Clinical trials: Osteoporotic Fractures
Hip Fracture
Study of Low-Magnitude, High-Frequency Vibration Treatment on Osteoporotic Hip Fracture Healing
Osteoporotic hip fracture is common in elderly. As a result of aging population in Hong Kong, the total number of hip fracture cases is anticipated to increase substantially in the future, and therefore draw more resources in…
- Trial name
- NCT01293721
- Testing
- Low-magnitude high - frequency vibration treatment
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Chinese University of Hong Kong
Osteoporosis, Vertebral Fracture
A Trial of Vertebroplasty for Painful Chronic Osteoporotic Vertebral Fractures (Vertos V)
Background The standard care in patients with a painful osteoporotic vertebral compression fracture (VCF) is conservative therapy.
- Trial name
- VERTOSV (NCT01963039)
- Testing
- percutaneous vertebroplasty
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- Elisabeth-TweeSteden Ziekenhuis
Type 2 Diabetes, Osteoporosis
Study on the Intervention Effect of Denosumab on High-Risk Patients With Osteoporotic Fractures in Type 2 Diabetes
This study will conduct a randomized controlled trial targeting patients with type 2 diabetes and a high risk of fractures. The aim is to evaluate the intervention effect of denosumab combined with edilossobulin on patients with…
- Conditions
- Type 2 Diabetes, Osteoporosis, Fractures
- Trial name
- NCT07063797
- Testing
- Denosumab treatment in type 2 diabetes mellitus (T2DM) with osteoporosis patients, Denosumab combined with eldecalcitol treatment in type 2 diabetes mellitus (T2DM) with osteoporosis patients
- Where
- 4 sites in China
- Volunteers
- 358 people
- Sponsor
- Peking Union Medical College Hospital
Hip Fractures, Osteoporotic Fractures
Fixation Methods of Basicervical Fractures
This prospective, randomized study included patients aged over 65 years with basicervical fracture of femur from January 2016 to January 2018.
- Trial name
- NCT04240743
- Testing
- cephalomedullary nail, sliding hip screw
- Volunteers
- 64 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Osteoporotic Vertebral Compression Fracture
The Comparative Study About the Effect of Vertebral Body Decompression Procedure
The purpose of this study is to compare the treatment efficacy between vertebral body decompression procedure and conservative treatment with non-inferiority design
- Trial name
- NCT02902250
- Testing
- Decompression, Conservative Treatment
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Seoul National University Hospital
Osteoporosis
Denosumab Fracture Intervention Randomized Placebo Controlled Trial in Japanese Patients With Osteoporosis
Evaluate the efficacy and safety of denosumab in the treatment of involutional (postmenopausal and senile) osteoporotic subjects with prevalent fragility vertebral fracture(s)
- Trial name
- DIRECT (NCT00680953)
- Testing
- Denosumab, Alendronate sodium hydrate
- Where
- 4 sites in Japan
- Volunteers
- 1,262 people
- Sponsor
- Daiichi Sankyo Co., Ltd.
Osteoporosis, Osteopenia
Peripheral Mononuclear Cells to Screen, Monitor and Stratify the Population at Risk of Osteoporosis and Fractures
Osteoporosis (OP) is one of most common age-associated and chronic metabolic bone diseases, featured by a decrease of bone mineral density (BMD) that increases the risk of bone fractures.OP guidelines agree that Dual-X-ray…
- Conditions
- Osteoporosis, Osteopenia, Osteoporosis Fracture
- Trial name
- DISCERN (NCT06551155)
- Testing
- Vitality and biological activity of peripheral blood mononuclear cells (PBMCs)
- Where
- 2 sites in Italy
- Volunteers
- 120 people
- Sponsor
- Istituto Ortopedico Rizzoli
Osteoporosis, Osteoporotic Fractures
RESTORE: REducing Future fractureS and Improving ouTcOmes of fRagility fracturE
RESTORE tests whether Augmented-FLS, where patients are contacted by a patient navigator (serving as the liaison) and referred to a bone health provider, is better than Enhanced Usual Care, which includes patient and PCP…
- Conditions
- Osteoporosis, Osteoporotic Fractures, Fragility Fracture
- Trial name
- RESTORE (NCT06455085)
- Testing
- Augmented-Fracture Liaison Service Arm, Enhanced Usual Care Arm
- Where
- 23 sites in United States
- Volunteers
- 2,634 people
- Sponsor
- University of Alabama at Birmingham
Spinal Fractures
Short Segment Fixation in Thoracolumbar Osteoporotic Fracture
Although long-segment posterior spinal fixation might provide more rigid fixation, the procedure increases perioperative morbidities in the elderly.
