Clinical trials: Osteopenia, Generalized, open to volunteers
Postmenopausal Osteoporosis, Postmenopausal Osteopenia
The Comparison of Ibandronate and Zoledronic Acid After Denosumab Discontinuation
This study is a prospective, multicenter, open-label, randomized non-inferiority trial comparing intravenous ibandronate and zoledronic acid as sequential therapy after denosumab discontinuation in postmenopausal women with…
- Conditions
- Postmenopausal Osteoporosis, Postmenopausal Osteopenia, Primary Osteoporosis, Osteoporosis
- Trial name
- NCT07406685
- Testing
- Ibandronate IV, Zoledronic acid IV
- Where
- Taiwan
- Volunteers
- 52 people
- Sponsor
- National Taiwan University Hospital
Osteoporosis, Musculoskeletal Health
Functional Muscle-Bone Incongruity Index (FKUI): A Prospective Observational Study
The Functional Muscle-Bone Incongruity Index (FKUI) is a novel approach developed to evaluate the relationship between muscle function and bone health.
- Conditions
- Osteoporosis, Musculoskeletal Health, Sarcopenia, Osteopenia
- Trial name
- FKUI (NCT07677033)
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Osteoporosis, Osteopenia
A Pilot Study of Vitamin K2 (Menaquinone-7, Soloways ™) in Patients With Osteopenia/Osteoporosis Carrying a VDR Gene Variant
This pilot, genotype-stratified clinical trial aims to evaluate the safety and preliminary efficacy of vitamin K2 (menaquinone-7, MK-7) supplementation in patients with low bone mineral density (osteopenia or osteoporosis) who…
- Trial name
- NCT06867952
- Testing
- Vitamin K2 plus vitamin D3
- Where
- Russia
- Volunteers
- 40 people
- Sponsor
- S.LAB (SOLOWAYS)
Meniere Disease, Osteoporosis
Menier's Disease - Bone Density Study
Meniere's disease is a progressive and debilitating inner ear disease characterised by vertigo and hearing loss. Several studies have linked Menierws disease with lower bone density and lower vitamin D levels.
- Conditions
- Meniere Disease, Osteoporosis, Osteopenia, Vitamin D Deficiency
- Trial name
- NCT05322538
- Testing
- vitamin D plasma levels baseline, Dual-energy X-ray absorptiometry at baseline, cervical Vestibular evoked myogenic potentials at baseline
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- HaEmek Medical Center, Israel
Osteopenia
Time-Restricted Eating and Exercise for Bone Health
The purpose of this study is to learn whether combining time-restricted eating with supervised resistance exercise can improve bone health in adults with osteopenia.
- Trial name
- OSTEO-FIT (NCT07824375)
- Testing
- Time-restricted eating combined with resistance exercise (TRE+Ex), Habitual eating pattern combined with resistance exercise (HE+Ex)
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Alabama at Birmingham
Osteopenia or Osteoporosis
Profylactic Treatment for Patients in Risk Osteoporosis
The aim is to compare the daily intake of Calsium (Ca) + vitamin D with and without daily optimal efficacy dose (OED) of Jarlsberg on Bone Mineral Density (BMD) and bone markers (BM) to Osteopeni patients (OP).
- Trial name
- PF-Jarlsberg (NCT05787808)
- Testing
- Calsium, Vitamin D, Jarlsberg cheese
- Where
- Norway
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Meddoc
Bone Disease, Metabolic
Elucidating the Minimal Effective Dose of Prunes for Bone Health in Postmenopausal Women
The objective of this study is to examine if calcium and vitamin D supplements and/or prune can prevent bone loss in postmenopausal women.
- Trial name
- NCT06184646
- Testing
- Prune
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- San Diego State University
Glucocorticoid-Associated Osteopenia and Osteoporosis
Romosozumab Versus Denosumab In Glucocorticoid-induced Osteoporosis: An Extended Observation Of a Clinical Trial at 6 Years
This is an extended observation study of a RCT comparing the efficacy of romorozumab and denosumab in high-risk patients using long-term glucocorticoids.
- Trial name
- NCT07757373
- Testing
- Romosozumab, Denosumab
- Where
- Hong Kong
- Volunteers
- 54 people
- Sponsor
- Tuen Mun Hospital
Vitamin D Deficiency, Osteopenia of Prematurity
The High Initial Dose of Monitored Vitamin D Supplementation in Preterm Infants.
The aim of this study will be to assess the effectiveness of monitored vit D supplementation in a population of preterm infants and to identify whether the proper vit D supplementation in preterm infants can reduce the incidence…
- Conditions
- Vitamin D Deficiency, Osteopenia of Prematurity, Nephrolithiasis, Metabolic Bone Disease
- Trial name
- HIDVID (NCT06199102)
- Testing
- cholecalciferol/ Devikap
- Where
- Poland
- Volunteers
- 130 people
- Sponsor
- Princess Anna Mazowiecka Hospital, Warsaw, Poland
Osteopenia, Osteoporosis
Food Trial Evaluating Fecal Abundance of SBD111 With Once-Daily Versus Twice-Daily Administration in Healthy Adults
The purpose of this study is to determine whether a modified formulation and daily intake schedule of SBD111 results in similar levels of probiotic microbes in the gut compared with the currently used formulation.
