Clinical trials: Out of Hospital Cardiac Arrest
Infection, Bacterial, Out-Of-Hospital Cardiac Arrest
Impact of Early Antibiotics on Non-Traumatic Out of Hospital Cardiac Arrest (OHCA)
Specific Aim : The specific aim is to conduct a randomized prospective clinical trial to determine whether no antibiotics in OHCA patients in the ED with very low likelihood of infection is non-inferior to early antibiotic…
- Trial name
- NCT05914779
- Testing
- No use of antibiotics, with antibiotics treatment
- Where
- Qatar
- Volunteers
- 1,000 people
- Sponsor
- Hamad Medical Corporation
Cardiac Arrest, Cardiopulmonary Resuscitation
Circulation Improving Resuscitation Care (CIRC)
During resuscitation of out of hospital cardiac arrest patients the use of a mechanical chest compression device Autopulse will improve survival compared to manual compressions.
- Trial name
- CIRC (NCT00597207)
- Testing
- AutoPulse, Manual
- Where
- 5 sites in United States, Austria and 1 more
- Volunteers
- 4,231 people
- Sponsor
- Zoll Medical Corporation
Cardiac Arrest
The Haemodynamic Effects of Mechanical Standard and Active Chest Compression-decompression During Out-of-hospital CPR
The aim of this randomized out-of-hospital cardiopulmonary resuscitation study is to investigate haemodynamics generated by the standard mechanical external chest compression device (LUCAS™ 2) compared to a new version generating…
- Trial name
- NCT02479152
- Testing
- LUCAS2 AD
- Where
- Norway
- Volunteers
- 126 people
- Sponsor
- Physio-Control
Cardiac Arrest
Phase 1 Study of HBN-1
Phase 1 First-in Human randomized, open-label, active control standard of care study of the safety of HBN-1 administered as pharmacologically induced hypothermia as an adjunct to standard of care targeted temperature management…
- Trial name
- NCT04094857
- Testing
- HBN-1
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- Hibernaid, Inc
Death, Sudden, Cardiac
An Observational Study to Assess the Risk of Out-of-Hospital Sudden Cardiac Death in Users of Domperidone, Users of Proton Pump Inhibitors, and Users of Metoclopramide
The purpose of this observational study is to assess the risk of out-of-hospital Sudden Cardiac (heart) Death (SCD) associated with current use of domperidone compared to current use of a Proton Pump Inhibitor (PPI), current use…
- Trial name
- NCT01907633
- Testing
- No intervention
- Volunteers
- 15,000 people
- Sponsor
- Janssen Research & Development, LLC
Cardiac Arrest
REBOA for Out-of-hospital Cardiac Arrest
Cardiac arrest is a major health problem that carries a high mortality rate. Substantial research and development have been put into changing the outcome of cardiac arrest and despite the advent of automated external…
- Trial name
- NCT04491903
- Testing
- REBOA
- Sponsor
- neurescue
Cardiac Arrest, Out-Of-Hospital
AED 3 Post-Approval Study
Demonstrate appropriate CPR sensor placement on pediatric and adult patients and demonstrate delivery of appropriate energy level of shocks to pediatric and adult patients.
- Trial name
- NCT05013333
- Testing
- AED 3 with Uni-padz
- Where
- 2 sites in United States
- Volunteers
- 38 people
- Sponsor
- Zoll Medical Corporation
Cardiac Arrest
Antioxidant and NMDA Receptor Blocker Wins Anoxic Brain Damage of KorEa OHCA Patients
This study aims to investigate the efficacy and safety of Neu2000KWL, a neuroprotectant, in patients resuscitated from out-of-hospital cardiac arrest and receiving therapeutic hypothermia.
- Trial name
- AWAKE (NCT03651557)
- Testing
- Neu2000KWL High-dose group, Neu2000KWL Low-dose group
- Where
- 6 sites in South Korea
- Volunteers
- 150 people
- Sponsor
- GNT Pharma
Heart Arrest
Thrombolysis Using Tenecteplase (Metalyse®) in Cardiac Arrest - The TROICA Trial
The general aim of this study is to compare the efficacy and safety of tenecteplase to standard treatment during cardiopulmonary resuscitation in patients suffering from out-of-hospital cardiac arrest.
- Trial name
- NCT00157261
- Testing
- tenecteplase
- Where
- 68 sites in Austria, Belgium and 7 more
- Volunteers
- 1,050 people
- Sponsor
- Boehringer Ingelheim
Resuscitation, Cardiopulmonary
Effect of Early High-dose Epoetin Alfa During Cardiac Arrest (Pilot Study)
The purpose of this study is to test the possible neuroprotective effect of early high dose erythropoietin alpha after out of hospital cardiac arrest (OHCA).
- Conditions
- Resuscitation, Cardiopulmonary, Cardiac Arrest
- Trial name
- NCT00719498
- Testing
- Epo-alpha
- Volunteers
- 20 people
- Sponsor
- Janssen Cilag S.A.S.
