Clinical trials: Otitis Media With Effusion (OME)
Otitis Media With Effusion in Children, Otitis Media Recurrent
Pediatric Pharmacokinetic (PK) Study of EXE844 Otic Suspension in Otitis Media at the Time of Tympanostomy Tube Insertion (OMTT)
The purpose of this study is to describe the pharmacokinetics (PK) of EXE844 Sterile Otic Suspension, 0.3% following a single bilateral ototopical dose in pediatric subjects, immediately after bilateral tympanostomy tube surgery.
- Trial name
- NCT02539654
- Testing
- EXE844 Sterile Otic Suspension, 0.3%, Tympanostomy Tube Insertion
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Alcon Research
Otitis Media
The Effects of Ventilation Tubes - The SIUTIT Trial
The prevalence of otitis media among Greenlandic children is one of the highest in the world and twenty per cent of schoolchildren have impaired hearing in the frequencies for normal speech.
- Trial name
- SIUTIT (NCT02490332)
- Testing
- Ventilation tube treatment
- Where
- 6 sites in Greenland
- Volunteers
- 31 people
- Sponsor
- Zealand University Hospital
Otitis Media With Effusion
Osteopathic Otitis Media Research Study
The purpose of this study is to determine if the application of osteopathic manipulative medicine speeds the rate of resolution of middle ear effusion (fluid) in children following an episode of acute otitis media.
- Trial name
- OOMRS (NCT00520039)
- Testing
- osteopathic manipulative medicine (OMM)
- Where
- 2 sites in United States
- Volunteers
- 52 people
- Sponsor
- West Virginia School of Osteopathic Medicine
Otitis Media With Effusion
Secretory Otitis Media in Adenoids Hypertrophy Patients
This study aims to compare the fate of Secretory Otitis Media in patients with adenoids hypertrophy undergoing Adenoidectomy alone or with Myringotomy or with Myringotomy and Tympanostomy Tube application
- Trial name
- NCT04584073
- Testing
- Adenoidectomy alone or with Myringotomy or with Myringotomy and Tympanostomy Tube application
- Volunteers
- 150 people
- Sponsor
- Assiut University
Otitis Media, Otitis Media Effusion
Osteopathic Manipulative Treatment for Children With Chronic or Recurrent Otitis Media
The goal of this clinical trial is to learn whether osteopathic manipulative treatment, or OMT, can reduce the need for tympanostomy tube surgery in children with recurrent or chronic otitis media who have been referred to an…
- Conditions
- Otitis Media, Otitis Media Effusion, Otitis Media Recurrent, Otitis Media With Effusion in Children
- Trial name
- NCT07639775
- Testing
- Experimental Osteopathic Manipulative Treatment (OMT) Protocol, Control Osteopathic Manipulative Treatment (OMT) Protocol
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Sarah Vidal
Otitis Media With Effusion After Nasopharyngeal Carcinoma
A Prospective, Randomized, Controlled Clinical Study of BET Combined With Tympanostomy Tube Insertion in the Treatment of Intractable OME After Radiotherapy for NPC
The primary purpose of this study is to compare balloon Eustachian tuboplasty (BET) combined with tympanostomy tube insertion and simply tympanostomy tube insertion in the treatment of otitis media with effusion (OME) in…
- Trial name
- NCT05449184
- Testing
- Balloon Eustachian Tuboplasty with Tympanostomy Tube Insertion, Tympanostomy Tube Insertion
- Where
- China
- Volunteers
- 208 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Otitis Media
Long-term Antibiotics for Treatment and Prevention of Otitis Media in Aborignal Children
This clinical trial was conducted in a population where tympanic membrane perforation occurs in 60% infants in the first year of life.
- Trial name
- COMIT1 (NCT00539149)
- Testing
- Amoxycillin
- Where
- Australia
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Menzies School of Health Research
Otitis Media With Effusion
Study of the Expression of MMPs in OME in Children With Atrophy of the Eardrum
Metalloproteinases (MMPs) constitute a family of endopeptidases that cleaves the extracellular matrix as collagen included in the eardrum. Activity of MMP has been shown in some otitis media with effusion (OME) fluids.
- Trial name
- MMP and OME (NCT03611842)
- Testing
- preservation of mucosal otitis media
- Where
- France
- Volunteers
- 35 people
- Sponsor
- University Hospital, Montpellier
Otitis Media With Effusion
Efficacy and Cost Analysis of Steroids in Treatment of Otitis Media With Effusion
We intend to study the cost of treatment, efficacy and adverse effects for Otitis media with effusion.
