Clinical trials: Other Disease/Injury
Chronic Kidney Disease, Acute Kidney Injuries
Dementia and Kidney Disease: Epidemiological Approaches to Risk Factors and Treatment Strategies
Kidney disease and dementia are both common in older adults, posing a significant burden on individuals and society. Growing evidence suggests that there may be links between the kidney and the brain.
- Conditions
- Chronic Kidney Disease, Acute Kidney Injuries, Real World Study, Dementia
- Trial name
- NCT07093684
- Testing
- Kidney disease
- Where
- Sweden
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Complete or Incomplete Paraplegia/quadriplegia, Spinal Cord Injury
Research on Wireless Brain Implant System for General Control of External Devices
The clinical trial aims to evaluate the safety and efficacy of the minimally invasive, wireless brain-machine interface system (WRS) in enabling general brain control of external devices, such as a cursor and other assistive…
- Conditions
- Complete or Incomplete Paraplegia/quadriplegia, Spinal Cord Injury, Brainstem Stroke, Amyotrophic Lateral Sclerosis
- Trial name
- RISE (NCT06829212)
- Testing
- WRS
- Where
- China
- Volunteers
- 4 people
- Sponsor
- Shanghai StairMed Technology Co., Ltd.
Traumatic Brain Injury
Use of Biperiden for the Prevention of Post-traumatic Epilepsy
There is no AED or medication that has been demonstrated to affect the development of post-traumatic epilepsy. Biperiden is a cholinergic antagonist, acting in the muscarinic receptor, that is widely used as an anti Parkinson…
- Trial name
- NCT01048138
- Testing
- Biperiden Lactate
- Where
- Brazil
- Volunteers
- 123 people
- Sponsor
- Federal University of São Paulo
Acute Kidney Injury
Application of Intraoperative Transesophageal Echocardiography Imaging of Vein and CLCVP in Early Prediction and Intervention CSA-AKI
The goal of this clinical trial is to learn about in postoperative acute kidney injury in cardiac surgery. The main questions it aims to answer are: Intraoperative Transesophageal Ultrasound Doppler venous imaging can be used to…
- Trial name
- NCT05682716
- Testing
- Controlled low central venous pressure (CLCVP) technology, Nitroglycerin
- Where
- China
- Volunteers
- 137 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Rotator Cuff, Syndrome, Frozen Shoulder
Validation of a Kinematic Functional Shoulder Score Including Only Essential Movements
A lot of shoulder function evaluation scores exist but none has been universally accepted as a gold standard. Recent studies have demonstrated the potential of computerized movement analysis with embedded sensors for objective…
- Conditions
- Rotator Cuff, Syndrome, Frozen Shoulder, Humerus, Fracture, Other Instability of Joint, Shoulder Region
- Trial name
- NCT01431417
- Where
- Switzerland
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Haute Ecole de Santé Vaud
SGLT2i Kideny Protection Against Contrast in Diabetic Kidney
SGLT2 Inhibitors Prophylaxis Against Post-contrast Acute Kidney Injury in Diabetic Kidney Disease?
We will look for the possible effect of SGLT2i as a single agent to prevent post-contrast Acute Kidney Injury in diabetic kidney disease.
- Trial name
- NCT04853615
- Testing
- Empagliflozin 25 MG
- Volunteers
- 800 people
- Sponsor
- Fayoum University
Bronchopulmonary Dysplasia
Pilot Study of Topical Steroid for Prevention of Chronic Lung Disease in Extremely Premature Infants.
A Pilot study to evaluate the safety and the efficacy of endotracheal instillation of pulmonary surfactant, with or without topical steroid (Budesonide), as a prophylactic treatment for Bronchopulmonary Dysplasia (a form of…
- Trial name
- NCT01268215
- Testing
- Infasurf, Pulmicort
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- East Carolina University
Critical Illness, Acute Kidney Injury
Skeletal Muscle Wasting and Renal Dysfunction After Critical Illness Trauma - Outcomes Study
This study aims to determine changes in kidney function during and after critical illness, comparing conventional creatinine based methods with the gold standard to accurately establish the presence of new or worsened chronic…
- Conditions
- Critical Illness, Acute Kidney Injury, Muscle Loss, Major Trauma
- Trial name
- KRATOS (NCT03736005)
- Testing
- Exposure of significant critical illness
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Queen Mary University of London
Renal Insufficiency or Renal Failure &or End-stage Renal Disease
Cytokine Adsorption in Sepsis and Acute Kidney Injury
Aim of the study is to reduce the incidence of RIFLE stadium L and E after acute kidney injury in patients with severe sepsis/septic shock
- Trial name
- CASAKI (NCT02588794)
- Testing
- CytoSorb 300 ml device (3804606CE01)
- Where
- Germany
- Volunteers
- 124 people
- Sponsor
- Technical University of Munich
Traumatic Brain Injury, Critical Illness
Sleep Management And Recovery After Traumatic Brain Injury in Kids: Pilot Intervention of Melatonin
Sleep wake disturbances compound recovery in over half of pediatric traumatic brain injury survivors, leading to impaired quality of life, and few effective interventions exist to treat this important morbidity.
- Conditions
- Traumatic Brain Injury, Critical Illness, Sleep
- Trial name
- SMARTKids (NCT04932096)
- Testing
- melatonin
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Oregon Health and Science University
Spinal Cord Injuries, Endothelial Dysfunction
Endothelial Dysfunction After SCI
This study plans to learn how endothelial cells, single cell lining of blood vessels may be dysfunctional after a spinal cord injury.