Cardiac Arrest, Post Cardiac Arrest Syndrome
Lung-cOnservative Liquid VEntilation for the Induction of Ultra-Rapid COOLing After Cardiac Arrest
Out-of-hospital cardiac arrest (OHCA) affects over 356,000 individuals annually in the United States, with fewer than 10% surviving to hospital discharge, mirroring statistics from Europe.
- Trial name
- OverCool (NCT06798818)
- Testing
- Ultra-rapid therapeutic hypothermia induction by total liquid ventilation
- Where
- France
- Volunteers
- 24 people
- Sponsor
- ORIXHA
Cardiac Arrest, Sudden Cardiac Death
Hemodynamic Effects of Standard Cardiopulmonary Resuscitation (CPR), Active Compression Decompression CPR With an Inspiratory Impedance Device, and Standard CPR With an Intrathoracic Pressure Regulator During Out-of-hospital Cardiac Arrest
More than 300,000 Americans experience out-of-hospital cardiac arrest annually, with overall survival rates averaging less than 5%.
- Trial name
- NCT01325870
- Testing
- ACD-CPR, ITPR, S-CPR
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Advanced Circulatory Systems
Out-Of-Hospital Cardiac Arrest
Finding the Optimal Cooling tempeRature After Out-of-HoSpiTal Cardiac Arrest
To assess the fraction of subjects surviving with good neurological outcome at 90 days for 3 different levels of hypothermia, in comatose survivors from out-of-hospital cardiac arrest.
- Trial name
- FROST (NCT02035839)
- Testing
- Target Temperature Management of 34°C, Target Temperature Management of 32°C, Target Temperature Management of 33°C
- Where
- 14 sites in Germany, Spain
- Volunteers
- 150 people
- Sponsor
- ZOLL Circulation, Inc., USA
Out of Hospital Cardiac Arrest
CAOCT: Intra CoronAry Optical Computerized Tomography in out-of Hospital Cardiac Arrest Patients
Out-of-hospital cardiac arrest (OHCA) is a leading cause of sudden death in Europe and the United States. Mortality is currently close to 40% among those patients who had been successfully resuscitated after OHCA associated with…
- Trial name
- NCT04431661
- Testing
- Optical Coherence Tomography, Coronary Angiography, Per cutaneous coronary intervention
- Where
- 7 sites in Belgium, France and 1 more
- Volunteers
- 28 people
- Sponsor
- Ceric Sàrl
Cardiac Arrest, Sudden
AED Log Analysis of 19 Cases in Out-of-hospital Environment
The study performed to demonstrate a reasonable assurance of safety and effectiveness of the Heart Guardian HR-501 when used in an out-of-hospital environment.
- Trial name
- NCT03969797
- Testing
- RADIAQBIO Heart Guardian HR-501
- Where
- South Korea
- Volunteers
- 19 people
- Sponsor
- RadianQbio
Post-Cardiac Arrest Syndrome
Xenon for Neuroprotection During Post-Cardiac Arrest Syndrome in Comatose Survivors of an Out of Hospital Cardiac Arrest
XePOHCAS: Prospective, randomized, multicenter interventional trial in adult subjects with out-of-hospital cardiac arrest comparing treatment with standard-of-care post-cardiac arrest intensive care (which is targeted temperature…
- Trial name
- XePOHCAS (NCT03176186)
- Testing
- Xenon
- Where
- 10 sites in United States, Denmark
- Volunteers
- 1,436 people
- Sponsor
- Invero Pharma, Inc.
Out of Hospital Cardiac Arrest
COOL-ARREST Pilot Study to Assess Intravascular Temperature Management (IVTM) in the Treatment of Cardiac Arrest
A multicenter prospective single arm interventional trial in hospitals where therapeutic hypothermia is standard practice. This trial will enroll 50 subjects to evaluate the ability of the ZOLL Intravascular Temperature…
- Trial name
- COOL-ARREST (NCT01818388)
- Testing
- ZOLL Intravascular Temperature Management System (IVTM)
- Where
- 9 sites in United States
- Volunteers
- 50 people
- Sponsor
- ZOLL Circulation, Inc., USA
Heart Arrest, Death, Sudden, Cardiac
ResQ Trial: Impact of an ITD and Active Compression Decompression CPR on Survival From Out-of-Hospital Cardiac Arrest
The purpose of this study is to determine whether performing active compression decompression cardiopulmonary resuscitation (ACD-CPR) with an impedance threshold device (ITD) compared to conventional standard cardiopulmonary…
- Conditions
- Heart Arrest, Death, Sudden, Cardiac, Cardiopulmonary Resuscitation, Cardiac Arrest
- Trial name
- ResQ (NCT00189423)
- Testing
- Use of an impedance threshold device (ITD) during the performance of active compression decompression CPR (ACD-CPR), Standard cardiopulmonary resuscitation (S-CPR)
- Where
- 7 sites in United States
- Volunteers
- 1,653 people
- Sponsor
- Advanced Circulatory Systems