Clinical trials: Otosclerosis
Otosclerosis, Cone Beam Computed Tomography
Cone-beam CT in the Diagnosis and Surgical Treatment of Otosclerosis.
Our studies will systematically investigate and establish evidence on whether Cone-beam computed tomography (CBCT) of the temporal bone could be used in the diagnosis and treatment of otosclerosis and in the post-operative…
- Conditions
- Otosclerosis, Cone Beam Computed Tomography, Stapes Fixation
- Trial name
- NCT05921578
- Testing
- Pre-operative planning based on CBCT
- Where
- Denmark
- Volunteers
- 100 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Otosclerosis
The Cost-effectiveness of Stapes Surgery for Otosclerosis Performed Under Local Versus General Anesthesia
Otosclerosis is a localized disorder of the otic capsule, characterized by bone resorption anterior to the oval window in the region of the fissula ante fenestram.
- Trial name
- CESSO (NCT06618053)
- Testing
- cost-effectiveness and audiometry outcomes
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Otosclerosis
Efficacy of Acetylcysteine in Patients Undergoing Surgery for Otosclerosis
In otosclerosis, one of the tiny bones of the middle ear is unable to move normally. Sounds cannot be transferred to the inner ear and a conductive hearing loss ensues.
- Trial name
- NCT00525551
- Testing
- Acetylcysteine
- Where
- 3 sites in Sweden
- Volunteers
- 152 people
- Sponsor
- Karolinska University Hospital
Otosclerosis, Otosclerosis Surgery
Patient Satisfaction After Surgery for Otosclerosis Under Local ou General Anesthesia
Main purpose of this study is to compare comfort level of patients, after otosclerosis surgery, under local or general anesthesia.
- Trial name
- SPOC (NCT03888079)
- Testing
- Local anesthetic, general anesthetic
- Where
- France
- Volunteers
- 103 people
- Sponsor
- Rennes University Hospital
Otosclerosis
Dexmedetomidine vs. Remifentanil Conscious Sedation for Stapedotomy/Stapedectomy
Dexmedetomidine continuous intravenous infusion vs. remifentanil target-controlled infusion conscious sedation for stapedotomy/stapedectomy- a prospective, single-center, double-masked randomized trial The goal of this clinical…
- Trial name
- NCT06283836
- Testing
- Dexmedetomidine, Remifentanil
- Where
- Romania
- Volunteers
- 74 people
- Sponsor
- Iuliu Hatieganu University of Medicine and Pharmacy
Otosclerosis
Ultra-high Resolution CT: the End of Stapes Prosthesis Measurement Misestimation
Actual CT scanners overestimate stapes piston size, and do not represent a valuable technique for their follow-up, especially in case of complication. Ultra-high resolution has not yet been evaluated in this setting.
- Trial name
- NCT06323863
- Testing
- stapedectomy, ultra high resolution CT
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Central Hospital, Nancy, France
Otosclerosis of Middle Ear, Bone Density
Investigating the Relationship Between Temporal Bone CT, Bone Density, and Hearing Loss in Otosclerosis Patients
The goal of this observational case-control study is to evaluate the relationship between temporal bone computed tomography (CT) findings, bone mineral density (BMD), and audiological parameters in adults diagnosed with…
- Conditions
- Otosclerosis of Middle Ear, Bone Density, Vitamin D Deficiency
- Trial name
- NCT06830187
- Where
- Turkey (Türkiye)
- Volunteers
- 86 people
- Sponsor
- İbrahim Emir Yeşil
CerebroSpinal Fluid (CSF) Leak, Chronic Otitis Media
Cone Beam CT for Diagnosis of Select Otorhinolaryngology (ENT) Indications at Lower Dose
The study objective is to compare the CBCT images generated by the CS 9300 to those generated by conventional CT.
- Conditions
- CerebroSpinal Fluid (CSF) Leak, Chronic Otitis Media, Otospongiosis, Otosclerosis
- Trial name
- CBCT-ENT (NCT01855425)
- Testing
- Radiation
- Where
- 3 sites in United States, Belgium and 1 more
- Volunteers
- 96 people
- Sponsor
- Carestream Health, Inc.
Otosclerosis
Outcome of Stapes Surgery in Otosclerotic Patients With Tinnitus Using Tinnitogram
This study will be conducted on patients with otosclerosis attending Assiut University Hospital and undergo stapedectomy operation Evaluation of each patient will conducted preoperatively and 3 month postoperatively Patient will…
- Trial name
- Otosclerosis (NCT06022471)
- Testing
- Stapes surgery
- Volunteers
- 32 people
- Sponsor
- Assiut University
Disorder of Middle Ear, Otosclerosis of Middle Ear
Objective Measurement of Ossicular Chain Mobility Using a Palpating Instrument Intraoperatively
Feasibility of the objective measurement of the ossicular chain mobility, by using a force-measuring device based on a fiber optics sensors (PalpEar).
- Conditions
- Disorder of Middle Ear, Otosclerosis of Middle Ear, Cholesteatoma, Middle Ear
- Trial name
- PalpEar (NCT02554422)
- Testing
- PalpEar
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Sensoptic SA
Severe to Profound Mixed Hearing Loss
Clinical Assessment of the External Sound Processor Worn by Patients Implanted With Codacs
The purpose of this study is to evaluate the effect of the sound processor upgrade from the C-DACS investigational device Freedom sound processor to the Nucleus® CP810 sound processor for the Codacs™ system on the speech…
- Trial name
- NCT02156167
- Testing
- CP810 and Codacs™ system test
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- Cochlear
Otosclerosis
Surgical and Audiological Outcomes of Endoscopic Stapes Surgery
Otosclerosis is a pathological bone remodeling process that affects the middle and inner ears. It was first reported by Antonio Maria Valsalva in 1735 and subsequently described pathologically by Adam Politzer in 1839 .
- Trial name
- NCT07304999
- Testing
- endsocopic stapedotomy
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Sohag University
Chorda Tympani Disorder, Taste Disorders
The Change of the Structure and Function of Taste Buds After the Otosclerosis Surgery
Patients admitted for the otosclerosis operation are included in the study. The Narrow Band Imaging (NBI) of their taste buds is performed before the operation.
- Conditions
- Chorda Tympani Disorder, Taste Disorders, Stapes Fixation
- Trial name
- NCT04881513
- Testing
- Narrow Band Imaging, Tongue sensitivity testing, Qualitiy of life
- Where
- Slovenia
- Volunteers
- 50 people
- Sponsor
- University Medical Centre Ljubljana
Otosclerosis
Cone Beam vs MDCT for Diagnosis and Pre-operative Evaluation of Otosclerosis
This study aims to compare the Cone Beam and the multi-detector computed tomography for diagnosis and pre-operative evaluation of otosclerosis in patients addressed for conductive hearing loss with intact tympanic membrane.
- Trial name
- CONBEAM OTO (NCT05214053)
- Testing
- Cone Beam CT
- Where
- France
- Volunteers
- 1 people
- Sponsor
- University Hospital, Bordeaux
Otosclerosis
KNOW HOW TO POSITION THE SACCULE AND UTRICULE IN SCANNING
Titanium pistons cause MRI artifacts that prevent interpretation of the vestibule. This disadvantage is not present on CT but the vestibule is not visible.
- Trial name
- Luxation (NCT06179251)
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Strasbourg, France
Otosclerosis of Middle Ear, Unilateral Hearing Loss
Study of Binaural Squelch Effect in Unilateral Otosclerosis
Patients with unilateral transmission hypoacusis due to otosclerosis undergoing stapedectomy surgery will be prospectively included.
- Trial name
- CBOU (NCT03587792)
- Testing
- stapedectomy
- Where
- France
- Volunteers
- 25 people
- Sponsor
- University Hospital, Grenoble
Otosclerosis
Cone Beam and CT Scan for the Diagnosis of Otosclerosis (TACOS)
Computed tomography scan (CT) is routinely used for the diagnosis and the pre-operative assessment of otosclerosis. The cone-beam computed tomography (CBCT) is a imaging technique with reduced irradiating and, therefore, could…
- Trial name
- TACOS (NCT02435446)
- Testing
- Cone-beam computed tomography
- Where
- France
- Volunteers
- 31 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Otosclerosis of Middle Ear
Endoscopic Classic Versus Reversal Stapedotomy
Aim of The Work The aim of this study is to compare hearing outcome and surgical complications between classic and reversal endoscopic stapedotomy.
- Trial name
- NCT05554796
- Testing
- Endoscopic classic stapedotomy, Endoscopic reversal stapedotomy
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Hearing Loss, Sensorineural, Hearing Loss, Conductive
Wide Frequency Band Test of Hearing in Veterans
The accurate assessment of auditory status is critical for planning treatment for Veterans with hearing loss to include medical and audiological management.
- Conditions
- Hearing Loss, Sensorineural, Hearing Loss, Conductive, Hearing Loss, Mixed Conductive-Sensorineural, Otosclerosis
- Trial name
- CWTBAFV (NCT02019888)
- Where
- 2 sites in United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Otosclerosis
Hearing Aid Versus Surgical Rehabilitation as Treatment of Otosclerosis: Pilot Study
This is a French pilot study in the Toulouse University Hospital that will include a minimum of 30 patients with proven unilateral or asymmetric otosclerosis.
- Trial name
- PARCO (NCT02456272)
- Testing
- External hearing aid, Otosclerosis surgery
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Toulouse