Clinical trials: Osteoporosis Fracture
Osteoporotic Fractures, Vertebral Fracture
Percutaneous Vertebroplasty Vs. Sham for Osteoporotic Vertebral Compression Fractures Focusing on Pain and Economy.
The purpose of this randomized double-blind clinical trial is to determine the efficacy of percutaneous vertebroplasty (PVP) in relieving severe pain in patients with MRI-verified acute or sub-acute osteoporotic vertebral…
- Trial name
- VOPE2 (NCT06141187)
- Testing
- Vertebroplasty
- Where
- Denmark
- Volunteers
- 240 people
- Sponsor
- Spine Centre of Southern Denmark
Femoral Neck Fractures, Bone Density
Radiostereometric Analysis of Acetabular Wear and Periprosthetic Bone Mineral Density Changes in Hemiarthroplasties
Substudy and continuation of HEMI-SAB-UUS (NCT00491673) Study on radiostereometric measurements of acetabular wear in bipolar hemiarthroplasties and measurements of periprosthetic bone mineral density in cemented and uncemented…
- Conditions
- Femoral Neck Fractures, Bone Density, Acetabular Wear, Hemiarthroplasty
- Trial name
- HEMI-RSADEXA (NCT00607516)
- Testing
- Cemented primary bipolar hemiarthroplasty of the hip, Uncemented primary bipolar hemiarthroplasty of the hip
- Where
- Norway
- Volunteers
- 22 people
- Sponsor
- Ullevaal University Hospital
Osteoporosis
Teriparatide Use in Hip Replaced Subjects
A pilot study on the use of Teriparatide in severe osteoporotic women with hip fracture and submitted to hip replacement The primary objective of this study is to obtain preliminary data, in a pilot group of postmenopausal women…
- Trial name
- NCT00191321
- Testing
- Teriparatide
- Where
- 11 sites in Italy
- Volunteers
- 60 people
- Sponsor
- Eli Lilly and Company
Menopause, Fracture
Forteo for the Treatment of Unexplained Osteoporosis in Premenopausal Women
Idiopathic osteoporosis (IOP) is an uncommon disorder in which otherwise healthy young individuals sustain one or more low-trauma fractures.
- Conditions
- Menopause, Fracture, Osteoporosis
- Trial name
- IOPForteo (NCT00697463)
- Testing
- Teriparatide (PTH 1-34)
- Where
- 2 sites in United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Columbia University
Postmenopausal Osteoporosis
VERtebral Fracture Treatment Comparisons in Osteoporotic Women
The primary purpose of participation in this study is to answer whether teriparatide is superior to risedronate in reducing the occurrence of new vertebral fractures during 24 months of therapy.
- Trial name
- VERO (NCT01709110)
- Testing
- Teriparatide, Risedronate, Calcium
- Where
- 103 sites in United States, Argentina and 13 more
- Volunteers
- 1,366 people
- Sponsor
- Eli Lilly and Company
Distal Radius Fractures, Poor Bone Quality
The Influence of Local Bone Status on Complications After Surgical Treatment of Distal Radius Fractures
The purpose of this study is to evaluate if poor bone quality increases the risk of specific types of treatment complications in patients with distal radius fractures treated with open reduction and Locking Compression…
- Conditions
- Distal Radius Fractures, Poor Bone Quality, Treatment Complications
- Trial name
- NCT01144208
- Where
- 11 sites in United States, Austria and 4 more
- Volunteers
- 244 people
- Sponsor
- AO Clinical Investigation and Publishing Documentation
Back Pain
The Effect of PTH(1-84) or Alendronate on Reduction of Back Pain in Postmenopausal Women With an Osteoporosis Related Vertebral Fracture(s) (FP-005-IM)
The primary objective of this trial is to show that PTH(1-84) is superior to alendronate in reducing back pain intensity over a 24-week treatment period in postmenopausal women with an osteoporosis related vertebral fracture(s).
- Trial name
- NCT00713258
- Testing
- Parathyroid hormone (PTH) (1-84), Alendronate
- Where
- Denmark
- Volunteers
- 75 people
- Sponsor
- Nycomed
Fractures, Bone, Patient Fall
Bone Strength and Physical Activity in Patients With a Recent Clinical Fracture
The risk for a subsequent fracture is significantly higher in patients presenting with a fracture compared to individuals without a previous fracture and is highest within the first 2 years after the initial fracture.
- Conditions
- Fractures, Bone, Patient Fall, Osteoporosis, Physical Activity
- Trial name
- NCT05138640
- Testing
- Not applicable. The study is designed as an observational cohort study
- Where
- Netherlands
- Volunteers
- 500 people
- Sponsor
- Joop P.W. van den Bergh
Healthy, Osteopenia
Clinical Study to Estimate Bone Mineral Density With the POROUS Ultrasound Device
Osteoporosis is a widespread medical condition among older people. It causes the bones to weaken and become more likely to break.
