Clinical trials: Out of Hospital Cardiac Arrest
Cardiac Arrest, Out-Of-Hospital
Pulse Checks Using Femoral Artery B-Mode Ultrasound With Compressibility Assessment
The goal of this prospective observational study is to investigate B-mode point-of care ultrasound with arterial compressibility assessment on the femoral artery as a method to determine the presence of a pulse and to compare it…
- Trial name
- NCT06491186
- Testing
- Point of Care Ultrasound
- Where
- Austria
- Volunteers
- 69 people
- Sponsor
- Medical University of Vienna
Heart Arrest, Out-Of-Hospital, CardioPulmonary Resuscitation
Ventilation in Cardiac Arrest Resuscitation Study
Out-of-hospital cardiac arrest (OHCA) is a major public health problem, with around 40,000 victims each year in France. Their survival rate remains dramatically low, at less than 10%.
- Conditions
- Heart Arrest, Out-Of-Hospital, CardioPulmonary Resuscitation, Basic Cardiac Life Support
- Trial name
- VECARS (NCT05992454)
- Testing
- EOLIFE
- Where
- France
- Volunteers
- 120 people
- Sponsor
- French Defence Health Service
Out-of-hospital Cardiac Arrest
Target Temperature Management After Cardiac Arrest
Experimental studies and previous clinical trials suggest an improvement in mortality and neurological function with hypothermia after cardiac arrest.
- Trial name
- TTM (NCT01020916)
- Testing
- Target temperature 36°C, Target Temperature 33°C
- Where
- 33 sites in Australia, Czechia and 8 more
- Volunteers
- 950 people
- Sponsor
- Niklas Nielsen
Out-of-hospital Cardiac Arrest
Application of Mechanical Cardiopulmonary Resuscitation Devices and Their Value in Out-of-hospital Cardiac Arrest: A Retrospective Analysis of the German Resuscitation Registry
The aim of this study was to analyse a large CPR database, the German Resuscitation Registry, to evaluate potential benefits of mechanical CPR devices over manual CPR in adult cardiac arrest victims.
- Trial name
- NCT02932124
- Testing
- mechanical chest compression device
- Volunteers
- 19,609 people
- Sponsor
- German Resuscitation Registry
Sudden Cardiac Arrest
LUCAS Chest Compressor Versus Manual Chest Compression in Out-of-hospital Sudden Cardiac Arrest. LUCAT Trial
The goal of this study is to show the superiority in survival at hospital admittance and in neurological outcome on hospital discharge of continuous mechanical chest compression using LUCAS device versus manual chest compressions…
- Trial name
- LUCAT (NCT01521208)
- Testing
- LUCAS (Lund University Cardiac Assist Sysrem), Manual chest compressions
- Where
- 2 sites in Spain
- Volunteers
- 400 people
- Sponsor
- Sistema d'Emergències Mèdiques
Cardiac Arrest (CA), Proteomics
Proteomic Analysis of Serum Samples After Cardiac Arrest: a TTM-trial Substudy
Cardiac arrest remains a large contributor to morbidity and mortality. Animal studies suggest an improvement in mortality and neurological function with hypothermia after cardiac arrest, a finding that could not be verified in…
- Trial name
- NCT07017374
- Testing
- Proteomic analysis, targeted temperature management
- Where
- Sweden
- Volunteers
- 682 people
- Sponsor
- Region Skane
Cardiac Arrest (CA)
The Variation in Electrode Configuration for Termination of Out-of-Hospital Rhythms That Are Shockable in Cardiac Arrest Trial
The purpose of this study is to compare the effectiveness of two defibrillator pad placements, one where pads are placed on the front of the chest and back (anterior-posterior [AP]) and one where the pads are placed on the front…
- Trial name
- VECTORS (NCT07818785)
- Testing
- defibrillator electrode pads
- Volunteers
- 1,500 people
- Sponsor
- Oregon Health and Science University
Out-Of-Hospital Cardiac Arrest
AMSA and Amiodarone Study in Cardiac Arrest
Investigators' aim is to assess whether the administration of amiodarone during resuscitation could cause a reduction of the values of the amplitude spectral area (AMSA).
- Trial name
- MOSAIC (NCT04997980)
- Testing
- Amiodarone Injection
- Where
- 4 sites in Italy, Norway and 1 more
- Volunteers
- 629 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Out-Of-Hospital Cardiac Arrest, Emotional Distress
Does Bystanders Emotional State Influence Dispatcher-assisted Cardiopulmonary?Resuscitation
The study aims to investigate bystanders' emotional stress state in out-of-hospital cardiac arrest (OHCA) emergency calls and the association with the quality of dispatcher-assisted cardiopulmonary resuscitation (DA-CPR).
- Trial name
- NCT05113706
- Where
- Denmark
- Volunteers
- 1,100 people
- Sponsor
- Emergency Medical Services, Capital Region, Denmark
Acute Kidney Failure, Renal Replacement Therapy for Acute Kidney Injury in ICU
Effects of Sedation, TEmperature and Pressure After Cardiac Arrest and REsuscitation on Major Adverse Kidney Events (STEPCARE-MAKE)
The STEPCARE-MAKE study is a predefined sub-study of the large Sedation, TEmperature and Pressure after Cardiac Arrest and REsuscitation (STEPCARE) trial, which evaluates the effects of three interventions in comatose adult…
- Conditions
- Acute Kidney Failure, Renal Replacement Therapy for Acute Kidney Injury in ICU, Sedation in Intensive Care Unit Patients, Sedation in the ICU
- Trial name
- STEPCARE-MAKE (NCT07579390)
- Testing
- Feedback-controlled temperature device, High MAP, Deep sedation
- Where
- 52 sites in Australia, Belgium and 12 more
- Volunteers
- 3,500 people
- Sponsor
- Helsinki University Central Hospital
Out-Of-Hospital Cardiac Arrest
Machine Learning Assisted Recognition of Out-of-Hospital Cardiac Arrest During Emergency Calls.