- Trial name
- EDASCI (NCT07227727)
- Testing
- Intra-arterial Infusion of Vasoactive Agents, Intra-arterial Vitamin C Infusion, Blood Sampling
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Craig Hospital
Acute Kidney Injury, Renal Replacement Therapy
Albumin To Enhance Recovery After Acute Kidney Injury
Study objectives: To determine whether, in critically ill patients with Acute Kidney Injury requiring renal replacement therapy (AKI-RRT), randomization to receive intravenous hyperoncotic albumin 20-25% (100 mL X two doses)…
- Conditions
- Acute Kidney Injury, Renal Replacement Therapy, Hypotension, Critical Illness
- Trial name
- ALTER-AKI (NCT04705896)
- Testing
- 20-25% Albumin fluid (100 mL), 0.9% Normal Saline (100 mL)
- Where
- 16 sites in Canada
- Volunteers
- 856 people
- Sponsor
- Ottawa Hospital Research Institute
Spinal Cord Injury Cervical, Spinal Cord Injury Thoracic
A Study to Evaluate the Safety of a Delivery Device for Administering LCTOPC1 in Participants With Spinal Cord Injury
The DOSED clinical study evaluates the safety and utility of a novel delivery device to deliver LCTOPC1, a cell therapy, to the spinal cord of patients with a spinal cord injury (SCI).
- Conditions
- Spinal Cord Injury Cervical, Spinal Cord Injury Thoracic, Spinal Cord Injury, Acute, Spinal Cord Injury
- Trial name
- DOSED (NCT06841770)
- Testing
- OPC1
- Where
- 2 sites in United States
- Volunteers
- 10 people
- Sponsor
- Lineage Cell Therapeutics, Inc.
Respiratory Syncytial Virus (RSV)
A Study to Assess the Safety and Effectiveness of Palivizumab Administered to Children at High Risk of Severe Respiratory Syncytial Virus (RSV) Infection in the Russian Federation and the Republic of Belarus
This is a Phase 3b, prospective, multicenter, open-label, non-controlled study to assess the safety and effectiveness of immunoprophylaxis with the intramuscular (IM) administration of the liquid formulation of palivizumab for…
- Trial name
- Synagis Russia (NCT02968173)
- Testing
- Palivizumab
- Volunteers
- 50 people
- Sponsor
- AbbVie
Congenital Heart Disease (CHD), Hypoxic Encephalopathy
Early Detection of Brain Injury After Congenital Heart Surgery in Infants
Infants with congenital heart disease undergoing cardiac surgery with extracorporeal circulation are at risk for perioperative hypoxic-ischaemic brain injury.
- Trial name
- NCT07424976
- Testing
- Observational study: blood analisys, EEG, MRI
- Where
- Slovenia
- Volunteers
- 30 people
- Sponsor
- University Medical Centre Ljubljana
Scorpion Sting
Randomized Controlled Trial to Compare Two Anti-scorpion Serums
The purpose of this study is to compare the efficiency and safety of the treatment against sting scorpion, using two serums, one elaborated by Birmex versus other commercial serum
- Trial name
- NCT00739440
- Testing
- serum antiscorpion
- Volunteers
- 120 people
- Sponsor
- Laboratorios de Biologicos y Reactivos de México, S.A. de C.V.
Ventilator Weaning, Weaning Failure
Voices of Patients' Relatives to Support Weaning From Mechanical Ventilation
Patients with severe brain injuries, such as ischemic stroke and intracranial hemorrhage, frequently require mechanical ventilation. Weaning of stroke patients is complicated by impaired consciousness and respiratory drive.
- Conditions
- Ventilator Weaning, Weaning Failure, Brain Injuries
- Trial name
- VOICE-WEANING (NCT03795623)
- Testing
- Voice-Weaning
- Where
- Germany
- Volunteers
- 45 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Choroidal Neovascularization, Myopia
Intravitreal Bevacizumab vs.Combination Therapy for CNV Due to Other Than AMD
Anti-VEGF therapy has been proven efficacious for the wet (neovascular) form of macular degeneration and may be beneficial for the treatment of choroidal neovascularization (CNV) due to other causes.
- Conditions
- Choroidal Neovascularization, Myopia, Punctate Inner Choroidopathy (PIC), Multifocal Choroiditis
- Trial name
- CNV (NCT01256580)
- Testing
- Bevacizumab (Avastin; Genentech, Inc.), Bevacizumab, Dexamethasone, Verteporfin Photodynamic Therapy
- Sponsor
- Massachusetts Eye and Ear Infirmary
Delirium, Ischemic Stroke
CTSN Embolic Protection Trial
This is a prospective, multi-center, randomized effectiveness trial of the CardioGard Embolic Protection Cannula in high-risk valve surgery patients.
- Conditions
- Delirium, Ischemic Stroke, Acute Kidney Injury, Heart Valve Disease
- Trial name
- EMPRO (NCT06027788)
- Testing
- CardioGard Embolic Protection Cannula, Standard Aortic Cannula
- Where
- 24 sites in United States, Canada
- Volunteers
- 842 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Brain Injury, Dementia
Neuropsychiatric Evaluation of Healthy Volunteers and Adults With Schizophrenia
The purpose of this study is to evaluate the cognitive processes of participants with schizophrenia, participants with nervous system and mental disorders, and healthy volunteers.
- Conditions
- Brain Injury, Dementia, Healthy, Mental Disorder
- Trial name
- NCT00001323
- Where
- United States
- Volunteers
- 810 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
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