Clinical trials: Other Disease/Injury
Spinal Cord Injuries, Osteoporosis
Statin Monotherapy for Treatment of Endocrine Metabolic Disease Risk
Rationale: After having a spinal cord injury (SCI), people develop changes in their body composition that influences their long-term health.
- Conditions
- Spinal Cord Injuries, Osteoporosis, Metabolic Syndrome
- Trial name
- RoBaCO (NCT03113994)
- Testing
- Rosuvastatin Calcium, Coenzyme Q10, Calcium Carbonate
- Where
- 2 sites in United States, Canada
- Volunteers
- 8 people
- Sponsor
- Dr. B. Catharine. Craven
Critically Ill, Acute Kidney Injury
Magnesium Balance of Citrate-based Continuous Venovenous Hemofiltration, Effect of Citrate Dose.
Rationale: A higher citrate dose during continuous venovenous hemofiltration provides better anticoagulation but possibly a higher risk of citrate accumulation in case of metabolic limitations.
- Trial name
- NCT02194569
- Testing
- Citrate
- Where
- Belgium
- Volunteers
- 36 people
- Sponsor
- Ziekenhuis Oost-Limburg
Dementia, Traumatic Brain Injury (TBI)
Clinical Characteristics of Dementias That Occur Remotely After Traumatic Brain Injury in Retired Military Personnel
The objective of this study is to measure the frequency and clinical types of mild cognitive impairment (MCI) or dementia that occur among up to 150 military retirees with and without a history of traumatic brain injury (TBI)…
- Conditions
- Dementia, Traumatic Brain Injury (TBI), Mild Cognitive Impairment (MCI), Chronic Traumatic Encephalopathy (CTE)
- Trial name
- NCT01891383
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Uniformed Services University of the Health Sciences
Chronic Renal Insufficiency, Diabete Mellitus
Safety Study of GE-145 320 mg I/mL Injection vs. Iopamidol 370 mg I/mL in Elderly Subjects Undergoing Coronary Procedure
To evaluate cardio-renal and overall safety profile of GE 145 320 mg I/ml Injection when compared to iopamidol 370 mg I/mL. The study will focus on elderly subjects with either chronic renal insufficiency, or diabetes mellitus…
- Conditions
- Chronic Renal Insufficiency, Diabete Mellitus, Congestive Heart Failure
- Trial name
- NCT01252810
- Testing
- GE-145
- Where
- United States
- Volunteers
- 284 people
- Sponsor
- GE Healthcare
Acute Kidney Injury, Chronic Kidney Disease Stage 5 on Dialysis
Non-invasive Assessment to Predict Tolerance to Fluid Removal on Intermittent Kidney Replacement Therapy
This prospective cohort study aim to investigate the ability of multiple types of assessments including 1) the modified Venous Excess Ultrasound (VExUS) assessment, 2) non-invasive estimation of absolute blood volume (ABV), and…
- Conditions
- Acute Kidney Injury, Chronic Kidney Disease Stage 5 on Dialysis, Chronic Kidney Failure, Intradialytic Hypotension
- Trial name
- TECHNO-HDF (NCT05270759)
- Testing
- Estimated absolute blood volume, Modified VExUS evaluation
- Where
- Canada
- Volunteers
- 93 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Alzheimer's Disease, Amyotrophic Lateral Sclerosis (ALS)
PRISM Registry: Pseudobulbar Affect Registry Series
PBA is a neurologic condition that is estimated to impact over a million patients and their families in the United States. PBA occurs secondary to an otherwise unrelated neurologic disease or injury, and manifests as involuntary…
- Conditions
- Alzheimer's Disease, Amyotrophic Lateral Sclerosis (ALS), Multiple Sclerosis (MS), Parkinson's Disease
- Trial name
- NCT01366027
- Where
- United States
- Volunteers
- 5,290 people
- Sponsor
- Avanir Pharmaceuticals
Chronic Traumatic Encephalopathy
Pilot Study Evaluating brainQuant's Ability to Detect Alterations in White Matter in Diffusion MRI, Indicative of Post-traumatic Lesions
Chronic traumatic encephalopathy (CTE) is a neurodegenerative disease described in boxing, but also in contact sports such as American football.
