Clinical trials: Other Disease/Injury
Therapeutic Endoscopic Ultrasound, Advanced Endoscopy
Therapeutic Endoscopic Ultrasound for Gastrointestinal Disorders: A Multicenter Registry Study
The purpose of this retrospective chart-review registry study is to evaluate the safety profile, efficacy profile and cost-effectiveness of the various therapeutic endoscopic ultrasound (EUS) procedures (for benign and malignant…
- Conditions
- Therapeutic Endoscopic Ultrasound, Advanced Endoscopy, Therapeutic Endoscopy, Interventional Endoscopy
- Trial name
- TEUS Registry (NCT05051358)
- Testing
- Therapeutic Endoscopic Ultrasound
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- Advanced Endoscopy Research, Robert Wood Johnson Medical School Rutgers University
Spinal Cord Injury
Pilot Study of a Sedentary Behaviour Intervention for Individuals With a Spinal Cord Injury
Individuals with spinal cord injury have a greater risk of heart disease and stroke than non-disabled individuals. This might be partly because wheelchair users engage in high amounts of sedentary behaviour.
- Trial name
- REACH-SCI (NCT06957483)
- Testing
- REACH-SCI (Reducing sedEntary Activities to improve Cardiovascular Health in individuals with a Spinal Cord Injury)
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Brunel University
Tetraplegia/Tetraparesis, Quadriplegia
Precise Robotically IMplanted Brain-Computer InterfacE
The PRIME Study is a first-in-human early feasibility study to evaluate the initial clinical safety and device functionality of the Neuralink N1 Implant and R1 Robot device designs in participants with tetraparesis or…
- Conditions
- Tetraplegia/Tetraparesis, Quadriplegia, Cervical Spinal Cord Injury, Amyotrophic Lateral Sclerosis
- Trial name
- PRIME (NCT06429735)
- Testing
- N1 Implant, R1 Robot
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Neuralink Corp
Acute Kidney Injury
Prevention of Acute Kidney Injury After Transcatheter Aortic Valve Implantation
Randomized controlled, single-center trial randomizing patients with chronic kidney disease and symptomatic severe aortic valve stenosis undergoing transcatheter aortic valve implantation (TAVI).
- Trial name
- NCT04537325
- Testing
- RenalGuard system
- Where
- Germany
- Volunteers
- 98 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Neuromuscular Disorders, Neurodevelopmental Disorders
Safety, Usability, and Effectiveness of a Gait Exoskeleton for Children and Adolescents With Neurodevelopmental Disorders.
Neurodevelopmental disorders often result in abnormal development of the Central Nervous System (CNS), frequently causing motor dysfunctions such as the inability to stand and walk.
- Trial name
- NCT07159360
- Testing
- CLINICAL EXPLORER
- Where
- 2 sites in Mexico, Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- MarsiBionics
Post-Acute COVID-19 Syndrome, ME/CFS
Unhide® Project: A Digital Health Platform to Collect Lifestyle Data for Brain Inflammation Research
The unhide® Project is a non-interventional, longitudinal research study designed to establish a secure data repository of demographic, health, and lifestyle information from individuals with brain inflammation and related…
- Conditions
- Post-Acute COVID-19 Syndrome, ME/CFS, Rheumatic Arthritis, Juvenile Rheumatoid Arthritis (JRA)
- Trial name
- NCT04806620
- Where
- United States
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Brain Inflammation Collaborative
Alcohol Use Disorder
Study on Thiamine Supplementation to REduce braiN Injury Associated With Chronic Alcohol Use in Outpatients With Alcohol Use Disorder
Chronic alcohol use and alcohol use disorder (AUD) affect 10% of the population in France. They are associated with brain damage and cognitive impairment.
- Trial name
- STRENA (NCT07844720)
- Testing
- Thiamine
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Premature Infant, Chronic Respiratory Disease
Genesis Electrical Impedance Tomography (EIT): A Preliminary Study
The purpose of this study is to evaluate the Genesis Electrical Impedance Tomography (EIT) imaging system for use in pediatric respiratory disease populations including neuromuscular and bronchopulmonary dysplasia, as well as in…
- Conditions
- Premature Infant, Chronic Respiratory Disease, Neuromuscular Diseases, Healthy
- Trial name
- NCT03797183
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Stroke, Spinal Cord Injury
ERIGO® Life- Control of Cardiovascular Parameters Via Verticalization and Simultaneous Mobilization
Early verticalization and stepping with the equipment of Hocoma ERIGO during monitoring of vital parameters. The device is already CE marked and, for the purposes of the study, will be used in accordance with the intended use…
- Trial name
- ERIGO®LIFE (NCT02268266)
- Testing
- Erigo
- Where
- 2 sites in Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Renal Impairment, Limb Ischemia, Critical
Ultra-low Dose Contrast for Endovascular Procedures
The purpose of this protocol is to study the safety and feasibility of using ultra-low dose iodinated contrast agent for infrainguinal endovascular revascularization procedures in patients with chronic limb-threatening lower limb…
- Trial name
- ULTRA-LOW (NCT06835127)
- Testing
- Infrainguinal peripheral endovascular revascularization
- Where
- Greece
- Volunteers
- 18 people
- Sponsor
- Attikon Hospital
Spinal Cord Injuries, Endothelial Dysfunction
Endothelial Dysfunction After SCI
This study plans to learn how endothelial cells, single cell lining of blood vessels may be dysfunctional after a spinal cord injury.
