Clinical trials: Otolaryngologic Disease
Allergic Rhinitis
Impact of Carrier Solutions for House Dust Mite Allergen on Allergic Reactions
Single-blind, within-block randomized, clean-air-controlled study to assess the effect of lactose and sodium chloride particles in patients with allergic rhinitis on nasal symptoms when challenged in the Fraunhofer Allergen…
- Trial name
- SIMBA (NCT05245175)
- Testing
- Sodium chloride particles, Lactose particles, Clean air
- Where
- Germany
- Volunteers
- 19 people
- Sponsor
- Fraunhofer-Institute of Toxicology and Experimental Medicine
Dysphagia
Intermittent Oro-esophageal Tube on Feeding Hesitancy in Stroke Patients
The aim of this clinical trial is to compare Feeding Hesitancy of ischemic stroke patients who receive enteral nutrition support through either Intermittent Oro-esophageal Tube or Nasogastric Tube.
- Trial name
- NCT06312371
- Testing
- Intermittent Oro-esophageal Tube Feeding, Nasogastric Tube Feeding
- Volunteers
- 80 people
- Sponsor
- Muhammad
Voice Disorders
Efficacy of Conversation Training Therapy (CTT)
Voice therapy is the standard-of-care for many of the nearly 140 million people in the United States who suffer from voice disorders,1 yet patients claim that current therapies are ineffective at meeting their voice needs.2…
- Trial name
- NCT02441348
- Testing
- Conversation Training Therapy
- Where
- United States
- Volunteers
- 67 people
- Sponsor
- University of Pittsburgh
Nasopharyngeal Neoplasms, Carcinoma
Docetaxel in Combination With Cisplatin-5-fluorouracil for the Induction Treatment of Nasopharyngeal Carcinoma in Children and Adolescents
The primary objective is to estimate the Complete Response rate of docetaxel to the combination of cisplatin-5-fluorouracil (TCF) compared to cisplatin-5-fluorouracil (CF) in the Induction treatment of Nasopharyngeal Carcinoma…
- Trial name
- NCT00565448
- Testing
- docetaxel, cisplatin, 5-fluorouracil
- Where
- 26 sites in Algeria, Brazil and 12 more
- Volunteers
- 75 people
- Sponsor
- Sanofi
Oropharyngeal Dysphagia, Geriatric Patients
Effect of Tongue-to-Palate Resistance Training in Geriatric Patients With Oropharyngeal Dysphagia
The goal of this randomized controlled trial is to learn if a home-based Tongue-to-Palate Resistance Training (TPRT) program can improve swallowing muscle activity and swallowing safety in geriatric patients (aged >60 years) with…
- Trial name
- NCT07203508
- Testing
- Tongue-to-Palate Resistance Training, Standard Dysphagia Therapy
- Where
- Indonesia
- Volunteers
- 17 people
- Sponsor
- Dr Cipto Mangunkusumo General Hospital
Sinusitis, Nasal Obstruction
Using ChatGPT to Help Guide Treatment for Sinus and Nasal Problems
The goal of this clinical trial is to evaluate whether ChatGPT can improve shared decision-making by increasing treatment-related knowledge and reducing decisional conflict in adult patients with chronic rhinosinusitis (CRS) or…
- Conditions
- Sinusitis, Nasal Obstruction, Rhinitis
- Trial name
- NCT07140250
- Testing
- Education with AI Technology, Education using Traditional Internet Search Engines
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Carol Yan
Usher Syndromes
Safety and Efficacy of NPI-001 Tablets for RP Associated With Usher Syndrome
This study will examine the safety and efficacy of NPI-001 Tablets as compared to placebo for 24 months in subjects with vision loss due to RP associated with Usher syndrome.
- Trial name
- SLO RP (NCT04355689)
- Testing
- NPI-001
- Where
- 4 sites in Australia
- Volunteers
- 49 people
- Sponsor
- Nacuity Pharmaceuticals, Inc.
Vertigo
Vestibular Evoked Myogenic Potentials in Benign Paroxysmal Positional Vertigo (VEMP in BPPV)
Benign Paroxysmal Positional Vertigo (BPPV) is the most frequent cause of vertigo of peripheral vestibular origin with life time incidence of 2.4%.
- Trial name
- NCT01004913
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Meir Medical Center
Laryngeal Disease, Spastic Dysphonia
Characteristics of Idiopathic Familial Voice Disorders
The purpose the study is to determine the genetic causes of specific voice disorders that run in families. Researchers are particularly interested in two conditions; 1. Spasmodic dysphonia 2.
- Conditions
- Laryngeal Disease, Spastic Dysphonia, Voice Disorder
- Trial name
- NCT00001552
- Where
- 4 sites in United States, United Kingdom
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Croup
A Cluster Controlled Trial Comparing Three Methods of Disseminating Practice Guidelines for Children With Croup
The purpose of this study is to identify, from a societal perspective, the costs and associated benefits of three strategies for disseminating and implementing a practice guideline that addresses the management of croup.
