Clinical trials: Otorhinolaryngologic Neoplasms
Larynx Cancer
Transoral Laser Surgery and Radiotheraphy for Early Stage Laryngeal Squamous Cell Cancer
Background: The investigators aimed to compare the oncological results of patients with early stage laryngeal squamous cell carcinoma (LSCC) treated with Transoral Laryngeal Surgery (TOLS) and Radiotheraphy (RT).
- Trial name
- NCT04778306
- Testing
- Transoral Laser Surgery
- Volunteers
- 261 people
- Sponsor
- Saglik Bilimleri Universitesi
Nasopharyngeal Carcinoma
Chemoradiotherapy for Patients With Locally Advanced Nasopharyngeal Carcinoma Using Raltitrexed-Cisplatin
The purpose of this study is to evaluate the efficacy and safety of raltitrexed and cisplatin neoadjuvant chemotherapy followed by concurrent radiotherapy with raltitrexed and cisplatin in patients with locally advanced…
- Trial name
- NCT02562599
- Testing
- raltitrexed-cisplatin, Intensity-modulated radiotherapy (IMRT)
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Hubei Cancer Hospital
Pancreatic Cancer, Thyroid Cancer
Integrated Cancer Repository for Cancer Research
The iCaRe2 is a multi-institutional resource created and maintained by the Fred \& Pamela Buffett Cancer Center to collect and manage standardized, multi-dimensional, longitudinal data and biospecimens on consented adult cancer…
- Conditions
- Pancreatic Cancer, Thyroid Cancer, Lung Cancer, Esophageal Cancer
- Trial name
- iCaRe2 (NCT02012699)
- Where
- 42 sites in United States
- Volunteers
- 999,999 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Head and Neck Cancer
Combination Chemotherapy Plus Radiation Therapy in Treating Patients With Advanced Mouth Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Trial name
- NCT00004901
- Testing
- ethynyluracil, fluorouracil, hydroxyurea
- Where
- 2 sites in United States
- Sponsor
- Robert H. Lurie Cancer Center
Nasopharyngeal Carcinoma
Reduced Target Delineation and Radiation Doses Chemoradiotherapy for Patients With Locoregionally Advanced Nasopharyngeal Carcinoma
To determine the efficacy and safety of sequential chemoradiotherapy with regimen of docetaxel, cisplatin and fluorouracil and reduced target delineation and radiation doses IMRT for patients with locoregionally advanced…
- Trial name
- NCT03389295
- Testing
- Reduced Target Delineation and Radiation Doses
- Where
- China
- Volunteers
- 118 people
- Sponsor
- Xiayun He, MD
Oropharyngeal Cancer, Dysphagia, Oropharyngeal
Liposomal Bupivacaine and Transoral Robotic Surgery
This study is for patients with oropharyngeal squamous cell carcinoma. We want to learn more about how we can optimize pain control in patients who undergo transoral robotic surgery (TORS) for oropharyngeal squamous cell…
- Conditions
- Oropharyngeal Cancer, Dysphagia, Oropharyngeal, Post Operative Pain, Transoral Robotic Surgery
- Trial name
- NCT05862792
- Testing
- Liposomal bupivacaine
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Geisinger Clinic
Head and Neck Cancer
Pre-habilitation of Patients With Head and Neck Cancer
The purpose of this study is to explore whether early initiated physical exercise concurrent with a swallowing and mouth opening exercise program will have a positive effect on swallowing function and other quality of life…
- Trial name
- SYNK (NCT02385929)
- Testing
- Swallowing therapy & resistance training
- Where
- 2 sites in Denmark
- Volunteers
- 240 people
- Sponsor
- Irene Wessel
Nasopharyngeal Carcinoma (NPC)
Brain Alterations Based on Multiplex MR Imaging in Nasopharyngeal Carcinoma Patients After Treatment, and Their Correlation With Clinical Cognitive Scores.
The objective of this study is to examine the potential impact of the treatment before, during, and/or after radiotherapy on the brain in patients with nasopharyngeal carcinoma (NPC) using Multiplex (MTP) MR imaging sequence…
- Trial name
- NPC (NCT07011329)
- Testing
- Changes in the brain MTP parameters after radiotherapy
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hubei Cancer Hospital
Oropharyngeal Cancer
PEARL PET-based Adaptive Radiotherapy Clinical Trial
The PEARL study will recruit approximately 50 patients with human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) who are about to undergo primary treatment with concurrent chemo-radiation from South…
- Trial name
- PEARL (NCT03935672)
- Testing
- PET-CT scans, Outlining the biological GTVs (bGTV_P and bGTV_iP), Blood samples for cell-free DNA analysis
- Where
- 3 sites in United Kingdom
- Volunteers
- 50 people
- Sponsor
- Velindre NHS Trust
Vestibular Schwannoma
Secondary Endolymphatic Hydrops and Vestibular Schwannomas on 3 Tesla MRI
Endolymphatic hydrops is well known of the lay public in its primary form that is Ménière disease. Nowadays, the best w ay to approach it in vivo, is to use magnetic resonance imaging (MRI).
- Trial name
- NCT03593577
- Where
- France
- Volunteers
- 185 people
- Sponsor
- University Hospital, Strasbourg, France
Oropharyngeal Carcinoma, Ultrasound
Transoral and Cervical Ultrasound of Patients With Suspected Oropharyngeal Cancer
Introduction The current diagnostic approach for patients with suspected oropharyngeal cancer involves a combination of clinical examination, tissue sampling, and relevant cross-sectional imaging.
