Clinical trials: Osteomyelitis of the Foot
Polydactyly Toe, Thumb Hypoplasia
Clonidine for Tourniquet-related Pain in Children
This study is designed as a randomized, placebo-controlled, double-blinded, clinical trial with two parallel groups. This study investigates the association between a single dose of the drug, Clonidine, and the total amount of…
- Conditions
- Polydactyly Toe, Thumb Hypoplasia, Trigger Finger, Polydactyly; Fingers
- Trial name
- CLOTCH (NCT04564430)
- Testing
- Catapresan, Saline
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Diabetic Foot Infection, Surgical Wound
Optimal Antibiotics for Operated Diabetic Foot Infections
Diabetic foot problems, especially infections (DFI), require multiple resources including iterative surgeries and amputations, long-lasting antibiotic therapies, education, off-loading and eventually revascularization and…
- Conditions
- Diabetic Foot Infection, Surgical Wound, Antibiotic Side Effect, Infection
- Trial name
- NCT04081792
- Testing
- Antibiotic therapy
- Where
- Switzerland
- Volunteers
- 643 people
- Sponsor
- Balgrist University Hospital
Diabetic Foot Osteomyelitis, Diabetic Foot Infection
Studying on the Difference Between Two Kinds of Osteomyelitis
To explore the microbial differences of diabetic foot osteomyelitis and osteomyelitis without diabetes.
- Conditions
- Diabetic Foot Osteomyelitis, Diabetic Foot Infection, Microbiome
- Trial name
- NCT04240964
- Where
- China
- Volunteers
- 28 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Subjects With Diabetes and DFU With a Suspicion of DFO
Bedside Bone Biopsy in Diabetic Foot Osteomyelitis
During their lifetime, 15 to 25% of patients with diabetes mellitus will develop a Diabetic Foot Ulcer (DFU) related to neuropathy and/or peripheral arterial disease.
- Trial name
- BOLBOC (NCT06066801)
- Testing
- Bedside blind bone biopsy procedure
- Where
- France
- Volunteers
- 320 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diabetes Mellitus, Foot Osteomyelitis
Assessment of PCR Multiplex Tests as a Tool to Obtain a Quicker Diagnosis of Bacteria Responsible for Foot Osteomyelitis Than Usual Cultures
Bone samples from infected diabetic feet will be collected and tests will be performed for the diagnosis of causative bacteria. Samples will be processed by PCR multiplex tests and usual cultures for identification of causative…
- Trial name
- RAPDIAGOS (NCT03434288)
- Testing
- Bone sampling
- Where
- France
- Volunteers
- 48 people
- Sponsor
- University Hospital, Montpellier
Diabetic Foot Osteomyelitis
Fungal Infection in Patients With Diabetic Foot Osteomyelitis
estimate the percentage of fungal infection in the pathogenesis of diabetic foot osteomyelitis and assess the outcome of patients with fungal diabetic foot osteomyelitis
- Trial name
- NCT04041739
- Testing
- fungal osteomyelitis culture and sensitivity
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Diabetic Foot Infection, Osteomyelitis
A Clinical Trial Testing the Efficacy of PDT in Preventing Amputation in Diabetic Patients
The feet of diabetic patients continue to be an important problem in medicine. In general, patients with diabetic foot have some sort of amputation, especially in underserved populations.
- Conditions
- Diabetic Foot Infection, Osteomyelitis, Photo Antimicrobial Chemotherapy
- Trial name
- NCT03380403
- Testing
- PDT, Ciprofloxacin
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Faculdade de Medicina do ABC
Diabetic Foot, Osteomyelitis
Risk Factors for Three Critical Stages of the Diabetic Foot Infections
In this study, it was aimed to evaluate the independent risk factors for osteomyelitis, amputation and major amputation of the diabetic foot infection in the forward direction without using standard scoring procedures.
- Trial name
- NCT02736253
- Where
- Turkey (Türkiye)
- Volunteers
- 379 people
- Sponsor
- Ege University
Diabetic Foot Infection
Real-World Efficacy and Safety Analysis of Omadacycline for the Treatment of Diabetic Foot Infections and Acute Osteomyelitis
This will be a prospective, open-label, two-center study to assess the safety of omadacycline use in the treatment of hospitalized subjects with moderate to severe DFI with or without Acute osteomyelitis (AOM) who are at a high…
- Trial name
- NCT04714411
- Testing
- Omadacycline
- Where
- 2 sites in United States
- Volunteers
- 42 people
- Sponsor
- Methodist Health System
Diabetic Foot Infections
18F-FDG PET/CT for Diagnosis of Diabetic Foot Osteomyelitis
Diabetic foot osteomyelitis (DFO) is a bone infection of the foot that can occur in people with diabetes and may lead to serious complications, including amputation. Diagnosing DFO can be difficult.
- Trial name
- NCT07828691
- Testing
- 18F-FDG PET/CT
- Where
- 4 sites in United States, Canada
- Volunteers
- 150 people
- Sponsor
- Jewish General Hospital
Osteomyelitis of Lower Extremities, Osteomyelitis - Foot
Comparison of Oral Antibiotics For Bone Infections of the Leg and Foot
The goal of this clinical trial is to compare different classes of oral antibiotics (beta-lactam and non-beta-lactam antibiotics) for the treatment of bone infections of the leg and foot.