- Trial name
- NCT00147849
- Testing
- mailing of printed educational materials, a combination of interactive educational meetings, educational outreach visits, and reminders, identification of local opinion leaders and establishment of local consensus processes
- Sponsor
- Canadian Institutes of Health Research (CIHR)
Ototoxic Hearing Loss
Efficacy of Sodium Thiosulfate and Mannitol in Reducing Ototoxicity in Adult Patients Receiving Cisplatin Chemotherapy
One common side effect of cisplatin chemotherapy is ototoxicity. The drugs sodium thiosulfate and mannitol may protect against cisplatin-induced hearing loss.
- Trial name
- NCT05129748
- Testing
- Sodium Thiosulfate + Mannitol
- Where
- Canada
- Volunteers
- 92 people
- Sponsor
- Sunnybrook Health Sciences Centre
Hearing Loss
AM-111 in the Treatment of Acute Inner Ear Hearing Loss
The purpose of this research study is to test the effectiveness and safety of the study drug, AM-111. AM-111 is tested for the treatment of sudden sensorineural hearing loss where the cause is unknown.
- Trial name
- HEALOS (NCT02561091)
- Testing
- AM-111 0.4 mg/ml, AM-111 0.8 mg/ml
- Where
- Bulgaria
- Volunteers
- 256 people
- Sponsor
- Auris Medical AG
Neurofibromatosis 1 and 2 (NF1 and NF2)
A Single Center Pilot Study to Assess the Intra-observer Reliability of Measuring Muscle Strength Using a Hand Held Dynamometer in Children and Adults With Neurofibromatosis Type 1 (NF1) and Type 2 (NF2)
Patients with clinically confirmed neurofibromatosis type 1 (NF1) or neurofibromatosis type 2 (NF2) or a known neurofibromatosis (NF) mutation aged 5 years and above will be eligible to participate and will be recruited from the…
- Trial name
- NCT03672838
- Testing
- hand-held dynamometer
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- NYU Langone Health
Vestibular Rehabilitation, Vestibular Disease
Investigation of The Effect of Web-Based System With Oculomotor and Optokinetic Stimulation on Rehabilitation in Vestibular Hypofunction
The aim of this study was to investigate of the effect of web-based System with oculomotor and optokinetic stimulation on rehabilitation in vestibular hypofunction.
- Trial name
- NCT04133025
- Testing
- Vestibular Rehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Istanbul Medipol University Hospital
Tinnitus, Hyperacusis
Evaluation of the Elimination of Tinnitus and Hyperacusis by the ØREBLUE® Method
Tinnitus and hyperacusis are two hearing disorders that can severely impact the patient and their quality of life, as they may induce sleeping disorders, concentration troubles, social life disturbances.
- Trial name
- NCT04752176
- Testing
- ØREBLUE® Method
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Mayfair Developments
Hereditary Hemorrhagic Telangiectasia
A Study to Evaluate ALN-6400 in Healthy Volunteers and Patients With Hereditary Hemorrhagic Telangiectasia (HHT)
The purpose of this study is to: evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamics (PD) of single ascending doses of ALN-6400 in healthy volunteers evaluate the efficacy, safety, tolerability and PD of…
- Trial name
- InsigHHT (NCT06659640)
- Testing
- ALN-6400
- Where
- 16 sites in United States, Australia and 4 more
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Alnylam Pharmaceuticals
Exercise Induced Asthma, House Dust Mite Allergy
Epigenetic Regulation of Exercise Induced Asthma
The purpose of this study is to investigate the micro ribonucleic acid (mRNA) profiles of patients with EIA without allergic sensitization and EIA with house dust mite sensitization compared to that of healthy controls.
- Trial name
- NCT05174689
- Testing
- Exercise challenge in the cold chamber (ECC), mRNA profile, standard diagnostic
- Where
- Germany
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Johann Wolfgang Goethe University Hospital
Head and Neck Cancer, Xerostomia
Xerostomia Pilot Fudan: Acupuncture for Prevention of Radiation-Induced Xerostomia
PRIMARY AIM 1. Determine the feasibility of providing true and sham acupuncture treatment to patients at Fudan University Cancer Hospital (Cancer Hospital) who are receiving radiation treatment for cancer of the head and/or neck…
- Trial name
- NCT00862550
- Testing
- Acupuncture
- Where
- China
- Volunteers
- 23 people
- Sponsor
- M.D. Anderson Cancer Center
Rhinitis
Intranasal SB-705498 in Non-allergic Rhinitis Patients
This study is designed to look at the affect of SB-705498 on rhinitis symptoms, as induced by capsaicin challenge
- Trial name
- NCT01439308
- Testing
- SB-705498
- Where
- Netherlands
- Volunteers
- 40 people
- Sponsor
- GlaxoSmithKline
Deglutition Disorders, Parkinson Disease
Outcomes to the Nutritional Need of Patients With Parkinson's Disease
The intervention involves the identification of 140 patients (70 per group), fed throughout the duration of the study with the two different solutions indicated.
- Conditions
- Deglutition Disorders, Parkinson Disease, Nursing, Quality of Life
- Trial name
- W-Domus (NCT04983290)
- Testing
- weancare-domus
- Where
- Italy
- Volunteers
- 140 people
- Sponsor
- Milko Zanini
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