Clinical trials: Osteosynthesis
Opioid Use, Fractures, Bone
Nonopioid Pain Control Regimen After Open Reduction and Internal Fixation of Traumatic Fractures
An open reduction and internal fixation is a painful procedure requiring intensive postoperative pain management. Traditionally, opioid analgesia has been the gold standard for postoperative pain control.
- Conditions
- Opioid Use, Fractures, Bone, Trauma
- Trial name
- NCT06113211
- Testing
- Narcotic pain medication, Nonnarcotic pain medications
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Henry Ford Health System
Multiple Closed Pelvic Fractures With Disruption of Pelvic Ring, Fragility Fracture
Early Internal Fixation Versus NonOperative Care With Early Rehabilitation for LC1 Fragility Fractures of the Pelvis
The goal of this randomized pilot study is to assess feasibility of the trial and to collect information to inform the design of a definitive trial.
- Conditions
- Multiple Closed Pelvic Fractures With Disruption of Pelvic Ring, Fragility Fracture, Internal Fixation, Nonoperative Care
- Trial name
- PIVOT-LC1-Pi (NCT06496867)
- Testing
- Early Internal Fixation, Nonoperative Care with Early Rehabilitation
- Where
- 13 sites in United States, Spain
- Volunteers
- 48 people
- Sponsor
- University of Southern California
Distal Radius Fracture
Postsurgical Bupivacaine Extended-release Liposome Injection for Open-reduction Internal Distal Radius Fixation.
For patients undergoing open-reduction internal-fixaton (ORIF) of isolated distal radius fractures, administration of 66.5 mg of liposomal bupivacaine to operative field may decrease the need for post-operative narcotic pain…
- Trial name
- NCT02515851
- Testing
- Exparel
- Volunteers
- 30 people
- Sponsor
- University of Louisville
Lower Limb Surgery
Retrospective Foot and Ankle Data Collection
A retrospective post-market data collection study of the following implant devices : DARCO™ Headed Cannulated Screw ORTHOLOC™ 3Di Recon-Midfoot/Flatfoot System ORTHOLOCTM 3Di 2 Foot Reconstruction System: CROSSCHECK™ Module
- Trial name
- NCT05234801
- Testing
- DARCO™ Headed Cannulated Screw, ORTHOLOC™ 3Di Recon-Midfoot/Flatfoot System, ORTHOLOCTM 3Di 2 Foot Reconstruction System: CROSSCHECK™ Module
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust
Chronic Post Operative Pain
Prevalence and Risk Factors for Postsurgical Pain After the Open Reduction and Internal Fixation of Lower Limbs.
The objective of this study is to specify the demographic and medical factors that most likely constitute a risk of developing CPSP in the patients with lower limb.
- Trial name
- NCT06136663
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Xuzhou Central Hospital
Distal Radius Fractures
Topical TRanexamic Acid vs. Placebo on Acute Postoperative Pain Following DRF Fixation
The goal of this study is to find out whether the use of topical tranexamic acid (TXA) into the surgical wound will result in less post-operative pain, less pain killer use, and better post-operative use of the wrist in people…
- Trial name
- TRADR (NCT06384456)
- Testing
- Topical TRanexamic Acid
- Where
- Canada
- Volunteers
- 90 people
- Sponsor
- University Health Network, Toronto
Trimalleolar Fracture, Posterior Malleolus
Fixation of the Posterior Malleolus in Medium-sized Trimalleolar AO Weber-B Fractures.
The optimal treatment of ankle fractures with involvement of the posterior malleolus remains a subject of debate. Despite a large amount of literature on the role of the posterior malleolus in a so-called trimalleolar fracture…
- Conditions
- Trimalleolar Fracture, Posterior Malleolus, Open Reduction and Internal Fixation
- Trial name
- POSTFIX (NCT02596529)
- Testing
- Fixation, NO Fixation
- Where
- 3 sites in Netherlands
- Volunteers
- 84 people
- Sponsor
- Medical Center Haaglanden
Acetabular Fracture
Quadrilateral Surface Plate (QSP) Focused Registry
The absence of methodologically, prospectively and retrospectively collected information on the use of the Quadrilateral Surface Plate (QSP) in the given indication requires a multicenter approach.
- Trial name
- NCT01839565
- Testing
- Quadrilateral Surface Plate
- Where
- 6 sites in Germany, Italy and 1 more
- Volunteers
- 13 people
- Sponsor
- AO Clinical Investigation and Publishing Documentation
Femur Fracture
Pediatric Femur Research Project
Current treatment protocol for pediatric femoral shaft fractures is immediate spica casting for patients 6 years and younger and for patients over 6 years and older is percutaneous or open placement of titanium elastic…
- Trial name
- NCT00943332
- Testing
- femur fracture repair
- Where
- 3 sites in United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Femoral Neck Fractures
Minimally Displaced Femoral Neck Fracture Pilot Study
The goal of this randomized pilot study is to assess feasibility of the trial and to collect information to inform the design of a definitive trial.
