Clinical trials: Otorhinolaryngologic Neoplasms
Nasopharyngeal Carcinoma
Positron Emission Tomography Scanning and Epstein-Barr Virus DNA Levels in the Staging and Follow-up of Nasopharyngeal Carcinoma.
The standard treatment for nasopharyngeal cancer involves either radiation alone or radiation plus chemotherapy. Before the start of treatment,patients require an imaging scan to assess the extent of disease.
- Trial name
- NCT00188253
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University Health Network, Toronto
Nasopharyngeal Cancer
Irinotecan Liposomes in Combination With Nituzumab for the Treatment of Recurrent/Metastatic Nasopharyngeal Carcinoma After Failure of First-Line or Higher Immunotherapy
Nasopharyngeal cancer is a malignant tumor that arises from the cells of the nasopharyngeal epithelium, with its occurrence spread across different regions worldwide.
- Trial name
- NCT06414577
- Testing
- Irinotecan Liposomal combined With Nituzumab
- Where
- China
- Volunteers
- 38 people
- Sponsor
- XIANG YANQUN
NASOPHARYNGEAL CARCINOMA
Study of LMP1- and LMP2- Specific Cytotoxic T-Lymphocytes (CTL)
In this study NPC patient will receive 4 days of treatment with CD45 antibody followed by one dose of LMP1- and LMP2-CTL. From this, we can learn if treating the patient first with the CD45 antibody will also let LMP1- and…
- Trial name
- DELLA (NCT00515957)
- Testing
- genetically modified CTLs in combo with CD45 antibodies
- Sponsor
- Baylor College of Medicine
BPPV, Residual Disease
Effective Treatments for Dizziness After BPPV: A Clinical Study
This clinical study aimed to evaluate how effective vestibular rehabilitation therapy (VRT) and Theta Binaural Beats (T-BB) are in reducing dizziness and anxiety in patients who continue to feel unsteady after successful…
- Conditions
- BPPV, Residual Disease, Vestibular Disease
- Trial name
- NCT06936345
- Testing
- Cawthorne-Cooksey Exercises, Brandt-Daroff Exercises, Theta Binaural Beats
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Medipol University
Nasopharyngeal Carcinoma
Study of Cytolytic Viral Activation Therapy (CVAT) for Recurrent/Metastatic Nasopharyngeal Carcinoma
Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus(EBV) related malignancy and is an endemic disease in Southeast Asian countries.
- Trial name
- NCT02761291
- Testing
- Gemcitabine, Valproic acid, Valganciclovir
- Where
- Taiwan
- Volunteers
- 18 people
- Sponsor
- Chang Gung Memorial Hospital
Metastatic Nasopharyngeal Carcinoma, Chemotherapy Effect
Efficacy and Safety of Sintilimab Plus Bevacizumab in Metastatic Nasopharyngeal Carcinoma After Failure of Platinum-based Chemotherapy: An Open-label Phase II Study
To evaluate the efficacy and safety of PD-1 immune checkpoint inhibitor combined with bevacizumab in the treatment of metastatic nasopharyngeal carcinoma after failure of platinum-based chemotherapy.
- Trial name
- NCT04872582
- Testing
- PD-1 Immune Checkpoint Inhibitor Combined With Bevacizumab
- Where
- China
- Volunteers
- 33 people
- Sponsor
- XIANG YANQUN
Supraglottic Cancer
Radiotherapy vs Neck Dissection for Clinical T1/2N0 Supraglottic Cancer
Supraglottic cancer is a main type of laryngeal carcinoma, which is one of the most common head and neck tumors. Cervical nodal metastasis is an important prognostic factor in supraglottic cancer.
- Trial name
- NCT03358602
- Testing
- Radiotherapy, Selective neck dissection
- Where
- China
- Volunteers
- 158 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Nasopharyngeal Carcinoma
Reduced-dose Radiotherapy for Low-risk Stage III Patients With Nasopharyngeal Carcinoma
To study the 2-year PFS (progression-free survival) of patients with stage III nasopharyngeal carcinoma of pretreatment EBV DNA<4000 copy/ml treated with induction chemotherapy followed by two different doses of…
- Trial name
- NCT03668730
- Testing
- Intensity-modulated radiation therapy, Paclitaxel liposome, Cisplatin
- Where
- China
- Volunteers
- 215 people
- Sponsor
- Sun Yat-sen University
Swallowing-induced Pain
Doxepin Solution for Alleviation of Stubborn Breakthrough Pain Induced by Swallowing in Patients Receiving Radiotherapy for Nasopharyngeal Carcinoma
The goal of this clinical trial is to explore the effectiveness and adverse reactions of doxepin solution spray for alleviation of stubborn breakthrough pain induced by swallowing in patients receiving radiotherapy for…
- Trial name
- NCT06017895
- Testing
- doxepin solution
- Where
- China
- Volunteers
- 178 people
- Sponsor
- Nanfang Hospital, Southern Medical University
Nasopharyngeal Carcinoma, De-escalation Therapy
Reduced-dose RT With/Without CCT Versus Standard CCRT for High-risk LANPC Who Achieved CR Post Induction Chemotherapy
This prospective trial aims to enroll patients with high-risk stage III-IVA (AJCC 8th, except T3N0) locoregionally-advanced nasopharyngeal carcinoma (LANPC).