- Trial name
- NCT02719340
- Testing
- short segment fixation
- Volunteers
- 20 people
- Sponsor
- National Cheng-Kung University Hospital
Osteoporosis, Vertebral Fracture
Study About the Effect of Preventive Adjacent Level Cement Augmentation After Osteoporotic Vertebral Compression Fractures
Vertebroplasty itself is challenged regarding its clinical efficacy. While two randomized controlled trials (RCTs) with substantial methodological problems have led to an intense discussion another RCT with larger case numbers…
- Trial name
- NCT02489825
- Testing
- Augmentation vertebroplasty, Augmentation and prophylactic vertebroplasty
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- University of Bern
Osteoporotic Fracture of Femur, Osteoarthritis, Hip
Study of Parameters of Osteosarcopenia in Patients With Hip Fracture
The study aims to assess the adequacy of a set of clinical and laboratory investigations for identifying the osteosarcopenia status in patients undergoing a hip replacement for a fragility fracture of the femoral neck.
- Trial name
- NCT04730622
- Testing
- SARC-F questionnaire, Bone tissue histology, Muscle tissue histology
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Istituto Ortopedico Rizzoli
Osteoporosis Fracture
Osteoporosis and Fall Prevention With Multiple Interventions in the Metropolitan Area
OBJECTIVES To determine the effects of 3 exercise interventions on sarcopenic indices among community-dwelling older adults with high osteoporotic fracture risks.
- Trial name
- NCT02483286
- Testing
- ICG, MTG, XBG
- Where
- Taiwan
- Volunteers
- 139 people
- Sponsor
- National Taiwan University Hospital
Osteoporotic Vertebral Compression Fractures, Restrictive Pulmonary Disorders
Inspiratory Muscle Training After Vertebroplasty in Osteoporotic Fracture Patients
This study investigates the long-term effects of inspiratory muscle training (IMT) on pulmonary function, functional capacity, and quality of life in individuals with osteoporotic vertebral compression fractures who have…
- Conditions
- Osteoporotic Vertebral Compression Fractures, Restrictive Pulmonary Disorders, Inspiratory Muscle Weakness, Postoperative Pulmonary Function
- Trial name
- NCT07024095
- Testing
- Inspiratory Muscle Training (IMT), control group
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Istinye University
Pain, Osteoporosis
Percutaneous Vertebroplasty Versus Conservative Treatment of Pain
The purpose of this study is to compare the effect of vertebroplasty with that of traditional medical treatment in the treatment of painful vertebral fractures in osteoporotic patients.
- Conditions
- Pain, Osteoporosis, Fracture
- Trial name
- NCT00203554
- Testing
- Poly methylmetacrylate, PMMA
- Where
- Denmark
- Volunteers
- 27 people
- Sponsor
- University of Aarhus
Osteoporosis, Bone Loss
Bone Microarchitectural Database Constitution From HR-pQCT Device in Clinical Situation Potentially Associated With Bone Loss
Bone fracture occurrence is associated with an increasing of morbidity and mortality. Some factors of fracture occurrence have been highlighted.
- Trial name
- DMPOs (NCT02532439)
- Testing
- HR-pQCT, DEXA, pQCT
- Where
- France
- Volunteers
- 287 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Vertebral Body Compression
Efficacy of Kyphoplasty With a New Intervertebral Expander
Balloon kyphoplasty is a well-established treatment option to achieve pain relief and to correct kyphotic deformity caused by osteoporotic vertebral compression fracture.
- Trial name
- NCT03521661
- Testing
- Kyphoplasty
- Volunteers
- 41 people
- Sponsor
- Mohammad ARAB MOTLAGH
Osteoporosis
Comparison of the Effect of an Ongoing Treatment With Alendronate or a Drug Holiday on the Fracture Risk in Osteoporotic Patients With Bisphosphonate Long Term Therapy
The purpose of this study is to evaluate the efficacy and safety of bisphosphonates in long term treatment of osteoporosis.
- Trial name
- BILANZ (NCT01512446)
- Testing
- Alendronate
- Where
- Germany
- Volunteers
- 436 people
- Sponsor
- Evangelisches Krankenhaus Lutherhaus gGmbH
Severe Fragility Fracture
Outcomes of Severe Osteoporotic Fractures Hospitalized in France: the CROSS Cohort
The purpose of this study is to determine the outcomes of severe osteoporotic fractures hospitalized in France, the risk of incident severe fracture at 2 years and 5 years and the risk of mortality over 2 and 5 years.
- Trial name
- CROSS (NCT02606162)
- Where
- France
- Volunteers
- 912 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Non-union or Delayed Healing Fractures
Evaluation of the Risk for Radiographic and Clinical Nonunion in Patients With Previous Bisphosphonates Therapy.
Dose and duration of bisphosphonate therapy will increase the likelihood that patients experience delayed healing of non-union fractures.
- Trial name
- NCT01731535
- Where
- United States
- Sponsor
- University of Wisconsin, Madison
Osteoporotic Fractures, Femoral Neck Fracture
Short-term Functional Recovery Between Early- and Late Bisphosphonate Treatment Following Hemiarthroplasty
Femoral neck fracture in the elderly is one indication for initiating osteoporosis treatment. Bisphosphonates remain the first line therapy; however, many orthopaedic surgeons concern regarding their effects on fracture healing…
- Trial name
- NCT02148848
- Testing
- Risedronate
- Where
- Thailand
- Volunteers
- 86 people
- Sponsor
- Mahidol University