- Trial name
- NCT05947058
- Testing
- Arthroplasty, Internal Fixation
- Where
- 12 sites in United States, Canada and 1 more
- Volunteers
- 40 people
- Sponsor
- University of Maryland, Baltimore
Femoral Neck Fractures, Pertrochanteric Fractures
Blood Loss and Complications of Internal Fixation of Femoral Neck Fractures in Patients Treated With Clopidogrel
Patients suffering from femoral neck or pertrochanteric fractures have a high rate of mortality and morbidity associated mainly with deconditioning and immobilization.
- Conditions
- Femoral Neck Fractures, Pertrochanteric Fractures, Antiaggregant Therapy
- Trial name
- NCT00749710
- Testing
- clopidogrel, no antiaggregant therapy
- Volunteers
- 100 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Proximal Humeral Fracture, Dislocation
Proximal Humerus Fracture Dislocation Direction and Avascular Necrosis
The purpose of the study is to see if there is a connection between a proximal humerus fracture dislocation direction and the likelihood of developing avascular necrosis.
- Conditions
- Proximal Humeral Fracture, Dislocation, Dislocation Shoulder, Avascular Necrosis
- Trial name
- PHF-D (NCT05735561)
- Testing
- X-Ray
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Fraser Orthopaedic Research Society
Acetabular Fracture
RCT Determining Best Treatment for Geriatric Acetabular Fractures
There is debate over the best management for acetabular (hip) fractures that occur within the geriatric population. Geriatric patients, 60 years or older, are at greater risk for operative complications because they tend to have…
- Trial name
- GeriTab (NCT03419182)
- Testing
- Open Reduction internal Fixation, Open Reduction Internal Fixation with Total Hip Arthroscopy
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- University of Maryland, Baltimore
Open Reduction Internal Fixation(ORIF) of Lateral Malleolus
Sciatic Nerve Block for Ankle/Foot Surgeries. A Comparison Between a Premixed Solution of Lidocaine Plus Bupivacaine and Consecutive Infiltration of Lidocaine and Bupivacaine
Regional anaesthesia has become the cornerstone of multimodal analgesia. With the advent of ultrasound guided nerve blocks regional anaesthesia has achieved both greater efficacy and a better safety profile as the injection of…
- Trial name
- NCT01756443
- Testing
- 2% lidocaine/adrenaline and 0.5% bupivacaine
- Where
- Ireland
- Volunteers
- 40 people
- Sponsor
- Cork University Hospital
Pain, Postoperative
Celecoxib in Postoperative Analgesia for Radius Fracture Surgery
Patients scheduled for elective osteosynthesis of the distal radius will be randomized to receive celecoxib 100 mg orally (PO) at 6 in the morning before surgery and every 12 hours for 2 days thereafter, or a placebo pill in the…
- Trial name
- NCT05288374
- Testing
- Celecoxib 100 mg
- Where
- 2 sites in Czechia
- Volunteers
- 42 people
- Sponsor
- Charles University, Czech Republic
Open Reduction and Internal Fixation of Extremity Fractures
MICRO Study: Detecting Bacterial Infections Related to Orthopaedic Surgical Implants
A prospective trial conducted at Shock Trauma of patients between 18 years of age and older who have sustained a fracture with metal implanted.
- Trial name
- MICRO (NCT03132246)
- Testing
- Blood draws
- Where
- United States
- Volunteers
- 260 people
- Sponsor
- University of Maryland, Baltimore
Osteopetrosis
Outcomes of Patients With Osteopetrosis Weight-bearing Bone Fractures
Osteopetrosis is a rare genetic disorder characterized by the abnormal hardening and density of bones, leading to increased brittleness and susceptibility to fractures.
- Trial name
- NCT06521580
- Testing
- Open reduction and internal fixation
- Where
- Egypt
- Volunteers
- 6 people
- Sponsor
- Kasr El Aini Hospital
Displaced Midshaft Fracture of the Collar Bone
Conservative Treatment Compared to Osteosynthesis in Patients With a Fractured Collar Bone
This study will compare non-operative treatment of displaced midshaft collarbone fractures with operative treatment using a precontoured titanium plate and screws.
- Trial name
- NCT01078480
- Testing
- Operation using a precontoured titanium plate and screws, Displaced midshaft fracture of the collar bone
- Where
- Denmark
- Volunteers
- 140 people
- Sponsor
- Northern Orthopaedic Division, Denmark
Distal Radius Fracture
Three Dimensional Digital Preoperative Planning for the Osteosynthesis of Distal Radius Fractures
Background: Three dimensional (3D) digital pre-operative planning software for osteosynthesis of fractures was developed. To assess the usefulness of the 3D planning, we evaluated the accuracy of the reduction shapes and selected…
- Trial name
- NCT02909647
- Testing
- Preoperative planning, Osteosynthesis
- Where
- Japan
- Volunteers
- 100 people
- Sponsor
- Tokyo Medical University
Spinal Disease
CT Mar Technology and MR Mavric, Semac Sequence in Removing Artifacts of Orthopedic Metal Internal Fixation
1. Objective to compare the effect of single energy imaging and mar technology in reducing artifacts of knee and hip replacement, and to explore the appropriate keV range of Mar technology in removing metal artifacts.,2.
- Trial name
- NCT04954963
- Testing
- Reduce metal artifacts examination
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking University Third Hospital