- Conditions
- Osteomyelitis of Lower Extremities, Osteomyelitis - Foot, Osteomyelitis of the Foot
- Trial name
- OSTEO (NCT07266753)
- Testing
- Oral Beta-Lactam Antibiotic, Oral Non-Beta-Lactam Antibiotic
- Where
- 3 sites in Canada
- Volunteers
- 1,418 people
- Sponsor
- Michael Garron Hospital
Diabetic Foot Osteomyelitis
A Feasibility Trial to Investigate the Safety and Between-group Effect Size of STIMULAN VG and Standard of Care (SoC) in Participants With Diabetic Foot Osteomyelitis
The purpose of this trial is to evaluate the safety and between-group effect size of STIMULAN VG compared to SoC treatment in patients with diabetic foot osteomyelitis (DFO).
- Trial name
- BLADE-VG2 (NCT05539963)
- Testing
- STIMULAN VG, Systemic Antibiotics
- Where
- 10 sites in United States
- Volunteers
- 61 people
- Sponsor
- Biocomposites Ltd
Infection; Diabetic Foot
Ertapenem Sodium (MK-0826) Versus Piperacillin/Tazobactam Sodium for the Treatment of Diabetic Foot Infections in Chinese Adults (MK-0826-061)
This study compared ertapenem sodium to piperacillin/tazobactam sodium for the treatment of moderate to severe diabetic foot infections.
- Trial name
- NCT01370616
- Testing
- Ertapenem sodium, Piperacillin/tazobactam sodium, Amoxicillin/clavulunate potassium
- Volunteers
- 565 people
- Sponsor
- Merck Sharp & Dohme LLC
Osteomyelitis of the Foot, Antibiotic Impregnated Beads
Antibiotic Impregnated Beads in Osteomyelitis
Lower extremity bone infections, such as osteomyelitis, often occur after bone fractures, surgery, or when prosthetic joints or hardware become infected.
- Conditions
- Osteomyelitis of the Foot, Antibiotic Impregnated Beads, Osteomyelitis of Lower Extremities
- Trial name
- NCT07072923
- Testing
- Antibiotic loaded calcium sulfate beads
- Volunteers
- 100 people
- Sponsor
- University of Arizona
Diabetic Foot, Chronic Osteomyelitis
Predictive Value of Nu.Q™ Biomarkers to Help Guiding the Management of Osteoarticular Infections
Diabetic foot ulcers are frequent with average lifetime risk of 15%, and can lead to bone and joint infections. Current protocols for their management include evaluation of ischemia, assessment of underlying bone infection, sharp…
- Conditions
- Diabetic Foot, Chronic Osteomyelitis, Septic Arthritis
- Trial name
- NCT05593874
- Testing
- Histones H3.1 blood levels
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University Hospital, Geneva
Foot Ulcers, Osteomyelitis
Investigation of the Use of Hyperspectral Imaging in Foot Surgery Patients
To investigate novel advanced imaging techniques (hyperspectral imaging) that could enable clinicians to determine the degree and effectiveness of blood flow to tissues during surgery.
- Conditions
- Foot Ulcers, Osteomyelitis, Amputation
- Trial name
- HSI (NCT03787862)
- Where
- 2 sites in United States
- Sponsor
- University of Texas Southwestern Medical Center
Diabetic Foot Infection
[124I]FIAU PET-CT Scanning in Diagnosing Osteomyelitis in Patients With Diabetic Foot Infection
This protocol will evaluate the sensitivity and specificity of [124I]FIAU as a diagnostic imaging agent for the detection of osteomyelitis in patients with diabetic foot infection.
- Trial name
- NCT01764919
- Testing
- [124I]FIAU
- Where
- 3 sites in United States
- Volunteers
- 4 people
- Sponsor
- BioMed Valley Discoveries, Inc
Pneumonia, Syncope
Quasi-Randomized Evaluation of the UCLA Next Day Clinic (NDC)
The Next Day Clinic (NDC) is a quality improvement initiative that will be launched and operated by UCLA Health starting July 22, 2024. Its goals are to improve patient care and safety and to maximize cost effectiveness.
- Conditions
- Pneumonia, Syncope, Congestive Heart Failure, Cellulitis
- Trial name
- NDC (NCT06526884)
- Testing
- Next Day Clinic
- Where
- United States
- Volunteers
- 570 people
- Sponsor
- University of California, Los Angeles
Diabetic Foot
a Randomized Controlled Trial Comparing Medical and Medical-surgical Treatment in Diabetic Foot Osteomyelitis
Osteomyelitis is a frequent complication of diabetic foot ulcer. Several therapeutic strategies are used : medical treatment with antibiotics and foot offloading or surgical treatment consisting in the resection of infected bone…
- Trial name
- DIPIOS (NCT00578890)
- Testing
- Medical/surgical treatment versus medical treatment
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diabetic Foot Infection
Antibiotic Therapy in Infections of the Diabetic Foot Syndrome
This retrospective study examines the surgical and antibiotic treatment of diabetic foot syndrome infections treated at the University Hospital Basel since 2019.
- Trial name
- DFO (NCT05616351)
- Testing
- Data collection in patients with diabetic foot syndrome and infections in the area of the foot
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- University Hospital, Basel, Switzerland