Clinical trials: Otorhinolaryngologic Diseases
Unilateral Hearing Loss, Asymmetric Hearing Loss
Evaluation of Cochlear Implantation in Unilateral or Asymmetric Hearing Loss in Children.
Today, unilateral hearing loss must be assessed and managed just as bilateral hearing loss is. It is recommended to consider the auditory difficulties caused by the loss of stereophonic hearing and to offer auditory…
- Trial name
- AsymIC-Ped (NCT06930170)
- Testing
- Cochlear implantation, CROS or BiCROS device fitting, French simplified matrix test (FraSimat)
- Where
- France
- Volunteers
- 36 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Tinnitus
Task-Based Functional MRI (fMRI) in Patients With Severely Bothersome Tinnitus
Tinnitus is a poorly understood symptom that is often described either as ringing, clicking, ocean sounds, or nature sounds. There is no cure for tinnitus.
- Trial name
- NCT01172262
- Testing
- MRI
- Sponsor
- Washington University School of Medicine
Allergic Asthma, Allergic Rhinitis
Efficacy of Face Mask in Reducing Respiratory Allergic Symptoms in Birch-allergic Subjects in ALYATEC Exposure Chamber
There is no clinical evidence that face masks are efficient in birch pollen-induced asthma. As the use of face masks has become widespread worldwide to limit the spread of SARS-CoV-2, this study aims to demonstrate the clinical…
- Trial name
- NCT06267261
- Testing
- KOLMI® surgical face mask (OP-Air)
- Where
- France
- Volunteers
- 24 people
- Sponsor
- Alyatec
Nasopharyngeal Carcinoma
Endostar Combined With Induction Chemotherapy and Concurrent Chemoradiotherapy for Locoregional Nasopharyngeal Carcinoma
Endostar Continuous Intravenous Infusion Combined With Induction Chemotherapy and Concurrent Chemoradiotherapy for Locoregionally Advanced Nasopharyngeal Carcinoma.
- Trial name
- NCT03932266
- Testing
- Endostar, Cisplatin, Docetaxel
- Volunteers
- 73 people
- Sponsor
- Jiangsu Cancer Institute & Hospital
Swallowing Disorder, Traumatic Brain Injury
Swallowing Disorders in Minimally Consciousness Patients (MCS)
This study aimed to characterize swallowing disorders in minimally consciousness patients after brain traumatic injury.
- Trial name
- TC-DEG (NCT03562104)
- Testing
- videofluoroscopy, Wessex Head Injury Matrix scale
- Where
- 2 sites in France
- Volunteers
- 34 people
- Sponsor
- University Hospital, Rouen
Dysphagia, Late Effect of Stroke
Capsaicin for Post-stroke Dysphagia
Randomised, double blind, Phase 2 Trial to evaluate the efficacy of oral Capsaicin in patients with post-stroke dysphagia in the (sub-)acute setting.
- Trial name
- CADYS (NCT04470752)
- Testing
- Capsaicin 1% oral solution, InOrpha Solution
- Where
- Switzerland
- Volunteers
- 82 people
- Sponsor
- Georg Kägi, MD
Chronic Rhinosinusitis Without Nasal Polyps
Corticosteroid Therapy for Chronic Rhinosinusitis Without Nasal Polyps (CRSsNP)
The purpose of this study is to determine the most effective route to administer steroids to patients with chronic sinusitis, specifically a type of chronic sinusitis not associated with nasal polyps (CRSsNP).
- Trial name
- NCT01676415
- Testing
- Prednisone, Topical mometasone
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Northwestern University
Infections, Child
Japanese Study Evaluating Safety, Efficacy and Acceptability of Telithromycin in Children With Infections
The primary objective is to assess the safety of telithromycin (HMR 3647) (20% fine granules) 1g filling sachet in children with infections (Respiratory tract infections, Dermatological infections, Otorhinolaryngological…
- Trial name
- NCT00408135
- Testing
- telithromycin (HMR3647)
- Where
- Japan
- Volunteers
- 111 people
- Sponsor
- Sanofi
Primary Ciliary Dyskinesia
Clearing Lungs With ENaC Inhibition in Primary Ciliary Dyskinesia
To evaluate the safety and efficacy of treatment with VX-371 with and without ivacaftor, and the effect of VX-371 with and without ivacaftor on quality of life (QOL) in subjects with primary ciliary dyskinesia (PCD).
- Trial name
- CLEAN-PCD (NCT02871778)
- Testing
- VX-371, Hypertonic Saline, VX-371 + HS
- Where
- 34 sites in United States, Canada and 6 more
- Volunteers
- 123 people
- Sponsor
- Parion Sciences
Nasopharyngeal Carcinoma
Induction Chemotherapy With GP Versus TPF in the Treatment of Advanced Nasopharyngeal Carcinoma
The present study is a randomized, control, phase II study of locally advanced nasopharyngeal carcinoma (NPC) treated with Gemcitabine plus cisplatin regimen (GP) or Docetaxel，cisplatin regimen plus 5-Fluorouracil (TPF) induction…
- Trial name
- NCT02016417
- Testing
- A combination of Gemcitabine and cisplatin, A combination of Docetaxel, cisplatin and 5-Fluorouracil
- Volunteers
- 120 people
- Sponsor
- Cancer Hospital of Guangxi Medical University
Hyperacusis
Exploratory Study on the Role of Somatic Modulation in Hyperacusis
This study focuses on patients with a primary complaint of hyperacusis. Hyperacusis has been defined as 'abnormally reduced tolerance to sound' and is commonly associated with tinnitus.