- Conditions
- Osteopenia, Osteoporosis, Menopause Related Conditions, Probiotic Intervention
- Trial name
- NCT07538167
- Testing
- SBD111(current formulation), SBD111 (new formulation)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Solarea Bio, Inc
Osteoporosis, Osteopenia
Peripheral Mononuclear Cells to Screen, Monitor and Stratify the Population at Risk of Osteoporosis and Fractures
Osteoporosis (OP) is one of most common age-associated and chronic metabolic bone diseases, featured by a decrease of bone mineral density (BMD) that increases the risk of bone fractures.OP guidelines agree that Dual-X-ray…
- Conditions
- Osteoporosis, Osteopenia, Osteoporosis Fracture
- Trial name
- DISCERN (NCT06551155)
- Testing
- Vitality and biological activity of peripheral blood mononuclear cells (PBMCs)
- Where
- 2 sites in Italy
- Volunteers
- 120 people
- Sponsor
- Istituto Ortopedico Rizzoli
Osteopenia, Osteoporosis
Exercise and Fall Prevention for Fracture Reduction
According to the current guideline of the German Osteology Association (DVO), pharmacological treatment is a cornerstone of osteoporosis-related fracture prevention, effectively increasing bone mineral density and reducing…
- Conditions
- Osteopenia, Osteoporosis, High Fall Risk
- Trial name
- OsteoApp (NCT07897929)
- Testing
- Guideline-based home exercise training
- Where
- Germany
- Volunteers
- 72 people
- Sponsor
- Wolfgang Kemmler, PhD
Osteoporosis, Osteopenia
A Study Evaluating the Performance of Using AI Software and Chest X-rays to Screen for Osteoporosis as Compared to Standard DXA Scans in Patients 50 Years and Older
The goal of this study is to assess the performance of an artificial intelligence software (Osteo Signal) in detecting osteoporosis risk in adults 50 years and older.
- Trial name
- NCT07421713
- Testing
- Osteo Signal
- Where
- 3 sites in Netherlands, United Kingdom
- Volunteers
- 595 people, healthy volunteers welcome
- Sponsor
- Promedius Inc
Osteopenia, Osteoporosis
Calcium-Rich Food Versus Calcium Carbonate for Bone Health
This study will compare adherence, tolerability, safety, and treatment satisfaction between a calcium-rich food and a traditional calcium carbonate supplement in women ages 40 to 90 who are at increased risk for osteoporosis.
- Conditions
- Osteopenia, Osteoporosis, Bone Health in Perimenopausal Women, Menopause Related Conditions
- Trial name
- NCT07763509
- Testing
- 500 mg calcium from milk-derived minerals, Calcium Carbonate 500 MG
- Where
- United States
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- Cornell University
HIV Infected Individuals, Osteopenia
Zoledronic Acid for the Prevention of TDF-sparing ART-induced Bone Mass Density Loss in Treatment-naive HIV Positive Individuals
The goal of this clinical trial is to learn if zolendric acid can prevent the anticipated deterioration of bone mass after antiviral treatment initiation for people that were recently diagnosed with HIV.
- Trial name
- NCT06762730
- Testing
- Zoledronic Acid 5 mg/Bag 100 ml Inj
- Where
- 3 sites in Israel
- Volunteers
- 110 people
- Sponsor
- Hadassah Medical Organization
Osteopenia, Osteoporosis
Periprosthetic Plate Over Humeral Nail
use of plate over humeral nail in deformity correction of femur in adult osteoporotic bone
- Trial name
- osteoporosis (NCT06812195)
- Testing
- Plate and nail
- Volunteers
- 3 people
- Sponsor
- Assiut University
Bone Loss
Bone, Exercise, Alendronate, and Caloric Restriction
The purpose of this research is to identify strategies that minimize bone loss that occurs when older adults lose weight. Participation in this research will involve up to nine assessment visits and last up to two years.
- Trial name
- BEACON (NCT05764733)
- Testing
- Bisphosphonate, Resistance Training/Bone-Loading Exercise
- Where
- 2 sites in United States
- Volunteers
- 900 people
- Sponsor
- Wake Forest University Health Sciences
Osteoporosis, Osteopenia
Serum Myostatin and Irisin Levels in Postmenopausal Women: Association With Bone Mineral Density and Muscle Strength
This study aims to evaluate the relationship between serum myostatin and irisin levels and bone mineral density and muscle strength in postmenopausal women.
- Trial name
- MYOIRISIN (NCT07519551)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Low Back Pain, Osteopenia
Effect of Manual Therapy on Low Back Pain in Osteopenic Postmenopausal Women
The purpose of this study is to determine the effect of manual therapy on low back pain in osteopenic postmenopausal women.
- Trial name
- NCT06671665
- Testing
- calcium supplementation, Manual therapy
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Cairo University
Osteopenia
Veverimer to Decrease Net Acid Excretion and Bone Resorption in Adults With Osteopenia
The goal of this clinical trial is to learn if veverimer will reduce urinary net acid excretion leading to reduced bone resorption in healthy adults with osteopenia.
- Trial name
- NCT07473713
- Testing
- veverimer daily, veverimer every other day
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Tufts Medical Center