Clinical trials: Other Disease
HIV, Hepatitis C
Sofosbuvir Based DAA Therapy in HIV/HCV Coinfected Pre or Post Liver Transplant
Retrospective/Prospective, open-label study using sofosbuvir based DAA therapy to treat HIV/HCV coinfected pre or post liver transplant participants
- Conditions
- HIV, Hepatitis C, Cirrhosis
- Trial name
- STOP-CO (NCT02533934)
- Testing
- Harvoni
- Where
- 8 sites in United States
- Volunteers
- 68 people
- Sponsor
- University of California, San Francisco
Portal Hypertension
Ultrasound Elastography Assessment of Spleen and Liver Stiffness Before and After Transjugular Intrahepatic Portosystemic Shunt (TIPS) Procedure
The primary purpose of this project is to determine if acute monitoring of shunt patency via ultrasound elastography measurements of splenic stiffness before and after TIPS placement results in reduced morbidity and mortality…
- Trial name
- NCT03427164
- Testing
- Transjugular Intrahepatic Portosystemic Shunt
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Kansas Medical Center
Degenerative Disc Disease, Spinal Stenosis Lumbar
Prospective Study of ProteiOS in Lumbar Interbody Fusion (TLIF)
This is a prospective, multicenter, randomized, controlled study evaluating Influx™ ProteiOS®, an allograft-derived growth factor product, in transforaminal lumbar interbody fusion (TLIF).
- Conditions
- Degenerative Disc Disease, Spinal Stenosis Lumbar, Lumbar Spine Fusion, Spondylolisthesis
- Trial name
- NCT07775729
- Testing
- Allograft-derived growth factor (ProteiOS®), Standard of Care (SOC)
- Volunteers
- 280 people
- Sponsor
- Isto Biologics
Plaque Psoriasis
A 12-week Dose-Ranging Trial in Patients With Moderate to Severe Plaque Psoriasis
IMO 8400 is a second-generation oligonucleotide antagonist of endosomal Toll-like receptors (TLR) 7, TLR8 and TLR9. These TLR react to complexes of exogenous nucleic acids (as might be encountered during infection) and endogenous…
- Trial name
- 8400-201 (NCT01899729)
- Testing
- IMO-8400 Regimen 1, IMO-8400 Regimen 2, IMO-8400 Regimen 3
- Where
- Netherlands
- Volunteers
- 46 people
- Sponsor
- Idera Pharmaceuticals, Inc.
Cognitive Dysfunction, Critical Illness
Trauma and Critical Care Exposure Examined With PET (TRAPETS)
The overall aim is to examine the impact of trauma and critical illness on the brain, peripheral immune system and cognition. This is a prospective study where a study group exposed to trauma and intensive care will be be…
- Conditions
- Cognitive Dysfunction, Critical Illness, Trauma
- Trial name
- TRAPETS (NCT05245253)
- Testing
- Positron Emission tomography
- Where
- Sweden
- Volunteers
- 20 people
- Sponsor
- Karolinska University Hospital
Scleroderma
Lung Clearance Index to Identify Scleroderma Patients at Risk for ILD
This National Jewish Health (NJH) Investigator Initiated pilot study funded by the Shah Foundation will prospectively perform a non invasive lung function test called Lung Clearance Index (LCI) to determine if 50 scleroderma…
- Trial name
- NCT04535245
- Testing
- LCI testing
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Jewish Health
Pulmonary Disease, COPD
The Virtual Reality Therapy as a Pulmonary Rehabilitation Supporting Method
This study evaluates the effectiveness of virtual reality (VR) therapy in the treatment of depression and anxiety symptoms in patients undergoing the pulmonary rehabilitation.
- Conditions
- Pulmonary Disease, COPD, Anxiety State, Stress
- Trial name
- NCT04601545
- Testing
- Pulmonary rehabilitation, Virtual therapeutic support
- Where
- 2 sites in Poland
- Volunteers
- 50 people
- Sponsor
- Wroclaw University of Health and Sport Sciences
Polyneuropathies
The Impact of IVIG Treatment on Critical Illness Polyneuropathy and/or Myopathy in Patients With MOF and SIRS/Sepsis
Critical illness polyneuropathy and/or myopathy (CIPNM) is a severe complication of critical illness. Retrospective data suggest that early application of IgM-enriched intravenous immunoglobulin (IVIG) may prevent or mitigate…
- Trial name
- CIPNM (NCT01867645)
- Testing
- IgM-enriched Intravenous Immunoglobulins, Human Albumin
- Where
- Austria
- Volunteers
- 38 people
- Sponsor
- Medical University of Vienna
Acute Renal Failure
AV Fistula Salvage in Advanced CKD Using Sodium Bicarbonate Prophylaxis
This is an observational study assessing the impact of conventional dose iodinated contrast on the renal function of advanced chronic kidney disease patients undergoing arteriovenous fistula evaluation using a standard sodium…
- Trial name
- NCT00621972
- Where
- United States
- Sponsor
- MaineHealth
Renal Insufficiency, Chronic, Food Insecurity
Penn Produce Prescription and Chronic Kidney Disease Study
The goal of this pilot clinical trial is to examine the feasibility, acceptability, and likely effect of a produce prescription intervention on patient-centered outcomes, health behaviors and health outcomes, among food insecure…
- Trial name
- NCT06561412
- Testing
- Produce Prescription
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Pennsylvania
HIV Infections
Effectiveness of a Telephone Intervention Program in Improving Depression, Coping, and Family Functioning in HIV-Infected Individuals and Caregivers
This study will evaluate the effectiveness of the Family Intervention: Telephone Tracking (FITT) program in improving depression, coping, and family functioning in HIV-infected individuals and their caregivers.
