Clinical trials: Osteoporosis, Osteopenia
Osteoporosis
Effects of Parathyroid Hormone in Men With Osteoporosis
Alendronate is a drug that blocks or reduces bone loss, while parathyroid hormone (PTH) stimulates the formation of new bone. The purpose of this study is to compare the bone-building effects of PTH alone, alendronate alone, and…
- Trial name
- NCT00000427
- Testing
- Parathyroid hormone, Alendronate
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Massachusetts General Hospital
Menopause, Osteopenia
Vascular and Skeletal Protective Effects of Genistein in Postmenopausal Women
The present research program is proposed deepening some pharmacological effects of the genistein therapy in order to individualize alternative treatments to the conventional hormonal replacement therapy useful to reduce the…
- Trial name
- NCT00355953
- Testing
- Genistein
- Volunteers
- 400 people
- Sponsor
- University of Messina
Osteoporosis
Radiological Biological Genetic and Micro-architectural Bone Determinants of Fractures in Men With Low Bone Mineral Density
Rational: Osteoporosis in men is responsible for one third of fragility fractures. However the definition and especially the determinants of fracture in humans are less well known than in women.
- Trial name
- OSTEHOM (NCT01250314)
- Testing
- Radiology, Biological, biochemical and genetic samples
- Where
- France
- Volunteers
- 79 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Osteoporosis, Osteopenia
The Effect of 16 Weeks of Hip Adduction and Abduction Resistance Exercise
Performing adduction and abduction resistance exercise will increase hip bone density and strength to a greater extent than doing squat and deadlift exercise.
- Conditions
- Osteoporosis, Osteopenia, Sarcopenia
- Trial name
- Ad/Ab (NCT01228877)
- Testing
- exercise
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Critical Illness, Osteoporosis
Bone Loss Prevention With Zoledronic Acid or Denosumab in Critically Ill Adults
The Bone Zone trial is a prospective, multi-centre, double-blind, phase II, randomised controlled trial evaluating the effect of denosumab or zoledronic acid compared to placebo on change in bone mineral density over one year in…
- Trial name
- BoneZone (NCT04608630)
- Testing
- Denosumab 60 MG/ML, Zoledronic Acid 5Mg/Bag 100Ml Inj, Sodium Chloride 0.9% or 5% Dextrose Intravenous
- Where
- 22 sites in Australia, New Zealand
- Volunteers
- 450 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Breast Cancer, Osteoporosis, Osteopenia
Vivomixx for Prevention of Bone Loss in Women With Breast Cancer Treated With an Aromatase Inhibitor
This study evaluates the efficacy of the probiotic food supplement Vivomixx in the prevention of bone loss occurring in post menopausal women with breast cancer treated with an aromatase inhibitor.
- Trial name
- NCT03518268
- Testing
- Vivomixx
- Volunteers
- 40 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Sarcopenia, Sarcopenic Obesity
Prevalence of Sarcopenia and Sarcopenic Obesity in Older Adults
Syndromes such as sarcopenia, sarcopenic obesity and osteosarcopenic obesity are commonly seen in older adults. They result from the impairment of muscle, bone and adipose tissue.
- Conditions
- Sarcopenia, Sarcopenic Obesity, Osteopenia, Osteoporosis
- Trial name
- NCT04122638
- Where
- Turkey (Türkiye)
- Volunteers
- 572 people, healthy volunteers welcome
- Sponsor
- Goztepe Training and Research Hospital
Healthy
Atenolol for the Prevention of Osteoporosis (APO)
Evaluate whether treatment with a widely used beta blocker, atenolol, will prevent bone loss at the lower back and hip in postmenopausal women.
- Trial name
- APO (NCT04905277)
- Testing
- Atenolol 50 MG
- Where
- 3 sites in United States
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- Sundeep Khosla, M.D.
Healthy, Osteopenia
Resistance Training and Rapamycin to Enhance Bone Formation in Postmenopausal Women
The aim of the present clinical trial is to examine the effects of everolimus, resistance training, or their combination on bone and muscle health formation in elderly women aged 60-75 years.
- Conditions
- Healthy, Osteopenia, Osteoporosis Risk
- Trial name
- StrongBone (NCT07191353)
- Testing
- Everolimus, Resistance training
- Where
- 2 sites in Denmark
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Breast Cancer, Breast Cancer Survivors
Impact of Pilates Exercises on Bone Mineral Density in Breast Cancer Survivors Receiving Hormonal Therapy
Breast cancer survivors receiving endocrine (hormonal) therapy (aromatase inhibitors) are at high risk for cancer treatment-induced bone loss and osteoporosis due to estrogen depletion.
- Conditions
- Breast Cancer, Breast Cancer Survivors, Aromatase Inhibitors, Osteoporosis or Osteopenia
- Trial name
- PilatesBCS2026 (NCT07334626)
- Testing
- Pilates Exercises, Calcium and Vitamin D Supplementation
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Benha University
Osteoporosis
Safety and Effectiveness of Soy Phytoestrogens to Prevent Bone Loss
The purpose of this study is to determine whether soy isoflavone supplementation is safe and effective to prevent bone loss in postmenopausal women.
