Clinical trials: Otorhinolaryngologic Diseases
Hearing Loss
Exploration of the Functional Effect of Modified Gain Precalculation on Soft Speech Intelligibility
An exploratory investigation of gain precalculation principles in CE-labelled Sonova brand hearing instruments (e.g. Phonak hearing instruments) is intended to be conducted on hearing impaired participants.
- Trial name
- NCT07388784
- Testing
- Competitor device, hearing aid with standard gain precalculation principle, Hearing aid with gain precalculation principle 1, Hearing aid with gain precalculation principle 2
- Where
- Switzerland
- Volunteers
- 14 people
- Sponsor
- Sebastian Griepentrog
Nasopharyngeal Carcinoma
Study of Concurrent Chemotherapy and Radiotherapy for Stage II Nasopharyngeal Carcinoma
The primary objective of this study is to determine the overall survival in patients with stage II (T1-2N1M0) NPC treated with concurrent chemotherapy and radiotherapy.
- Trial name
- NCT00817258
- Testing
- cisplatin, 3D-CRT (three-dimensional conformal radiation therapy) or IMRT (intensity-modulated radiation therapy)
- Where
- China
- Volunteers
- 37 people
- Sponsor
- Fudan University
Postoperative Vocal Cord Mobility, Recurrent Laryngeal Nerve Injury
C-MAC D-Blade vs Macintosh for Postoperative Vocal Cord Evaluation
This study compares two different laryngoscopes-the C-MAC D-Blade videolaryngoscope and the Macintosh direct laryngoscope-for evaluating vocal cord mobility after thyroidectomy.
- Trial name
- NCT07277985
- Testing
- Videolaryngoscope (C-MAC D-Blade), Direct Laryngoscope (Macintosh)
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people
- Sponsor
- Inonu University
Nasopharyngeal Carcinoma
Gemcitabine and Camrelizumab Plus Apatinib Versus Cisplatin in First-line Treatment of RM-NPC
This study aims to explore a new, more effective and tolerable treatment regimen for patients with advanced recurrent/metastatic nasopharyngeal carcinoma.
- Trial name
- NCT05854849
- Testing
- Camrelizumab, Gemcitabine, Cisplatin
- Where
- China
- Volunteers
- 244 people
- Sponsor
- Sun Yat-sen University
Otitis Media With Effusion
OTO-201 for the Treatment of Middle Ear Effusion in Pediatric Subjects Requiring Tympanostomy Tube Placement
The purpose of this study is to confirm the effectiveness, safety and tolerability of OTO-201 in the treatment of pediatric subjects with bilateral middle ear effusion who require tympanostomy tube placement.
- Trial name
- NCT01949155
- Testing
- OTO-201
- Where
- United States
- Volunteers
- 266 people
- Sponsor
- Otonomy, Inc.
Sleep Apnea
Evolution of Swallowing in Patients Undergoing Lateral Pharyngoplasty With Preservation Stylopharyngeal Muscle
Evolution of swallowing in patients undergoing lateral pharyngoplasty with preservation stylopharyngeal muscle.
- Trial name
- NCT01576926
- Where
- Brazil
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Hospital do Servidor Publico Estadual
House Dust Mite Allergy
Safety and Efficacy of House Dust Mite Allergen Extract in the Treatment of Allergic Rhinoconjunctivitis
The trial is performed to assess efficacy and safety of Novo-Helisen Depot in allergic Rhinoconjunctivitis
- Trial name
- NCT00263549
- Testing
- House dust mite Novo Helisen Depot
- Where
- Germany
- Sponsor
- Allergopharma GmbH & Co. KG
Dysphagia
Effect of Myofascial Release on Dysphagia in Stroke Survivors
The goal of this clinical trial is to explore Clinical Effect of Myofascial Release Therapy in Dysphagic Stroke Survivors. The main question it aims to answer is: Can Myofascial Release Therapy improve swallowing function in…
- Trial name
- NCT06256848
- Testing
- Rehabilitation treatment, Myofascial Release Therapy
- Where
- Philippines
- Volunteers
- 80 people
- Sponsor
- Zeng Changhao
Hearing Loss
Hearing Aid Transmitter Performance Study - SRF-366
Sonova Hearing Systems pass through different development and study stages. At an early stage, feasibility studies are conducted to investigate new algorithms, features and functions in an isolated manner.
- Trial name
- NCT04774185
- Testing
- New hearing aid loudspeaker, Standard hearing aid loudspeaker
- Where
- Australia
- Volunteers
- 23 people
- Sponsor
- Sonova AG
Hearing Loss, Noise-Induced
Risk Factors for Hearing Loss as a Result of Exposure to Noise During Military Training in the IDF
As part of the proposed work, the investigators would like to examine whether there is a need to use a training video to train IDF combat soldiers to improve the use of ear plugs and to prevent hearing loss from exposure to…
- Trial name
- NCT03314116
- Testing
- Guidance on auditory protection
- Where
- Israel
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Medical Corps, Israel Defense Force
Conductive Hearing Loss, Middle Ear
Ossiview Normative Mobility Data Collection Protocol
The goal of this observational study is to learn about the sound-induced vibration level of certain structures in the middle ear in the normal-hearing population.