- Conditions
- Healthy, Osteopenia, Osteoporosis
- Trial name
- POROUS-BMD (NCT07187518)
- Testing
- Measurements with the POROUS R4C ultrasound device at the midshaft tibia, DXA measurement of the hip and lumbar spine
- Where
- 2 sites in Germany
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- POROUS GmbH
Osteopenia, Osteoporosis
FREE Study - Fracture Reduction Evaluation
The primary objective of this study is to compare the effectiveness of standard medical therapy alone to kyphoplasty using the KyphX system for the treatment of acute vertebral body compression fractures.
- Conditions
- Osteopenia, Osteoporosis, Multiple Myeloma, Bone Neoplasms
- Trial name
- NCT00211211
- Testing
- Balloon Kyphoplasty
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Medtronic Spine LLC
Osteoporosis
36-month Special Drug Use Surveillance on Frequency of Bone Fractures With Sodium Risedronate 75 mg Tablets
The purpose of this survey is to evaluate the effectiveness (endpoints: frequency of bone fractures, percent change in bone density, etc.) and safety of administration of sodium risedronate tablets 75 mg for 36 months in…
- Trial name
- NCT02106442
- Testing
- Sodium risedronate
- Where
- 2 sites in Japan
- Volunteers
- 579 people
- Sponsor
- Takeda
Osteoporosis
A New Active Vitamin D, ED-71 for Osteoporosis
A prospective, randomized, double-blind study to compare the effect of ED-71 with that of alfacalcidol on fracture incidence
- Trial name
- NCT00144456
- Testing
- ED-71, Alfacalcidol
- Volunteers
- 1,056 people
- Sponsor
- Chugai Pharmaceutical
Osteoporosis
Effects of Jumping on Growing Bones
In this study we will investigate the effects of a high-impact exercise program involving jumping on bone mass (the amount of bone) of the hip and backbone in the growing skeleton.
- Trial name
- NCT00000405
- Testing
- Exercise intervention
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Oregon State University
Fall Injury, Osteoporotic Fractures
Pole Walking Intervention in Retirement Communities
This patient-oriented, multi-site study aims to co-design and test a pole walking program with resident and staff representatives from participating independent living and retirement communities.
- Trial name
- NCT05388227
- Testing
- Pole walking
- Where
- Canada
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Compression Fracture
Comparison of Treatments of Osteoporotic Compression Fracture Using Rigid Brace, Soft Brace, and no Brace
The treatment outcomes in the treatment without brace would be non-inferior to those in use of rigid or soft brace.
- Trial name
- NCT02049931
- Testing
- No brace treatment, Rigid brace, Soft brace
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Osteoporosis, Age-Related, Humeral Fractures
Teriparatide for Fracture Repair in Humans
This study will test the hypothesis that daily subcuaneous administration of 20µg of teriparatide (TPTD) as compared to daily subcuaneous placebo for twelve weeks accelerates proximal 2-segment humerus fracture healing and…
- Trial name
- TERAFRAP (NCT02091492)
- Testing
- Teriparatide
- Where
- Austria
- Sponsor
- Medical University of Vienna
Beta Blocker Toxicity
Clinical Study Evaluating Beta Blockers Use and Fracture Risk in Patients With Primary Osteoporosis
Clinical study evaluating selective or nonselective beta blockers use and fracture risk in patients with primary osteoporosis
- Trial name
- NCT04704947
- Testing
- nonselective beta blocker, cardio-selective beta blocker group, alendronate sodium
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Sherief Abd-Elsalam
Osteoporosis
Trial of Osteoporosis Intervention Strategies in Hip Fracture Patients
The objective of this study is to determine if an intervention with a fracture manager to arrange bone densitometry after a hip fracture is more effective in diagnosing and treating osteoporosis when compared to "usual care".
- Trial name
- NCT00136058
- Testing
- bone densitometry (DEXA), alendronate or risedronate
- Where
- Canada
- Volunteers
- 250 people
- Sponsor
- University of Alberta
Bone Fractures
Kefir Peptides for Bone Fracture Healing
This study is designed to evaluate the effects of kefir-derived peptides on bone healing in patients with upper limb fractures. Kefir peptides are natural protein fragments that may promote bone formation and reduce inflammation.
- Trial name
- KPs-Fracture (NCT07166458)
- Testing
- Kefir Peptide, Standard Care (in control arm)
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Jen-Chieh Lai
Osteoporosis
Does Vibration Therapy Induce Higher Than Normal Bone Strains and Strain Rates Than Those Experienced During Habitual Daily Activities
The overall aim of this study is to test the hypothesis that vibration exercise can induce higher than normal bone strains and strain rates than are experienced during habitual locomotor activities.
- Trial name
- NCT01430858
- Testing
- Strain Gauge, Vibration therapy
- Where
- United Kingdom
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust