Clinical trials: Osteoporosis Fracture
Osteoporosis
RECONFIRM - Study of AGN1 LOEP in Patients with Osteoporosis
The research will be conducted as a prospective, post-market, multi-center study within Europe. The maximum number of subjects to be treated is 150 across up to 20 sites. This will be a non-randomized and open-label study.
- Trial name
- NCT05202678
- Testing
- AGN1 LOEP
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- AgNovos Healthcare, LLC
Osteoporotic Fractures
Impact of Osteoporotic Fractures on Work: Data From a Fracture Liaisons Service
Osteoporosis is a bone disease characterized by a decrease in bone density with deterioration of the micro-architecture and the appearance of bone fragility, responsible for an increased risk of fractures.
- Trial name
- OPTIWORK (NCT04781556)
- Testing
- No intervention
- Where
- France
- Volunteers
- 121 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Osteoporosis
C-STOP Fracture Trial
The objective of the proposed research is to improve quality of care for older outpatients who present to Emergency Departments and Fracture Clinics with an osteoporosis-related wrist or other upper extremity fracture.
- Trial name
- C-STOP# (NCT01401556)
- Testing
- case management, Multifaceted quality improvement intervention
- Where
- Canada
- Volunteers
- 441 people
- Sponsor
- University of Alberta
Osteoporosis, Fracture
Imaging Parameters to Predict Future Vertebral Fracture in Osteoporosis
After vertebroplasty, many patients will suffer from 2nd fracture in the vertebral column. With analyzing of the images done right after the 1st vertebroplasty, we can define the parameters from different imaging and they can be…
- Trial name
- NCT01653873
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Spinal Cord Injuries (SCI), Osteoporosis
Osteoporosis Awareness in Chronic Spinal Cord Injury
Osteoporosis is a common and serious complication of spinal cord injury (SCI), substantially increasing the risk of fragility fractures.
- Conditions
- Spinal Cord Injuries (SCI), Osteoporosis, Health Knowledge, Attitudes
- Trial name
- NCT07725081
- Where
- Turkey (Türkiye)
- Volunteers
- 94 people
- Sponsor
- Afyonkarahisar Health Sciences University
Osteoporotic Fracture of Vertebra
Vertebroplasty and Kyphoplasty in Osteoporotic Vertebral Body Fractures.
Vertebral body fractures are a major health care problem in all countries with incidence 1.4%. They are a common cause of severe debilitating pain, with consequent deteriorated quality of life, physical function and psychosocial…
- Trial name
- NCT03682328
- Testing
- vertebroplasty, kyphoplaty
- Volunteers
- 23 people
- Sponsor
- Assiut University
Osteoporosis, Fracture Risk Assessment
Five-Year CT Follow-Up of Vertebral Fracture Risk Using Opportunistic Osteoporosis Screening
This study evaluates whether opportunistic osteoporosis screening using routinely acquired computed tomography (CT) scans improves fracture risk prediction compared with guideline-recommended FRAX-based screening from age 50.
- Conditions
- Osteoporosis, Fracture Risk Assessment, Osteoporotic Fracture of Vertebra
- Trial name
- NCT07487688
- Testing
- Opportunistic osteoporosis screening
- Where
- Germany
- Volunteers
- 2,799 people
- Sponsor
- Technical University of Munich
Osteoporosis
People With Osteoporosis Can Walk-BEST to Reduce Fall and Fracture Risk
The aim of the Walk BEST study is to provide evidence that it is feasible to implement the technology assisted gait- focused walking program Walk-BEST™ in older adults with osteoporosis, and that this program is acceptable to…
- Trial name
- Walk-BEST (NCT07621679)
- Testing
- Device: Heel2Toe[TM] sensor, Technology-assisted therapeutic walking program
- Where
- Canada
- Volunteers
- 28 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Arthralgia
Changes in Knee Articular Cartilage Volume in Women on Aromatase Inhibitors
Many women with breast cancer are treated with a class of drugs called aromatase inhibitors (mainly letrozole or anastrozole), which lowers the amount of estrogen being produced in the body.
- Trial name
- NCT00111241
- Testing
- aromatase inhibitors (letrozole, anastrozole)
- Where
- Australia
- Volunteers
- 115 people
- Sponsor
- Monash University
Osteoporosis, Bone Fracture
Longitudinal Effects of Denosumab on Trabecular Bone Score and Femur Strength Index
The purpose of this study is to validate the long-term benefit of denosumab for osteoporosis treatment in a real-world clinical practice setting.
- Trial name
- NCT02435147
- Testing
- denosumab
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- HealthEast Care System
Post-Menopausal Osteoporosis
Intra-venous Zoledronic Acid Once Yearly
The study will assess the real life effectiveness of zoledronic acid in the management of patients with osteoporosis over 4 years of treatment.
- Trial name
- IVORY (NCT00984893)
- Testing
- zoledronic acid, Any oral bisphosphonates marketed in Canada
- Where
- 3 sites in Canada
- Volunteers
- 1,551 people
- Sponsor
- Novartis Pharmaceuticals
Osteoporosis, Interstitial Lung Disease
Opportunistic Screening for Osteoporotic Vertebral Fractures in Patients With Diffuse Interstitial Lung Disease
It is well known that some chronic respiratory pathologies such as asthma or chronic obstructive pulmonary disease (COPD) are associated with an increased risk of osteoporosis, due to the pathology itself and the therapies…
- Conditions
- Osteoporosis, Interstitial Lung Disease, Vertebral Fracture
- Trial name
- NCT05714787
- Testing
- Chest CT Scan examination
- Where
- France
- Volunteers
- 202 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Patient Compliance, Communication
Improving Osteoporosis Care in High-Risk Home Health Patients
SPECIFIC AIMS: We propose a three-year study to develop a high-intensity intervention to improve osteoporosis care and test a novel intervention in a group-randomized trial of 27 home health offices and 1,000 patients referred to…
- Conditions
- Patient Compliance, Communication, Osteoporosis, Fractures, Bone
- Trial name
- NCT00679198
- Testing
- nurse-patient communication
- Where
- United States
- Volunteers
- 667 people
- Sponsor
- University of Alabama at Birmingham
Vertebral Fracture, Compression Fracture
Spine Bone Cements Outcomes - Post Market Follow-up
A Post-Market Clinical Follow-Up (PMCF) Study to collect clinical data on safety and performance of all TEKNIMED Spine range of products: SPINEFIX, HIGH V+, OPACITY+ and F20 bone cements and mixing and injection systems, and all…
- Conditions
- Vertebral Fracture, Compression Fracture, Osteoporotic Fractures
- Trial name
- NCT06367582
- Testing
- Vertebroplasty (VP), Kyphoplasty (KP), Pedicular Screw Augmentation (PSA)
- Where
- 12 sites in France, Portugal and 2 more
- Volunteers
- 500 people
- Sponsor
- Teknimed
Femoral Fractures, Hip Fractures
Influence of Bone Strength Measured by DensiProbe on Bone Related Fixation Failure
Hip fractures mostly occur in elderly people with low bone strength. Bone strength is determined by bone mineral density (BMD), bone turnover, microarchitectural and geometrical properties of the bone.
- Conditions
- Femoral Fractures, Hip Fractures, Osteoporosis, Bone Density
- Trial name
- Densiprobe (NCT00822159)
- Testing
- DensiProbe Hip
- Where
- 8 sites in Austria, Germany and 2 more
- Volunteers
- 198 people
- Sponsor
- AO Clinical Investigation and Publishing Documentation
Osteoporosis
Comparison of the Effect of an Ongoing Treatment With Alendronate or a Drug Holiday on the Fracture Risk in Osteoporotic Patients With Bisphosphonate Long Term Therapy
The purpose of this study is to evaluate the efficacy and safety of bisphosphonates in long term treatment of osteoporosis.
- Trial name
- BILANZ (NCT01512446)
- Testing
- Alendronate
- Where
- Germany
- Volunteers
- 436 people
- Sponsor
- Evangelisches Krankenhaus Lutherhaus gGmbH
Hip Fractures, Osteoporosis
Secondary Prevention of Osteoporotic Fractures in Residents of Long-Term Care Facilities
Osteoporotic fractures of the hip are a major cause of admission to long-term care facilities. Such fractures put patients at high risk for further fractures, pain and disability.
- Trial name
- NCT00280943
- Testing
- Long-term care facilities in the intervention arm will receive education and feedback audit on performance
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Duke University
Osteoporosis, Osteoporosis, Postmenopausal
Romosozumab Use to Build Skeletal Integrity
The purpose of this study is to find out if one year of romosozumab (Evenity®), a monthly injection given in the arm under the skin, prior to an infusion of zoledronic acid Reclast®, works to treat bone loss and prevent it from…
- Conditions
- Osteoporosis, Osteoporosis, Postmenopausal, Osteoporosis Fracture
- Trial name
- RUBI (NCT05058976)
- Testing
- Romosozumab, Zoledronic acid, Calcium and Vitamin D
- Where
- United States
- Volunteers
- 184 people
- Sponsor
- Susan L. Greenspan
Osteoporosis, Fracture
Comparison of the Effectiveness of a Web Fracture Liaison Service (e_FLS) to Fracture Liaison Services in France: the evAB Study (evAB)
The purpose of this study is to compare web FLS model (e_FLS) to conventional FLS in terms of increasing the proportion of patients receiving an antiosteoporotic treatment in the year after a low trauma fracture.
- Trial name
- evAB (NCT05303350)
- Where
- France
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Osteoporotic Vertebral Compression Fractures
Tripod-Fix Vertebral Body Augmentation System in Osteoporotic Vertebral Compression Fractures Treatment
This study is to evaluate the safety and effectiveness of the Tripod-Fix with Tecres Mendec® Spine HV System to treat subjects with osteoporotic vertebral compression fractures.
- Trial name
- NCT06261242
- Testing
- Tripod-Fix Vertebral Body Augmentation System (Tripod-Fix)
- Where
- Taiwan
- Volunteers
- 12 people
- Sponsor
- National Cheng-Kung University Hospital