- Trial name
- OPUS (NCT00665860)
- Testing
- Soy isoflavones
- Where
- 3 sites in United States
- Volunteers
- 403 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Bone Density, Osteopenia
The Influence of Vibration on Bone Mineral Density in Women Who Have Weak Bones After Menopause
This study will examine whether whole-body vibration slows down bone loss in healthy postmenopausal women with osteopenia. Whole-body vibration is a promising novel therapy that involves standing on a platform which produces…
- Conditions
- Bone Density, Osteopenia, Osteoporosis, Post-Menopause
- Trial name
- NCT00420940
- Testing
- Juvent 1000 Dynamic Motion Therapy (DMT) Platform
- Where
- Canada
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Osteoporosis
Cancer and Osteoporosis Research With Alendronate and Lupron (C.O.R.A.L )
Multi-center,double blind randomized phase III placebo controlled study in 250 men with histologically proven prostate cancer with out bone metastases who are beginning ADT therapy and who will receive concomitant treatment with…
- Trial name
- NCT00236002
- Testing
- Alendronate
- Volunteers
- 182 people
- Sponsor
- Canadian Urology Research Consortium
Osteopenia, Osteoporosis
Feasibility of a Novel Resistance Exercise in Individuals With Osteoporosis
The aim of the 2 month randomized controlled trial is to investigate the feasibility of a novel progressive muscle resistance exercise in individuals with low bone mass.
- Conditions
- Osteopenia, Osteoporosis, Postmenopausal Osteoporosis, Sarcopenia
- Trial name
- NCT05060380
- Testing
- Exercise training
- Sponsor
- University of Alabama at Birmingham
Sickle Cell Disease, Osteoporosis
Interest of Nutritional Care of Children With Sickle Cell Disease on Bone Mineral Density and Body Composition
This study is design to assess the effects of an increase in nutritional intake on the bone mineral density of children with sickle cell disease, for 12 months.
- Conditions
- Sickle Cell Disease, Osteoporosis, Osteopenia
- Trial name
- NUTRIDREP (NCT04754711)
- Testing
- Oral Nutritional Supplement
- Where
- France
- Volunteers
- 72 people
- Sponsor
- Centre Hospitalier Régional d'Orléans
Breast Cancer, Osteoporosis
Zoledronate in Preventing Bone Loss in Postmenopausal Women Who Are Receiving Letrozole for Stage I, Stage II, or Stage IIIA Breast Cancer
RATIONALE: Estrogen can cause the growth of breast cancer cells. Hormone therapy using letrozole may fight breast cancer by lowering the amount of estrogen the body makes.
- Trial name
- NCT00107263
- Testing
- letrozole, zoledronic acid
- Volunteers
- 558 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Osteoporosis, Atypical Femoral Fracture
Fracture (FX) Improvement With Teriparatide: FiX-IT Study
This open label comparison study examines the hypothesis that teriparatide given immediately following repair of an atypical subtrochanteric or diaphyseal femoral shaft fracture will enhance healing and improve bone mineral…
- Trial name
- FiX-IT (NCT01705587)
- Testing
- teriparatide
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Susan L. Greenspan
Breast Cancer, Osteoporosis
Zoledronate in Preventing Bone Loss in Premenopausal Women Receiving Chemotherapy After Surgery For Early Stage Breast Cancer
RATIONALE: It is not yet known whether zoledronate is effective in preventing bone loss in premenopausal women who are receiving adjuvant chemotherapy after undergoing surgery for early stage breast cancer.
- Trial name
- NCT00049452
- Testing
- zoledronic acid
- Where
- 3 sites in United States
- Volunteers
- 120 people
- Sponsor
- Herbert Irving Comprehensive Cancer Center
Osteopenia, Complications of Heart-lung Transplant
Comparison of Pamidronate With Zoledronic Acid for Transplant Related Bone Loss Prevention
The purpose of this trial is to see whether zoledronic acid is better than pamidronate to treat low bone density in heart and lung transplant patients.
- Conditions
- Osteopenia, Complications of Heart-lung Transplant, Other Complications of Lung Transplant
- Trial name
- NCT00164008
- Testing
- zoledronic acid vs pamidronate
- Volunteers
- 56 people
- Sponsor
- Bayside Health
Osteopenia, Osteoporosis
Safety And Tolerability Study Of RN564 In Women With Osteopenia And Healthy Men.
The purpose of this study is to determine the safety and tolerability of RN564 in women with osteopenia and healthy men.
- Conditions
- Osteopenia, Osteoporosis, Bone Disease
- Trial name
- NCT01293487
- Testing
- RN564
- Where
- 8 sites in United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Pfizer