- Trial name
- NCT03590912
- Testing
- Mometasone 50 Mcg/Inh Nasal Spray, Antibiotics + Antihistamine (levocetirizine) + Nasal decongestants (Oxymetazoline 0.025%), Steroid Drug (prednisolone)
- Where
- Nepal
- Volunteers
- 160 people
- Sponsor
- Lumbini Medical College
Otitis Media, Middle Ear Effusion
Middle Ear Disease Before Age 3, Treatment With Ear Tubes, and Literacy and Attentional Abilities at Ages 9 to 11
Middle-ear disease (infection and fluid) is the most common illness in young children after the common cold. Because hearing loss accompanies middle-ear disease, and because early life is a period of rapid development, concern…
- Trial name
- NCT00365092
- Testing
- Insertion of tympanostomy tubes
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Otitis Media With Effusion
The Effect of Osteopatic Cranial Techniques on the Audiometric and Tympanometric Values in Children Suffering From Otitis Media With Effusion.
Children with otitis media with effusion will be treated with osteopatic cranial techniques or with a placebo treatment. Before and after the treatment audiometric and tympanometric measures will take place.
- Trial name
- NCT00547326
- Testing
- treated with osteopatic cranial techniques
- Where
- Belgium
- Sponsor
- University Hospital, Ghent
Otitis Media, Middle Ear Effusion
Clinical Study of Solo Tympanostomy Tube Device (TTD)
This is a multi-centre, single arm study to evaluate the placement of tympanostomy tubes with the AventaMed Solo Tympanostomy Tube Device (TTD)
- Trial name
- NCT02957578
- Testing
- Solo TTD
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Otitis Media Effusion, Nasopharyngeal Carcinoma
Distribution of Bacteria in OME After Radiotherapy For NPC.
To observe the prognostic difference of tympanocentesis in different kinds of otitis media effusion.
- Trial name
- NCT06523933
- Where
- China
- Volunteers
- 234 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Enlargement of Tonsil or Adenoid
Bioclinical Profile of Adenotonsillar Hypertrophy in the Pediatric Population
Adenotonsillar hypertrophy is the principal cause of obstructive sleep apnea of childhood, yet little is known with regard to its pathophysiologic and molecular mechanisms.
- Trial name
- NCT03541434
- Testing
- Complete Blood Count, Tympanometry, Tonsillectomy and/or adenoidectomy
- Where
- 2 sites in Greece
- Volunteers
- 134 people
- Sponsor
- University of Patras
Bilateral Middle Ear Effusion
Open-Label Study of OTO-201 for Middle Ear Effusion Evaluating Trans-Tympanostomy Tube Administration
This is a 1-month, prospective, multicenter, open-label study in pediatric subjects with bilateral middle ear effusion requiring tympanostomy tube placement.
- Trial name
- NCT02350998
- Testing
- OTO-201
- Where
- 5 sites in United States
- Volunteers
- 33 people
- Sponsor
- Otonomy, Inc.
Otitis Media With Effusion
A Non-invasive Device to Remove Fluid From the Middle Ear
A feasibility study for evaluating efficacy and satisfaction is treated using a non-invasive device for middle ear ventilation. The study is designed to test the device's effectiveness by encouraging the evacuation of fluid from…
- Trial name
- NCT03978195
- Testing
- Non-invasive device for middle ear ventilation
- Volunteers
- 40 people
- Sponsor
- Yuinvent Innovations Ltd.
Hearing Loss, Otitis Media With Effusion
Sound Ear Check (SEC) in Hearing Diagnostics in Young Children
Study Sound Ear Check (SEC) hearing test among 3-10 years old otherwise healthy children referred to tympanostomy tube placement.
- Conditions
- Hearing Loss, Otitis Media With Effusion, Tympanostomy
- Trial name
- NCT05535634
- Testing
- Sound Ear Check
- Where
- Finland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vesa Lahdes
Otalgia, Otitis Media
Validating and AI Software for Assessment of Children With Ear Concerns
The goal of this observational study is to determine if the Glimpse machine learning algorithm can accurately assess ear diseases in children.
- Conditions
- Otalgia, Otitis Media, Otitis Media Effusion
- Trial name
- NCT07243093
- Volunteers
- 658 people
- Sponsor
- Glimpse Diagnostics, Inc.
Chronic Otitis Infections in pédiatric Patients
Efficacy of KNT® (KINETUBE) in Recurrent Chronic Otitis Media in Children
Otitis media are the consequence of bacterial infection. They are characterized by middle ear inflammations with a collection of fluid behind the eardrum.
- Trial name
- KINETUBE (NCT02038400)
- Testing
- KINETUBE medical Device, insertion of tympanic ventilation tubes (tympanostomy)
- Where
- France
- Volunteers
- 140 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Otitis Media With Effusion, Acute Otitis Media
Evaluation of Outcomes Following In-office Tympanostomy Using the Tula® System: a Prospective, Multi-center Registry
This prospective, single-arm, multicenter registry is being conducted to collect real world post-market data from patients aged from 6 months to 17 years of age who are undergoing an in-office ear tube placement procedure…
- Conditions
- Otitis Media With Effusion, Acute Otitis Media, Otitis Media
- Trial name
- NCT05915078
- Testing
- Iontophoresis and tube placement
- Where
- 6 sites in United States
- Volunteers
- 200 people
- Sponsor
- Smith & Nephew, Inc.