Clinical trials: Osteoporosis Fracture
Osteoporosis, Hip Fracture
Evaluating the Ability of Zoledronic Acid to Reduce the Rate of Subsequent Osteoporotic Fractures After a Hip Fracture
The purpose of this study is to evaluate whether zoledronic acid given once yearly for two years to men and women after surgical repair of a recent hip fracture will significantly reduce the rate of all re-occurring (new)…
- Trial name
- NCT00046254
- Testing
- Zoledronic Acid
- Where
- 28 sites in United States, Germany
- Volunteers
- 2,127 people
- Sponsor
- Novartis Pharmaceuticals
Osteoporosis, Postmenopausal, Osteoporosis Fracture
New Biomarkers and Therapeutic Targets in Osteoporosis Via Omics Technologies
This study aims to discover novel biomarkers and therapeutic targets for osteoporosis through the use of advanced omics technologies, including proteomics and metabolomics.
- Conditions
- Osteoporosis, Postmenopausal, Osteoporosis Fracture, Osteoporosis, Severe
- Trial name
- NCT06525688
- Testing
- Bone, Serum and Plasma sample
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- National and Kapodistrian University of Athens
Duchenne Muscular Dystrophy (DMD)
Bone Health in Adults With Duchenne Muscular Dystrophy: A Survey on Osteoporosis, Fractures and Treatment.
Background and Rationale Duchenne muscular dystrophy (DMD) is a genetic disorder caused by mutations in the dystrophin gene, resulting in progressive muscle weakness and multiple complications, including respiratory and cardiac…
- Trial name
- GUP23005 (NCT07890883)
- Where
- 15 sites in Italy
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Istituto Giannina Gaslini
Osteoporotic Fractures
Evaluation of a Fracture Liaison Service in the Osteoporosis Care
The St JOSEPH'S HOSPITAL set up a fracture liaison service for osteopotic fracture. A specific nurse screens eligible patient admitted in emergency yard and call them to propose a bone densitometry and a medical coverage..
- Trial name
- NCT03484208
- Testing
- osteoporotic fracture liaison service
- Where
- France
- Volunteers
- 346 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Osteoporosis, Bone Mineral Density
Metabolic Determinants of DXA-Measured Bone Mineral Density
This retrospective observational study will examine bone mineral density measurements and their metabolic and clinical determinants in adults aged 40 years and older.
- Trial name
- NCT07836868
- Where
- Turkey (Türkiye)
- Volunteers
- 750 people
- Sponsor
- Mardin Artuklu University
Osteoporotic Fractures, Osteoporosis, Postmenopausal
A 5-Year Follow-up Study Investigating Factors Associated With Osteoporotic Fracture in Chinese Postmenopausal Women
This proposed study was designed to investigate the prevalence of a 5-year incident osteoporotic fracture and evaluate the association of a 5-year change of 25-hydroxyvitamin D (25[OH]D)/bone turnover makers/bone mineral density…
- Trial name
- PK-VF (NCT02247011)
- Testing
- Questionaire survey, Bone mineral density examination, Vertebral fracture assessment
- Where
- China
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Hip Fracture
A Proof-of-Concept Study Investigating the Safety and Efficacy of ZT-031 on Hip Fracture Healing in Men and Postmenopausal Women
The purpose of this research study is to test if an experimental drug called ZT-031 can help men over 30 years or post-menopausal women over 55 years of age with certain types of hip fracture to heal better or faster following…
- Trial name
- SHIFT (NCT00787358)
- Testing
- ZT-031
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Zelos Therapeutics
Osteoporosis, Postmenopausal Osteoporosis
AGE Burden and Response to Antiresorptive Therapy in Osteoporosis
Osteoporosis is a common condition that increases the risk of bone fractures. Although antiresorptive treatments such as bisphosphonates and denosumab are effective in increasing bone mineral density, some patients continue to…
- Trial name
- NCT07329543
- Volunteers
- 240 people
- Sponsor
- Bursa City Hospital
Osteoporosis, Lower Limb Fracture
OsteoPorotic fracTure preventION System (OPTIONS) Research Study
Osteoporosis is a disease that weakens bones so the bones may break easily. The risk for osteoporosis increases with age in both women and men. Osteoporosis affects 10 million older adults in the US.
- Trial name
- OPTIONS (NCT06731608)
- Testing
- OPTIONS, Enhanced usual care
- Where
- 2 sites in United States
- Volunteers
- 1,344 people
- Sponsor
- Brigham and Women's Hospital
Osteoporosis, Postmenopausal Osteoporosis
Study to Evaluate the Safety and Efficacy of BA058 (Abaloparatide) for Prevention of Fracture in Postmenopausal Women
The purpose of this study is to determine whether BA058 (abaloparatide), a parathyroid hormone-related peptide, is effective in preventing fractures in postmenopausal women with severe osteoporosis who are at risk of fractures.
- Trial name
- ACTIVE (NCT01343004)
- Testing
- BA058 80 mcg, teriparatide
- Where
- 28 sites in United States, Argentina and 8 more
- Volunteers
- 2,463 people
- Sponsor
- Radius Health, Inc.
