Clinical trials: Otorhinolaryngologic Diseases
Hearing Loss
Sound Processing Innovations in Adult and Paediatric Cochlear Implant Recipients.
This is a feasibility, prospective with sequential enrolment, multicenter, clinical investigation in adults and paediatrics with a CE approved Nucleus cochlear implant. Subjects older than 5 years will be included.
- Trial name
- NCT05476328
- Testing
- SPACE, OPAL-SPACE, ACE
- Where
- 5 sites in Australia, Belgium
- Volunteers
- 8 people
- Sponsor
- Cochlear
Primary Ciliary Dyskinesia
Respiratory Muscle Strength, Exercise Capacity and Physical Activity Levels in Children Primary Ciliary Dyskinesia
Primary ciliary dyskinesia is an autosomal recessive disorder characterized by abnormal ciliary movement and disrupted mucociliary clearance.
- Trial name
- NCT03370029
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Gazi University
Larynx Cancer
Clinical Feasibility of New Tracheoesophageal Puncture Set
During a total laryngectomy a puncture is created in the tracheoesophageal wall and a voice prosthesis is inserted. With this voice prosthesis the patient learns to speak again.
- Trial name
- NCT01045057
- Testing
- Puncture Set and Flexible Protector
- Where
- 5 sites in Belgium, Germany and 2 more
- Volunteers
- 27 people
- Sponsor
- Atos Medical AB
Dysphagia, Sarcopenia
Masseter and Rectus Femoris Ultrasound for Dysphagia and Sarcopenia in Critically Ill Patients
Dysphagia and sarcopenia are common complications in critically ill patients and are associated with increased morbidity, prolonged hospitalization, nutritional complications, and poorer clinical outcomes.
- Trial name
- NCT07787312
- Where
- Spain
- Volunteers
- 323 people
- Sponsor
- Sara Casanova Prieto
Nasopharyngeal Carcinoma (NPC)
Toripalimab, Induction Chemotherapy, Radiation Therapy With Omega-3 for Locally Advanced Nasopharyngeal Carcinoma
The aim of this study is to evaluate the efficacy, adverse reactions, nutritional status analysis, and quality of life analysis of Toripalimab Plus Induction Chemotherapy Followed by Radiation Therapy Combined with Omega-3 in the…
- Trial name
- NCT07136519
- Testing
- Toripalimab, Omega-3, radiotherapy
- Where
- 3 sites in China
- Volunteers
- 30 people
- Sponsor
- Affiliated Hospital of Guangdong Medical University
Oral Cancer, Chatbot
Enhancing Oral Cancer Awareness
To evaluate the impact of AI-powered chatbot interactions versus traditional educational handouts on increasing participants' knowledge of oral cancer and its prevention
- Conditions
- Oral Cancer, Chatbot, Patient Education, Prevention
- Trial name
- NCT06682494
- Testing
- Traditional Education, AI-powered Chatbox
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Allergic Rhinitis
Allergen Challenge Chamber Study With Single Dose Intranasal GSK1004723 Compared With Placebo
This is a placebo-controlled, 3-period crossover study to assess the efficacy and safety of two single doses of an intranasal anti-histamine GSK1004723 compared with placebo in an allergen challenge chamber in male subjects with…
- Trial name
- NCT00824356
- Testing
- GSK1004723 (200mg), GSK1004723 (1000mg)
- Where
- Germany
- Volunteers
- 54 people
- Sponsor
- GlaxoSmithKline
BPPV
Efficacy of a New Type of Mechanical Rotational Chair in Treating BPPV
A study to establish the efficacy of a new type of mechanical rotational chair in treating BPPV. In addition, comparison of three types of treatment maneuvers using the mechanical rotational chair.
- Trial name
- NCT04147156
- Testing
- Epley's Maneuver, Semont Maneuver, 360 degree vertical rotation
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- Aalborg University Hospital
Larynx, Lip, Oral Cavity and Pharynx
Nivolumab, Ipilimumab, and Radiation Therapy in Treating Patients With Stage III-IVB Head and Neck Cancer
This pilot clinical trial studies the side effects of nivolumab, ipilimumab and radiation therapy in treating patients with stage IVA-B head and neck cancer.
- Trial name
- NCT03162731
- Testing
- Nivolumab, Ipilimumab, Simultaneous-Integrated Boost Intensity-Modulated Radiation Therapy
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University
Nasopharyngeal Carcinoma (NPC), Minimal Residual Disease
Integrating Allogeneic NK Cells in High-risk Advanced Stage III-IV Nasopharyngeal Cancer Patients
This clinical trial aims to determine whether Natural Killer (NK) cell therapy administered in combination with concurrent chemoradiotherapy (CRT) can reduce recurrence in patients with advanced nasopharyngeal cancer (NPC), and…
- Conditions
- Nasopharyngeal Carcinoma (NPC), Minimal Residual Disease, Recurrent Nasopharyngeal Carcinoma, Maximum Tolerated Dose
- Trial name
- AlloNK1 (NCT07247201)
- Testing
- Allogenic expanded Natural Killer Cells (AlloNK1)
- Where
- Singapore
- Volunteers
- 31 people
- Sponsor
- Singapore General Hospital
TPF, Immunotherapy
A Phase II Study of TPF With PD-1 Inhibitor Induction Therapy for Locally Advanced Nasopharyngeal Carcinoma
NPC is one of the most common malignant tumors in the head and neck region of China. Currently, the main treatment regimen for LA-NPC is radical concurrent chemoradiotherapy combined with induction or adjuvant chemotherapy.