- Trial name
- BQ TC-foot (NCT07302503)
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Strasbourg, France
Sickle Cell Disease Vaso-occlusive Crisis
Safety, Efficacy, and Pharmacokinetics of CSL889 in Adults and Adolescents With Sickle Cell Disease During Vaso-Occlusive Crisis
This is a phase 2, randomized, multiple-dose, placebo-controlled study designed to evaluate the safety, efficacy, and pharmacokinetics (PK) of CSL889 (human hemopexin) when given intravenously (IV) to adults and adolescents with…
- Trial name
- NCT06699849
- Testing
- CSL889
- Where
- 30 sites in United States, Turkey (Türkiye) and 1 more
- Volunteers
- 70 people
- Sponsor
- CSL Behring
Kidney Failure, Acute, Kidney Failure, Chronic
Does An Abnormal PFA 100 Predict Bleeding After Renal Biopsy?
The kidneys are highly vascular organs and any trauma or surgery poses risk of severe bleeding. Platelet function is an integral part of the blood clotting during the initial, so-called vascular phase.
- Conditions
- Kidney Failure, Acute, Kidney Failure, Chronic, Blood Platelet Disorders, Hemorrhage
- Trial name
- NCT00334204
- Testing
- measuring Platelet Function Analyser-100 (PFA-100) platelet function before kidney biopsy
- Where
- United States
- Volunteers
- 58 people
- Sponsor
- University of Mississippi Medical Center
Hepatic Encephalopathy, Acute on Chronic Liver Failure (ACLF)
A Study to See if an Investigational Medicine Called VS-01 Can Help and How Safe it is in the Treatment of Patients With Overt Hepatic Encephalopathy
A Phase 2, Randomized, Controlled, Open-Label, Adaptive Dose Design, Proof-of-Concept Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of Two Different Dwell Times of VS-01 on Top of Standard of Care versus Standard…
- Conditions
- Hepatic Encephalopathy, Acute on Chronic Liver Failure (ACLF), Decompensated Cirrhosis
- Trial name
- NCT06987968
- Testing
- VS-01 on top of SOC (Active Treatment Group), SOC
- Where
- 6 sites in United States, France and 1 more
- Volunteers
- 3 people
- Sponsor
- Genfit
Bronchopulmonary Dysplasia, Preterm Birth
Bronchopulmonary Dysplasia: From Neonatal Chronic Lung Disease to Early Onset Adult COPD
The investigators will apply xenon-129 (129Xe) and non-contrast enhanced magnetic resonance imaging (MRI) acquisition and analysis methods in 50 subjects aged between 20 and 29 years born pre-term (with and without a diagnosis of…
- Trial name
- NCT02723513
- Testing
- Hyperpolarized Xenon-129
- Where
- Canada
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Mental Illness, Schizophrenia
Cognitive Training to Enhance VA Work Program Outcomes
The purpose of this study is to determine whether augmenting work services with cognitive remediation can improve vocational outcomes for psychiatrically disabled participants in VA work services.
- Conditions
- Mental Illness, Schizophrenia, Depression, PTSD
- Trial name
- NCT00829400
- Testing
- Cognitive Remediation, Nintendo Brain Age
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- VA Connecticut Healthcare System
Contrast-induced Nephropathy, Kidney Injury
Intravenous vs. Oral Hydration to Reduce the Risk of Post-Contrast Acute Kidney Injury After Intravenous Contrast-Enhanced Computed Tomography in Patients With Severe Chronic Kidney Disease
The use of contrast media (CM) poses a risk of post-contrast acute kidney injury (PC-AKI), especially among patients chronic kidney disease (CKD).