- Trial name
- NCT00183781
- Testing
- FITT: Family Intervention - Telephone Tracking
- Where
- United States
- Volunteers
- 270 people
- Sponsor
- Butler Hospital
Colorectal Cancer, Adult
PIN in Combination With Sintilimab in Previously Treated pMMR/MSS CRC With Hepatic Metastases
In this single-center,open-label, phase I study, the safety and efficacy of PIN in combination with anti-programmed cell death -1 (anti-PD1) antibody therapeutic regimen (sintilimab) will be evaluated in patients with advanced…
- Trial name
- NCT07411781
- Testing
- PIN+sintilimab
- Where
- China
- Volunteers
- 25 people
- Sponsor
- Chinese PLA General Hospital
Gastrointestinal Diseases
Regulation of Human Intestinal Bile Acid Transport in Health and Disease
This study investigates distribution and regulation of bile acid transport in the human intestine.
- Trial name
- NCT00018681
- Where
- United States
- Sponsor
- US Department of Veterans Affairs
Heart Disease, Heart Failure
Investigating Systemic and Local Vascular Responses to Apelin in the Context of Renin-angiotensin Upregulation
The apelin-APJ system is a relatively new discovery. It has generated interest in part due to it's apparent ability to counteract the renin-angiotensin system, which is frequently overactive in many cardiovascular disease.
- Conditions
- Heart Disease, Heart Failure, Vasodilatation
- Trial name
- NCT00901719
- Testing
- Apelin, Acetylcholine, Sodium nitroprusside
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Pain, Acute, Emergencies
Inhaled vs IV Opioid Dosing for the Initial Treatment of Severe Acute Pain in the Emergency Department
Prospective single-blind, multicenter, national, randomized, controlled trial in 15 Emergency Department to compare two ways of morphine titration.
- Conditions
- Pain, Acute, Emergencies, Morphine
- Trial name
- CLIN-AEROMORPH (NCT03257319)
- Testing
- inhaled titration of morphine chlorhydrate, IV titration of morphine chlorhydrate
- Where
- 20 sites in France
- Volunteers
- 226 people
- Sponsor
- University Hospital, Rouen
Pulmonary Disease, Chronic Obstructive
Prevalence of Different Haptoglobin Phenotypes in Patients With COPD- Frequent Exacerbators Versus Non Exacerbators
Chronic obstructive pulmonary disease (COPD) is a common disease in smokers. COPD has a slowly deteriorating course, punctuated by exacerbations- acute events characterized by increasing shortness of breath and putrid sputum.
- Trial name
- NCT01745419
- Where
- Israel
- Volunteers
- 105 people
- Sponsor
- Carmel Medical Center
Relapse/Refractory B-cell Acute Lymphoblastic Leukemia
Safety and Efficacy of CAR T Cell Therapy in Patients with R/r B-ALL
The goal of this clinical trial is to evaluate the safety and efficacy of CD19 CAR-T cells in pediatric patients of all genders, aged 2 to 18 years, with relapsing or refractory B cell acute lymphoblastic leukemia (r/r B-ALL).
- Trial name
- NCT06635330
- Testing
- anti-CD19 CAR T cell therapy
- Where
- Iran
- Volunteers
- 5 people
- Sponsor
- Kara Yakhteh Tajhiz Azma Company
Asthma
Real Life Effectiveness of Easyhaler (Orion)
The aim of this study is to compare the clinical effectiveness and cost-effectiveness of the Easyhaler® (EH) device and other DPI devices commonly used in the UK in a UK primary care asthma population of patients aged 6 to 80…
- Trial name
- NCT02048930
- Testing
- Budesonide Easyhaler, Budesonide dry powder inhaler
- Volunteers
- 24,003 people
- Sponsor
- Research in Real-Life Ltd
Venous Thromboembolism
Prophylactic Use of Sodium Enoxaparin for Venous Thromboembolism in High-Risk Abdominal Surgery
The purpose of this study is to compare the safety and security and efficacy of sodium enoxaparin Cristália Produtos Químicos Farmaceuticos Ltda - Endocris with Clexane (Sanofi-Aventis) to prevent Venous Thromboembolism in…
- Trial name
- NCT01308528
- Testing
- Sodium enoxaparin, Sodium Enoxaparin clexane
- Where
- 9 sites in Brazil
- Volunteers
- 243 people
- Sponsor
- Cristália Produtos Químicos Farmacêuticos Ltda.
Crohn's Disease
A Study of the Efficacy and Safety of Risankizumab in Participants With Moderately to Severely Active Crohn's Disease
The purpose of this study is to evaluate the efficacy and safety of risankizumab versus placebo during induction therapy in participants with moderately to severely active Crohn's disease (CD).
- Trial name
- NCT03105128
- Testing
- risankizumab IV, risankizumab SC
- Where
- 475 sites in United States, Argentina and 42 more
- Volunteers
- 931 people
- Sponsor
- AbbVie
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