- Trial name
- NCT06310278
- Testing
- Ossicular mobility measurement
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Audioptics Medical Incorporated
Parkinson Disease, Dysphagia
Impact of Swallowing Impairment on Individuals With Parkinson Disease
In this online study, investigators will explore the psychosocial burdens of swallowing difficulties in people with Parkinson's Disease.
- Trial name
- NCT04769843
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Northern Arizona University
Sinusitis, Chronic, Asthma
Aggravated Airway Inflammation: Research on Genomics and Optimal Operative Treatment (AirGOs Operative)
This randomized study compares operative techniques in chronic rhinosinusitis with polyposis (CRSwNP) surgery. It aims to evaluate outcomes in asthma and CRSwNP, safety and costs.
- Conditions
- Sinusitis, Chronic, Asthma, Nasal Polyps, Aspirin Sensitivity
- Trial name
- NCT03704415
- Testing
- Extended endoscopic sinus surgery, Limited endoscopic sinus surgery
- Where
- 3 sites in Finland, Netherlands
- Volunteers
- 97 people
- Sponsor
- Helsinki University Central Hospital
Dysphagia
TTE and Dysphagia in Anterior Cervical Surgery
The purpose of this study is to evaluate if Tracheal Traction Exercises (TTE) performed prior to anterior cervical spine surgery can result in a decreased rate of dysphagia.
- Trial name
- NCT02326116
- Testing
- Trachael Preparation Education
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Rochester
Tinnitus, Acute
In This Study, we Are Testing Whether Combining Two Interventions, in the Early Stages of Tinnitus, is More Effective in Quieting Tinnitus Than Using One Treatment Alone in the Later Stages of Tinnitus
Tinnitus affects one in seven adults long-term Once present persistently for 4 weeks, tinnitus does not usually disappear People generally become less aware of, and less affected by, their tinnitus over time Only one in six…
- Trial name
- ATtDCS (NCT07128004)
- Testing
- tDCS, sound therapy
- Volunteers
- 80 people
- Sponsor
- Newcastle University
Sensorineural Hearing Loss, Bilateral, Cochlear Implants
Feasibility of the Mi2000 Totally Implantable Cochlear Implant in Severely to Profoundly Deaf Adults.
This clinical investigation aims to collect data on the use of the Mi2000 system, a totally implantable cochlear implant system, for the first time in human subjects.
- Trial name
- TICI (NCT04571333)
- Testing
- Mi2000 Totally Implantable Cochlear Implant
- Where
- 2 sites in Belgium, Germany
- Volunteers
- 6 people
- Sponsor
- MED-EL Elektromedizinische Geräte GmbH
Acute Otitis Externa
A Phase III Study of an Otic Formulation in Acute Otitis Externa
The purpose of this study is to determine if an otic formulation is safe and effective for the treatment of acute otitis externa (AOE).
- Trial name
- NCT00750633
- Testing
- Moxidex otic solution, Moxifloxacin otic solution, Dexamethasone phosphate otic solution
- Volunteers
- 990 people
- Sponsor
- Alcon Research
Primary Ciliary Dyskinesia
Clearing Lungs With ENaC Inhibition in Primary Ciliary Dyskinesia
To evaluate the safety and efficacy of treatment with VX-371 with and without ivacaftor, and the effect of VX-371 with and without ivacaftor on quality of life (QOL) in subjects with primary ciliary dyskinesia (PCD).
- Trial name
- CLEAN-PCD (NCT02871778)
- Testing
- VX-371, Hypertonic Saline, VX-371 + HS
- Where
- 34 sites in United States, Canada and 6 more
- Volunteers
- 123 people
- Sponsor
- Parion Sciences
Vestibular Disorder
Vestibular Function and Vestibular Rehabilitation in SSHL With Vertigo
To evaluate the vestibular function and vestibular rehabilitation in sudden sensorneural hearing loss(SSHL) with vertigo
- Trial name
- NCT03431506
- Testing
- Vestibular rehabilitation
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Eye & ENT Hospital of Fudan University
Allergic Rhinitis, Allergic Rhinitis Due to Grass Pollen
Study to Assess the Safety, Tolerability, and Preliminary Efficacy of B244 in Healthy Volunteers and Subjects With Seasonal Allergic Rhinitis
This is a Prospective, Controlled, Double Blinded, Single Center, Randomized, 3 Arm, Parallel Assignment, Phase 1b/2a Study to assess the safety, tolerability, and preliminary efficacy of B244 delivered as an intranasal spray in…
- Conditions
- Allergic Rhinitis, Allergic Rhinitis Due to Grass Pollen, Healthy Volunteers
- Trial name
- NCT03290248
- Testing
- B244 suspension, Vehicle
- Where
- 2 sites in United States, Canada
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- AOBiome LLC
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