Emergency medical Services Copenhagen has developed a machine learning model that analyzes the calls to 1-1-2 (9-1-1) in real time. The model are able to recognize calls where a cardiac arrest is suspected.
- Trial name
- NCT04219306
- Testing
- Alert on dispatchers screen 'Suspect cardiac arrest'
- Where
- Denmark
- Volunteers
- 5,242 people
- Sponsor
- Emergency Medical Services, Capital Region, Denmark
Out-Of-Hospital Cardiac Arrest
Targeted Therapeutic Mild Hypercapnia After Resuscitated Cardiac Arrest
The TAME Cardiac Arrest trial will study the ability of higher arterial carbon dioxide (PaCO2) levels to reduce brain damage, comparing giving patients 'normal' to 'slightly higher than normal' blood PaCO2 levels and assessing…
- Trial name
- TAME (NCT03114033)
- Testing
- Targeted therapeutic mild hypercapnia, Targeted normocapnia (Standard care)
- Where
- 52 sites in Australia, Belgium and 12 more
- Volunteers
- 1,700 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Out-Of-Hospital Cardiac Arrest
iGOGO -Assessment of CPR Skill,Willingness and Public AED in Layperson:A Cohort Study
Out-of-hospital cardiac arrest (OHCA) is an important public health issue. Chang Gung Memorial Hospital, a university affiliated medical center in Taoyuan city, northern Taiwan, actively cooperated with government policy with 250…
- Trial name
- NCT05659108
- Testing
- CPR
- Where
- Taiwan
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Cardiac Arrest, Out-Of-Hospital, Ventricular Fibrillation
Utility and Procedural Feasibility of REBOA Operationalized for Non-Trauma Application (UP-FRONT)
Single center randomized-controlled trial in out-of-hospital cardiac arrest (OHCA) patients. This study will investigate the feasibility and utility of the Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA)…
- Conditions
- Cardiac Arrest, Out-Of-Hospital, Ventricular Fibrillation, Ventricular Tachycardia
- Trial name
- UP-FRONT (NCT05236920)
- Testing
- Resuscitative Endovascular balloon occlusion of the aorta using a REBOA catheter device
- Sponsor
- University of Alabama at Birmingham
Cardiac Arrest
Pre-shock Cardiopulmonary Resuscitation to Patients With Out-of-hospital Resuscitation, A Randomised Clinical Trial
1. Pre-shock cardiopulmonary resuscitation might benefit the survival of out-of-hospital cardiac patients with ventricular fibrillation / ventricular tachycardia in a post-hoc analysis of a prehospital trial conducted in Europe…
- Trial name
- CPR (NCT00650962)
- Testing
- cardiopulmonary resuscitation, Rhythm analysis
- Where
- Taiwan
- Volunteers
- 1,666 people
- Sponsor
- National Taiwan University Hospital
Cardiopulmonary Resuscitation, Cardiac Arrest
Cardiac Arrest Bundle of cARE Trial
An out-of-hospital cardiac arrest is a sudden event where the heart stops beating and a person becomes unresponsive. During this event, vital organs in the body receive no blood flow, causing them to shut down.
- Conditions
- Cardiopulmonary Resuscitation, Cardiac Arrest, Out of Hospital Cardiac Arrest
- Trial name
- CABARET (NCT05917717)
- Testing
- Neuroprotective 'bundle of care'
- Where
- United Kingdom
- Volunteers
- 32 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Cardiac Arrest
REBOA for Out-of-hospital Cardiac Arrest
Cardiac arrest is a major health problem that carries a high mortality rate. Substantial research and development have been put into changing the outcome of cardiac arrest and despite the advent of automated external…
- Trial name
- NCT04491903
- Testing
- REBOA
- Sponsor
- neurescue
Cardiac Arrest, Out-Of-Hospital, Ventricular Fibrillation
Ventricular Fibrillation Following Out-of-hospital Cardiac Arrest
The majority of survivors suffering an out-of-hospital cardiac arrest (OHCA) are those who initially present with a shockable rhythm, which is usually ventricular fibrillation (VF).
- Trial name
- NCT05325385
- Testing
- There are no interventions - this is a database study only
- Where
- United Kingdom
- Volunteers
- 15,000 people
- Sponsor
- University Hospital Southampton NHS Foundation Trust
Cardiac Arrest, Out-Of-Hospital, Ketamine
The Application of Ketamine for Sedation in Patients With Cardiac Arrest - - KetCat (KETamine in Cardiac ArresT) Study
Recent evidence suggests ketamine may attenuate harmful cellular cascades taking place after brain injury that result in permanent damage.
- Conditions
- Cardiac Arrest, Out-Of-Hospital, Ketamine, Neurologic Manifestations
- Trial name
- KetCat (NCT04360070)
- Testing
- Ketamine Hydrochloride
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- Fraser Health
Out-of-hospital Cardiac Arrest
Induction of Mild Hypothermia Following Out-of-hospital Cardiac Arrest
The overall goal of this study is to determine whether initiating hypothermia in cardiac arrest patients as soon as possible in the field results in a greater proportion of patients who survive to hospital discharge compared to…
- Trial name
- NCT00391469
- Testing
- Rapid infusion of 2 liters of 4oC normal saline, Rapid infusion of cold normal saline
- Where
- United States
- Volunteers
- 1,359 people
- Sponsor
- University of Washington