Clinical trials: Osteoporosis Fracture
Osteoporosis, Postmenopausal, Osteoporosis Fracture
New Biomarkers and Therapeutic Targets in Osteoporosis Via Omics Technologies
This study aims to discover novel biomarkers and therapeutic targets for osteoporosis through the use of advanced omics technologies, including proteomics and metabolomics.
- Conditions
- Osteoporosis, Postmenopausal, Osteoporosis Fracture, Osteoporosis, Severe
- Trial name
- NCT06525688
- Testing
- Bone, Serum and Plasma sample
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- National and Kapodistrian University of Athens
Atypical Femur Fracture
Personalizing Osteoporosis Care: Clinical & Genetic Risk Factors for AFFs
The overall objective of this project is to identify clinical and genetic risk factors for Atypical Femur Fractures (AFFs) in Anti-resorptive therapy (ART) users by conducting a case control study of 330 cases of AFFs and 660…
- Trial name
- NCT04110795
- Testing
- No Intervention
- Where
- 3 sites in Canada
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Vertebral Fracture, Osteonecrosis
Vertebral Fracture and Osteonecrosis Associated With High-dose Glucocorticoid
Osteoporotic vertebral fracture (VF) and osteonecrosis of the femoral head (OFH) are major concerns in patients with systemic rheumatic diseases treated with high-dose glucocorticoids (GCs).
- Conditions
- Vertebral Fracture, Osteonecrosis, Rheumatic Diseases
- Trial name
- NCT00679978
- Volunteers
- 60 people
- Sponsor
- Saitama Medical University
Osteoporosis, Postmenopausal, Vertebral Fracture
Comparation of Treatment Strategies for OVF: Teriparatide Injection and PVP
This study aimed to compare teriparatide treatments and PVPs, focusing on its effects on life qualities and effect/coast ratio and evaluate which method is better for patients.
- Conditions
- Osteoporosis, Postmenopausal, Vertebral Fracture, Quality of Life
- Trial name
- NCT03692143
- Testing
- Teriparatide, PVP, Alendronate
- Volunteers
- 90 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Osteoporosis, Postmenopausal, Osteoporotic Fractures
Evaluation of the Prognostic Role of the Systemic Immune Inflammation Index in Postmenopausal Osteoporosis
This study is a retrospective case-control study. In the study, the data of 304 patients who were evaluated in our clinic between January 2017 and January 2020 with a pre-diagnosis or diagnosis of postmenopausal osteoporosis were…
- Trial name
- NCT04748029
- Testing
- Systemic immune inflammation index
- Where
- Turkey (Türkiye)
- Volunteers
- 139 people
- Sponsor
- Ufuk University
Menopausal Symptoms, Physical Activity and Sedentary Behavior
Prevalence of Menopause-associated Symptoms Throughout the Menopausal Transition in Women Aged 40 to 70 Residing in Spain and Its Relationship With Physical Activity - MdH Study
The goal of this observational study is to learn about menopause-related symptoms in women aged 40 to 70 years who live in Spain.
- Trial name
- NCT07596069
- Testing
- Reproductive stage, Physical Activity Level
- Where
- 2 sites in Spain
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- Cuerpos Serranos S.L.
Osteoporotic Fractures
Impact of Osteoporotic Fractures on Work: Data From a Fracture Liaisons Service
Osteoporosis is a bone disease characterized by a decrease in bone density with deterioration of the micro-architecture and the appearance of bone fragility, responsible for an increased risk of fractures.
- Trial name
- OPTIWORK (NCT04781556)
- Testing
- No intervention
- Where
- France
- Volunteers
- 121 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Cancer, Myocardial Infarction
NORVIT and WENBIT - Long-term Follow-up
Two large homocysteine-lowering B-vitamin intervention trials have been performed in Norway during the period 1998 to 2005, NORVIT and WENBIT.
- Conditions
- Cancer, Myocardial Infarction, Cerebrovascular Stroke
- Trial name
- NORVITWENBIT (NCT00671346)
- Where
- 2 sites in Norway
- Volunteers
- 6,839 people
- Sponsor
- Haukeland University Hospital
Osteoporosis, Liver Transplantation
The Effect of Zoledronic Acid on Bone Density in Liver Transplant Patients
Following liver transplantation, rapid bone loss occurs, particularly within the first 6 months post-transplant. This may be associated with fractures, most notable vertebral.