- Trial name
- NCT04693819
- Testing
- Somatic modulation
- Where
- Belgium
- Volunteers
- 18 people
- Sponsor
- University Hospital, Antwerp
Nasopharyngeal Carcinoma, Nasopharyngeal Cancer
Nivolumab in Children and Adults With Nasopharyngeal Carcinoma
The purpose of this study is to assess whether the addition of the immune checkpoint inhibitor Nivolumab to induction chemotherapy will increase the percentage of patients with a complete response on MRI and PET after 3 cycles of…
- Conditions
- Nasopharyngeal Carcinoma, Nasopharyngeal Cancer, Nasopharyngeal Neoplasms, Nasopharynx Cancer
- Trial name
- NPC-Nivo (NCT06019130)
- Testing
- Nivolumab, Cisplatin, 5-Fluorouracil
- Where
- 31 sites in Germany
- Volunteers
- 57 people
- Sponsor
- German Society for Pediatric Oncology and Hematology GPOH gGmbH
Hearing Impaired Children
Bimodal Stimulation Compared to Unilateral Cochlear Implant
The majority of studies about bimodal hearing advantages have been conducted on adults but scant relevant studies into pediatric users, therefore more comparative studies are required to compare the effect of bimodal stimulation…
- Trial name
- NCT04093830
- Testing
- hearing aid
- Volunteers
- 25 people
- Sponsor
- Assiut University
Head and Neck Basaloid Carcinoma, Recurrent Head and Neck Squamous Cell Carcinoma
Ficlatuzumab w/wo Cetuximab in Patients w/Cetuximab-Resistant, Recurrent or Metastatic Head/Neck Squamous Cell Carcinoma
This randomized phase II trial studies how well ficlatuzumab with or without cetuximab works in treating patients with head and neck squamous cell carcinoma that has come back or spread to other places in the body and resistant…
- Conditions
- Head and Neck Basaloid Carcinoma, Recurrent Head and Neck Squamous Cell Carcinoma, Recurrent Oropharyngeal Squamous Cell Carcinoma, Squamous Cell Carcinoma of Unknown Primary Origin
- Trial name
- NCT03422536
- Testing
- Cetuximab, Ficlatuzumab
- Where
- 6 sites in United States
- Volunteers
- 78 people
- Sponsor
- University of Arizona
Dysphagia, Sarcopenia
Masseter and Rectus Femoris Ultrasound for Dysphagia and Sarcopenia in Critically Ill Patients
Dysphagia and sarcopenia are common complications in critically ill patients and are associated with increased morbidity, prolonged hospitalization, nutritional complications, and poorer clinical outcomes.
- Trial name
- NCT07787312
- Where
- Spain
- Volunteers
- 323 people
- Sponsor
- Sara Casanova Prieto
Hearing Loss
Assessment of Novel Sound Changing Principles in Hearing Instruments to Determine Their Application - 2020_09
Participants will perform two different listening tasks: (1) listening to, and repeating back, sentence lists presented in noise, and (2) Subjective rating of effort \& performance following each condition.
- Trial name
- NCT04578457
- Testing
- Hearing Aid without NR enabled, Hearing Aid with NR(1), Hearing Aid with NR(2)
- Where
- Switzerland
- Volunteers
- 19 people
- Sponsor
- Sonova AG
Intubation
Evaluation of the Accuracy of the POGO Score
A classification method describing the larynx appearance during laryngoscopy accepted by all anesthetists has not been defined yet. In one study, it was shown that anesthetists mis classed the glottis image by 50%.
- Trial name
- NCT03960567
- Testing
- Videolaryngoscopy
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Diskapi Teaching and Research Hospital
Nasopharyngeal Carcinoma, Endoscopic Surgery
Endoscopic Nasopharyngectomy for Newly Diagnosed Stage I Nasopharyngeal Carcinoma Patients
Nasopharyngeal carcinoma (NPC) is most prevalent in eastern Asia, with the highest incidence reported among the Cantonese population from the province of Guangdong.
- Conditions
- Nasopharyngeal Carcinoma, Endoscopic Surgery, Primary Napharyngeal Carcinama, Stage I Nasopharyngeal Cancer
- Trial name
- NCT03353467
- Testing
- Endoscopic surgery, Intensity-modulated radiotherapy
- Where
- 5 sites in China
- Volunteers
- 228 people
- Sponsor
- Sun Yat-sen University
Allergic Asthma, Atopic Dermatitis
A Phase 1, Randomized, Placebo-controlled, Dose-escalation Safety Study of MEDI4212 in Subjects With IgE >= 30 IU/mL
Phase 1 study to evaluate the safety of MEDI4212.
- Conditions
- Allergic Asthma, Atopic Dermatitis, Allergic Rhinitis, Healthy Volunteers
- Trial name
- NCT01544348
- Testing
- Omalizumab, MEDI4212 5 mg Subcutaneous, MEDI4212 15 mg Subcutaneous
- Where
- 7 sites in United States
- Volunteers
- 295 people, healthy volunteers welcome
- Sponsor
- MedImmune LLC
HPV-Related Squamous Cell Carcinoma
A Phase 1/2 Study in Patients With HPV16+ Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma and Other Cancers
This is a First in Human (FIH) Phase I/II, multinational, multicenter, open-label study of HB-201 single vector therapy and HB-201 \& HB-202 two-vector therapy in patients with HPV 16+ confirmed cancers comprising two parts…
- Trial name
- NCT04180215
- Testing
- HB-201 intravenous administration., HB-202 intravenous administration alternating with HB-201 intravenous administration., HB-201 intravenous administration + standard of care regimen including pembrolizumab.
- Where
- 34 sites in United States, Netherlands and 1 more
- Volunteers
- 198 people
- Sponsor
- Hookipa Biotech GmbH
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