Clinical trials: Osteoradionecrosis of Jaw, active
Osteoradionecrosis of the Jaw, Medicine Related Osteonecrosis of the Jaw
L-PRF in Prevention of ORN and MRONJ Following Tooth Extractions;v3.0
Osteoradionecrosis (ORN) and medication-related osteonecrosis of the jaw (MRONJ) are debilitating complications following dental extractions in patients who have received head and neck radiotherapy or antiresorptive therapy.
- Trial name
- NCT07585123
- Testing
- L-PRF, Standard Extraction
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Swansea Bay University Health Board
Head and Neck Cancer, Osteonecrosis
Prospective Registry of Prosthodontic Rehabilitation in Oncology Patients Undergoing Jaw Reconstruction
The investigators aim to develop a prospective database in which patient demographics, surgical, dental, prosthetic and QOL parameters collected during consecutive visits within the framework of routine practice, are being…
- Conditions
- Head and Neck Cancer, Osteonecrosis, Osteoradionecrosis
- Trial name
- O-BRIDGE (NCT02661139)
- Where
- Belgium
- Volunteers
- 55 people
- Sponsor
- AZ Sint-Jan AV
Nasopharyngeal Carcinoma (NPC), Osteoradionecrosis of the Jaw
Impacted Tooth Management and Osteoradionecrosis Risk in NPC
This multicenter, randomized controlled trial is designed to determine whether omitting prophylactic extraction of impacted teeth before radiotherapy leads to an unacceptably higher risk of jaw osteoradionecrosis (JORN) compared…
- Trial name
- NCT07764887
- Testing
- Omission of Prophylactic Impacted Tooth Extraction, Prophylactic Impacted Tooth Extraction
- Where
- 11 sites in China
- Volunteers
- 536 people
- Sponsor
- First Affiliated Hospital of Guangxi Medical University
Head and Neck Cancer (H&N), Trauma Sequelae
Immunomonitoring of Circulating Immune Cells in Maxillofacial Surgery
The immune response following facial reconstruction may help predict healing time and the date of discharge after maxillofacial surgery.
- Conditions
- Head and Neck Cancer (H&N), Trauma Sequelae, Osteoradionecrosis of Jaws
- Trial name
- IMMUNOFACE (NCT07772063)
- Testing
- Treg
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Osteoradionecrosis, Radiotherapy
Risk Factors of Jaw Osteoradionecrosis in Oral Cavity Cancer Patients Post-Radiotherapy
Osteoradionecrosis (ORN) of the jaw is a serious complication that can occur after radiation therapy for head and neck cancers, including oral cavity cancer (OCC).
- Conditions
- Osteoradionecrosis, Radiotherapy, Risk Factors, Oral Cancer
- Trial name
- AOITC (NCT07836829)
- Volunteers
- 1,000 people
- Sponsor
- AO Innovation Translation Center
Osteoradionecrosis of the Jaw
Platelet-Rich Fibrin for Preventing Osteoradionecrosis After Dental Extractions
The goal of this clinical trial is to learn whether platelet-rich fibrin (PRF) can help prevent osteoradionecrosis (ORN) after dental extractions in adults who previously received radiation therapy to the head and neck.
- Trial name
- NCT07856875
- Testing
- Platelet-rich fibrin (PRF), Standard Dental Extraction Care
- Where
- 2 sites in Canada
- Volunteers
- 112 people
- Sponsor
- University of Manitoba
Osteoradionecrosis, Osteoradionecrosis of Jaw
Combination Therapy: Hyperbaric Oxygen and PENTOCLO for Treatment of Osteoradionecrosis of the Mandible
Radiation is commonly used to treat cancer in the head and neck, however, this can lead to a serious complication called osteoradionecrosis (ORN), where there is necrotic (dead) open bone inside or outside of the mouth.
- Conditions
- Osteoradionecrosis, Osteoradionecrosis of Jaw, Osteoradionecrosis of the Mandible
- Trial name
- NCT06055257
- Testing
- modified PENTOCLO (mPENTOCLO)
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Sunnybrook Health Sciences Centre