- Conditions
- Osteoporosis, Liver Transplantation, Fractures
- Trial name
- NCT00114556
- Testing
- zoledronic acid
- Where
- Australia
- Volunteers
- 100 people
- Sponsor
- Royal Prince Alfred Hospital, Sydney, Australia
Osteoporosis, Fractures in the Elderly
Fractures in the Elderly Population of El Salvador at Hospital Zacamil: Exploring Knowledge, Causes, Risk Factors, and Outcomes
As the population's life expectancy increases, fractures among the elderly in El Salvador are also increasing. There is currently limited data specific to the incidence and cause of fractures in the elderly within developing…
- Trial name
- NCT00625599
- Testing
- Osteoporosis Prevention Information
- Where
- 2 sites in El Salvador
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Edward Via Virginia College of Osteopathic Medicine
Spinal Fractures
Short Segment Fixation in Thoracolumbar Osteoporotic Fracture
Although long-segment posterior spinal fixation might provide more rigid fixation, the procedure increases perioperative morbidities in the elderly.
- Trial name
- NCT02719340
- Testing
- short segment fixation
- Volunteers
- 20 people
- Sponsor
- National Cheng-Kung University Hospital
Osteoporosis, Vertebral Fracture
Study About the Effect of Preventive Adjacent Level Cement Augmentation After Osteoporotic Vertebral Compression Fractures
Vertebroplasty itself is challenged regarding its clinical efficacy. While two randomized controlled trials (RCTs) with substantial methodological problems have led to an intense discussion another RCT with larger case numbers…
- Trial name
- NCT02489825
- Testing
- Augmentation vertebroplasty, Augmentation and prophylactic vertebroplasty
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University of Bern
HIV, Osteoporosis
Fracture and Bone Mineral Density in HIV+ Patients Recently Started on Antiretroviral Therapy (ART)
In a group of HIV-positive patients under observation since their first exposure to ART or monitored off of ART, BMD changes over one year will be determined.
- Trial name
- NCT01591252
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Alabama at Birmingham
Bone Demineralization
Alendronate for Prevention of AntiRetroviral Therapy-associated Bone Loss
Antiretroviral therapy (ART) initiation is associated with a significant loss of bone mineral density (BMD), characterised by increases in bone turnover, which is largely limited to the first 48 weeks of therapy.
- Trial name
- APART (NCT02322099)
- Testing
- Alendronate, calcium carbonate and colecalciferol, Tenofovir disoproxil
- Where
- 2 sites in Ireland
- Volunteers
- 53 people
- Sponsor
- University College Dublin
Osteoporosis, Osteoporotic Fractures
Chinese Osteoporotic Fracture Registration Network Platform
China has gradually entered an aging society, and the incidence of osteoporotic fractures is increasing rapidly. Although the harm of osteoporotic fracture is huge, its diagnostic rate in China is still low.
- Trial name
- CORN (NCT05339425)
- Testing
- No additional intervention will be administered.
- Where
- 39 sites in China
- Volunteers
- 50,000 people
- Sponsor
- Peking Union Medical College Hospital
Senile Osteoporosis With Current Pathological Fracture Lower Leg (Diagnosis)
Rare Variation and Remote Gene Regulation of Osteoporosis Related Phenotypes in Han Chinesse
Bone density is recognized as the most important factor to measure osteoporosis, and the prevalence of osteoporosis increases with age.
- Trial name
- NCT04129671
- Testing
- No intervention was applied
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Distal Radius Fracture, Osteoporosis
Utility of Cortical Bone Tissue Properties in the Assessment of Fracture Risk
The objective of this study is to determine whether a new minimally invasive method for in vivo measurement of cortical bone tissue properties can identify those who are at risk for fragility fractures of the hip and radius.
- Conditions
- Distal Radius Fracture, Osteoporosis, Hip Fractures
- Trial name
- NCT03076034
- Testing
- Reference Point Indentation
- Where
- United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Chronic Stroke, Osteoporosis
Incidence of Fragility Fractures and Osteoporosis Screening in Chronic Stroke Patients
Stroke is a known risk factor for the development of osteoporosis, leading to an increased risk of falls and fractures. Several international studies have associated stroke with hip fractures, showing an odds ratio ranging…
- Conditions
- Chronic Stroke, Osteoporosis, Fragility Fractures
- Trial name
- NCT06804252
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- University of Palermo
Osteoporosis in Post-menopausal Women, Vertebral Body Fractures
Effect of Muscle Stiffness on Vertebral Fractures in Women Over 60
This study aims to assess the quality of lumbar and abdominal core muscles through elastography and evaluate its impact on vertebral fracture risk.
- Conditions
- Osteoporosis in Post-menopausal Women, Vertebral Body Fractures, Balance, Postural
- Trial name
- NCT06687889
- Testing
- Elastography Measurements, Bone Mineral Density Measurement (DEXA), Berg balance scale
- Where
- Turkey (Türkiye)
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Ankara City Hospital Bilkent
Osteoporosis, Vertebral Fracture
Effectiveness of Physiotherapy for Osteoporotic Spinal Fracture
The aim of this pilot study was to determine the effect of physiotherapy on impairments and health-related quality of life in people with a painful osteoporotic spinal fracture.
- Trial name
- NCT00638768
- Testing
- Physiotherapy
- Where
- Australia
- Volunteers
- 20 people
- Sponsor
- University of Melbourne