Clinical trials: Otorhinolaryngologic Diseases
Hearing Loss
Validation Of Cambodia Version of Five Minutes Hearing Test
Seek the simple tool as questionnaire for screening hearing loss. The FMHT was developed by American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS). It is a standard hearing questionnaire.
- Trial name
- CAM-FMHT (NCT05736055)
- Testing
- Cambodia Version Five Minutes Hearing Test
- Where
- Cambodia
- Volunteers
- 481 people
- Sponsor
- Khon Kaen University
Advanced Solid Tumors, Genital Neoplasm, Female
A Study of a Selective T Cell Receptor (TCR) Targeting, Bifunctional Antibody-fusion Molecule STAR0602 in Participants With Advanced Solid Tumors
This is an open label, multicenter, phase 1/2 study to assess the safety/tolerability and preliminary clinical activity of STAR0602 as a single agent and in combination with chemotherapy administered intravenously in participants…
- Conditions
- Advanced Solid Tumors, Genital Neoplasm, Female, Urogenital Neoplasms, Lung Neoplasm
- Trial name
- START-001 (NCT05592626)
- Testing
- STAR0602, Irinotecan (Camptosar), Docetaxel (Taxotere)
- Where
- 19 sites in United States, Canada and 2 more
- Volunteers
- 366 people
- Sponsor
- Marengo Therapeutics, Inc.
Nasopharyngeal Carcinoma
Safety and Efficacy Study of Icotinib With Intensity-modulated Radiotherapy in Nasopharyngeal Carcinoma
Nasopharyngeal carcinoma (NPC) is a prevalent disease in southeast of China. Radiation therapy with or without chemotherapy is a standard therapy for nasopharyngeal cancer.
- Trial name
- NCT01534585
- Testing
- Icotinib, intensity-modulated radiotherapy, Paclitaxel and Cisplatin
- Where
- China
- Volunteers
- 48 people
- Sponsor
- Taizhou Hospital
Rhinitis, Allergic, Perennial
A Clinical Study With Fluticasone Furoate Nasal Spray And Vehicle Placebo For The Treatment Of Perennial (Year-round) Allergic Rhinitis
The purpose of this study is to assess long-term ocular safety of fluticasone furoate nasal spray in adult and adolescent subjects diagnosed with perennial allergic rhinitis.
- Trial name
- NCT00682643
- Testing
- fluticasone furoate nasal spray
- Where
- 56 sites in United States
- Volunteers
- 550 people
- Sponsor
- GlaxoSmithKline
Allergic Rhinitis
Safety of Astepro 0.15% Nasal Spray and Astepro 0.1% Nasal Spray in Children Ages >6 Months to <6 Years With AR
The purpose of this study is to compare the safety of 2 different doses of the investigational use of an allergy medication (Astepro Nasal Spray) in the treatment of allergic rhinitis (AR).
- Trial name
- NCT01880840
- Testing
- 205.5 mcg of azelastine hydrochloride, 137 mcg of azelastine hydrochloride
- Where
- 14 sites in United States
- Volunteers
- 191 people
- Sponsor
- Meda Pharmaceuticals
Asthma, Respiratory Tract Infections
VItamin D in pregnanCy for prevenTion Of eaRlY Childhood Asthma
The overall aim of the study is to develop a nutritional preventive vitamin D supplementation strategy in pregnancy for early childhood asthma/persistent wheeze during the first three years of life as we hypothesize that…
- Conditions
- Asthma, Respiratory Tract Infections, Gastrointestinal Infection, Croup
- Trial name
- VICTORY (NCT06570889)
- Testing
- Cholecalciferol D3, Olive oil
- Where
- Denmark
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Professor Klaus Bønnelykke
Mucormycosis; Rhinocerebral (Etiology), Post COVID-19 Condition, Unspecified
Post-COVID-19 Mucormycosis in Critical Care
Background: Mucormycosis is a life-threatening opportunistic fungal infection. Despite mucormycosis having existed for decades, it has gained notice of its widespread in many parts of the world during the second wave of the…
- Trial name
- NCT05911035
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Zagazig University
Hearing Loss
Safety and Effectiveness of the MED-EL Electric-Acoustic System
The purpose of this investigation is to demonstrate the safety and effectiveness of the MED-EL Electric-Acoustic System (EAS), a medical device that combines the use of a cochlear implant with an external electric-acoustic…
- Trial name
- EAS (NCT00747435)
- Testing
- Electric Acoustic System
- Where
- 14 sites in United States
- Volunteers
- 73 people
- Sponsor
- Med-El Corporation
Microplastics, Otitis Media With Effusion
Microplastics in Otitis Media With Effusion Material
Microplastic rate is increasing ib athmosphere. They can be found in lung, kidney, heart, even placenta. Otitis media with effusion (OME) is a clinical condition that is ver common in children.
- Conditions
- Microplastics, Otitis Media With Effusion, Biofilms
- Trial name
- NCT06316635
- Testing
- ventilation tube insertion
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Kerem Kökoğlu
Misophonia, Emotion Dysregulation
Using Neurostimulation to Accelerate Change in Misophonia: a Pilot Study
Misophonia, the inability to tolerate certain repetitive distressing sounds that are common, is gaining, recognition as an impairing condition. It is not a well-understood condition and there are no known treatments.