- Trial name
- NCT06092957
- Testing
- Cisplatin-based induction chemotherapy, Full course of PD-1/PD-L1 blockades, Reduced-dose IMRT
- Where
- China
- Volunteers
- 504 people
- Sponsor
- Sun Yat-sen University
Nuclear Medicine, Oncology
Application of 18F-FDG PET/MRI for Initial Staging in Locally Advanced Nasopharyngeal Carcinoma
This single-center prospective observational study aims to evaluate the feasibility, cost-effectiveness, and clinical value of positron emission tomography/magnetic resonance imaging (PET/MRI) for initial staging in patients with…
- Trial name
- NCT06947759
- Testing
- PET/MRI
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Taichung Veterans General Hospital
Solid Tumor Cancer, Locally Advanced
AVENTINE-1: Study of AVZO-1418 as a Single Agent and in Combination Therapy in Patients With Locally Advanced or Metastatic Solid Tumors (AVZO-1418-1001)
This study, the first clinical trial of AVZO-1418, aims to determine the safety, tolerability, pharmacokinetics, pharmacodynamics, maximum tolerated dose, and antitumor activity of AVZO-1418 when administered intravenously as a…
- Conditions
- Solid Tumor Cancer, Locally Advanced, Metastatic Solid Tumors, Lung Cancers
- Trial name
- NCT07038343
- Testing
- AVZO-1418, Combination Agent 1, Combination Agent 2
- Where
- 27 sites in United States, China
- Volunteers
- 480 people
- Sponsor
- Avenzo Therapeutics, Inc.
Vestibular Schwannoma
Evolution of Balance and Vestibular Function in Patients Treated With Gammaknife Radiosurgery for Vestibular Schwannoma
Vestibular schwannomas are benign lesions of the ponto-cerebellar angle that are potentially dangerous because of their growth in a cramped space and the compressive phenomena they can cause.
- Trial name
- EQUI-GAMMA (NCT04859335)
- Testing
- gammaknife radiosurgery
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Toulouse
Laryngeal Neoplasms
Investigation of Contralateral Arytenoid Sparing IMRT for T1a & T2a Larynx Cancer & Analysis of Post-treatment Laryngeal Function
The aim of this study is to define a new treatment technique for T1a larynx cancer that maintains excellent local control with less extensive radiation fields.
- Trial name
- NCT02633540
- Testing
- IMRT Radiation
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Fox Chase Cancer Center
Dizziness
Vestibular Evaluation After Vestibular Schwannoma Treatment
Vestibular schwannoma is a benign tumor located on the vestibular nerve. Patient could present dizziness symptoms cause to the tumor, and at least after the treatment by gamaknife radiosurgery or microsurgery resection.
- Trial name
- EVTSVCGEC (NCT03670589)
- Testing
- Radiosurgery gammaknife, Microsurgery resection
- Where
- France
- Volunteers
- 51 people
- Sponsor
- University Hospital, Grenoble
Cancer in Children, Hearing Loss
Cancer and Hearing Loss Related in Children
A limited number of relatively contradictory studies have suggested that the development of serious ototoxicity in children treated with cisplatin or, more rarely, carboplatin could be partly related to genetic risk factors…
- Trial name
- OTOPLAT (NCT02425397)
- Testing
- Genetic study, Genetic study MT-RN1
- Where
- France
- Volunteers
- 119 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Head and Neck Cancer, Dysphagia
A Pilot Study of ALTENS in Improving Dysphagia Induced by IMRT for Head and Neck Cancers
Study hypothesis: ALTENS techniques, administered within the first 3 months after radiation completion, can improve radiation-induced dysphagia and associated symptoms in head and neck cancer patients.
- Trial name
- NCT01697891
- Testing
- Codetron ALTENS
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- McMaster University
Nasopharyngeal Cancinoma (NPC), Nasopharyngeal Cancer
Dynamic Plasma EBV DNA-Guided Risk-Adapted Treatment With Becotatug Vedotin (MRG003) Plus PD-1 Blockade in Locoregionally Advanced Nasopharyngeal Carcinoma
The purpose of this study is to evaluate the efficacy and safety of a risk-adapted treatment strategy incorporating induction therapy with becotatug vedotin (MRG003) plus pucotenlimab, followed by treatment allocation based on…
- Trial name
- NCT07524413
- Testing
- Becotatug Vedotin, Pucotenlimab, Intensity-Modulated Radiotherapy
- Volunteers
- 298 people
- Sponsor
- Sun Yat-sen University
Solid Tumor Malignancies, Testicular Cancer
Ph. I/II Sodium Thiosulfate for OtoProtection During Cisplatin (STOP-CIS)
The purpose of this study is to assess the safety and effectiveness of a drug called Pedmark® sodium thiosulfate (STS) in reducing hearing impairment with standard of care cisplatin therapy.
- Conditions
- Solid Tumor Malignancies, Testicular Cancer, Head and Neck Cancer, Thoracic Cancer
- Trial name
- NCT07407582
- Testing
- Pedmark® STS
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Arizona
Rare Disorders, Undiagnosed Disorders
Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford
The Coordination of Rare Diseases at Sanford (CoRDS) is an international patient registry that serves as a centralized resource for rare disease research.
- Conditions
- Rare Disorders, Undiagnosed Disorders, Disorders of Unknown Prevalence, Cornelia De Lange Syndrome
- Trial name
- CoRDS (NCT01793168)
- Where
- United States
- Volunteers
- 20,000 people
- Sponsor
- Sanford Health
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