- Trial name
- NCT07548268
- Testing
- Ultrasound of the oropharynx
- Where
- 4 sites in Denmark
- Volunteers
- 180 people
- Sponsor
- Tobias Todsen
Oropharyngeal Squamous Cell Carcinoma (OPSCCA), Oropharyngeal Cancer
Intratumoral Lidocaine Injection Before Oropharyngeal Cancer Surgery
Based on evidence that the local anesthetic lidocaine may have anticancer effects, this study will assess the safety and efficacy of intratumoral lidocaine injection at the time of direct laryngoscopy prior to TransOral Robotic…
- Conditions
- Oropharyngeal Squamous Cell Carcinoma (OPSCCA), Oropharyngeal Cancer, Human Papilloma Virus, Squamous Cell Carcinoma
- Trial name
- 856397 (NCT06747390)
- Testing
- Lidocaine 1% Injectable Solution
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Ryan Carey
Breast Cancer, Colorectal Cancer
Positron Emission Tomography/Computed Tomography Scanning Before Surgery in Patients With Non-Small Cell Lung Cancer, Colorectal Cancer, Breast Cancer, Esophageal Cancer, or Head and Neck Cancer
RATIONALE: Diagnostic procedures, such as positron emission tomography/computed tomography (PET/CT) scanning before surgery, may help measure the extent of disease.
- Conditions
- Breast Cancer, Colorectal Cancer, Esophageal Cancer, Head and Neck Cancer
- Trial name
- NCT01254591
- Testing
- 18F-fluoromisonidazole, fluorescence angiography, laboratory biomarker analysis
- Where
- United Kingdom
- Volunteers
- 500 people
- Sponsor
- University College London (UCL) Cancer Institute
Total Laryngectomy
Short-term Clinical Feasibility of the New Provox Vega 22.5 Voice Prosthesis
The purpose of this study is to investigate the performance of a new voice prosthesis in comparison with the Provox2 and the Provox ActiValve voice prosthesis in 15 laryngectomized patients.
- Trial name
- NCT00743262
- Testing
- Provox voice prosthesis
- Where
- Netherlands
- Volunteers
- 15 people
- Sponsor
- Atos Medical AB
Bladder Cancer, Cervical Cancer
Counseling and Nicotine Replacement Therapy in Helping Adult Smokers Quit Smoking
RATIONALE: Stop-smoking plans, including counseling and nicotine replacement therapy, may help smokers quit smoking. It is not yet known whether counseling and the nicotine lozenge is more effective than counseling and the…
- Conditions
- Bladder Cancer, Cervical Cancer, Esophageal Cancer, Gastric Cancer
- Trial name
- NCT00365508
- Testing
- nicotine lozenge, nicotine patch
- Where
- 10 sites in United States
- Volunteers
- 642 people
- Sponsor
- Fox Chase Cancer Center
Head and Neck Cancer, Nasopharynx Cancer
The Head and Neck Registry of the European Reference Network on Rare Adult Solid Cancers
Cancer care for head and neck cancers is multidisciplinary and complex and knowledge on the rare ones is limited. There is a wide consensus that to support clinical research on rare cancers, clinical registries should be…
- Conditions
- Head and Neck Cancer, Nasopharynx Cancer, Nasal Cavity and Paranasal Sinus Cancer, Salivary Gland Cancer
- Trial name
- EURACAN (NCT05483374)
- Testing
- observation
- Where
- 10 sites in Czechia, Germany and 1 more
- Volunteers
- 13,600 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Nasopharyngeal Carcinoma
Trial of VELCADE in Patients With Metastatic or Locally Recurrent Nasopharyngeal Carcinoma
This study seeks to test the Efficacy in terms of rates of disease response in metastatic nasopharyngeal carcinoma of the standard dose of velcade 1.3 mg/m2 given at the day 1,4,8,and 11 every 21 days schedule.
- Trial name
- NCT00367718
- Testing
- Velcade
- Where
- 3 sites in China, Singapore
- Sponsor
- Johns Hopkins University
Nasopharyngeal Carcinoma
Verification of Harmonization of Plasma Epstein-Barr Virus DNA Measurements
Plasma Epstein-Barr virus (EBV) DNA will be measured in native plasma samples of nasopharyngeal carcinoma (NPC) patients, respectively, by three medical centers and a qualified laboratory in Southern China, the highest endemic…
- Trial name
- NCT05037357
- Testing
- Plasma EBV DNA qPCR test
- Where
- China
- Volunteers
- 370 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Laryngeal Neoplasm
The Efficacy of Superficial Cervical Block Application in Postoperative Analgesia Management in Patients Undergoing Total Laryngectomy and Bilateral Neck Dissection
The goal of this clinical trial is to evaluate the efficacy of the superficial cervical block in postoperative pain management for patients undergoing total laryngectomy and bilateral neck dissection.
- Trial name
- NCT06852651
- Testing
- Superficial Cervical Block (SCB) Group
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Advanced Head and Neck Squamous Cell Carcinoma, Advanced Hypopharyngeal Squamous Cell Carcinoma
Testing the Addition of M3814 (Peposertib) to Radiation Therapy for Patients With Advanced Head and Neck Cancer Who Cannot Take Cisplatin
This phase I trial investigates the side effects and best dose of peposertib when given together with radiation therapy in treating patients with head and neck cancer that has spread to other places in the body (advanced) who…
- Conditions
- Advanced Head and Neck Squamous Cell Carcinoma, Advanced Hypopharyngeal Squamous Cell Carcinoma, Advanced Laryngeal Squamous Cell Carcinoma, Advanced Oral Cavity Squamous Cell Carcinoma
- Trial name
- NCT04533750
- Testing
- Intensity-Modulated Radiation Therapy, Peposertib
- Where
- 27 sites in United States
- Volunteers
- 21 people
- Sponsor
- National Cancer Institute (NCI)
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