Osteoporosis, Frailty
Spitex-SpiTal-Autonomie-Reha-Kraft
The primary purpose of this study is to test if the STARK comprehensive autonomy health care package improves lower extremity function over time at 6 weeks, 3, 6 and 12 months after hip or pelvis fracture compared to the standard…
- Conditions
- Osteoporosis, Frailty, Hip Fractures
- Trial name
- STARK (NCT03154684)
- Testing
- STARK intervention, Standard of Care
- Where
- Switzerland
- Volunteers
- 5 people
- Sponsor
- University of Zurich
Osteoporosis, Osteoporotic Fracture
Post-osteoporotic Fracture Exercise Program
Those with osteoporosis often have weaker bones and this leads to higher chances of fractures. Therefore, the investigators want to evaluate the feasibility and safety of group exercise classes specifically designed for…
- Trial name
- NCT07595991
- Testing
- Exercise Program
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Western University, Canada
Osteoporosis
Closing The Post Fracture Care Gap In Manitoba
The objective of this study is to evaluate a post-fracture intervention for improving osteoporosis care in older men and women who have suffered a fracture that may indicate the presence of osteoporosis.
- Trial name
- NCT00594789
- Testing
- Information letters
- Where
- Canada
- Volunteers
- 4,264 people
- Sponsor
- University of Manitoba
Osteoporosis in Post-menopausal Women
Efficacy of Romosozumab and Denosumab Combined Treatment in Postmenopausal Osteoporosis Patients with Multiple Fragility Fractures
The aim of this clinical trial is to investigate the effectiveness of romosozumab started without stopping denosumab in patients diagnosed with postmenopausal osteoporosis with a very high risk of fragility fractures and who is…
- Trial name
- MORD (NCT06720350)
- Testing
- Romosozumab and Denosumab Combination Therapy, Romosozumab Prefilled Syringe [Evenity], Denosumab (Prolia)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Marmara University
Osteoporotic Fractures, Osteoporosis
Stop At One Stockholm (SAOS)- Secondary Fracture Prevention Through Active Patient Identification and Staff Education.
This is a study on the effects of education on secondary fracture prevention in primary health care centers (PHCC) and referral from hospitals to these PHCC of patients with recent fragility fractures.
- Conditions
- Osteoporotic Fractures, Osteoporosis, Osteoporosis Risk
- Trial name
- SAOS (NCT04565743)
- Testing
- Support on dentification and treatment of patients with high risk of osteoporotic fractures
- Where
- Sweden
- Volunteers
- 38 people
- Sponsor
- Helena Salminen
Prostate Cancer, Osteoporosis
Toremifene Citrate for Prevention of Bone Fractures in Men With Prostate Cancer on Androgen Deprivation Therapy
Androgen deprivation therapy (ADT) treatment for prostate cancer decreases the natural hormone called testosterone. This type of therapy is very effective for the treatment of prostate cancer.
- Conditions
- Prostate Cancer, Osteoporosis, Fractures
- Trial name
- NCT00129142
- Testing
- Toremifene Citrate
- Where
- 155 sites in United States, Mexico
- Volunteers
- 1,200 people
- Sponsor
- GTx
Spinal Cord Injuries (SCI), Osteoporosis
Osteoporosis Awareness in Chronic Spinal Cord Injury
Osteoporosis is a common and serious complication of spinal cord injury (SCI), substantially increasing the risk of fragility fractures.
- Conditions
- Spinal Cord Injuries (SCI), Osteoporosis, Health Knowledge, Attitudes
- Trial name
- NCT07725081
- Where
- Turkey (Türkiye)
- Volunteers
- 94 people
- Sponsor
- Afyonkarahisar Health Sciences University
Osteoporosis
A New Active Vitamin D, ED-71 for Osteoporosis
A prospective, randomized, double-blind study to compare the effect of ED-71 with that of alfacalcidol on fracture incidence
- Trial name
- NCT00144456
- Testing
- ED-71, Alfacalcidol
- Volunteers
- 1,056 people
- Sponsor
- Chugai Pharmaceutical
Vertebral Fracture, Osteoporotic Fractures
CCEF in the Treatment of Acute VFFs: Randomized Controlled Trial
in recent years the search for therapeutic protocols that could enhance the VFFs healing, thus reducing bed rest-related complications and improving the quality of life of osteoporotic patients.
- Trial name
- NCT05803681
- Testing
- Capacitive Coupled Electric Fields (CCEF), Calssic clinical protocol
- Volunteers
- 70 people
- Sponsor
- University of Bari Aldo Moro
Low Trauma Non Vertebral Fracture
Study of Current Practice Evaluating the Efficacy of a Mobile Short Message Service (SMS) on Post-fracture Management.
The purpose of the study is to show that the standardized sending of SMS improve the bone mineral density (BMD) screening of patients seen in the Emergency department for low trauma fracture.
- Trial name
- Ostéo-SMS (NCT01915745)
- Testing
- Use of SMS
- Where
- France
- Volunteers
- 97 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris