Clinical trials: Otorhinolaryngologic Neoplasms
Imaging of Bony Structures of the Head (Various Conditions), Hearing Loss
MRI-based Synthetic CT Images of the Head and Neck
In case of surgical procedures in the head and neck region, MRI in combination with CT of the bone is often the standard modality to visualise bony landmarks for planning, navigation and risk assessment.
- Conditions
- Imaging of Bony Structures of the Head (Various Conditions), Hearing Loss, Cholesteatoma, Sinusitis
- Trial name
- NCT06016335
- Testing
- CT scan, MRI scan, Synthetic CT scan
- Where
- Netherlands
- Volunteers
- 80 people
- Sponsor
- Amsterdam UMC, location VUmc
Vestibular Schwannoma, Meningioma
Exploratory Evaluation of AR-42 Histone Deacetylase Inhibitor in the Treatment of Vestibular Schwannoma and Meningioma
This will be a multi-center, proof of concept phase 0 study to assess the suppression of p-AKT in Vestibular Schwannoma (VS) and meningiomas by AR-42 in adult patients undergoing tumor resection.
- Conditions
- Vestibular Schwannoma, Meningioma, Acoustic Neuroma, Neurofibromatosis Type 2
- Trial name
- NCT02282917
- Testing
- AR-42
- Where
- 4 sites in United States
- Volunteers
- 7 people
- Sponsor
- Massachusetts Eye and Ear Infirmary
Nasopharyngeal Cancinoma (NPC)
Radiotherapy Omitting Prophylactic Neck Irradiation With Neoadjuvant and Adjuvant Toripalimab in Nasopharyngeal Carcinoma
This single-arm, phase 2 trial evaluates the efficacy and safety of de-escalated radiotherapy (restricted to the primary tumor, omitting prophylactic neck irradiation) combined with neoadjuvant and adjuvant toripalimab…
- Trial name
- PUPA (NCT07110558)
- Testing
- Without prophylactic neck irradiation, PD-1 antibody (Toripalimab), Cisplatin
- Where
- China
- Volunteers
- 59 people
- Sponsor
- Sun Yat-sen University
Oropharyngeal Cancer
Assessment of Swallowing Function and Quality of Life in Oropharyngeal Cancer Patients Treated by Chemo-radiotherapy
Open-label, interventional, multicentric, randomized, phase III study. Cancer studied is the oropharyngeal cancer. Study is composed by 2 arms of subjects: prophylactic or reactive percutaneous endoscopic gastrostomy tube…
- Trial name
- SwallPEG (NCT04019548)
- Testing
- Percutaneous Endoscopic Gastrotomy tube placement, Cisplatin injection, Radiotherapy
- Where
- 2 sites in Belgium
- Volunteers
- 110 people
- Sponsor
- Jules Bordet Institute
Larynx Cancer
Induction Docetaxel/Cisplatin/5-fluorouracil (TPF) as Selector for Chemo Radiation Therapy (RT) Versus Partial Laryngectomy in Advanced Laryngeal Cancer
Treatment of patients with one cycle of induction chemotherapy to select for organ preservation of the larynx has been proven as a standard approach. When compared to historical controls.
- Trial name
- NCT01073683
- Testing
- laryngoscopy, Taxotere (Docetaxel), Cisplatin, 5FU
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Rabin Medical Center
Nasopharyngeal Cancers, Intensity Modulated Radiotherapy With Chemotherapy
Parotid-sparing IMRT for Nasopharyngeal Cancer
In the treatment of nasopharyngeal cancers, to determine the incidence of high grade (≥G2) subjective xerostomia at 1 year.
- Trial name
- NCT02149641
- Testing
- Intensity modulated radiotherapy with chemotherapy
- Where
- United Kingdom
- Volunteers
- 42 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Nasopharyngeal Carcinoma
Camrelizumab Combined With Apatinib in Patients With First-line Platinum-resistant Recurrent/Metastatic Nasopharyngeal Carcinoma
The purpose of this study is to explore the efficacy and safety of a combination of Camrelizumab and Apatinib regimen in treating recurrent or metastatic nasopharyngeal carcinoma patients who have failed first-line platinum-based…
- Trial name
- NCT04547088
- Testing
- Camrelizumab, Apatinib
- Where
- China
- Volunteers
- 27 people
- Sponsor
- Sun Yat-sen University
Oropharyngeal Cancer
Evaluation of HPV OncoTect ™ for the Etiological Diagnosis of HPV-induced Oropharyngeal Cancers
To determine the sensitivity of HPV OncotectTM to diagnose oropharyngeal cancers induced by oncogenic HPV
- Trial name
- HPV OncoTect™ (NCT03604588)
- Testing
- HPV OncoTect™
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Gustave Roussy, Cancer Campus, Grand Paris
Oropharyngeal Cancer
Improving Trans-oral Surgical Outcomes Through Intra-operative Image Guidance
The objective of this research is to perform a pilot study on patients undergoing laryngoscopy for diagnostic and tumor staging purposes (for pharyngeal or laryngeal cancer) in which intraoperative CT imaging will be performed…
- Trial name
- NCT02405000
- Testing
- Intraoperative CT imaging
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Adult Giant Cell Glioblastoma, Adult Glioblastoma
18F-FPPRGD2 PET/CT or PET/MRI in Predicting Early Response in Patients With Cancer Receiving Anti-Angiogenesis Therapy
The purpose of the study is to conduct research of a new PET radiopharmaceutical in cancer patients. The uptake of the novel radiopharmaceutical 18F-FPPRGD2 will be assessed in study participants with glioblastoma multiforme…
- Conditions
- Adult Giant Cell Glioblastoma, Adult Glioblastoma, Adult Gliosarcoma, Male Breast Cancer
- Trial name
- NCT01806675
- Testing
- 18F-fludeoxyglucose (18F-FDG), 18F-FPPRGD2
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Sanjiv Sam Gambhir
Vaginal Cancer, Cervical Cancer
T Cell Receptor Immunotherapy Targeting HPV-16 E6 for HPV-Associated Cancers
Background: The National Cancer Institute (NCI) Surgery Branch has developed an experimental therapy for treating patients with cancer that involves taking white blood cells from the patient, growing them in the laboratory in…
- Conditions
- Vaginal Cancer, Cervical Cancer, Anal Cancer, Penile Cancer
- Trial name
- NCT02280811
- Testing
- Fludarabine, Cyclophosphamide, E6 TCR
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Cancer Institute (NCI)
Drug/Agent Toxicity by Tissue/Organ, Head and Neck Cancer
Chemotherapy Plus Radiation Therapy With or Without Amifostine in Treating Patients With Locally Advanced Cancer of the Nasopharynx
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Radiation therapy uses high-energy x-rays to damage tumor cells.
- Conditions
- Drug/Agent Toxicity by Tissue/Organ, Head and Neck Cancer, Oral Complications, Radiation Toxicity
- Trial name
- NCT00025298
- Testing
- amifostine trihydrate, carboplatin, cisplatin
- Where
- 13 sites in Belgium, France and 4 more
- Volunteers
- 5 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Nasopharyngeal Cancer
Elimination of Adjuvant Chemotherapy for Selected Stage II and III Nasopharyngeal Carcinoma
This study evaluates whether some patients with nasopharyngeal carcinoma but with low risk of distant metastasis can be treated with only radiotherapy and concomitant chemotherapy but without additional adjuvant chemotherapy.
- Trial name
- NCT03175939
- Testing
- Radiotherapy, Cisplatin, 5-FU
- Volunteers
- 263 people
- Sponsor
- Sun Yat-sen University
Oral Cancer, Laryngeal Cancer
The Role of Lymphangiogenesis in Head and Neck Cancer Metastasis
The purpose of this study is to investigate the role of lymphangiogenesis in the metastasis of head and neck cancer.
- Conditions
- Oral Cancer, Laryngeal Cancer, Hypopharyngeal Cancer
- Trial name
- NCT00173381
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Nasopharyngeal Carcinoma
Induction Chemotherapy and Immunotherapy Combined Radiotherapy With or Without Concurrent Chemotherapy for Stage III-IVa NPC
The purpose of this study is to compare induction chemotherapy (gemcitabine+cisplatin) plus immunotherapy with concurrent chemoradiotherapy (CCRT) or RT alone in patients with stage III-IVa nasopharyngeal carcinoma(NPC), in order…
- Trial name
- NCT06095167
- Testing
- without concurrent cisplatin chemotherapy, with concurrent cisplatin chemotherapy
- Where
- China
- Volunteers
- 476 people
- Sponsor
- Fujian Cancer Hospital
Nasopharyngeal Carcinoma, Nasopharyngeal Cancer
The Protection of Thyroid Function in IMRT for Nasopharyngeal Carcinoma
This study aimed to reduce radiation-induced thyroid injury without compromising control of the cervical region by optimizing the delineation of the cervical lymph node drainage area.
- Conditions
- Nasopharyngeal Carcinoma, Nasopharyngeal Cancer, Hypothyroidism
- Trial name
- NCT06268600
- Testing
- Modified neck target volume delineation
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Jiangxi Provincial Cancer Hospital
Cisplatin Adverse Reaction, Hearing Loss Ototoxic
Protective Role of N-acetylcisteine From Cisplatin-induced Ototoxicity in Patients With Head and Neck Cancer
Introduction. Cisplatin-induced ototoxicity is a very frequent event and its consequences can cause a lot of deterioration in patients.
- Trial name
- NCT03400709
- Testing
- N Acetylcysteine
- Where
- Chile
- Volunteers
- 45 people
- Sponsor
- Hospital San Juan de Dios, Santiago
Oropharynx Cancer, Stage I
Pre-operative Atezolizumab in Patients With Resectable, Human Papillomavirus Related Oropharyngeal Carcinoma
This phase II trial tests how well atezolizumab works in treating patients with human papillomavirus (HPV) related oropharyngeal squamous cell carcinoma that is able to be removed with surgery (resectable).
- Trial name
- NCT06254911
- Testing
- Atezolizumab, Transoral Surgery with cervical lymphadenctomy (neck dissection), Computed Tomography
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Emory University
Nasopharyngeal Carcinoma
Optimization of Cervical Nodal CTV for Early and Medium Stage NPC
Current radiotherapy guidelines and consensus statements uniformly recommend elective region irradiation (ERI) as the standard strategy for nasopharyngeal carcinoma (NPC).
- Trial name
- NCT05145660
- Testing
- intensity-modulated radiotherapy (IMRT) with reduced-volume, Chemotherapy
- Where
- China
- Volunteers
- 414 people, healthy volunteers welcome
- Sponsor
- Yi Junlin
Nasopharyngeal Neoplasms, Stomatitis
Predictive Factors of Acute Oral Mucositis Induced by Chemo-radiotherapy for Local Advanced Nasopharyngeal Carcinoma
This is a prospective, observational study to analyze the clinical and dosimetric factors about the radiation oral mucositis caused by radical chemo-radiotherapy for nasopharyngeal carcinoma patients and try to find the…
- Trial name
- NCT02945878
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Zhejiang Cancer Hospital
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