- Conditions
- Contrast-induced Nephropathy, Kidney Injury, Kidney Failure, Chronic, Risk Reduction
- Trial name
- ENRICH (NCT05283512)
- Testing
- Preventive treatment with IV-hydration, Preventive treatment with oral hydration
- Where
- Denmark
- Volunteers
- 254 people
- Sponsor
- Odense University Hospital
Bladder Cancer, Prostate Cancer
Medtronic Hugo™ Robotic Assisted Surgery (RAS) System in Urologic Surgery (Expand URO)
This study will evaluate the safety and performance of the Medtronic Hugo™ RAS System when used for urologic RAS procedures.
- Conditions
- Bladder Cancer, Prostate Cancer, Kidney Cancer, Pelvic Tumor
- Trial name
- NCT05696444
- Testing
- RAS Prostatectomy, RAS Cystectomy, RAS Nephrectomy
- Where
- 6 sites in United States
- Volunteers
- 144 people
- Sponsor
- Medtronic - MITG
Humerus Fracture, Humerus
RSA vs. Nonop for 3 & 4-Part Proximal Humerus Fractures
There is currently no consensus amongst orthopedic specialists on the best way to treat 3- and 4-part proximal humerus fractures.
- Conditions
- Humerus Fracture, Humerus, Shoulder Fractures, Shoulder Arthropathy Associated With Other Conditions
- Trial name
- NCT03599336
- Testing
- Reverse Total Shoulder Arthroplasty (rTSA), Nonoperative Treatment
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Mayo Clinic
Acute Respiratory Failure, Critical Illness
Exhaled Breath Condensate Analysis in Mechanically Ventilated Patients
Mechanically ventilated intensive care patients will be sampled for a small amount of exhaled breath condensate from the ventilator circuit and for venous blood.
- Trial name
- NCT06189924
- Testing
- Proteomic analysis of exhaled breath condensate
- Where
- 2 sites in Czechia
- Volunteers
- 200 people
- Sponsor
- The Institute of Molecular and Translational Medicine, Czech Republic
Traumatic Brain Injury, Mild Traumatic Brain Injury
Comparison of Two Group Wellness Interventions for Individuals With Neurologic Conditions and Their Support Persons
Approximately 5.3 million people live with a long-term disability resulting from a traumatic brain injury (TBI) and between 5-8% of those older than 60 suffer from Alzheimer's disease or other forms of dementia (ADRD).
- Conditions
- Traumatic Brain Injury, Mild Traumatic Brain Injury, Alzheimer's Disease, Brain Injury Traumatic Moderate
- Trial name
- NCT05048966
- Testing
- Group Wellness Class 1, Group Wellness Class 2
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- Kessler Foundation
Critical Illness, Acute Kidney Injury
Balanced Solution Versus Saline in Intensive Care Study
A 2x2 factorial randomized study to evaluate the effect of a balanced crystalloid solution compared with 0.9% saline, and of rapid vs. slow infusion on clinical outcomes of critically ill patients
- Trial name
- BaSICS (NCT02875873)
- Testing
- Plasma-Lyte, Saline 0.9%, Slow infusion speed
- Where
- Brazil
- Volunteers
- 11,075 people
- Sponsor
- Hospital do Coracao
End Stage Liver DIsease, Liver Transplant; Complications
Intraoperative Normal Saline Administration and Acute Kidney Injury in Patients Undergoing Liver Transplantation
The investigators attempted to investigate the association of the type of crystalloid administered during liver transplantation with postoperative clinical outcomes.
- Conditions
- End Stage Liver DIsease, Liver Transplant; Complications, Liver Cirrhosis
- Trial name
- NCT05386953
- Testing
- Normal saline, Balanced crystalloid solution
- Where
- South Korea
- Volunteers
- 1,440 people
- Sponsor
- Seoul National University Hospital
Major Depressive Disorder, Bi-Polar Disorder
DELPhI Evaluation of Psychiatric Conditions
DELPhI acquisition and analysis software, a QuantalX Neuroscience development, which is designed to measure, analyze, and display brain electrical activity of human electroencephalogram (EEG), to transcranial magnetic stimulation…
- Conditions
- Major Depressive Disorder, Bi-Polar Disorder, ADHD, Schizophrenia
- Trial name
- NCT03842345
- Sponsor
- QuantalX Neuroscience
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