- Conditions
- TPF, Immunotherapy, Nasopharyngeal Carcinoma, Phase II Clinical Study
- Trial name
- NCT06781112
- Testing
- albumin paclitaxel (200mg/m2), cisplatin (60mg/m2, infused over 3 days), 5-fluorouracil (3000mg/m2, continuously intravenously pumped for 120 hours), and tislelizumab ( 200mg).
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Weiwei Zhang
Allergic Rhinitis
Two Formulations and Concentrations of Epinastine Nasal Spray Versus Azelastine Nasal Solution for Allergic Rhinitis
The objectives of this study were to: Examine the tolerability of two formulations and two dose concentrations of epinastine. Select formulation(s) of epinastine for future studies by evaluating the individual sensory attribute…
- Trial name
- NCT01382654
- Testing
- epinastine 0.1%, epinastine 0.1% with taste masking agent, epinastine 0.2%
- Volunteers
- 131 people
- Sponsor
- Merck Sharp & Dohme LLC
Unilateral Deafness
Evaluation of BiCROS Fitting Benefits
22 candidates for BiCROS hearing aids will be recruited and fitted with a hearing aid and a CROS device. Following a real-world trial, each participant will be tested on a range of outcome measures including speech recognition in…
- Trial name
- NCT05379231
- Testing
- Hearing aid fitting
- Where
- 2 sites in Canada
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Sonova AG
Velopharyngeal Insufficiency
Effect of Velopharyngeal Gap Size on Laryngeal Morphology and Vocal Function in Children With VPI
Speech production relies on the precise coordination of the respiratory, phonatory, resonatory, and articulatory systems . The velopharyngeal mechanism is essential in separating the oral and nasal cavities during speech and…
- Trial name
- NCT07832812
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Assiut University
Sinusitis
Rates of Middle Meatal Synechia Formation Following Functional Endoscopic Sinus Surgery
Functional endoscopic sinus surgery (FESS) is the best method of surgically treating patients who suffer from sinus disease. Synechiae formation in the nose is the most common complication after sinus surgery.
- Trial name
- SYNECHIAE (NCT02077322)
- Testing
- Silastic Spacer, Merocel Spacer
- Where
- Canada
- Volunteers
- 48 people
- Sponsor
- St. Paul's Hospital, Canada
Seasonal Allergic Rhinitis
Prospective, Randomized, Multinational, Multicenter, Double-blind, Placebo and Active Controlled Trial in 4 Parallel-groups of Patients Suffering From Seasonal Allergic Rhinitis
The trial will be conducted as a prospective, randomized, multinational, multicenter, double-blind, placebo and active controlled trial in 4 parallel-groups of patients suffering from seasonal allergic rhinitis.
- Trial name
- NCT05311475
- Testing
- Mometasone, Azelastine
- Where
- 28 sites in Bulgaria, Germany and 2 more
- Volunteers
- 669 people
- Sponsor
- Sandoz
Nasopharyngeal Carcinoma
Neoadjuvant Therapy of GP Chemotherapy Combined With Tislelizumab in Locoregionally Advanced NPC
The purpose of this study is to explore the efficacy and safety of a combination of GP chemotherapy and tislelizumab in neoadjuvant therapy of locoregionally advanced nasopharyngeal carcinoma patients.
- Trial name
- NCT04833257
- Testing
- GP combine with Tislelizumab neoadjuvant therapy+CCRT
- Where
- China
- Volunteers
- 63 people
- Sponsor
- Sun Yat-sen University
Seasonal Allergic Rhinitis
Montelukast in Patients With Seasonal Allergic Rhinitis - Spring 2000 Study (MK-0476A-162)(COMPLETED)
This study will evaluate the ability of montelukast to improve the signs and symptoms of seasonal allergic rhinitis compared with loratadine and placebo.
- Trial name
- NCT00979901
- Testing
- Comparator: montelukast, Comparator: loratadine, Comparator: montelukast/loratadine
- Volunteers
- 1,577 people
- Sponsor
- Organon and Co
Hearing Loss
Clinical Validation of the Lexie Lumen Hearing Aid
More than half a billion people globally have hearing loss. Most hearing loss is sensorineural, meaning that the hearing loss is irreversible and requires rehabilitation.
- Trial name
- NCT05337748
- Testing
- Lexie Self Test and Fit Group, Lexie Professional Test and Fit Group
- Where
- South Africa
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- hearX Group
Nasal Polyps
A Study of the Effectiveness and Safety of Mometasone Furoate Nasal Spray (MFNS, SCH 032088) for the Treatment of Nasal Polyps (P05604)
This study will evaluate the effectiveness and safety of MFNS in improving nasal congestion/obstruction and in reducing bilateral nasal polyps.
- Trial name
- NCT01386125
- Testing
- Mometasone Furoate Nasal Spray (MFNS)
- Volunteers
- 748 people
- Sponsor
- Organon and Co
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