- Conditions
- Misophonia, Emotion Dysregulation, Sensory Processing Disorder, Auditory Over Responsivity
- Trial name
- MISO-STIM (NCT06333925)
- Testing
- High Frequency Repetitive Transcranial Magnetic Stimulation (HF rTMS), Cognitive Restructuring
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Duke University
Rhinitis, Allergic, Seasonal
An Evaluation of the Efficacy and Safety of TOLAMBA™ for Ragweed-Allergic Rhinitis in an Environmental Exposure Chamber
This will be a randomized, double-blind, placebo-controlled, parallel-group, multicenter study. After passing the initial Screening Visit, subjects will be in the environmental exposure chamber(EEC), a room with a controlled…
- Trial name
- NCT00537355
- Testing
- Amb a 1 Immunostimulatory Oligoribonucleotide Conjugate, Histamine
- Where
- 6 sites in Canada
- Volunteers
- 271 people
- Sponsor
- Dynavax Technologies Corporation
Migraine, Headache
Is Topiramate Effective in Treating Dizziness in Patient's With Migraine-Associated Dizziness
The purpose of this study is to determine whether topiramate effective in treating dizziness symptoms that are associated with migraine headaches.
- Conditions
- Migraine, Headache, Dizziness
- Trial name
- NCT00732108
- Testing
- topiramate
- Where
- United States
- Sponsor
- University of California, San Francisco
Hearing Loss, Fatigue
Fatigue and Hearing Loss.
An intervention group and a control group will complete a battery of questionnaires at four time points to investigate the impact of first-ever hearing aid fitting on fatigue and associated variables.
- Trial name
- NCT04875117
- Testing
- Hearing aid
- Where
- 2 sites in United Kingdom
- Volunteers
- 129 people
- Sponsor
- University of Nottingham
Allergic Rhinitis
Efficacy and Safety of Arbidol in the Treatment of Allergic Rhinitis
The most important treatment for AR is topical nasal medications (including nasal corticosteroids, nasal antihistamines, nasal decongestants, and nasal saline irrigation etc.), which are still limited.
- Trial name
- NCT06462417
- Testing
- Arbidol
- Where
- 2 sites in China
- Volunteers
- 15 people
- Sponsor
- Zheng Liu
Hearing Loss, Depression
Treating Hearing Loss to Improve Mood and Cognition in Older Adults
Age-related hearing loss (ARHL) is the third most common health condition affecting older adults after heart disease and arthritis and is the fifth leading cause of years lived with disability worldwide.
- Trial name
- NCT03321006
- Testing
- Phonak Audeo B-R 90 hearing aid device (Active), Duloxetine or escitalopram
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- New York State Psychiatric Institute
Vestibular System Disorder
The Effect of Galvanic Stimulation on vHIT and VEMP Tests
Introduction: Galvanic vestibular stimulation (GVS) is a well-established technique with a history spanning over a century, primarily used to manipulate the vestibular system.
- Trial name
- NCT06123949
- Testing
- Galvanic Vestibular Stimulation
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Neurofibromatosis 1 and 2 (NF1 and NF2)
A Single Center Pilot Study to Assess the Intra-observer Reliability of Measuring Muscle Strength Using a Hand Held Dynamometer in Children and Adults With Neurofibromatosis Type 1 (NF1) and Type 2 (NF2)
Patients with clinically confirmed neurofibromatosis type 1 (NF1) or neurofibromatosis type 2 (NF2) or a known neurofibromatosis (NF) mutation aged 5 years and above will be eligible to participate and will be recruited from the…
- Trial name
- NCT03672838
- Testing
- hand-held dynamometer
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- NYU Langone Health
Nasopharyngeal Cancers, Lung Cancer (NSCLC)
The Clinical Application Value of CAIX-Targeted PET Hypoxia Imaging in Malignant Tumors
This project involves conducting integrated PET/MR or PET/CT imaging using a CAIX-targeted PET tracer (e.g., [68Ga]Ga-DOTA-CAIX peptide) in clinically diagnosed malignant tumor patients, aiming to achieve the following…
- Conditions
- Nasopharyngeal Cancers, Lung Cancer (NSCLC), Esophageal Cancer, Glioma
- Trial name
- NCT07890038
- Testing
- Specific PET Imaging Agent Targeting CAIX
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Nasopharyngeal Carcinoma
18F-FMISO PET Guided Dose Escalation in Nasopharyngeal Carcinoma - a Feasibility and Planning Study
This study aims to investigate the use of 18F-FMISO PET in identifying hypoxic subvolume for dose escalation radiotherapy in nasopharyngeal cancer and thus improve local control without significant increase in toxicities.
- Trial name
- NCT04995185
- Testing
- (18)F-fluoromisonidazole (FMISO)
- Where
- 2 sites in Singapore
- Volunteers
- 9 people
- Sponsor
- National Cancer Centre, Singapore
Eustachian Tube Dysfunction, Middle Ear Disease
Ph.D.-Project: Eustachian Tube Dysfunction: Causes, Diagnosis, Treatment, and Prognosis
Background: The Eustachian Tube (ET) is a mucosa-lined connection between the nasopharynx and the middle ear cavity. It is believed to have three functions: 1) ventilation of and pressure equalization in the middle ear cavity, 2)…
- Conditions
- Eustachian Tube Dysfunction, Middle Ear Disease, Hearing Loss, Conductive, Middle Ear Problem
- Trial name
- NCT05055115
- Testing
- Balloon Eustachian Tuboplasty
- Where
- Denmark
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Regional Hospital West Jutland
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