
- Testing
- Antibiotic therapy
- Where
- Switzerland
- Volunteers
- 643 people
- Sponsor
- Balgrist University Hospital
Osteomyelitis of Lower Extremities
Osteomyelitis Multi-center Prospective Cohort Study
To establish a prospective, multicenter, real-world cohort of patients with osteomyelitis, by systematically collecting and analyzing detailed treatment and follow-up data, in order to provide clinical evidence for the…
- Trial name
- NCT07251374
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- Southwest Hospital, China
Diabetic Foot Ulcers, Diabetes Mellitus
Assessment of Non Vascular Risk Factors for Severity of Diabetic Foot Ulcers (DFUs)
Diabetes mellitus is a chronic disease that occurs either when pancreas does not produce enough insulin or when the body can't use it effectively.
- Trial name
- DFUs (NCT07193992)
- Volunteers
- 100 people
- Sponsor
- Assiut University
Subjects With Diabetes and DFU With a Suspicion of DFO
Bedside Bone Biopsy in Diabetic Foot Osteomyelitis
During their lifetime, 15 to 25% of patients with diabetes mellitus will develop a Diabetic Foot Ulcer (DFU) related to neuropathy and/or peripheral arterial disease.
- Trial name
- BOLBOC (NCT06066801)
- Testing
- Bedside blind bone biopsy procedure
- Where
- France
- Volunteers
- 320 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diabetes Mellitus, Foot Osteomyelitis
Assessment of PCR Multiplex Tests as a Tool to Obtain a Quicker Diagnosis of Bacteria Responsible for Foot Osteomyelitis Than Usual Cultures
Bone samples from infected diabetic feet will be collected and tests will be performed for the diagnosis of causative bacteria. Samples will be processed by PCR multiplex tests and usual cultures for identification of causative…
- Trial name
- RAPDIAGOS (NCT03434288)
- Testing
- Bone sampling
- Where
- France
- Volunteers
- 48 people
- Sponsor
- University Hospital, Montpellier
Diabetes, Foot Ulcer
Osteomyelitis: Procalcitonin to Diagnose and Monitor Osteomyelitis
The investigator plans a cohort study of 80 subjects admitted to hospital with a diabetic foot infection in order to compare serial bone biopsies (the current "gold standard") and procalcitonin to diagnose and monitor the…
- Conditions
- Diabetes, Foot Ulcer, Osteomyelitis
- Trial name
- NCT02165579
- Testing
- 1 cohort, standard care, observational
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Texas Southwestern Medical Center
Diabetic Foot Infection, Osteomyelitis
A Clinical Trial Testing the Efficacy of PDT in Preventing Amputation in Diabetic Patients
The feet of diabetic patients continue to be an important problem in medicine. In general, patients with diabetic foot have some sort of amputation, especially in underserved populations.
- Conditions
- Diabetic Foot Infection, Osteomyelitis, Photo Antimicrobial Chemotherapy
- Trial name
- NCT03380403
- Testing
- PDT, Ciprofloxacin
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Faculdade de Medicina do ABC
Diabetic Foot, Osteomyelitis
Risk Factors for Three Critical Stages of the Diabetic Foot Infections
In this study, it was aimed to evaluate the independent risk factors for osteomyelitis, amputation and major amputation of the diabetic foot infection in the forward direction without using standard scoring procedures.
- Trial name
- NCT02736253
- Where
- Turkey (Türkiye)
- Volunteers
- 379 people
- Sponsor
- Ege University
Diabetic Foot Infections
18F-FDG PET/CT for Diagnosis of Diabetic Foot Osteomyelitis
Diabetic foot osteomyelitis (DFO) is a bone infection of the foot that can occur in people with diabetes and may lead to serious complications, including amputation. Diagnosing DFO can be difficult.
- Trial name
- NCT07828691
- Testing
- 18F-FDG PET/CT
- Where
- 4 sites in United States, Canada
- Volunteers
- 150 people
- Sponsor
- Jewish General Hospital
Osteomyelitis of Lower Extremities, Osteomyelitis - Foot
Comparison of Oral Antibiotics For Bone Infections of the Leg and Foot
The goal of this clinical trial is to compare different classes of oral antibiotics (beta-lactam and non-beta-lactam antibiotics) for the treatment of bone infections of the leg and foot.