- Trial name
- EDASCI (NCT07227727)
- Testing
- Intra-arterial Infusion of Vasoactive Agents, Intra-arterial Vitamin C Infusion, Blood Sampling
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Craig Hospital
Spinal Cord Injuries, Cardiovascular Diseases
Role of Endothelial Function in SCI CVD Risk
Individuals with spinal cord injury have heart attacks and strokes more frequently, and much earlier in life. People with spinal cord injuries develop plaque in vessels much faster, and the reasons why are unclear.
- Conditions
- Spinal Cord Injuries, Cardiovascular Diseases, Endothelial Dysfunction
- Trial name
- NCT06443151
- Testing
- Brachial intra-arterial infusion of vasoactive and antioxidant drugs (acetylcholine, nitroprusside, ascorbic acid), venous occlusion plethysmography, Acetylcholine
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Craig Hospital
Diabetes Mellitus, Type 2, Kidney Disease, Chronic
Randomized Study Comparing Metabolic Surgery With Intensive Medical Therapy to Treat Diabetic Kidney Disease
Proven therapy for DKD is primarily limited to RAAS blockers and SLGT2i. Weight reduction has the potential to become an additional and much needed treatment option.
- Conditions
- Diabetes Mellitus, Type 2, Kidney Disease, Chronic, Kidney Injury
- Trial name
- OBESE-DKD (NCT04626323)
- Testing
- Roux-en-Y gastric bypass, Best medical treatment
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- Hospital Alemão Oswaldo Cruz
Respiratory Distress Syndrome, Adult
Significance of Biological Markers in Patients With Acute Lung Injury/Acute Respiratory Disease
The purpose of this study is to identify biological markers of disease in patients with acute lung injury (ALI) that are predictive of either disease susceptibility or prognosis, or that identify novel targets of therapeutic…
- Trial name
- NCT00217880
- Testing
- Bronchoscopy
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of Michigan
Congenital Heart Disease, Acute Kidney Injury
Nitric Oxide During CPB to Reduce AKI in Neonates
This is a prospective, randomized, double-blind, placebo-controlled pilot study to investigate whether supplemental Nitric Oxide (NO) gas delivered during cardiac surgery with cardiopulmonary bypass (CPB) reduces the incidence…
- Trial name
- NCT03946462
- Testing
- NO gas delivered during cardiac surgery
- Where
- United States
- Sponsor
- Fabio Savorgnan
Graves Disease, Graves Ophthalmopathy
Liver Function After Intravenous Methylprednisolone Administration
Graves' orbitopathy (GO) is a characterized by orbital soft tissue inflammation and oedema associated with glycosaminoglycan deposition and fibrosis. The most frequent cause is Graves' disease.
- Conditions
- Graves Disease, Graves Ophthalmopathy, Liver Diseases, Liver Failure
- Trial name
- NCT03667157
- Testing
- every week IVMP therapy, very high doses IVMP therapy
- Volunteers
- 68 people
- Sponsor
- Medical University of Warsaw
Intra-Operative Injury - Other, Post Operative Hemorrhage
Preoperative Hexakapron Reduces Bleeding in Bariatric Surgery
Prophylactic use of tranexamic acid to reduce intra and postoperative bleeding in primary sleeve gastrectomy procedures will be studied.
- Conditions
- Intra-Operative Injury - Other, Post Operative Hemorrhage, Tranexamic Acid
- Trial name
- PHORBBS (NCT03085394)
- Testing
- tranexamic acid
- Where
- Israel
- Volunteers
- 152 people
- Sponsor
- Sheba Medical Center
Arterial Stiffness
Arterial Stiffness in Heart Failure and Chronic Kidney Disease
This observational study is assessing the effects that arterial stiffness may have on patients with heart failure (HF) and chronic kidney disease (CKD). Arterial stiffness will be measured by assessing pulse wave velocity (PWV).
- Trial name
- ASHFCKD (NCT05012722)
- Testing
- Sphygmocor CVMS (Atocr Medical, Sydney Australia) PWV measurement
- Where
- United Kingdom
- Volunteers
- 119 people
- Sponsor
- University Hospitals Coventry and Warwickshire NHS Trust
Tetraplegia/Tetraparesis, Quadriplegia
VOICE: An Early Feasibility Study of a Precise Robotically Implanted Brain-Computer Interface for Communication Restoration
The VOICE Study is an early feasibility study to evaluate the initial clinical safety and efficacy of the N1 and R1 Systems device design concept in providing an ability to communicate.
- Conditions
- Tetraplegia/Tetraparesis, Quadriplegia, Cervical Spinal Cord Injury, Amyotrophic Lateral Sclerosis
- Trial name
- NCT07224256
- Testing
- N1 Implant, R1 Robot
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Neuralink Corp
Postoperative Myocardial Injury
Direct Evaluation of Postoperative Myocardial Injury Using Coronary Computed Tomography Angiography After Non-Cardiac Surgery
This is a prospective study in patients who undergo routine postoperative troponin assessment after major (semi-)elective noncardiac surgery.
- Trial name
- NCT02682966
- Testing
- Coronary Computed Tomography Angiography
- Volunteers
- 354 people
- Sponsor
- UMC Utrecht
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