- Conditions
- Osteomyelitis of Lower Extremities, Osteomyelitis - Foot, Osteomyelitis of the Foot
- Trial name
- OSTEO (NCT07266753)
- Testing
- Oral Beta-Lactam Antibiotic, Oral Non-Beta-Lactam Antibiotic
- Where
- 3 sites in Canada
- Volunteers
- 1,418 people
- Sponsor
- Michael Garron Hospital
Infection; Diabetic Foot
Ertapenem Sodium (MK-0826) Versus Piperacillin/Tazobactam Sodium for the Treatment of Diabetic Foot Infections in Chinese Adults (MK-0826-061)
This study compared ertapenem sodium to piperacillin/tazobactam sodium for the treatment of moderate to severe diabetic foot infections.
- Trial name
- NCT01370616
- Testing
- Ertapenem sodium, Piperacillin/tazobactam sodium, Amoxicillin/clavulunate potassium
- Volunteers
- 565 people
- Sponsor
- Merck Sharp & Dohme LLC
Osteomyelitis of the Foot, Antibiotic Impregnated Beads
Antibiotic Impregnated Beads in Osteomyelitis
Lower extremity bone infections, such as osteomyelitis, often occur after bone fractures, surgery, or when prosthetic joints or hardware become infected.
- Conditions
- Osteomyelitis of the Foot, Antibiotic Impregnated Beads, Osteomyelitis of Lower Extremities
- Trial name
- NCT07072923
- Testing
- Antibiotic loaded calcium sulfate beads
- Volunteers
- 100 people
- Sponsor
- University of Arizona
Diabetic Foot, Chronic Osteomyelitis
Predictive Value of Nu.Q™ Biomarkers to Help Guiding the Management of Osteoarticular Infections
Diabetic foot ulcers are frequent with average lifetime risk of 15%, and can lead to bone and joint infections. Current protocols for their management include evaluation of ischemia, assessment of underlying bone infection, sharp…
- Conditions
- Diabetic Foot, Chronic Osteomyelitis, Septic Arthritis
- Trial name
- NCT05593874
- Testing
- Histones H3.1 blood levels
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University Hospital, Geneva
Foot Ulcers, Osteomyelitis
Investigation of the Use of Hyperspectral Imaging in Foot Surgery Patients
To investigate novel advanced imaging techniques (hyperspectral imaging) that could enable clinicians to determine the degree and effectiveness of blood flow to tissues during surgery.
- Conditions
- Foot Ulcers, Osteomyelitis, Amputation
- Trial name
- HSI (NCT03787862)
- Where
- 2 sites in United States
- Sponsor
- University of Texas Southwestern Medical Center
Diabetic Foot
a Randomized Controlled Trial Comparing Medical and Medical-surgical Treatment in Diabetic Foot Osteomyelitis
Osteomyelitis is a frequent complication of diabetic foot ulcer. Several therapeutic strategies are used : medical treatment with antibiotics and foot offloading or surgical treatment consisting in the resection of infected bone…
- Trial name
- DIPIOS (NCT00578890)
- Testing
- Medical/surgical treatment versus medical treatment
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diabetic Foot Osteomyelitis
White Blood Cell SPECT/CT and Diabetic Foot Osteomyelitis
Osteomyelitis is a risk factor for lower extremity amputation in diabetic people. Antibiotic therapy allows a remission in 60 to 80% of cases.
- Trial name
- NCT02927678
- Testing
- white blood cell SPECT/CT (Single Photon Emission Computed Tomography/Computed Tomography) imaging
- Where
- France
- Volunteers
- 56 people
- Sponsor
- Hospices Civils de Lyon
Osteomyelitis Tibia, Surgical Site Infection
Acute Posttraumatic Osteomyelitis in Patients With High-energy Tibial Fractures and Biomarkers
The present trial was aimed to identify which biomarkers could be associated in perioperative period after surgical treatment of tibial fracture to the development of POM.
- Trial name
- POMTIBIAL (NCT03459261)
- Testing
- blood sample on admission (ADD), first postoperative day (POD1) and fourth postoperative day (POD4)
- Volunteers
- 86 people
- Sponsor
- University Medical Centre Ljubljana
Open tíbia Fracture, Osteomyelitis Tibia
Intramedullary Calcium Sulfate Antibiotic Depot
The goal of this randomized clinical trial is to study the best treatment for open lower leg fractures to prevent infection. The main questions it aims to answer is if treating tibia fracture patients with a calcium sulfate…
- Conditions
- Open tíbia Fracture, Osteomyelitis Tibia, Tibial Fractures
- Trial name
- NCT05766670
- Testing
- Vancomycin Hydrochloride, Gentamicin, Standard Intramedullary Nail
- Where
- 12 sites in United States
- Volunteers
- 242 people
- Sponsor
- Wake Forest University Health Sciences